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    • 11. 发明申请
    • H3LMN COMPOUND USED AS RADIOACTIVE AGENT FOR TREATMENT OF LIVER CANCER AND MANUFACTURING METHOD THEREOF
    • 用于治疗肝癌的放射性药物的H3LMN化合物及其制造方法
    • US20110065904A1
    • 2011-03-17
    • US12558911
    • 2009-09-14
    • Show-Wen LiuCheng-Hsien LinTsyh-Lang LinCheng-Fang Hsu
    • Show-Wen LiuCheng-Hsien LinTsyh-Lang LinCheng-Fang Hsu
    • C07F13/00C07C237/04C07C69/003
    • C07C323/41C07F13/005
    • H3LMN series compounds used as radioactive agents for treatment of liver cancer and a manufacturing method thereof are revealed. 2-thioethylamine hydrochloride is reacted with triphenylmethanol for protection of thiol to obtain 2-[(triphenylmethyl)thio]ethylamine. Then obtain N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide by a transamidation reaction between 2-[(triphenylmethyl)thio]ethylamine and chloroactyl chloride. Next produce a amine-amide-thiol ligand-N-[2-((triphenylmethyl)thio)ethyl][2-((triphenylmethyl)thio)ethylamino]acetamide by a substitution reaction of N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide and 2-[(triphenylmethyl)thio]ethylamine. After respective reaction with 1-bromotetradecane, 1-bromohexadecane and ethyl 16-bromohexadecanoate, H3LMN series compounds are obtained. These amine-amide-dithiols quadridentate ligands can react with MO3+ (M=Tc or Re) to produce electrically neutral complexes. The complexes have high lipophilicity, allowing them soluble in lipiodol to be applied to radiation therapy for liver cancer.
    • 揭示了用作肝癌治疗放射剂的H3LMN系列化合物及其制造方法。 将2-硫代乙胺盐酸盐与三苯基甲醇反应以保护硫醇,得到2 - [(三苯基甲基)硫代]乙胺。 然后通过2 - [(三苯基甲基)硫代]乙胺和氯代酰氯的酰胺化反应获得N- [2 - ((三苯基甲基)硫基)乙基]氯乙酰胺。 接着通过N- [2 - ((三苯基甲基)硫代)的取代反应生成胺 - 酰胺 - 硫醇配体-N- [2 - ((三苯基甲基)硫代)乙基] [2 - ((三苯基甲基)硫基)乙基氨基] )乙基]氯乙酰胺和2 - [(三苯甲基)硫基]乙胺。 在与1-溴十四烷,1-溴十六烷和16-溴十六烷酸乙酯反应后,得到H3LMN系列化合物。 这些胺 - 酰胺 - 二硫醇三元配体可以与MO3 +(M = Tc或Re)反应,产生电中性络合物。 复合物具有高亲脂性,使其可溶于碘油以适用于放射治疗肝癌。
    • 15. 发明授权
    • Printed circuit boards
    • 印刷电路板
    • US08049113B2
    • 2011-11-01
    • US12047152
    • 2008-03-12
    • Dong-Qing HeMing WangChih-Yi TuCheng-Hsien Lin
    • Dong-Qing HeMing WangChih-Yi TuCheng-Hsien Lin
    • H05K1/02
    • H05K1/025H05K1/111H05K2201/09727Y02P70/611
    • The present invention relates to a printed circuit board. In one embodiment, a printed circuit board includes a dielectric layer and a conductive trace formed on the dielectric layer. The conductive layer includes a first conductive portion, a connecting portion and a second conductive portion. The connecting portion includes a first end and a second end. The first end is connected to the first conductive portion; the second end is connected to the second conductive portion. A width of the connecting portion gradually decreases from the first end to the second end. Reflection and cross talk of signals transmitted in the presented printed circuit board can be reduced.
    • 印刷电路板技术领域本发明涉及印刷电路板。 在一个实施例中,印刷电路板包括介电层和形成在电介质层上的导电迹线。 导电层包括第一导电部分,连接部分和第二导电部分。 连接部分包括第一端和第二端。 第一端连接到第一导电部分; 第二端连接到第二导电部分。 连接部的宽度从第一端到第二端逐渐减小。 可以减少在所呈现的印刷电路板中传输的信号的反射和串扰。
    • 20. 发明申请
    • Folding bed with a spine-stretching function
    • 具有脊柱拉伸功能的折叠床
    • US20050043663A1
    • 2005-02-24
    • US10642792
    • 2003-08-18
    • Cheng-Hsien Lin
    • Cheng-Hsien Lin
    • A61F5/04A61F5/00
    • A61F5/04
    • A bed includes a front frame having a front mattress mounted thereon, a rear frame having a rear mattress mounted thereon, a stretching mechanism and a legrest device. The stretching mechanism includes two handles mounted in front of the front frame for a user's gripping. The handles are movable along a longitudinal direction of the bed. The legrest device is mounted to the rear frame and movable relative to the rear frame along the longitudinal direction of the bed. The legrest positions the feet of the user. A first elastic element is attached between the rear frame and the legrest device. When a stretching force provided by the stretching mechanism imparted to the legrest device is greater than a pulling stress of the first elastic element, the first elastic element is pulled and thus moves the legrest device along the longitudinal direction relative to the rear frame.
    • 床包括前框架,其上安装有前床垫,后框架,其上安装有后床垫,拉伸机构和支腿装置。 拉伸机构包括安装在前框架前面的两个把手,用于使用者的抓握。 把手可以沿床的纵向移动。 支架装置安装到后框架并且沿着床的纵向相对于后框架移动。 legrest定位用户的脚。 第一弹性元件安装在后框架和支架装置之间。 当由拉伸机构提供的拉伸力大于第一弹性元件的拉应力时,第一弹性元件被拉动,从而相对于后框架沿纵向方向移动支架装置。