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11. 发明申请

US20100260859A1 CONTROLLED-RELEASE CLOZAPINE COMPOSITIONS 审中-公开
标题翻译：受控释放的CLOZAPINE组合物
公开(公告)号：US20100260859A1
公开(公告)日：2010-10-14
申请号：US12757024
申请日：2010-04-08
申请人： Stephen B. Ruddy , Simon L. McGurk , Rakesh Patel , John Bullock , Raj Kewalramani
发明人： Stephen B. Ruddy , Simon L. McGurk , Rakesh Patel , John Bullock , Raj Kewalramani
IPC分类号： A61K9/14 , A61K31/5513 , A61P25/18
CPC分类号： A61K9/5078 , A61K9/5047 , A61K31/167 , A61K31/185 , A61K31/403 , A61K31/436 , A61K31/551 , A61K31/5513 , A61K47/20 , Y02A50/402
摘要： A composition for delivery of a drug is disclosed. The composition has a semipermeable coating, particles of clozapine having an effective average particle size of less than or about 2 μm and at least one surface stabilizer adsorbed on the surface of the clozapine particles, and a solubilizing agent.
摘要翻译：公开了用于递送药物的组合物。该组合物具有半透性涂层，氯氮平颗粒具有小于或约2μm的有效平均粒度和至少一种吸附在氯氮平颗粒表面的表面稳定剂和增溶剂。

12. 发明申请

US20100260858A1 DRUG DELIVERY COMPOSITION 审中-公开
标题翻译：药物输送组合物
公开(公告)号：US20100260858A1
公开(公告)日：2010-10-14
申请号：US12757005
申请日：2010-04-08
申请人： Stephen B. Ruddy , Simon L. McGurk , Rakesh Patel , John Bullock , Raj Kewalramani
发明人： Stephen B. Ruddy , Simon L. McGurk , Rakesh Patel , John Bullock , Raj Kewalramani
IPC分类号： A61K9/14 , A61K38/43 , A61K31/5513 , A61K31/436 , A61K31/403 , A61K31/167 , A61P43/00
CPC分类号： A61K9/5078 , A61K9/5047 , A61K31/167 , A61K31/185 , A61K31/403 , A61K31/436 , A61K31/551 , A61K31/5513 , A61K47/20 , Y02A50/402
摘要： A composition for delivery of a drug is disclosed. The composition has a semipermeable coating, particles of a medicament having an effective average particle size of less than or about 2 μm and at least one surface stabilizer adsorbed on the surface of the medicament particles, and a solubilizing agent.
摘要翻译：公开了用于递送药物的组合物。该组合物具有半透性涂层，具有小于或约2μm的有效平均粒度的药物颗粒和吸附在药物颗粒表面上的至少一种表面稳定剂和增溶剂。

13. 发明授权

US5503723A Isolation of ultra small particles 失效
标题翻译：隔离超小颗粒
公开(公告)号：US5503723A
公开(公告)日：1996-04-02
申请号：US385531
申请日：1995-02-08
申请人： Stephen B. Ruddy , W. Mark Eickhoff
发明人： Stephen B. Ruddy , W. Mark Eickhoff
IPC分类号： A61K9/14 , B03C3/00 , G01N15/02 , B01D57/02
CPC分类号： A61K9/146 , B03C3/00 , G01N15/0266 , Y10S977/773 , Y10S977/901
摘要： The present invention is a method and apparatus for further reducing the size of nanoparticles. Nanoparticles are defined as having an effective average particle size of less than about 400 nm. The present invention separates the nanoparticles further using electric fields.
摘要翻译：本发明是进一步减小纳米颗粒尺寸的方法和装置。纳米颗粒被定义为具有小于约400nm的有效平均粒度。本发明使用电场进一步分离纳米颗粒。

14. 发明授权

US5492687A Compositions of iodophenoxy alkylene ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract 失效
标题翻译：碘苯氧基亚烷基醚的组合物和用于胃肠道可视化的药学上可接受的粘土
公开(公告)号：US5492687A
公开(公告)日：1996-02-20
申请号：US237502
申请日：1994-05-03
申请人： Stephen B. Ruddy , Gregory L. McIntire , Mary E. Roberts , Edward R. Bacon
发明人： Stephen B. Ruddy , Gregory L. McIntire , Mary E. Roberts , Edward R. Bacon
IPC分类号： A61K49/04 , C07C43/225
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0461 , C07C43/225
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译：公开了用于口服或逆行检查胃肠道的x射线造影剂组合物，其包含药学上可接受的载体中的碘苯氧基亚烷基醚和药学上可接受的粘土; 以及它们用于胃肠道诊断放射学的方法。

15. 发明授权

US06908626B2 Compositions having a combination of immediate release and controlled release characteristics 有权
标题翻译：具有立即释放和控制释放特征组合的组合物
公开(公告)号：US06908626B2
公开(公告)日：2005-06-21
申请号：US10268928
申请日：2002-10-11
申请人： Eugene R. Cooper , Stephen B. Ruddy
发明人： Eugene R. Cooper , Stephen B. Ruddy
IPC分类号： A61K9/16 , A61K9/12 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/50 , A61K9/51 , A61K9/64 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/24 , A61K9/46
CPC分类号： A61K9/5084 , A61K9/146
摘要： Disclosed are compositions exhibiting a combination of immediate release and controlled release characteristics. The compositions comprise at least one poorly soluble active ingredient having a nanoparticulate particle size, at least one surface stabilizer adsorbed onto the surface of the nanoparticulate active agent particles, and at least one active ingredient having a microparticulate particle size.
摘要翻译：公开了显示即时释放和控释特征组合的组合物。所述组合物包含至少一种具有纳米颗粒粒度的难溶性活性成分，至少一种吸附在纳米颗粒活性剂颗粒表面上的表面稳定剂和至少一种具有微粒尺寸的活性成分。

16. 发明授权

US5718919A Nanoparticles containing the R(-)enantiomer of ibuprofen 失效
标题翻译：含有布洛芬的R（ - ）对映异构体的纳米粒子
公开(公告)号：US5718919A
公开(公告)日：1998-02-17
申请号：US393648
申请日：1995-02-24
申请人： Stephen B. Ruddy , Mary E. Roberts
发明人： Stephen B. Ruddy , Mary E. Roberts
IPC分类号： A61K9/14 , A61K31/192 , A61K9/16
CPC分类号： A61K9/146 , A61K31/192 , Y10S977/775 , Y10S977/915
摘要： There is described a composition comprised of nanoparticles of a therapeutic agent having a surface modifier adsorbed on the surface thereof. The present composition is characterized in that the therapeutic agent is ibuprofen or fenoprofen which is substantially enriched in the R(-) enantiomer.
摘要翻译：描述了由表面改性剂吸收在其表面上的具有治疗剂的纳米颗粒组成的组合物。本发明的组合物的特征在于治疗剂是基本上富含R（ - ）对映异构体的布洛芬或非诺洛芬。

17. 发明授权

US5593657A Barium salt formulations stabilized by non-ionic and anionic stabilizers 失效
标题翻译：由非离子和阴离子稳定剂稳定的钡盐制剂
公开(公告)号：US5593657A
公开(公告)日：1997-01-14
申请号：US386027
申请日：1995-02-09
申请人： Stephen B. Ruddy , W. Mark Eickhoff , Gary Liversidge , Mary E. Roberts
发明人： Stephen B. Ruddy , W. Mark Eickhoff , Gary Liversidge , Mary E. Roberts
IPC分类号： A61K49/04
CPC分类号： A61K49/0404 , Y10S514/941 , Y10S977/773 , Y10S977/927 , Y10S977/928
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising nanoparticles of a barium salt having associated with its surface non-ionic and anionic stabilizers; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译：公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含与其表面非离子和阴离子稳定剂相关联的钡盐纳米颗粒; 以及它们用于胃肠道诊断放射学的方法。

18. 发明授权

US5466440A Formulations of oral gastrointestinal diagnostic X-ray contrast agents in combination with pharmaceutically acceptable clays 失效
标题翻译：口服胃肠道诊断X射线造影剂与药学上可接受的粘土的配方
公开(公告)号：US5466440A
公开(公告)日：1995-11-14
申请号：US367407
申请日：1994-12-30
申请人： Stephen B. Ruddy , W. Mark Eickhoff , Gary Liversidge , Eugene R. Cooper
发明人： Stephen B. Ruddy , W. Mark Eickhoff , Gary Liversidge , Eugene R. Cooper
IPC分类号： A61K49/04
CPC分类号： B82Y5/00 , A61K49/0423 , A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Nanoparticulate crystalline substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline substances and the gastrointestinal tract. These formulations have improved safety profiles, a low potential for absorption, are not viscous and are not contraindicated for GI perforations or intestinal obstructions. The properties of the surfactant stabilizers are independent of the crystalline drug used and largely determine the extent to which the formulation coats the GI tract.
摘要翻译：用稳定剂和药学上可接受的粘土配制的纳米微晶状物质，以增强结晶物质与胃肠道之间的接触。这些制剂具有改善的安全性，吸收的低潜力不粘稠，并且不禁忌GI穿孔或肠梗阻。表面活性剂稳定剂的性质与使用的结晶药物无关，并且在很大程度上决定了制剂涂敷胃肠道的程度。

19. 发明授权

US08623412B2 Abuse-resistant pharmaceutical compositions 有权
标题翻译：滥用药物组合物
公开(公告)号：US08623412B2
公开(公告)日：2014-01-07
申请号：US10528727
申请日：2003-09-23
申请人： Vaghefi Farid , Gary G. Liversidge , Stephen B. Ruddy , Eugene R. Cooper
发明人： Vaghefi Farid , Gary G. Liversidge , Stephen B. Ruddy , Eugene R. Cooper
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50 , A61K9/44
CPC分类号： A61K9/16 , A61K9/1617 , A61K9/1652 , A61K9/1664 , A61K9/1694 , A61K9/4808 , A61K31/485 , A61K47/14 , A61K47/44
摘要： An abuse-resistant controlled release pharmaceutical composition comprising a pharmaceutically effective amount of discrete particles of an active capable of abuse, wherein surfaces of said particles are wetted with a water insoluble coating material, and preferably wherein said composition comprises a matrix, in which said particles are distributed, and which renders the abuse-capable compound within the matrix difficult to separate from the matrix; and a method for the preparation of a controlled release pharmaceutical composition having a reduced potential for abuse, comprising applying a pressure force to a mixture comprising a water insoluble material, and particles of a pharmaceutically active compound capable of inducing in a subject a reaction that is physiologically or psychologically detrimental if administered in an immediate release dosage form, thereby resulting in surface coated particles, and incorporating said surface coated particles into a pharmaceutical composition.
摘要翻译：一种抗滥用药物组合物，其包含药学有效量的能够滥用的活性成分的离散颗粒，其中所述颗粒的表面用水不溶性涂层材料润湿，并且优选地，其中所述组合物包含基质，其中所述颗粒分布，并使基质中的可滥用化合物难以与基质分离; 以及用于制备具有降低的滥用潜力的控释药物组合物的方法，包括对包含水不溶性材料的混合物施加压力，以及能够在受试者中诱导作用的反应的药物活性化合物的颗粒，生理或心理上有害，如果以立即释放剂型给药，从而导致表面包被的颗粒，并将所述表面包被的颗粒并入药物组合物中。

20. 发明授权

US07998507B2 Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors 有权
标题翻译：丝裂原活化蛋白（MAP）激酶抑制剂的纳米颗粒组成
公开(公告)号：US07998507B2
公开(公告)日：2011-08-16
申请号：US11275069
申请日：2005-12-07
申请人： H. William Bosch , Greta G. Cary , Douglas C. Hovey , Rajeev A. Jain , Laura J. Kline , Elaine Merisko-Liversidge , Kevin D. Ostrander , Niels P. Ryde , Stephen B. Ruddy
发明人： H. William Bosch , Greta G. Cary , Douglas C. Hovey , Rajeev A. Jain , Laura J. Kline , Elaine Merisko-Liversidge , Kevin D. Ostrander , Niels P. Ryde , Stephen B. Ruddy
IPC分类号： A61K9/14 , A61K9/00 , A61K31/66 , A61K31/385 , A61K31/522 , A61K31/525 , A61K31/557 , A61K36/82 , A61K36/328 , A61K36/886 , A61K38/17 , A61K48/00
CPC分类号： A61K38/1709 , A61K9/0075 , A61K9/146 , A61K9/2022 , A61K31/385 , A61K31/522 , A61K31/525 , A61K31/557 , A61K31/66
摘要： Nanoparticulate compositions comprising at least one poorly soluble MAP kinase inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译：描述了包含至少一种难溶性MAP激酶抑制剂和至少一种表面稳定剂的纳米颗粒组合物。纳米颗粒组合物具有小于约2000nm的平均粒度。本发明还描述了制备和使用这些组合物的方法。

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