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11. 发明授权

US08278309B2 Synthetic mimetics of host defense and uses thereof 有权
标题翻译：宿主防御的合成模拟物及其用途
公开(公告)号：US08278309B2
公开(公告)日：2012-10-02
申请号：US12605584
申请日：2009-10-26
申请人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号： A01N43/54 , C07D239/02
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译：本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。

12. 发明申请

US20120202887A1 Facially Amphiphilic Polyaryl and Polyarylalkynyl Polymers and Oligomers and Uses Thereof 有权
标题翻译：两亲聚芳基和聚芳基炔基聚合物及其低聚物及其用途
公开(公告)号：US20120202887A1
公开(公告)日：2012-08-09
申请号：US13365840
申请日：2012-02-03
申请人： William F. DeGRADO , Dahui Liu , Gregory N. Tew , Michael L. Klein
发明人： William F. DeGRADO , Dahui Liu , Gregory N. Tew , Michael L. Klein
IPC分类号： A61K31/155 , A61P31/12 , A61P31/10 , A61P31/00 , A61P31/04
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78
摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。

13. 发明授权

US06677431B2 Design, preparation, and properties of antibacterial &bgr;-peptides 有权
标题翻译：抗菌β-肽的设计，制备和性质
公开(公告)号：US06677431B2
公开(公告)日：2004-01-13
申请号：US09732911
申请日：2000-12-11
申请人： William F. DeGrado , Yoshimoto Hamuro , Dahui Liu
发明人： William F. DeGrado , Yoshimoto Hamuro , Dahui Liu
IPC分类号： A61K3804
CPC分类号： C07C237/12 , A61K47/56 , A61K47/6903 , C07C271/22 , C07C2603/18
摘要： An antibacterial &bgr;-peptide having the following formula: wherein R1 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R2 is an amine-containing alkyl group having the formula —(CH2)mNH2, wherein m=1, 2, 3, 4, or 5, (CH2)xNHC═NHNH2 wherein x is 1, 2, 3, 4, or 5, a pyridyl, an alkylpryidyl, an amidine-substituted benzyl, a phenyl group, or a cyclic amidine; R3 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; X is —NH2, —OH, —NHR, or OR where R is alkyl, aryl or acyl groups either free or polymer-supported, a carboxamide, a substituted carboxamide, or a polymer; Y is H, an alkyl group, an acyl group, an acyl-terminated polymer, a sulphonamide, an ether, a urea, a urethane, or a polymer; and n is 2, 3, 4, 5, 6, or 7.
摘要翻译：具有下式的抗菌β-肽：其中R 1是H，包含1-4个碳原子的烷基，苯基，杂芳基或烷基 - 芳基; R 2是具有式 - （CH 2）m NH 2的含胺烷基其中m = 1,2,3,4或5，（CH 2）x NHC = NHNH 2其中x为1,2,3,4或5，吡啶基，烷基基团，脒取代的苄基，苯基或环状脒; R 3为H，包含1-4个碳原子的烷基，苯基，杂芳基或烷基 - 芳基; X为-NH 2，-OH，-NHR或OR，其中R为烷基，芳基或 Y是H，烷基，酰基，酰基封端的聚合物，磺酰胺，醚，脲，氨基甲酸酯，氨基甲酸酯，氨基甲酸酯，或聚合物; andn是2,3,4,5,6或7。

14. 发明授权

US08354556B2 Processes for preparing a polymeric compound 失效
公开(公告)号：US08354556B2
公开(公告)日：2013-01-15
申请号：US12908977
申请日：2010-10-21
申请人： Robert W. Kavash , Haizhong Tang , Carol Mulrooney , Dahui Liu
发明人： Robert W. Kavash , Haizhong Tang , Carol Mulrooney , Dahui Liu
IPC分类号： C07C233/65 , C07C229/44
CPC分类号： C07C231/12 , C07C231/02 , C07C231/10 , C07C231/14 , C07C235/12 , C07C237/34 , C07C271/22 , C07C271/52 , C07C237/44
摘要： The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.

15. 发明申请

US20110124664A1 Polycationic Compounds And Uses Thereof 有权
标题翻译：聚阳离子化合物及其用途
公开(公告)号：US20110124664A1
公开(公告)日：2011-05-26
申请号：US12971006
申请日：2010-12-17
申请人： Shaker Mousa , Dahui Liu
发明人： Shaker Mousa , Dahui Liu
IPC分类号： A61K31/167 , C07C323/42 , C07C323/63 , C07D403/12 , C07C243/38 , C07D239/28 , C07C69/736 , A61K31/24 , A61K31/4178 , A61K31/505 , A61P9/00 , A61P1/04 , A61P15/08 , A61P35/00 , A61P19/02 , A61P17/06 , A61P9/10
CPC分类号： C07C323/63 , A61K31/167 , C07C219/06 , C07C235/20 , C07C235/56 , C07C235/60 , C07C235/62 , C07C237/40 , C07C237/42 , C07C237/44 , C07C243/38 , C07C279/12 , C07C279/14 , C07C323/42 , C07C2601/14 , C07C2603/92 , C07D239/28
摘要： Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
摘要翻译：本发明的方面涉及可用于调节血管发生的化合物和方法以及通过施用聚阳离子化合物治疗或预防与血管生成相关的疾病的方法。本发明涉及包括动物和人在内的哺乳动物中用于抑制血管发生介导的疾病的使用方法和组合物。另外，本发明涉及聚阳离子与其它抗血管生成剂的组合使用，用于治疗不同的血管发生介导的病症。此外，这些聚阳离子化合物可以与各种抗炎和细胞毒剂以及癌症患者中的放射治疗剂一起使用以预防和治疗肿瘤生长和转移。

16. 发明申请

US20100298344A1 Polycationic Compounds And Uses Thereof 有权
标题翻译：聚阳离子化合物及其用途
公开(公告)号：US20100298344A1
公开(公告)日：2010-11-25
申请号：US12720734
申请日：2010-03-10
申请人： Shaker Mousa , Dahui Liu
发明人： Shaker Mousa , Dahui Liu
IPC分类号： A61K31/167 , C07C279/14 , A61K31/17 , C07C233/80 , C07C233/81 , C07D403/12 , A61K31/4178 , C07D239/28 , A61K31/505 , C07C243/38 , A61K31/166 , A61P9/00 , A61P35/00 , A61P29/00 , A61P27/02 , A61P19/02 , A61P1/00
CPC分类号： C07C323/63 , A61K31/167 , C07C219/06 , C07C235/20 , C07C235/56 , C07C235/60 , C07C235/62 , C07C237/40 , C07C237/42 , C07C237/44 , C07C243/38 , C07C279/12 , C07C279/14 , C07C323/42 , C07C2601/14 , C07C2603/92 , C07D239/28
摘要： Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
摘要翻译：本发明的方面涉及可用于调节血管发生的化合物和方法以及通过施用聚阳离子化合物治疗或预防与血管生成相关的疾病的方法。本发明涉及包括动物和人在内的哺乳动物中用于抑制血管发生介导的疾病的用途方法和组合物。另外，本发明涉及聚阳离子与其它抗血管生成剂的组合使用，用于治疗不同的血管发生介导的病症。此外，这些聚阳离子化合物可以与各种抗炎和细胞毒剂以及癌症患者中的放射治疗剂一起使用以预防和治疗肿瘤生长和转移。

17. 发明申请

US20100105703A1 Synthetic Mimetics Of Host Defense And Uses Thereof 有权
标题翻译：主机防御及其应用的合成模拟
公开(公告)号：US20100105703A1
公开(公告)日：2010-04-29
申请号：US12605584
申请日：2009-10-26
申请人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号： A61K31/506 , C07D403/14 , A61P31/04
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译：本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。

18. 发明申请

US20100081665A1 Anti-Malarial Compounds 有权
标题翻译：抗疟药
公开(公告)号：US20100081665A1
公开(公告)日：2010-04-01
申请号：US12510593
申请日：2009-07-28
申请人： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
发明人： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC分类号： A61K31/496 , C07C237/14 , A61K31/167 , C07D403/12 , A61K31/495 , C07D239/26 , A61P33/06
CPC分类号： C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
摘要： The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要翻译：本发明提供了三环化合物，芳酰胺化合物和其它化合物及其组合物，包含其的用于治疗疟疾的组合物，以及治疗疟疾的方法，包括向动物施用此类化合物。

19. 发明授权

US08975262B2 Synthetic mimetics of host defense and uses thereof 有权
标题翻译：宿主防御的合成模拟物及其用途
公开(公告)号：US08975262B2
公开(公告)日：2015-03-10
申请号：US13563928
申请日：2012-08-01
申请人： William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
发明人： William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
IPC分类号： C07D403/14
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译：本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。

20. 发明授权

US08716530B2 Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof 有权
标题翻译：表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
公开(公告)号：US08716530B2
公开(公告)日：2014-05-06
申请号：US13365840
申请日：2012-02-03
申请人： William F. DeGrado , Dahui Liu , Gregory N. Tew , Michael L. Klein
发明人： William F. DeGrado , Dahui Liu , Gregory N. Tew , Michael L. Klein
IPC分类号： C07C211/27 , C07C279/06 , C07C233/77 , A61K31/135 , A61K31/155 , A61K31/16 , A61K31/132
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78
摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。

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