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11. 发明授权

US5412992A Differential pressure sensor capable of removing influence of static pressure and a method of assembling the same 失效
标题翻译：能够去除静压影响的差压传感器及其组装方法
公开(公告)号：US5412992A
公开(公告)日：1995-05-09
申请号：US986023
申请日：1992-12-04
申请人： Tomoyuki Tobita , Akira Sase , Yoshimi Yamamoto , Kenichi Aoki
发明人： Tomoyuki Tobita , Akira Sase , Yoshimi Yamamoto , Kenichi Aoki
IPC分类号： G01L13/00 , G01L9/00 , G01L13/06 , G01L19/02 , G01L9/06
CPC分类号： G01L19/146 , G01L15/00 , G01L9/065
摘要： A differential pressure sensor is disclosed, and in particular, there is disclosed a multiple function type differential pressure sensor capable of reducing a zero-point-change and a span change of means for detecting a differential pressure when applying a static pressure and being readily manufactured at high accuracy. The multiple function type differential pressure sensor is constructed by a semiconductor chip 1 for detecting a differential pressure, a fixing base 2 which has a joining part 21 joined to a thick part of the semiconductor chip 1 and which has a thickness less than or equal to that of the semiconductor chip 1, and also which has at least one thin part 22 in an outer periphery other than the joining part 21, and a housing 4 joined to the fixing base.
摘要翻译：公开了一种差压传感器，特别是公开了一种多功能型差压传感器，其能够降低在施加静压时易于制造的用于检测压差的装置的零点变化和跨度变化高精度。多功能型差压传感器由用于检测差压的半导体芯片1构成，固定座2具有接合部分21，该接合部21接合到半导体芯片1的厚部，并且具有小于或等于半导体芯片1，以及在接合部21以外的外周具有至少一个薄部22，以及与固定基部接合的壳体4。

12. 发明授权

US4995266A Differential pressure transmitter 失效
标题翻译：差压变送器
公开(公告)号：US4995266A
公开(公告)日：1991-02-26
申请号：US399916
申请日：1989-08-29
申请人： Tomoyuki Tobita , Yoshimi Yamamoto
发明人： Tomoyuki Tobita , Yoshimi Yamamoto
IPC分类号： G01L13/00 , G01L9/00 , G01L13/02
CPC分类号： G01L19/0645 , G01L13/025 , G01L19/0038
摘要： In a differential pressure transmitter having pressure receiving diaphragms forming recesses, a center diaphragm therebetween so as to define two chambers filled with pressure transmission medium, first communication passages respectively connecting the two chambers to the recesses and second communication passages respectively connecting the two chambers to pressure measuring chambers. The diameters of the first communication passages are less than predetermined values determined by the viscosity and volume modulus of the pressure passages, and the volume of the pressure-measuring chamber. The frequency of characteristic vibration and gain of the pressure-measuring chamber and the second communication passage in one side is respectively and substantially equal to that in the other side. A drastic transient pressure transmitted to sensors in the pressure-receiving recesses is absorbed by the communication passages and is not transmitted to the sensor in the form of a differential pressure.
摘要翻译：在具有形成凹部的压力接收膜片的差压变送器中，其间具有中心隔膜，以限定两个填充有压力传递介质的室，分别将两个室连接到凹部的第一连通通道和分别将两个室连接到压力的第二连通通道测量室。第一连通通道的直径小于由压力通道的粘度和体积模量和压力测量室的体积确定的预定值。一侧的压力测量室和第二连通通路的特征振动和增益的频率分别基本上等于另一侧的频率。传递到压力接收凹部中的传感器的剧烈的瞬时压力被连通通道吸收，并且不以差压的形式传递到传感器。

13. 发明授权

US5469749A Multiple-function fluid measuring and transmitting apparatus 失效
标题翻译：多功能流体测量和传输装置
公开(公告)号：US5469749A
公开(公告)日：1995-11-28
申请号：US411922
申请日：1995-03-28
申请人： Satoshi Shimada , Seiichi Ugai , Tomoyuki Tobita , Yoshimi Yamamoto
发明人： Satoshi Shimada , Seiichi Ugai , Tomoyuki Tobita , Yoshimi Yamamoto
IPC分类号： G01F1/38 , G01F1/36 , G01F1/37 , G01F1/42 , G01F1/44 , G01F1/50 , G01F15/02 , G01F23/14 , G01F23/16 , G01L9/00 , G01L19/00 , G01L7/08
CPC分类号： G01F1/363 , G01F1/372 , G01F1/383 , G01F1/44 , G01F23/164 , G01L19/0092 , G01L9/0054
摘要： A measuring and controlling system is provided which has a control function as well as a measurement function to perform the measurement and control of fluid amounts such as the flow rate, pressure, liquid level, weight and so on by itself in the same field. A pressure receiving unit is directly mounted on a pipe or a container, in which a fluid under measurement exists, in order to detect the temperature, differential pressure and static pressure of the fluid under measurement independently of each other. Means for storing the characteristic of fluids under measurement is provided such that the mass flow rate, weight and liquid level can be calculated. By providing the transmitter with the measurement and control functions, the measurement and control of fluid amounts such as flow rate, pressure, liquid level, weight and so on can be performed in a closed form, thereby making it possible to simplify a correction procedure for the static pressure and temperature, improve the responsibility, and enhance the control performance of the whole plant. Also, a measuring and controlling system can be realized which reduces a wiring amount for connecting with an upper level control unit.
摘要翻译：提供了一种测量和控制系统，其具有控制功能和测量功能，以在相同的领域中自身进行流量，压力，液位，重量等流体量的测量和控制。压力接收单元直接安装在其上存在测量流体的管道或容器上，以便彼此独立地检测待测流体的温度，压差和静压力。提供了用于存储测量流体特性的装置，以便可以计算质量流量，重量和液位。通过向变送器提供测量和控制功能，可以以封闭形式执行流量，压力，液位，重量等流体量的测量和控制，从而可以简化对静态压力和温度，提高责任感，提高整厂的控制性能。此外，可以实现减少与上位控制单元连接的配线量的测量和控制系统。

14. 发明授权

US4972716A Semiconductor pressure converting device 失效
标题翻译：半导体压力转换装置
公开(公告)号：US4972716A
公开(公告)日：1990-11-27
申请号：US392298
申请日：1989-08-11
申请人： Tomoyuki Tobita , Akira Sase , Yoshimi Yamamoto , Satoshi Shimada
发明人： Tomoyuki Tobita , Akira Sase , Yoshimi Yamamoto , Satoshi Shimada
IPC分类号： G01L9/04 , G01L9/00 , G01L9/06 , G01L13/06 , G01L19/00
CPC分类号： G01L19/146 , G01L19/0076 , G01L19/147 , G01L9/0054
摘要： A semiconductor pressure converting device including a fixing table joined to a silicon diaphragm consists of 2 structures superposed on each other, in which the longitudinal elastic modulus of the first fixing table is significantly different from the longitudinal elastic modulus of the semiconductor diaphragm. The first fixing table is highly insulating and the linear expansion coefficient thereof is approximately equal to the linear expansion coefficient of the semiconductor diaphragm. The second fixing table is made of a material having a longitudinal elastic modulus and a linear expansion coefficient approximately equal to those of the semiconductor diaphragm.
摘要翻译：一种半导体压力转换装置，包括与硅膜连接的固定台，由彼此重叠的2个结构构成，其中第一固定台的纵向弹性模量与半导体膜片的纵向弹性模量显着不同。第一固定台是绝热的，其线膨胀系数近似等于半导体膜片的线膨胀系数。第二固定台由纵向弹性模量和线膨胀系数近似等于半导体膜片的材料制成。

15. 发明申请

US20090221060A1 NUCLEIC ACID ANALYZER 审中-公开
标题翻译：核酸分析仪
公开(公告)号：US20090221060A1
公开(公告)日：2009-09-03
申请号：US12372343
申请日：2009-02-17
申请人： Shuhei Yamamoto , Toshinari Sakurai , Yoshiyuki Shoji , Takehiko Hosoiri , Yoshihiro Yamashita , Tomoyuki Tobita
发明人： Shuhei Yamamoto , Toshinari Sakurai , Yoshiyuki Shoji , Takehiko Hosoiri , Yoshihiro Yamashita , Tomoyuki Tobita
IPC分类号： C12M1/00
CPC分类号： B01L7/52 , B01L3/50851 , B01L3/50853 , B01L2200/142 , B01L2300/1844 , B01L2300/1861 , G01N35/025
摘要： It is an object of the present invention to prevent condensation occurring when reaction solutions in sealed vessels are heated in a nucleic acid analyzer for performing sequential processing in which individual reaction vessels are sequentially fed to a nucleic acid amplification unit in a given cycle. This invention relates to a nucleic acid analyzer including a vessel mounting rack capable of holding the plurality of reaction vessels, wherein the reaction vessel mounted on the vessel mounting rack is heated by an adjacent noncontact heat source and air circulation from the heat source to a reaction vessel upper portion, and a temperature of the reaction vessel upper portion is kept higher than a temperature of a reaction vessel lower portion. With this invention, condensation possibly occurring on the inner wall of the sealed vessel upper portion due to heating during nucleic acid amplification can be prevented, and more accurate nucleic acid analysis is enabled.
摘要翻译：本发明的目的是防止在密封容器中的反应溶液在核酸分析仪中加热以进行顺序加工的冷凝，其中将各个反应容器依次加入到给定循环中的核酸扩增单元中。本发明涉及一种核酸分析仪，其包括能够保持多个反应容器的容器安装架，其中安装在容器安装架上的反应容器被相邻的非接触式热源加热，并且从热源到反应的空气循环容器上部，并且反应容器上部的温度保持高于反应容器下部的温度。通过本发明，可以防止由于核酸扩增期间的加热而在密封容器上部的内壁上发生的冷凝，从而能够进行更准确的核酸分析。

16. 发明申请

US20080302665A1 CAPILLARY ARRAY APPARATUS, METHOD OF MANUFACTURING THE SAME, AND ELECTROPHORESIS ANALYSIS METHOD 审中-公开
标题翻译：毛细管阵列装置，其制造方法和电泳分析方法
公开(公告)号：US20080302665A1
公开(公告)日：2008-12-11
申请号：US12189629
申请日：2008-08-11
申请人： Syozo Kasai , Takayasu Furukawa , Ryoji Inaba , Daiki Numai , Tomoyuki Tobita
发明人： Syozo Kasai , Takayasu Furukawa , Ryoji Inaba , Daiki Numai , Tomoyuki Tobita
IPC分类号： G01N27/26 , B29C65/52
CPC分类号： B01L7/00 , B01L3/5025 , B01L2300/0838 , B01L2300/1805 , B01L2300/1894 , B01L2400/0421 , G01N27/44726
摘要： An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids, liquids and gels is filled in substantially all of the gaps between the electrode and each capillary. A hollow electrode into which a capillary is inserted has a plurality of retaining shapes such that the capillary can be fixed at the center of the electrode. The heat from the capillary can be efficiently dissipated via the electrode, and also the temperature increase in the capillary can be prevented. Further, temperature increases due to the heating of the capillaries during operation can be controlled and thereby thermal deterioration of the gel can be prevented.
摘要翻译：一种能够在重复使用相同凝胶时保持高可靠性的电泳分析方法和装置。选自固体，液体和凝胶的传热介质填充在电极和每个毛细管之间的基本上所有的间隙中。插入有毛细管的中空电极具有多个保持形状，使得毛细管可以固定在电极的中心。可以通过电极有效地消耗来自毛细管的热量，并且可以防止毛细管中的温度升高。此外，可以控制由于操作期间毛细管的加热引起的温度升高，从而可以防止凝胶的热劣化。

17. 发明授权

US5259248A Integrated multisensor and static and differential pressure transmitter and plant system using the integrated multisensor 失效
标题翻译：集成多传感器和静压差压变送器和工厂系统采用集成式多传感器
公开(公告)号：US5259248A
公开(公告)日：1993-11-09
申请号：US672113
申请日：1991-03-19
申请人： Seiichi Ugai , Satoshi Shimada , Tomoyuki Tobita , Akira Sase
发明人： Seiichi Ugai , Satoshi Shimada , Tomoyuki Tobita , Akira Sase
IPC分类号： G01L9/00 , G01L9/06 , G01L19/00 , G01L13/02
CPC分类号： G01L19/0092 , G01L9/0054 , G01L9/065
摘要： In an integrated multisensor used in a differential and static pressure transmitter, a pair of static pressure gages are formed on a static pressure detecting diaphragm and another pair of static pressure gages are formed at positions on a fixed portion which are near to the center of a differential pressure detecting diaphragm. The second term generated by a differential pressure appearing in a static pressure sensor is a function of a distance. Therefore, equal influence is exerted on each static pressure gage. Accordingly, by constructing a static pressure sensor so as to form a bridge circuit, a static pressure value free of the influence of a differential pressure can be detected, thereby making it possible to determine an accurate differential and static pressure.
摘要翻译：在用于差压静态压力变送器的集成多传感器中，静压检测膜上形成一对静压计，另一对静压计则形成在靠近中心的固定部位差压检测膜片。通过出现在静压传感器中的差压产生的第二项是距离的函数。因此，对每个静压力表施加相等的影响。因此，通过构造静压传感器以形成桥接电路，可以检测到不受压差影响的静压值，从而可以确定精确的差动静压。

18. 发明授权

US07027935B2 Sample dispensing apparatus and automatic analyzer using the same 有权
标题翻译：样品分配装置和使用其的自动分析仪
公开(公告)号：US07027935B2
公开(公告)日：2006-04-11
申请号：US10634775
申请日：2003-08-06
申请人： Akihiro Shimase , Hiroyasu Uchida , Katsuhiro Kambara , Tomoyuki Tobita
发明人： Akihiro Shimase , Hiroyasu Uchida , Katsuhiro Kambara , Tomoyuki Tobita
IPC分类号： G01F1/00 , G01F7/00
CPC分类号： G01N35/1016 , G01N35/1004
摘要： A sample dispensing apparatus is realized which can detect a dispensing abnormality occurred during the sample dispensing operation regardless of the type and the extent of the abnormality. A pressure sensor is connected to a dispensing flow passage system, including a sample probe and a dispensing syringe, and a plurality of output values of the pressure sensor during the sample dispensing operation are taken in. A multi-item analysis (based on the Mahalanobis distance) is carried out by using, as items, the plurality of taken-in output values of the pressure sensor. Whether the dispensing is normally performed or not is determined by comparing an analysis result with a threshold. A highly reliable determination result is obtained in spite of variations of sensitivity of the pressure sensor.
摘要翻译：实现了一种样品分配装置，其可以检测在样品分配操作期间发生的分配异常，而不管异常的类型和程度如何。压力传感器连接到分配流路系统，包括样品探针和分注注射器，并且在样品分配操作期间采用压力传感器的多个输出值。多项目分析（基于马哈拉诺比斯距离）通过使用压力传感器的多个取入输出值作为项目进行。通过将分析结果与阈值进行比较来确定分配是否正常执行。尽管压力传感器的灵敏度变化，但获得了高度可靠的测定结果。

19. 发明授权

US07422672B2 Capillary array apparatus, method of manufacturing the same, and electrophoresis analysis method 有权
标题翻译：毛细管阵列装置及其制造方法以及电泳分析方法
公开(公告)号：US07422672B2
公开(公告)日：2008-09-09
申请号：US10732221
申请日：2003-12-11
申请人： Syozo Kasai , Takayasu Furukawa , Ryoji Inaba , Daiki Numai , Tomoyuki Tobita
发明人： Syozo Kasai , Takayasu Furukawa , Ryoji Inaba , Daiki Numai , Tomoyuki Tobita
IPC分类号： G01N27/453
CPC分类号： B01L7/00 , B01L3/5025 , B01L2300/0838 , B01L2300/1805 , B01L2300/1894 , B01L2400/0421 , G01N27/44726
摘要： An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids, liquids and gels is filled in substantially all of the gaps between the electrode and each capillary. A hollow electrode into which a capillary is inserted has a plurality of retaining shapes such that the capillary can be fixed at the center of the electrode. The heat from the capillary can be efficiently dissipated via the electrode, and also the temperature increase in the capillary can be prevented. Further, temperature increases due to the heating of the capillaries during operation can be controlled and thereby thermal deterioration of the gel can be prevented.
摘要翻译：一种能够在重复使用相同凝胶时保持高可靠性的电泳分析方法和装置。选自固体，液体和凝胶的传热介质填充在电极和每个毛细管之间的基本上所有的间隙中。插入有毛细管的中空电极具有多个保持形状，使得毛细管可以固定在电极的中心。可以通过电极有效地消耗来自毛细管的热量，并且可以防止毛细管中的温度升高。此外，可以控制由于操作期间毛细管的加热引起的温度升高，从而可以防止凝胶的热劣化。

20. 发明授权

US07053367B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07053367B2
公开(公告)日：2006-05-30
申请号：US10494335
申请日：2001-11-07
申请人： Tomoyuki Tobita , Toshihiro Ishizuka , Masaru Tomioka , Kiyomi Yoshinari , Masami Sakamoto
发明人： Tomoyuki Tobita , Toshihiro Ishizuka , Masaru Tomioka , Kiyomi Yoshinari , Masami Sakamoto
IPC分类号： H01J49/00
CPC分类号： H01J49/067 , H01J49/044
摘要： In a mass spectrometer utilizing an atmospheric pressure ion source, the amount of un-vaporized droplets that reach a mass spectrometric section is reduced. A mass spectrometer comprises: an ionization section for ionizing a sample at substantially atmospheric pressure; a first and a second intermediate pressure section in which the pressure is maintained lower than the pressure in said ionization section; a high vacuum section in which the pressure is maintained lower than the pressure in said intermediate pressure section and in which a mass spectrometric means for subjecting ions to mass spectrometry is disposed; a first pore electrode disposed between said ionization section and said first intermediate pressure section; an intermediate pore electrode disposed between said first intermediate pressure section and said second intermediate pressure section; and a second pore electrode disposed between said second intermediate pressure section and said high vacuum section. A first converging electrode is provided in the first intermediate pressure section, the first converging electrode having an opening towards the first pore electrode and another opening towards the intermediate pore electrode. The opening towards the first pore electrode has a larger diameter than the opening towards the intermediate pore electrode, such that the first converging electrode has a tapered shape.
摘要翻译：在使用大气压离子源的质谱仪中，达到质谱分析的未汽化液滴的量减少。质谱仪包括：用于在基本上大气压下电离样品的电离部分; 第一和第二中间压力段，其中所述压力保持低于所述电离部分中的压力; 其中压力保持低于所述中压部分中的压力并且其中设置用于使离子进行质谱分析的质谱装置的高真空部分; 设置在所述电离部和所述第一中间压部之间的第一孔电极; 设置在所述第一中间压力部分和所述第二中间压力部分之间的中间孔电极; 以及设置在所述第二中间压力部分和所述高真空部分之间的第二孔电极。第一会聚电极设置在第一中间压力部分中，第一会聚电极具有朝向第一孔电极的开口和朝向中间孔电极的另一开口。朝向第一孔电极的开口具有比朝向中间孔电极的开口更大的直径，使得第一会聚电极具有锥形形状。

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