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11. 发明申请

US20120225793A1 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS 审中-公开
标题翻译：鉴别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US20120225793A1
公开(公告)日：2012-09-06
申请号：US13409416
申请日：2012-03-01
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C40B30/04
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

12. 发明授权

US08131475B2 Methods for identifying, diagnosing, and predicting survival of lymphomas 有权
标题翻译：识别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US08131475B2
公开(公告)日：2012-03-06
申请号：US11493387
申请日：2006-07-25
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

13. 发明申请

US20110230834A1 SYSTEMS AND METHODS ALLOWING FOR RESERVOIR AIR BUBBLE MANAGEMENT 有权
标题翻译：用于储存空气泡沫管理的系统和方法
公开(公告)号：US20110230834A1
公开(公告)日：2011-09-22
申请号：US13118358
申请日：2011-05-27
申请人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
发明人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
IPC分类号： A61M5/142 , B23P17/00 , A61M5/14
CPC分类号： A61M5/36 , A61J1/201 , A61J1/2075 , A61J1/2096 , A61M5/1413 , A61M5/14248 , A61M5/165 , A61M5/38 , A61M2005/14268 , A61M2005/341 , A61M2209/045 , Y10T29/494
摘要： Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.
摘要翻译：本发明的各种实施方案涉及限制储存器中流体介质中气泡的存在。空气通道可允许空气从储存器中的流体介质中逸出。在流体介质进入储存器之前，膜可以允许在流体介质中捕获气泡。膜可以允许空气从包含流体介质的第一储存器流动到第二储存器，而每个储存器内的柱塞头在储存器内移动。具有膜的内部储存器可以在外部储存器内移动以允许空气从外部储存器移动到内部储存器。含有加压气体的内部容器可允许将流体介质转移到外部储存器。

14. 发明授权

US07959715B2 Systems and methods allowing for reservoir air bubble management 有权
标题翻译：允许储层气泡管理的系统和方法
公开(公告)号：US07959715B2
公开(公告)日：2011-06-14
申请号：US12111815
申请日：2008-04-29
申请人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
发明人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
IPC分类号： B01D53/22 , B01D19/00
CPC分类号： A61M5/36 , A61J1/201 , A61J1/2075 , A61J1/2096 , A61M5/1413 , A61M5/14248 , A61M5/165 , A61M5/38 , A61M2005/14268 , A61M2005/341 , A61M2209/045 , Y10T29/494
摘要： Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.
摘要翻译：本发明的各种实施方案涉及限制储存器中流体介质中气泡的存在。空气通道可允许空气从储存器中的流体介质中逸出。在流体介质进入储存器之前，膜可以允许在流体介质中捕获气泡。膜可以允许空气从包含流体介质的第一储存器流动到第二储存器，而每个储存器内的柱塞头在储存器内移动。具有膜的内部储存器可以在外部储存器内移动以允许空气从外部储存器移动到内部储存器。含有加压气体的内部容器可允许将流体介质转移到外部储存器。

15. 发明授权

US07772238B2 Benzothiophene hydroxamic acid derivatives 有权
标题翻译：苯并噻吩异羟肟酸衍生物
公开(公告)号：US07772238B2
公开(公告)日：2010-08-10
申请号：US11918912
申请日：2006-04-14
申请人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
发明人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
IPC分类号： A61K31/496 , A61K31/381 , C07D405/04 , C07D333/56
CPC分类号： C07D333/70 , A61K31/38 , A61K31/381 , A61K31/41
摘要： The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
摘要翻译：本发明涉及一类新型异羟肟酸衍生物。异羟肟酸化合物可用于治疗癌症。异羟肟酸化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经变性疾病本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。

16. 发明申请

US20100180786A1 INITIATION OF EXPLOSIVES MATERIALS 有权
标题翻译：爆炸物质的启动
公开(公告)号：US20100180786A1
公开(公告)日：2010-07-22
申请号：US12450137
申请日：2008-03-14
申请人： Richard John Goodridge , Rodney Wayne Appleby , David Olaf Johnson , Thomas Miller
发明人： Richard John Goodridge , Rodney Wayne Appleby , David Olaf Johnson , Thomas Miller
IPC分类号： F42B3/113
CPC分类号： F42D1/043 , F42B3/113
摘要： A detonator free blasting system, which comprises: a bulk explosive; a confined explosive; a fiber optic adapted to deliver laser light to the confined explosive, wherein the confined explosive is provided relative to the bulk explosive such that detonation of the confined explosive causes initiation of the bulk explosive.
摘要翻译：爆炸器自由爆破系统，包括：爆炸物; 限制爆炸物适用于向受限制的炸药传送激光的光纤，其中所述密封的爆炸物相对于大量爆炸物提供，使得限制的爆炸物的爆炸引起爆炸物的爆发。

17. 发明授权

US07715546B2 System and method for updating contact records 有权
标题翻译：用于更新联系人记录的系统和方法
公开(公告)号：US07715546B2
公开(公告)日：2010-05-11
申请号：US10776775
申请日：2004-02-09
申请人： Ezra U. Pagel , Daniel N. Duncan , Thomas Miller
发明人： Ezra U. Pagel , Daniel N. Duncan , Thomas Miller
IPC分类号： H04M3/00
CPC分类号： H04M3/5158
摘要： A system and method for updating contact records automates analysis of contact results for one or more contact devices performing a contact campaign in order to select contact records for skip trace updates to contact information with the updated contact information for real time use by the contact devices. For instance, an update engine analyzes contact records returned by dialers to a distribution module to select contact records to skip trace based on rules, such as where a wrong number code is indicated, or cost analysis, such as where the predicted result of an update has a value greater than the cost of obtaining the update. The distribution model provides the updated contact information for real time use by the dialers of the updated contact numbers.
摘要翻译：用于更新联系人记录的系统和方法自动分析执行联系人活动的一个或多个联系人设备的联系人结果，以便选择用于跳过跟踪更新的联系人记录以与所更新的联系人信息联系以供由联系人设备实时使用。例如，更新引擎将拨号器返回的联系人记录分析到分发模块，以选择联系人记录以基于规则跳过跟踪，例如指示错误的号码代码或成本分析，例如更新的预测结果具有大于获取更新的成本的值。分发模型提供更新的联系人信息，供拨号器更新联系电话号码的实时使用。

18. 发明授权

US07570157B2 Method and apparatus for adjusting the pressure sensor measurement range in a tire pressure monitoring system 有权
标题翻译：用于调整轮胎压力监测系统中的压力传感器测量范围的方法和装置
公开(公告)号：US07570157B2
公开(公告)日：2009-08-04
申请号：US11163586
申请日：2005-10-24
申请人： Thomas Miller , Thomas McQuade , Greg Swadling , Karl Wojcik
发明人： Thomas Miller , Thomas McQuade , Greg Swadling , Karl Wojcik
IPC分类号： B60C23/00 , G01F23/00
CPC分类号： B60C23/0408 , B60C23/0474
摘要： A tire pressure monitoring system (12) for a vehicle (10) has a pressure sensor circuit (16A) that includes an ECU (95), a transmitter/receiver (90), and pressure sensor (94). A method of operating a tire pressure monitoring system includes calibrating a tire pressure sensor circuit in a first range and a second range and generating a first calibration data for the first range and second calibration data for the second range. The first calibration data and the second calibration data are stored in a memory of the tire pressure sensing circuit (16A). A data signal corresponding to the pressure is generated. The first or second calibration data is generated in response to the range of the data signal to form a selected calibration. The data signal is calibrated with the selected calibration to form a pressure indicative signal. The pressure indicative signal is transmitted to a receiver (28) within the vehicle (10) with a range status corresponding to the selected calibration. A pressure signal is formed in response to the pressure indicative signal and the range status and the tire pressure monitoring system is operated with the pressure signal.
摘要翻译：一种用于车辆（10）的轮胎压力监测系统（12）具有包括ECU（95），发射器/接收器（90）和压力传感器（94）的压力传感器电路（16A）。一种操作轮胎压力监测系统的方法包括在第一范围和第二范围内校准轮胎压力传感器电路，并且产生用于第一范围的第一校准数据和用于第二范围的第二校准数据。第一校准数据和第二校准数据被存储在轮胎压力检测电路（16A）的存储器中。产生与压力对应的数据信号。响应于数据信号的范围产生第一或第二校准数据以形成选定的校准。数据信号用所选校准进行校准，以形成压力指示信号。压力指示信号以对应于所选择的校准的范围状态传送到车辆（10）内的接收器（28）。响应于压力指示信号形成压力信号，并且使用压力信号来操作范围状态和轮胎压力监测系统。

19. 发明申请

US20090090707A1 Combination Cooking Appliance Including Multiple Microwave Heating Units with Rotatable Antennae 有权
标题翻译：组合烹饪设备，包括多个可旋转天线的微波加热单元
公开(公告)号：US20090090707A1
公开(公告)日：2009-04-09
申请号：US12248657
申请日：2008-10-09
申请人： Robert McNamee , Thomas Miller
发明人： Robert McNamee , Thomas Miller
IPC分类号： H05B6/80
CPC分类号： H05B6/647 , H05B6/725
摘要： A microwave cooking appliance includes first and second side mounted microwave systems, each including an associated antenna. Drive structure is provided to establish an oscillating operation for each of the antennae, wherein the angles through which the antennae rotate are configured to assure that the cooking appliance operates in favorable mode patterns. In accordance with the invention, the antenna preferably only oscillates through less than or equal to 180° and, most preferably, approximately 150°.
摘要翻译：微波烹饪器具包括第一和第二侧面安装的微波系统，每个微波系统包括相关联的天线。提供驱动结构以建立每个天线的振荡操作，其中天线旋转的角度被配置为确保烹饪器具以有利的模式模式工作。根据本发明，天线优选地仅振荡小于或等于180°，最优选地大约为150°。

20. 发明申请

US20080125687A1 MEDICAL DEVICE 有权
标题翻译：医疗装置
公开(公告)号：US20080125687A1
公开(公告)日：2008-05-29
申请号：US11930541
申请日：2007-10-31
申请人： A. Bartholomew Flick , Gregg Silver , Thomas Miller
发明人： A. Bartholomew Flick , Gregg Silver , Thomas Miller
IPC分类号： A61F13/00
CPC分类号： A61F13/00063 , A61F13/022 , A61F13/36 , A61F2013/00119 , A61F2013/00251 , A61F2013/00327 , A61F2013/00553 , A61F2013/00578 , A61F2013/00604 , A61F2013/0074 , A61F2013/00859 , A61F2013/0091 , A61F2013/00936
摘要： A medical device for example a wound dressing having antibacterial and optionally, antifungal properties, are provided together with methods for making the device. An exemplary dressing includes a layer of silver-containing fabric, (optionally) a layer of absorbent material, and (optionally) a layer of flexible air-permeable and/or water-impermeable material. The dressing can be used for prophylactic and therapeutic care and treatment of skin infections and surface wounds (including surgical incisions), as a packing material, and as a swab for surface cleaning.
摘要翻译：提供具有抗细菌和任选的抗真菌性质的伤口敷料的医疗装置与制造该装置的方法一起提供。示例性敷料包括一层含银织物（任选地）一层吸收材料，和（任选地）一层柔性透气和/或不透水材料。敷料可用于预防和治疗护理和治疗皮肤感染和表面伤口（包括手术切口），作为包装材料，以及用于表面清洁的拭子。

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