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11. 发明授权

US10426752B2 Menthol-derivative compounds and use thereof as oral and systemic active agents 有权
公开(公告)号：US10426752B2
公开(公告)日：2019-10-01
申请号：US13258142
申请日：2009-04-01
申请人： Harsh M. Trivedi , Tao Xu , Davide Miksa , Cortney Worrell , Chanda Macias , Ying Yang , Yanan Hu
发明人： Harsh M. Trivedi , Tao Xu , Davide Miksa , Cortney Worrell , Chanda Macias , Ying Yang , Yanan Hu
IPC分类号： A61K31/33 , A61K31/265 , A61K8/37 , A61K8/41 , A61K8/42 , A61K31/27 , A61Q11/00
摘要： The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.

12. 发明授权

US08753820B2 Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention 有权
标题翻译：用于软组织疾病诊断的蛋白质生物标志物和用于口腔护理干预的治疗靶标
公开(公告)号：US08753820B2
公开(公告)日：2014-06-17
申请号：US13262038
申请日：2010-04-01
申请人： Harsh M. Trivedi , Tao Xu , Ying Yang
发明人： Harsh M. Trivedi , Tao Xu , Ying Yang
IPC分类号： C12Q1/68 , G01N33/52
CPC分类号： G01N33/56955 , G01N2333/96486 , G01N2800/60
摘要： Methods for identifying compounds useful for treating diseases or conditions of the oral cavity are described herein.
摘要翻译：本文描述了用于鉴定可用于治疗口腔疾病或病症的化合物的方法。

13. 发明授权

US08617523B2 Anti-biofilm carbonate compounds for use in oral care compositions 有权
标题翻译：用于口腔护理组合物的抗生物膜碳酸盐化合物
公开(公告)号：US08617523B2
公开(公告)日：2013-12-31
申请号：US13260920
申请日：2009-04-01
申请人： Harsh M. Trivedi , Tao Xu , Davide Miksa
发明人： Harsh M. Trivedi , Tao Xu , Davide Miksa
IPC分类号： A61K8/00
CPC分类号： A61K31/265 , A61K8/37 , A61Q11/00
摘要： The present invention includes oral care compositions and methods for inhibiting growth and formation of oral biofilms by quorum sensing inhibition and/or bactericidal activity. In some embodiments, the present invention discloses an oral care composition including a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient: wherein, R1 and R2 are independently: an aliphatic radical; a hydroxyaliphatic radical; or an aryl radical. In some embodiments, the present invention discloses a method of providing oral care benefits including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient. In some embodiments, the present invention discloses a method of up-regulating or down-regulating periodontal disease metabolites including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least on carbonate compound of Formula (1) and at least one excipient.
摘要翻译：本发明包括口腔护理组合物和通过群体感测抑制和/或杀菌活性抑制口腔生物膜生长和形成的方法。在一些实施方案中，本发明公开了一种口腔护理组合物，其包含治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂：其中，R 1和R 2独立地为：脂族基团; 羟基脂肪族基团; 或芳基。在一些实施方案中，本发明公开了一种提供口腔护理益处的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂的口腔护理组合物。在一些实施方案中，本发明公开了一种上调或降低牙周病代谢物的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物的口腔护理组合物，并且至少一种赋形剂

14. 发明授权

US08568695B2 Oral care composition with silicone composite 有权
标题翻译：有机硅复合材料的口腔护理组合物
公开(公告)号：US08568695B2
公开(公告)日：2013-10-29
申请号：US11739393
申请日：2007-04-24
申请人： Prithwiraj Maitra , Suman K. Chopra , Harsh M. Trivedi , Sayed Ibrahim , Tao Xu , Michael Prencipe
发明人： Prithwiraj Maitra , Suman K. Chopra , Harsh M. Trivedi , Sayed Ibrahim , Tao Xu , Michael Prencipe
IPC分类号： A61K8/89 , A61K8/11
CPC分类号： A61K8/891 , A61K8/0279 , A61K8/8147 , A61K2800/56 , A61Q11/00
摘要： A composite comprising a silicone compound sorbed onto a porous cross-linked polymer. This composition can be included in an oral care composition and inhibit bacterial adhesion on an oral surface.
摘要翻译：包含吸附在多孔交联聚合物上的硅氧烷化合物的复合材料。该组合物可以包含在口腔护理组合物中并且抑制口腔表面上的细菌粘附。

15. 发明申请

US20120020896A1 ANTI-BIOFILM CARBONATE COMPOUNDS FOR USE IN ORAL CARE COMPOSITIONS 有权
标题翻译：用于口腔护理组合物的抗生物素碳酸酯化合物
公开(公告)号：US20120020896A1
公开(公告)日：2012-01-26
申请号：US13260920
申请日：2009-04-01
申请人： Harsh M. Trivedi , Davide Miksa , Tao Xu
发明人： Harsh M. Trivedi , Davide Miksa , Tao Xu
IPC分类号： A61K8/37 , A61Q11/00
CPC分类号： A61K31/265 , A61K8/37 , A61Q11/00
摘要： The present invention includes oral care compositions and methods for inhibiting growth and formation of oral biofilms by quorum sensing inhibition and/or bactericidal activity. In some embodiments, the present invention discloses an oral care composition including a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient: wherein, R1 and R2 are independently: an aliphatic radical; a hydroxyaliphatic radical; or an aryl radical. In some embodiments, the present invention discloses a method of providing oral care benefits including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient. In some embodiments, the present invention discloses a method of up-regulating or down-regulating periodontal disease metabolites including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least on carbonate compound of Formula (1) and at least one excipient.
摘要翻译：本发明包括口腔护理组合物和通过群体感测抑制和/或杀菌活性抑制口腔生物膜生长和形成的方法。在一些实施方案中，本发明公开了一种口腔护理组合物，其包含治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂：其中，R 1和R 2独立地为：脂族基团; 羟基脂肪族基团; 或芳基。在一些实施方案中，本发明公开了一种提供口腔护理益处的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂的口腔护理组合物。在一些实施方案中，本发明公开了一种上调或降低牙周病代谢物的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物的口腔护理组合物，并且至少一种赋形剂

16. 发明申请

US20070253916A1 Oral Care Composition with Silicone Composite 有权
标题翻译：有机硅复合材料口腔护理组成
公开(公告)号：US20070253916A1
公开(公告)日：2007-11-01
申请号：US11739393
申请日：2007-04-24
申请人： Prithwiraj Maitra , Suman K. Chopra , Harsh M. Trivedi , Sayed Ibrahim , Tao Xu , Michael Prencipe
发明人： Prithwiraj Maitra , Suman K. Chopra , Harsh M. Trivedi , Sayed Ibrahim , Tao Xu , Michael Prencipe
IPC分类号： A61K8/89
CPC分类号： A61K8/891 , A61K8/0279 , A61K8/8147 , A61K2800/56 , A61Q11/00
摘要： A composite comprising a silicone compound sorbed onto a porous cross-linked polymer. This composition can be included in an oral care composition and inhibit bacterial adhesion on an oral surface.
摘要翻译：包含吸附在多孔交联聚合物上的硅氧烷化合物的复合材料。该组合物可以包含在口腔护理组合物中并且抑制口腔表面上的细菌粘附。

17. 发明授权

US09023323B2 Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces 有权
标题翻译：用于预防和减少细菌粘附到口腔表面的口服组合物
公开(公告)号：US09023323B2
公开(公告)日：2015-05-05
申请号：US11244663
申请日：2005-10-06
申请人： Harsh M. Trivedi , Tao Xu , Kimberlee Panaligan
发明人： Harsh M. Trivedi , Tao Xu , Kimberlee Panaligan
IPC分类号： A61K8/00 , A61K8/66 , A61K8/49 , A61Q11/00
CPC分类号： A61K8/66 , A61K8/4926 , A61Q11/00
摘要： The present invention encompasses an oral composition containing an anti-adhesion agent, preferably a cysteine protease and most preferably ficin. In another aspect, the cysteine protease is in combination with one or more ingredients, such as antibacterial agent and surfactant. The anti-adhesion agent mitigates interaction between a subject oral cavity and plaque-forming materials.
摘要翻译：本发明包括含有抗粘连剂，优选半胱氨酸蛋白酶，最优选蓖麻毒素的口腔组合物。另一方面，半胱氨酸蛋白酶与一种或多种成分如抗菌剂和表面活性剂组合。抗粘连剂可减轻受试者口腔与斑块形成材料之间的相互作用。

18. 发明授权

US08900644B2 Oral care compositions containing compounds from magnolia and hops extracts 有权
标题翻译：含有来自木兰和啤酒花提取物的化合物的口腔护理组合物
公开(公告)号：US08900644B2
公开(公告)日：2014-12-02
申请号：US11244693
申请日：2005-10-06
申请人： Harsh M. Trivedi , Tao Xu , Susan Herles
发明人： Harsh M. Trivedi , Tao Xu , Susan Herles
IPC分类号： A61K36/899 , A61Q11/00 , A61K8/34 , A61K8/35 , A61K8/97
CPC分类号： A61Q11/00 , A61K8/347 , A61K8/35 , A61K8/97
摘要： An efficacious antibacterial and anti-inflammatory oral composition is provided having an active ingredient combination comprising one or more active compounds from an extract of magnolia and an extract of hops. Preferably, the active compounds from magnolia extract comprise honokiol and magnolol, and the active compounds from hops extract comprise hexahydrogenated beta acids. The oral composition can be in the form of a mouth rinse or dentifrice, including toothpaste, gels, powders, confectionaries, lozenges, animal products, and the like. Methods of making and using the oral composition are also provided.
摘要翻译：提供了具有活性成分组合的有效的抗细菌和抗炎口腔组合物，其包含来自木兰提取物的一种或多种活性化合物和啤酒花提取物。优选地，来自木兰提取物的活性化合物包括和厚朴酚和厚朴酚，并且来自啤酒花提取物的活性化合物包含六氢化的β-酸。口腔组合物可以是口腔冲洗剂或洁齿剂的形式，包括牙膏，凝胶，粉末，糖果，锭剂，动物产品等。还提供了制备和使用口腔组合物的方法。

19. 发明授权

US08895084B2 Oral care composition containing extract of unoxidized Camellia 有权
标题翻译：含有未氧化山茶提取物的口腔护理组合物
公开(公告)号：US08895084B2
公开(公告)日：2014-11-25
申请号：US11256860
申请日：2005-10-24
申请人： Cortney L. Worrell , Harsh M. Trivedi , Kimberlee Panaligan , Tao Xu
发明人： Cortney L. Worrell , Harsh M. Trivedi , Kimberlee Panaligan , Tao Xu
IPC分类号： A61K8/02 , A61K36/82 , A61K31/075 , A61Q11/00 , A61K8/97 , A61K8/49
CPC分类号： A61Q11/00 , A61K8/498 , A61K8/97
摘要： An oral composition for at least one or treating and inhibiting an oral inflammatory condition comprising: a Camellia extract including at least about 30% epigallocatechin gallate, at least about 50% total catechins, and at least about 60% total polyphenols; and a substantially water insoluble non-cationic anti-bacterial agent.
摘要翻译：一种用于至少一种或治疗和抑制口腔炎性病症的口腔组合物，包括：山茶提取物，其包含至少约30％的表没食子儿茶素没食子酸酯，至少约50％的总儿茶素和至少约60％的总多酚; 和基本上不溶于水的非阳离子抗菌剂。

20. 发明授权

US08894977B2 Oral treatment compositions containing an anti-adhesion agent, antibacterial agent and incompatible compound 有权
标题翻译：含有抗粘连剂，抗菌剂和不相容化合物的口腔治疗组合物
公开(公告)号：US08894977B2
公开(公告)日：2014-11-25
申请号：US11239490
申请日：2005-09-29
申请人： Harsh M. Trivedi , Tao Xu , Ramachandra Shastry , James Masters , André Michelle Morgan
发明人： Harsh M. Trivedi , Tao Xu , Ramachandra Shastry , James Masters , André Michelle Morgan
IPC分类号： A61K8/66 , A61Q11/00 , A61K38/48 , A61K45/06 , A61K31/14 , A61K45/00
CPC分类号： A61K31/14 , A61K38/4873 , A61K45/00 , A61K45/06 , C12Y304/22002 , A61K2300/00
摘要： The present invention encompasses an oral treatment composition containing an anti-adhesion agent, preferably a cysteine protease and most preferably ficin. In another aspect, the cysteine protease is in combination with one or more ingredients, such as antibacterial agent and surfactant. The anti-adhesion agent mitigates interaction between a subject oral cavity and plaque-forming materials.
摘要翻译：本发明包括含有抗粘连剂，优选半胱氨酸蛋白酶，最优选蓖麻毒素的口服治疗组合物。另一方面，半胱氨酸蛋白酶与一种或多种成分如抗菌剂和表面活性剂组合。抗粘连剂可减轻受试者口腔与斑块形成材料之间的相互作用。

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