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11. 发明申请

US20070217997A1 Metalloproteinase binding proteins 有权
标题翻译：金属蛋白酶结合蛋白
公开(公告)号：US20070217997A1
公开(公告)日：2007-09-20
申请号：US11648423
申请日：2006-12-29
申请人： Laetitia Devy , Henk Pieters , Robert Ladner , Rene Hoet , Daniel Dransfield , Clive Wood
发明人： Laetitia Devy , Henk Pieters , Robert Ladner , Rene Hoet , Daniel Dransfield , Clive Wood
IPC分类号： A61K51/00 , G01N33/574 , A61K39/395 , C07K16/30
CPC分类号： C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要： Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译：描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。

12. 发明申请

US20060111296A1 Plasmin-inhibitory therapies 审中-公开
标题翻译：纤溶酶抑制疗法
公开(公告)号：US20060111296A1
公开(公告)日：2006-05-25
申请号：US11287121
申请日：2005-11-22
申请人： Laetitia Devy , Arthur Ley , Robert Ladner
发明人： Laetitia Devy , Arthur Ley , Robert Ladner
IPC分类号： A61K38/38
CPC分类号： A61K38/57 , A61K38/38
摘要： The disclosure features a method of treating cancers, angiogenesis-related disorders and lymphangiogenesis-related disorders with plasmin inhibitors. An exemplary method includes: administering, to a subject, a plasmin inhibitor, such as a protein that includes a Kunitz domain that inhibits plasmin.
摘要翻译：该公开内容特征在于用纤溶酶抑制剂治疗癌症，血管发生相关疾病和淋巴管生成相关疾病的方法。一种示例性方法包括：向受试者施用纤溶酶抑制剂，例如包含抑制纤溶酶的Kunitz结构域的蛋白质。

13. 发明申请

US20050222023A1 Albumin-fused kunitz domain peptides 审中-公开
标题翻译：白蛋白融合kunitz结构域肽
公开(公告)号：US20050222023A1
公开(公告)日：2005-10-06
申请号：US10503834
申请日：2003-02-07
申请人： Hans-Peter Hauser , Thomas Weimer , Val Romberg , Scott Kee , Darrell Sleep , Robert Ladner , Arthur Ley
发明人： Hans-Peter Hauser , Thomas Weimer , Val Romberg , Scott Kee , Darrell Sleep , Robert Ladner , Arthur Ley
IPC分类号： C07K14/675 , C12N15/62
CPC分类号： C12N15/62 , C07K2319/31
摘要： The invention relates to proteins comprising serine protease inhibiting peptides, such as Kunitz domain peptides (including, but not limited to, fragments and variants thereof) fused to albumin, or fragments or variants thereof. These fusion proteins are herein collectively referred to as “albumin fusion proteins of the invention.” These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The invention encompasses, therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for inhibiting neutrophil elastase, kallikrein, and plasmin. The invention further relates to compositions and methods for treating cystic fibrosis and cancer.
摘要翻译：本发明涉及包含丝氨酸蛋白酶抑制肽的蛋白质，例如与白蛋白或其片段或变体融合的Kunitz结构域肽（包括但不限于其片段和变体）。这些融合蛋白在本文中统称为“本发明的白蛋白融合蛋白”。这些融合蛋白在溶液中表现出延长的保质期和/或延长或治疗活性。本发明包括治疗性白蛋白融合蛋白，组合物，药物组合物，制剂和试剂盒。本发明还包括编码本发明的白蛋白融合蛋白的核酸分子以及含有这些核酸的载体，用这些核酸和载体转化的宿主细胞，以及使用这些核酸制备本发明的白蛋白融合蛋白的方法，载体和/或宿主细胞。本发明还涉及抑制嗜中性粒细胞弹性蛋白酶，激肽释放酶和纤溶酶的组合物和方法。本发明还涉及治疗囊性纤维化和癌症的组合物和方法。

14. 发明申请

US20050201934A1 Binding peptides for carcinoembryonic antigen (CEA) 有权
公开(公告)号：US20050201934A1
公开(公告)日：2005-09-15
申请号：US11045477
申请日：2005-01-26
申请人： Isaac Rondon , Robert Ladner
发明人： Isaac Rondon , Robert Ladner
IPC分类号： C12N7/00 , A61K45/00 , A61K47/02 , A61K47/42 , A61K47/48 , A61K51/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/705 , C40B40/02 , C40B50/06 , G01N33/574
CPC分类号： C07K7/06 , C07K7/08 , C07K14/705
摘要： The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens such as NCA, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding CEA, which is overexpressed in adenocarcinomas of endodermally derived digestive system epithelia and fetal colon. Such polypeptides and disclosed derivatives are useful, e.g., as imaging agents for CEA-expressing tumors.

15. 发明申请

US20090162835A9 Novel methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries 有权
标题翻译：构建文库的新方法，其包括肽，多肽或蛋白质不同家族的显示和/或表达成员以及新文库
公开(公告)号：US20090162835A9
公开(公告)日：2009-06-25
申请号：US10045674
申请日：2001-10-25
申请人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet , Hendricus Mattheus Hoogenboom
发明人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet , Hendricus Mattheus Hoogenboom
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K16/005 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/622 , C12N15/10 , C12N15/1037 , C12N15/1093 , C12N15/66 , C40B40/02 , C40B40/08
摘要： Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
摘要翻译：用于构建共同显示和/或表达肽，多肽或蛋白质不同家族成员的文库的方法和使用这些方法产生的文库。筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

16. 发明申请

US20050250700A1 KDR and VEGF/KDR binding peptides 审中-公开
标题翻译： KDR和VEGF / KDR结合肽
公开(公告)号：US20050250700A1
公开(公告)日：2005-11-10
申请号：US10939890
申请日：2004-09-13
申请人： Aaron Sato , Daniel Sexton , Daniel Dransfield , Robert Ladner , Christophe Arbogast , Phillipe Bussat , Hong Fan , Sudha Khurana , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski
发明人： Aaron Sato , Daniel Sexton , Daniel Dransfield , Robert Ladner , Christophe Arbogast , Phillipe Bussat , Hong Fan , Sudha Khurana , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski
IPC分类号： A61K38/00 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/00 , G01N33/574 , G01N33/68
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/001 , G01N33/574 , G01N33/6872 , G01N2333/515 , G01N2500/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides, inter alia, peptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译：本发明尤其提供了包含至少一个KDR或VEGF / KDR复合物结合部分的肽，肽二聚体和多聚体复合物，其在治疗，检测，分离或定位血管发生的任何地方都具有多种用途。特别公开的是能够以高亲和力结合KDR或VEGF / KDR复合物的合成的分离的多肽（例如，具有K SUB D <1μM），以及包含这些多肽的二聚体和多聚体构建体。

17. 发明申请

US20050164928A1 Kallikrein-inhibitor therapies 有权
标题翻译：激肽释放酶抑制剂治疗
公开(公告)号：US20050164928A1
公开(公告)日：2005-07-28
申请号：US10953902
申请日：2004-09-27
申请人： Robert Ladner , Arthur Ley , Shirish Hirani , Anthony Williams , Maria De Simoni , Luigi Bergamaschini
发明人： Robert Ladner , Arthur Ley , Shirish Hirani , Anthony Williams , Maria De Simoni , Luigi Bergamaschini
IPC分类号： A61K38/17 , A61K38/54 , C07K14/47
CPC分类号： A61K38/57
摘要： Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
摘要翻译：描述了用于预防或减少患者中局部缺血，例如脑缺血和/或再灌注损伤（例如与脑缺血相关的再灌注损伤）的方法。

18. 发明申请

US20050089515A1 Poly-pegylated protease inhibitors 审中-公开
标题翻译：聚聚乙二醇化蛋白酶抑制剂
公开(公告)号：US20050089515A1
公开(公告)日：2005-04-28
申请号：US10931153
申请日：2004-08-30
申请人： Arthur Ley , Aaron Sato , Robert Ladner , Mark Stochl
发明人： Arthur Ley , Aaron Sato , Robert Ladner , Mark Stochl
IPC分类号： A61K38/43 , C07F20060101 , C12N9/99 , C12N15/09
摘要： Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
摘要翻译：公开的化合物包括：（i）Kunitz结构域多肽，其包含结合并抑制蛋白酶的Kunitz结构域; 和（ii）连接到Kunitz结构域多肽的多个聚乙二醇部分。 Kunitz结构域多肽的每个可接触的伯胺可以连接到其中一个部分。还公开了相关方法。

19. 发明申请

US20070049522A1 KALLIKREIN-INHIBITOR THERAPIES 有权
标题翻译： KALLIKREIN-INHIBITOR治疗
公开(公告)号：US20070049522A1
公开(公告)日：2007-03-01
申请号：US11466979
申请日：2006-08-24
申请人： Robert Ladner , Arthur Ley , Shirish Hirani , Anthony Williams , Maria De Simoni , Luigi Bergamaschini
发明人： Robert Ladner , Arthur Ley , Shirish Hirani , Anthony Williams , Maria De Simoni , Luigi Bergamaschini
IPC分类号： A61K38/55
CPC分类号： A61K38/57
摘要： Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
摘要翻译：描述了用于预防或减少患者中局部缺血，例如脑缺血和/或再灌注损伤（例如与脑缺血相关的再灌注损伤）的方法。

20. 发明申请

US20070041959A1 POLY-PEGYLATED PROTEASE INHIBITORS 有权
标题翻译：聚乙二醇化蛋白酶抑制剂
公开(公告)号：US20070041959A1
公开(公告)日：2007-02-22
申请号：US11458773
申请日：2006-07-20
申请人： Arthur Ley , Aaron Sato , Robert Ladner , Mark Stochl
发明人： Arthur Ley , Aaron Sato , Robert Ladner , Mark Stochl
IPC分类号： A61K38/54 , C12N9/99
CPC分类号： C07K14/8114 , A61K47/60 , A61K49/0002
摘要： Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
摘要翻译：公开的化合物包括：（i）Kunitz结构域多肽，其包含结合并抑制蛋白酶的Kunitz结构域; 和（ii）连接到Kunitz结构域多肽的多个聚乙二醇部分。 Kunitz结构域多肽的每个可接触的伯胺可以连接到其中一个部分。还公开了相关方法。

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