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11. 发明申请

US20060210985A1 Dna fragment amplification method, reaction apparatus for amplifying dna fragment and process for producing the same 审中-公开
标题翻译： Dna片段扩增法，扩增dna片段的反应装置及其制备方法
公开(公告)号：US20060210985A1
公开(公告)日：2006-09-21
申请号：US10548590
申请日：2004-03-17
申请人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
发明人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/54366 , C12Q1/686 , C12Q2565/518 , C12Q2523/307
摘要： A reaction apparatus (10) includes a substrate (12) and a plurality of columnar members (14) formed on the substrate (12). Oligonucleotides for immobilization (16) having sequences complementary to sequences of both ends of a starting template DNA (18) is adhered on the surfaces of the substrate (12) and the columnar members (14). The starting template DNA (18) can be immobilized over the adjacent columnar members (14) by introducing the starting template DNA (18) under the elongated condition. PCR is conducted in such condition.
摘要翻译：反应装置（10）包括基板（12）和形成在基板（12）上的多个柱状部件（14）。具有与起始模板DNA（18）两端的序列互补的序列的固定化寡核苷酸（16）粘附在基材（12）和柱状构件（14）的表面上。通过在细长条件下引入起始模板DNA（18），起始模板DNA（18）可以固定在相邻的柱状构件（14）上。 PCR在这种条件下进行。

12. 发明申请

US20060206010A1 Diagnostic support system and mobile terminal 审中-公开
标题翻译：诊断支持系统和移动终端
公开(公告)号：US20060206010A1
公开(公告)日：2006-09-14
申请号：US10554532
申请日：2004-05-07
申请人： Kazuhiro Iida , Toru Sano , Wataru Hattori
发明人： Kazuhiro Iida , Toru Sano , Wataru Hattori
IPC分类号： A61B5/00
CPC分类号： G06Q10/10 , A61B5/0002 , A61B5/411 , G16H50/30 , G16H50/80
摘要： A diagnostic support system includes a mobile terminal (14) and an analytical center (20), which are connected to each other through a network, and judges a morbidity possibility that a user holding the mobile terminal (14) is suffering from a disease. The analytical center (20) includes a data obtaining unit (26) which obtains symptom data representing the symptom of the user from the mobile terminal (14) in correspondence with a position at which and a date on which the symptom data was made, a morbidity possibility calculation unit (36) which judges the morbidity possibility that the user is suffering from the disease, based on the symptom data and a reference parameter representing the feature generated in sufferers of the disease, and an estimation processing unit (34) which estimates the existing states of sufferers of the disease for each area and in each period, based on morbidity possibilities of a plurality of users, and corresponding positions and dates.
摘要翻译：诊断支持系统包括通过网络彼此连接的移动终端（14）和分析中心（20），并且判断持有移动终端（14）的用户患有疾病的发病可能性。分析中心（20）包括数据获取单元（26），其从与移动终端（14）对应的症状数据的位置和日期获得表示用户的症状的症状数据，基于症状数据和表示在疾病患者中产生的特征的参考参数，判断用户患有疾病的发病可能性的发病率可能性计算单元（36）和估计处理单元（34），其估计基于多个用户的发病可能性的每个区域和每个时期的疾病患者的现有状态以及相应的位置和日期。

13. 发明申请

US20060172436A1 Diagnosis supporting system 审中-公开
标题翻译：诊断支持系统
公开(公告)号：US20060172436A1
公开(公告)日：2006-08-03
申请号：US10549116
申请日：2004-02-26
申请人： Wataru Hattori , Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Hiroko Someya
发明人： Wataru Hattori , Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Hiroko Someya
IPC分类号： G01N33/543 , G06F19/00
CPC分类号： G01N27/44717 , G16H10/60 , G16H15/00
摘要： A diagnosis supporting system (10) includes a diagnosis data obtaining unit (20) that obtains diagnosis data in which a movement parameter reflecting a movement speed of each component in separating a sample collected from a test subject into plural components with a chip (12) and a character of each component is in correspondence, a parameter storing unit (34) that stores the movement parameter of a characteristic component showing a state of suffering from a specific disease in correspondence with the disease, a relationship data storing unit (35) that stores relationship data showing a relationship between the character of the characteristic component and a possibility of suffering from a specific disease, a detecting unit (21) that detects the characteristic component from the diagnosis data based on the movement parameter of the characteristic component and the movement parameter of the diagnosis data by making reference to the parameter storing unit (34), and an inference processing unit (22) that infers the possibility that the test subject is suffering by making reference to the relationship data storing unit (35) based on the character of the detected characteristic component.
摘要翻译：诊断支持系统（10）包括诊断数据获取单元（20），该诊断数据获取单元（20）获取诊断数据，其中，用芯片（12）将反映从测试对象收集的样本的每个组件的移动速度反映成多个组件的移动参数，并且每个部件的字符相对应，存储与疾病相对应地显示出患有特定疾病的状态的特征部件的移动参数的参数存储部（34），关系数据存储部（35），其中，存储表示特征成分的特征与患有特定疾病的可能性之间的关系的关系数据，根据特征成分的移动参数和运动来检测来自诊断数据的特征成分的检测部（21）参考存储单元（34）的诊断数据的参数，以及inf （22），其基于检测到的特征成分的特性，通过参照所述关系数据存储部（35）推测出所述检测对象所遭受的可能性。

14. 发明申请

US20060102836A1 Liquid switch, and microchip and mass-analyzing system using the same 失效
标题翻译：液体开关，微芯片和质量分析系统使用相同
公开(公告)号：US20060102836A1
公开(公告)日：2006-05-18
申请号：US10537295
申请日：2003-12-02
申请人： Kazuhiro Iida , Masakazu Baba , Hisao Kawaura , Toru Sano , Noriyuki Iguchi , Hiroko Someya , Wataru Hattori , Minoru Asogawa
发明人： Kazuhiro Iida , Masakazu Baba , Hisao Kawaura , Toru Sano , Noriyuki Iguchi , Hiroko Someya , Wataru Hattori , Minoru Asogawa
IPC分类号： H01J49/00
CPC分类号： B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2400/0688 , G01N30/20 , H01J49/04 , Y10T137/4891
摘要： A liquid sample (104) introduced in a main flow passage (101) is held in a dam portion (105), and a trigger liquid (106) is filled in a trigger flow passage (102). In this state, the trigger liquid (106) is further introduced at desired timing into the trigger flow passage (102) so that the front end portion of the level of the trigger liquid (106) is advanced and the front end portion is brought to be into contact with the dam portion (105). This causes the liquid sample (104) to move to the right (downstream side) in the figure, resulting in the liquid sample (104) flowing out to the downstream side of the main flow passage (101). This means that the trigger liquid (106) provides priming to realize a liquid switch.
摘要翻译：引入到主流路（101）中的液体样品（104）保持在坝部（105）中，并且将触发液体（106）填充在触发流路（102）中。在这种状态下，触发液体（106）在所需的时刻被进一步引入到触发流路（102）中，使得触发液体（106）的高度的前端部分前进，前端部分与坝部（105）接触。这使得液体样品（104）移动到图中的右侧（下游侧），导致液体样品（104）流出到主流动通道（101）的下游侧。这意味着触发液体（106）提供启动以实现液体开关。

15. 发明授权

US5420004A Direct positive silver halide emulsion and color diffusion transfer light-sensitive material therewith 失效
公开(公告)号：US5420004A
公开(公告)日：1995-05-30
申请号：US103705
申请日：1993-08-10
申请人： Munehisa Fujita , Toru Sano
发明人： Munehisa Fujita , Toru Sano
IPC分类号： G03C1/015 , G03C1/053 , G03C1/08 , G03C1/485 , G03C8/06 , G03C8/08 , G03C8/10
CPC分类号： G03C1/48538 , G03C1/48576 , G03C8/08
摘要： An internal latent image type positive silver halide emulsion has improved sensitivity reduction in low illuminance exposures. A color diffusion transfer light-sensitive material incorporates the emulsion and has reduced sensitivity reduction. The internal latent image type positive silver halide emulsion is prepared using a polymer having a repetitive unit derived from an ethylenically unsaturated monomer having at least one thioether structure on a side chain as a deflocculating agent to form silver halide grains and subjecting the grain surfaces to a chemical sensitization in the presence of a polymer having a repetitive unit represented by the following Formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a substituted or unsubstituted alkyl group and Q represents a group selected from the group consisting of groups represented by the following Formula (1) to Formula (4): ##STR2## wherein q represents an integer of 2 to 4; ##STR3## wherein R.sup.2 and R.sup.3 each independently represents a hydrogen atom or a substituted or unsubstituted alkyl group; ##STR4## wherein Z.sup.1 represents a group of atoms necessary to form a substituted or unsubstituted lactam ring, a substituted or unsubstituted oxazolidone ring, or a substituted or unsubstituted pyridone ring; and A represents a single bond, a --C(.dbd.O)-- group, or a group represented by the following Formula (3a): ##STR5## wherein B represents an --O-- group or an --N(R.sup.4)-- group, in which R.sup.4 represents a hydrogen atom or a substituted or unsubstituted alkyl group; and k represents an integer of 1 to 6; ##STR6## wherein A has the same meaning as A in the above Formula (3); D represents a single bond, an --O-- group or an --N(R.sup.5)-- group; m and n each represents an integer of 1 to 6, which satisfy the relationship of m+n.dbd.4 to 7, in which R.sup.5 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or a group represented by the following Formula (4a): ##STR7## wherein R.sup.6 represents a substituted or unsubstituted alkyl group.

16. 发明申请

US20140193052A1 INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD, INFORMATION PROCESSING APPARATUS, CONTROL METHOD THEREOF AND CONTROL PROGRAM 审中-公开
标题翻译：信息处理系统，信息处理方法，信息处理装置，其控制方法和控制程序
公开(公告)号：US20140193052A1
公开(公告)日：2014-07-10
申请号：US14239801
申请日：2012-08-22
申请人： Yoshiko Yoshihara , Tomoharu Kiyuan , Toru Sano , Kenichi Kamijo
发明人： Yoshiko Yoshihara , Tomoharu Kiyuan , Toru Sano , Kenichi Kamijo
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G01N33/4833 , G06F19/321 , G06K9/0014 , G06K9/6253 , G06T2207/10056 , G06T2207/30024
摘要： Disclosed is an information processing apparatus that supports diagnosis based on a tissue sample image obtained from imaging a biological tissue, including: a tissue sample image cutting unit that individually cuts out the tissue sample image from a plurality of slides that includes the plurality of tissue sample images; and a display position setting unit that sets a display position on a display screen where a reduced image of each tissue sample image is displayed, on the basis of a characteristic amount of each tissue sample image cut by the tissue sample image cutting unit.
摘要翻译：公开了一种信息处理设备，其基于从生物组织成像获得的组织样本图像来支持诊断，所述信息处理设备包括：组织样本图像切割单元，其从包括所述多个组织样本的多个幻灯片中单独地切出组织样本图像图片; 以及显示位置设定单元，其基于由组织样本图像切割单元切割的每个组织样本图像的特征量，在显示屏幕上设置显示每个组织样本图像的缩小图像的显示位置。

17. 发明授权

US07785533B2 Chip, device using the chip, and method of using the same 失效
标题翻译：使用芯片的芯片，器件及其使用方法
公开(公告)号：US07785533B2
公开(公告)日：2010-08-31
申请号：US10571585
申请日：2004-09-13
申请人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
发明人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
IPC分类号： G01N21/01
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L2200/0689 , B01L2200/141 , B01L2300/041 , B01L2300/0816 , B82Y30/00 , B82Y35/00 , G01N27/44791
摘要： A channel formed on a chip is opened without contaminating contents of the channel. Channels (107a) and (107b) provided on a substrate (103) are covered by pressing a lid (113) composed of a resin layer (102) and a plate-like lid (101) to a surface of the substrate (103). A fixing device has a retainer plate (104), which retains the plate-like lid (101) of a chip (112), a board (108) on which the substrate (103) is placed, and a screw (106). When covering the channels (107a) and (107b), the screw (106) is fastened and the lid (113) is pressed to the substrate (103) to be fixed. And, when opening an upper portion of the channels (107a) and (107b), the screw (106) is turned upward and a pressure is released, and the lid (113) is removed from the upper potion of the substrate (103).
摘要翻译：形成在芯片上的通道打开而不污染通道的内容物。设置在基板（103）上的通道（107a）和（107b）通过将由树脂层（102）和板状盖（101）构成的盖（113）压在基板（103）的表面上而被覆盖，。定影装置具有保持片（112）的板状盖（101），放置有基板（103）的基板（108）和螺钉（106））的保持板（104）。当覆盖通道（107a）和（107b）时，螺钉（106）被紧固并且盖（113）被压到基板（103）上以被固定。并且，当打开通道（107a）和（107b）的上部时，螺杆（106）向上转动并释放压力，并且从基板（103）的上部移除盖（113）。

18. 发明申请

US20070048179A1 Chip, device using the chip, and method of using the same 失效
标题翻译：使用芯片的芯片，器件及其使用方法
公开(公告)号：US20070048179A1
公开(公告)日：2007-03-01
申请号：US10571585
申请日：2004-09-13
申请人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
发明人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
IPC分类号： G01N31/22
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L2200/0689 , B01L2200/141 , B01L2300/041 , B01L2300/0816 , B82Y30/00 , B82Y35/00 , G01N27/44791
摘要： A channel formed on a chip is opened without contaminating contents of the channel. Channels (107a) and (107b) provided on a substrate (103) are covered by pressing a lid (113) composed of a resin layer (102) and a plate-like lid (101) to a surface of the substrate (103). A fixing device has a retainer plate (104), which retains the plate-like lid (101) of a chip (112), a board (108) on which the substrate (103) is placed, and a screw (106). When covering the channels (107a) and (107b), the screw (106) is fastened and the lid (113) is pressed to the substrate (103) to be fixed. And, when opening an upper portion of the channels (107a) and (107b), the screw (106) is turned upward and a pressure is released, and the lid (113) is removed from the upper potion of the substrate (103).
摘要翻译：形成在芯片上的通道打开而不污染通道的内容物。设置在基板（103）上的通道（107a）和（107b）通过将由树脂层（102）和板状盖（101）构成的盖（113）压到基板的表面 103）。定影装置具有保持片（112）的板状盖（101），放置有基板（103）的基板（108）和螺钉（106））的保持板（104）。当覆盖通道（107a）和（107b）时，螺钉（106）被紧固并且盖（113）被压到基板（103）上以被固定。并且，当打开通道（107a）和（107b）的上部时，螺杆（106）向上转动并释放压力，并且将盖（113）从基板的上部移除（ 103）。

19. 发明申请

US20070026456A1 Method of biomolecule analysis and method of identifying biomolecule therewith 审中-公开
标题翻译：生物分子分析方法及其识别生物分子的方法
公开(公告)号：US20070026456A1
公开(公告)日：2007-02-01
申请号：US10570205
申请日：2004-09-02
申请人： Kenichi Kamijo , Hisao Kawaura , Toru Sano , Yo Tabuse , Hirotaka Minagawa , Kenji Miyazaki
发明人： Kenichi Kamijo , Hisao Kawaura , Toru Sano , Yo Tabuse , Hirotaka Minagawa , Kenji Miyazaki
IPC分类号： G01N33/53
CPC分类号： G01N33/6803
摘要： A biomolecule is analyzed with high accuracy. A biomolecule is analyzed with high likelihood. A biomolecule as an analysis subject is modified with a marker binding or adsorbing to only its specific portion (S101). Next, the biomolecule modified with the marker is developed on a base plate (S102). The arrangement of the biomolecule on the base plate is detected using a marker (S103). Then, scanning is performed along the shape of the biomolecule present on the detected position (S104). The biomolecule is analyzed based on an information relating to the shape or arrangement of the biomolecule obtained by scanning or an information relating to the arrangement of the marker on the biomolecule (S105).
摘要翻译：以高精度分析生物分子。分析生物分子的可能性很高。作为分析对象的生物分子用仅结合或吸附到其特定部分的标记进行修饰（S 101）。接下来，在基板上显影用标记物修饰的生物分子（S102）。使用标记检测基板上的生物分子的排列（S103）。然后，沿检测位置上存在的生物分子的形状进行扫描（S104）。基于与通过扫描获得的生物分子的形状或排列相关的信息或与生物分子上的标记的排列有关的信息来分析生物分子（S105）。

20. 发明申请

US20060070951A1 Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system 审中-公开
标题翻译： Microchip，使用微芯片的溶剂置换法，浓缩法和质谱系统
公开(公告)号：US20060070951A1
公开(公告)日：2006-04-06
申请号：US10536597
申请日：2003-11-28
申请人： Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya , Minoru Asogawa
发明人： Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya , Minoru Asogawa
IPC分类号： C02F1/44 , B01D15/08
CPC分类号： B01D67/0062 , B03C5/00 , G01N1/40
摘要： A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.
摘要翻译：样品中的特定组分以高浓度回收并进行溶剂置换。分离器100放置在微芯片上，并且包括用于流动特定部件的通道112。通道112包括样品供给通道300以及从样品供给通道300分支的滤液排出通道302和样品回收部分308。在滤液排出通道302的入口处，从样品供给通道300形成防止特定成分通过的过滤器304。此外，在样品回收部的入口处形成防止液体样品进入的阻止区域（疏水区域）306，同时允许通过施加等于或大于给定水平的外力使液体样品通过 308。

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