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11. 发明授权

US07812025B2 Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder 失效
标题翻译：脑/神经元细胞保护剂和睡眠障碍治疗剂
公开(公告)号：US07812025B2
公开(公告)日：2010-10-12
申请号：US11990385
申请日：2006-08-11
申请人： Takahiro Matsumoto , Masakuni Kori , Mitsunori Kouno
发明人： Takahiro Matsumoto , Masakuni Kori , Mitsunori Kouno
IPC分类号： A61K31/501 , A61K31/497 , A61K31/44 , C07D237/02 , C07D401/06 , C07D403/06 , C07D413/06 , C07D241/06 , C07D401/02 , C07D213/02
CPC分类号： C07D213/75 , C07D237/20 , C07D261/14 , C07D333/20 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the formula (I) or a salt thereof; and an agent for protecting a brain/neuronal cell or a therapeutic agent for sleep disorder comprising the compound or salt: wherein Z represents an oxygen or sulfur; R1 represents an aryl or heterocyclic group which may be substituted, provided that R1 is not a 3-ethyl-6-methoxy-2-methyl-5-naphthalen-1-yl group; R1a represents a hydrogen atom, a hydrocarbon group which may be substituted, a hydroxyl group or the like; R2 represents a piperidin-1,4-diyl or piperazin-1,4-diyl which may be substituted; R3 represents a bivalent group which is formed by removing two hydrogen atoms from a benzene ring or 6-membered aromatic heterocyclic ring which may have a substituent, provided that R3 is not a pyridazin-3,6-diyl; and R4 represents a group which is formed by removing one hydrogen atom from a benzene ring or 5- to 6-membered heterocyclic ring which may be substituted, provided that the substituent on the heterocyclic ring is not a phenylethyl group which may be substituted when Z is sulfur.
摘要翻译：由式（I）表示的化合物或其盐; 以及用于保护脑/神经元细胞或用于睡眠障碍的治疗剂的药剂，其包含所述化合物或盐：其中Z表示氧或硫; R1表示可被取代的芳基或杂环基，条件是R 1不是3-乙基-6-甲氧基-2-甲基-5-萘-1-基; R 1a表示氢原子，可被取代的烃基，羟基等; R2代表可被取代的哌啶-1,4-二基或哌嗪-1,4-二基; R3表示通过从可以具有取代基的苯环或6元芳族杂环除去2个氢原子而形成的二价基团，条件是R 3不是哒嗪-3,6-二基; 并且R 4表示通过从可以被取代的苯环或5-至6-元杂环除去一个氢原子而形成的基团，条件是杂环上的取代基不是Z时可以被取代的苯基乙基是硫。

12. 发明授权

US07790189B2 Immunostimulating agents 有权
标题翻译：免疫刺激剂
公开(公告)号：US07790189B2
公开(公告)日：2010-09-07
申请号：US10557108
申请日：2004-05-13
申请人： Masami Mizu , Seiji Shinkai , Kazuo Sakurai , Kazuya Koumoto , Munenori Numata , Takahiro Matsumoto
发明人： Masami Mizu , Seiji Shinkai , Kazuo Sakurai , Kazuya Koumoto , Munenori Numata , Takahiro Matsumoto
IPC分类号： A61K45/00 , A61K38/16 , A61K31/70 , A61K31/715 , A01N43/04
CPC分类号： A61K9/0019 , A61K31/7125 , A61K47/36 , A61K2039/55561 , C08B37/0024
摘要： Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.
摘要翻译：公开了一种新型的免疫刺激剂，其包括与载体复合的免疫刺激寡核苷酸，其是安全的并且具有高的转染效果。与免疫刺激寡核苷酸复合以形成免疫刺激剂的载体是具有＆bgr; -1,3键的多糖（优选的是诸如分枝杆菌分子-1,3-β-葡聚糖）。免疫刺激寡核苷酸的优选实例是含有未甲基化CpG基序的寡核苷酸。所用的多糖优选用核酸结合官能团和/或细胞膜亲和官能团修饰。

13. 发明申请

US20090244513A1 POSITION DETECTION APPARATUS, POSITION DETECTION METHOD, EXPOSURE APPARATUS, AND DEVICE FABRICATION METHOD 有权
标题翻译：位置检测装置，位置检测方法，曝光装置和装置制造方法
公开(公告)号：US20090244513A1
公开(公告)日：2009-10-01
申请号：US12412295
申请日：2009-03-26
申请人： Takahiro Matsumoto , Koichi Sentoku , Satoru Oishi
发明人： Takahiro Matsumoto , Koichi Sentoku , Satoru Oishi
IPC分类号： G03B27/32 , G01B11/14
CPC分类号： G01B11/024 , G03B27/32 , G03F9/7046 , G03F9/7065 , G03F9/7088
摘要： The present invention provides a position detection apparatus including a first obtaining unit configured to obtain imaging characteristics of an imaging optical system for a plurality of light beams, having different wavelength with each other, of the light having the wavelength width, a second obtaining unit configured to obtain optical images of a target object for the plurality of light beams, a restoration unit configured to restore optical images of the target object for the plurality of light beams by correcting, deterioration in the obtained optical images of the target object attributed to the imaging optical system, based on the obtained imaging characteristics of the imaging optical system, and a generation unit configured to generate an optical image of the target object for light including the plurality of light beams by synthesizing the restored optical images of the target object for the plurality of light beams.
摘要翻译：本发明提供了一种位置检测装置，包括第一获取单元，被配置为获得具有波长宽度的光彼此具有不同波长的多个光束的成像光学系统的成像特性，第二获取单元配置以获得所述多个光束的目标物体的光学图像;恢复单元，被配置为通过校正所获得的所述目标对象的光学图像的劣化来恢复所述多个光束中的目标对象的光学图像光学系统，基于所获得的成像光学系统的成像特性，以及生成单元，被配置为通过合成复原的多个目标对象的光学图像来生成包括多个光束的光的目标对象的光学图像的光束。

14. 发明申请

US20090219499A1 SURFACE SHAPE MEASURING APPARATUS, EXPOSURE APPARATUS, AND DEVICE MANUFACTURING METHOD 失效
标题翻译：表面形状测量装置，曝光装置和装置制造方法
公开(公告)号：US20090219499A1
公开(公告)日：2009-09-03
申请号：US12393767
申请日：2009-02-26
申请人： Wataru Yamaguchi , Takahiro Matsumoto , Hideki Ina
发明人： Wataru Yamaguchi , Takahiro Matsumoto , Hideki Ina
IPC分类号： G01B9/02
CPC分类号： G01B11/2441 , G01B9/02063 , G01B9/02072 , G01B9/0209 , G01B11/0608 , G01B2290/70 , G03F9/7026 , G03F9/7049
摘要： A surface shape measuring apparatus includes an illumination system and a light receiving system. The illumination system splits wide-band light from a light source into measurement light and reference light, illuminates the measurement light to obliquely enter a surface of the film, and illuminates the reference light to obliquely enter a reference mirror. The light receiving system combines the measurement light reflected by the surface of the film and the reference light reflected by the reference mirror with each other and introduces the combined light to a photoelectric conversion element. An incident angle of the measurement light upon the surface of the film and an incident angle of the reference light upon the reference mirror are each larger than the Brewster's angle. S-polarized light and p-polarized light included in the measurement light entering a surface of the substrate have equal intensity on the photoelectric conversion element.
摘要翻译：表面形状测量装置包括照明系统和光接收系统。照明系统将来自光源的宽带光分解为测量光和参考光，照射测量光以倾斜地进入胶片的表面，并照亮参考光以倾斜地进入参考镜。光接收系统将由膜的表面反射的测量光与由参考反射镜反射的参考光相互组合，并将组合的光引入光电转换元件。在薄膜表面上的测量光的入射角和参考反射镜上的参考光的入射角均大于布鲁斯特角。入射到衬底表面的测量光中包括的S偏振光和p偏振光在光电转换元件上具有相等的强度。

15. 发明授权

US07582651B2 Pyrrolopyridine derivative and use thereof 失效
标题翻译：吡咯并吡啶衍生物及其用途
公开(公告)号：US07582651B2
公开(公告)日：2009-09-01
申请号：US10520784
申请日：2003-07-10
申请人： Takahiro Matsumoto , Osamu Kurasawa , Tsuneo Oda , Hiroshi Nagabukuro , Manabu Mochizuki
发明人： Takahiro Matsumoto , Osamu Kurasawa , Tsuneo Oda , Hiroshi Nagabukuro , Manabu Mochizuki
IPC分类号： A61K31/44 , C07D513/02
CPC分类号： C07D471/04
摘要： A novel pyrrolopyridine derivative which is a compound represented by the formula wherein Ring A represents an optionally substituted pyridine ring; X represents an electron-attracting group; Y represents an optionally substituted divalent C1-6 chain hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; and R2 and R3 each independently represents hydrogen, an optionally substituted hydrocarbon group or an optionally-substituted heterocyclic group, or R2 and R3 may form an optionally substituted ring in cooperation with the adjacent nitrogen atom, or a salt of the compound. The pyrrolopyridine derivative has vanilloid receptor agonist activity and is useful as medicines such as a preventive/therapeutic agent and analgesic for overactive bladder.
摘要翻译：一种新的吡咯并吡啶衍生物，其为下式表示的化合物：其中环A表示任选取代的吡啶环; X表示吸电子基团; Y表示任选取代的二价C 1-6链烃基; R1表示任选取代的烃基; 并且R 2和R 3各自独立地表示氢，任选取代的烃基或任选取代的杂环基，或者R 2和R 3可以与相邻的氮原子或化合物的盐协合形成任选取代的环。吡咯并吡啶衍生物具有香草素受体激动剂活性，并且可用作药物，例如预防/治疗剂和膀胱过度活动症的止痛剂。

16. 发明授权

US07528966B2 Position detection apparatus and exposure apparatus 失效
标题翻译：位置检测装置和曝光装置
公开(公告)号：US07528966B2
公开(公告)日：2009-05-05
申请号：US11965868
申请日：2007-12-28
申请人： Takahiro Matsumoto
发明人： Takahiro Matsumoto
IPC分类号： G01B11/14
CPC分类号： G03F9/7026
摘要： The position detection apparatus includes a light projecting optical system which has an optical axis, and which cause two light beams symmetrical about the optical axis to enter a substrate, a light receiving optical system which receives the two light beams which have emerged from the light projecting optical system and are reflected by the substrate, a light receiving unit which is arranged at a position shifted in the optical axis direction, a detection unit which respectively detects the positions of the two light beams which have entered the light receiving unit, and a calculator which calculates the surface position of the substrate in the normal direction based on the positions of the two light beams, which are detected by the detection unit. At least one of the light projecting optical system and the light receiving optical system is shared for the two light beams.
摘要翻译：位置检测装置包括具有光轴的光投射光学系统，其使得关于光轴对称的两个光束进入基板;受光光学系统，其接收从光投射的两个光束光学系统，并被基板反射，布置在沿光轴方向偏移的位置的光接收单元，分别检测已经进入光接收单元的两个光束的位置的检测单元和计算器其基于由检测单元检测到的两个光束的位置来计算基板在法线方向上的表面位置。光投射光学系统和光接收光学系统中的至少一个被共享用于两个光束。

17. 发明申请

US20080262210A1 Immunostimulating Agents 有权
标题翻译：免疫刺激剂
公开(公告)号：US20080262210A1
公开(公告)日：2008-10-23
申请号：US10557108
申请日：2004-05-13
申请人： Masami Mizu , Seiji Shinkai , Kazuo Sakurai , Kazuya Koumoto , Munenori Numata , Takahiro Matsumoto
发明人： Masami Mizu , Seiji Shinkai , Kazuo Sakurai , Kazuya Koumoto , Munenori Numata , Takahiro Matsumoto
IPC分类号： C07H21/00
CPC分类号： A61K9/0019 , A61K31/7125 , A61K47/36 , A61K2039/55561 , C08B37/0024
摘要： Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.
摘要翻译：公开了一种新型的免疫刺激剂，其包括与载体复合的免疫刺激寡核苷酸，其是安全的并且具有高的转染效果。与免疫刺激寡核苷酸复合以形成免疫刺激剂的载体是具有β-1,3-键的多糖（优选β-1,3-葡聚糖如分枝孢子菌素）。免疫刺激寡核苷酸的优选实例是含有未甲基化CpG基序的寡核苷酸。所用的多糖优选用核酸结合官能团和/或细胞膜亲和官能团修饰。

18. 发明申请

US20080151258A1 SHAPE MEASURING APPARATUS, SHAPE MEASURING METHOD, AND EXPOSURE APPARATUS 有权
标题翻译：形状测量装置，形状测量方法和曝光装置
公开(公告)号：US20080151258A1
公开(公告)日：2008-06-26
申请号：US11942348
申请日：2007-11-19
申请人： Takahiro Matsumoto , Ryo Sasaki
发明人： Takahiro Matsumoto , Ryo Sasaki
IPC分类号： G01B9/023
CPC分类号： G01B11/2441 , G03F9/7026 , G03F9/7034
摘要： A shape measuring method for measuring a surface shape of a measurement target includes dividing light from a light source into measurement light and reference light, the measurement light being obliquely incident upon a surface of the measurement target, the reference light being incident upon a reference mirror, introducing the measurement light reflected by the measurement target and the reference light reflected by the reference mirror to a photoelectric conversion element, detecting interference light formed by the measurement light and the reference light by the photoelectric conversion element while moving the measurement target, and measuring the surface shape of the measurement target based on an interference signal obtained from the measurement light that has been reflected at the same position on the surface of the measurement target.
摘要翻译：用于测量测量对象的表面形状的形状测量方法包括将来自光源的光分成测量光和参考光，测量光倾斜地入射到测量对象的表面上，参考光入射到参考反射镜将由测量对象反射的测量光和由参考反射镜反射的参考光引入光电转换元件，在移动测量目标的同时检测由光电转换元件测量的光和参考光形成的干涉光，并测量基于从已经在测量对象的表面上的相同位置反射的测量光获得的干涉信号来测量目标的表面形状。

19. 发明授权

US07382134B2 Superconducting magnet apparatus for MRI 失效
标题翻译： MRI超导磁体设备
公开(公告)号：US07382134B2
公开(公告)日：2008-06-03
申请号：US11305010
申请日：2005-12-19
申请人： Takahiro Matsumoto
发明人： Takahiro Matsumoto
IPC分类号： G01V3/00
CPC分类号： G01R33/3815 , G01R33/3806
摘要： In a superconducting magnets for MRI configured to generate a homogeneous magnetic field and a gradient magnetic field in a space between a top superconducting magnet and a bottom superconducting magnet, the bottom superconducting magnet is provided with a supporting member that supports a helium vessel, and the supporting member is fixed to a vacuum vessel of the bottom superconducting magnet at one end, and is fixed to the floor surface in the vicinity of the end fixed to the vacuum vessel. A high-quality MR image can be thus obtained by preventing direct transmission of oscillation of the gradient coils to the superconducting magnet and reducing oscillation of the gradient coils while achieving a reduction of the overall superconducting magnet in size.
摘要翻译：在用于MRI的超导磁体被配置为在顶部超导磁体和底部超导磁体之间的空间中产生均匀的磁场和梯度磁场，底部超导磁体设置有支撑氦容器的支撑构件，并且支撑构件在一端固定到底部超导磁体的真空容器，并且固定到固定到真空容器的端部附近的地板表面。因此可以通过防止梯形线圈的振荡直接传递到超导磁体并减小梯度线圈的振荡，同时实现整个超导磁体的尺寸的减小，从而可以获得高质量的MR图像。

20. 发明授权

US07265841B2 Position detecting method 有权
标题翻译：位置检测方法
公开(公告)号：US07265841B2
公开(公告)日：2007-09-04
申请号：US10872031
申请日：2004-06-18
申请人： Takahiro Matsumoto
发明人： Takahiro Matsumoto
IPC分类号： G01B11/00
CPC分类号： G03F9/7092 , G03F9/7046
摘要： A method for calculating a position of an image of an alignment mark formed on an object to be detected includes the steps of obtaining first information indicative of a center position in the alignment mark based on a detection signal, obtaining a waveform characteristic of the detection signal as second information, and correcting the first information based on the second information that has been obtained, and a measurement error of the center position of the alignment mark, which result from an optical system for detecting the alignment mark.
摘要翻译：用于计算形成在待检测物体上的对准标记的图像的位置的方法包括以下步骤：基于检测信号获得指示对准标记中的中心位置的第一信息，获得检测信号的波形特性作为第二信息，并且基于获得的第二信息和由用于检测对准标记的光学系统产生的对准标记的中心位置的测量误差来校正第一信息。

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