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    • 15. 发明申请
    • Medical device drug release regions containing non-covalently bound polymers
    • 包含非共价结合聚合物的医疗装置药物释放区域
    • US20060165753A1
    • 2006-07-27
    • US11042037
    • 2005-01-25
    • Robert Richard
    • Robert Richard
    • A61F2/28A61M31/00
    • A61L27/54A61L29/16A61L31/16A61L2300/00A61L2300/602
    • According to one aspect, implantable or insertable medical devices are provided, which contain polymeric release regions that release one or more therapeutic agents. The polymeric release regions, in turn, contain the following: (i) a first bonding polymer having a first polymer block and a first bonding group and (ii) a second bonding polymer having a second polymer block and a second bonding group. A therapeutic agent is disposed beneath or within the polymeric release region. The first and second polymer blocks can be the same as or different from one another, as can the first and second bonding groups. The first and second bonding groups are bound to one another via non-covalent bonding, for example, via electrostatic interaction, coordinative bonds, π-π stacking, or hydrogen bonding. According to another aspect, implantable or insertable medical devices are provided, which have a polymeric region that comprises (a) a first polymer having a first polymer block and a first bonding group and (b) a therapeutic agent having a bonding group that bonds to said first bonding group via non-covalent bonding at ambient temperature.
    • 根据一个方面,提供了可植入或可插入的医疗装置,其包含释放一种或多种治疗剂的聚合物释放区域。 聚合物释放区域又包含以下物质:(i)具有第一聚合物嵌段和第一键合基团的第一键合聚合物和(ii)具有第二聚合物嵌段和第二键合基团的第二键合聚合物。 治疗剂设置在聚合物释放区域的下方或内部。 第一和第二聚合物嵌段可以彼此相同或不同,第一和第二键合基团也可以相同或不同。 第一和第二键合基团通过非共价结合彼此结合,例如通过静电相互作用,配位键,π-π层叠或氢键结合。 根据另一方面,提供了可植入或可插入的医疗装置,其具有聚合物区域,所述聚合物区域包含(a)具有第一聚合物嵌段和第一键合基团的第一聚合物,和(b)具有键合基团 所述第一键合基团在环境温度下通过非共价键键合。