专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US4143425A Left atrial to descending thoracic aorta left ventricular assist device 失效
标题翻译：左心房下降胸主动脉左心室辅助装置
公开(公告)号：US4143425A
公开(公告)日：1979-03-13
申请号：US846109
申请日：1977-10-27
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1046 , A61M1/1041 , A61M1/1051 , A61M1/122 , A61M1/106 , Y10T74/18312
摘要： An implanted tether-free externally powered motor with suitable reduction gearing drives a spirally grooved shaft having a ring housing for a shaft follower pin. A rectangular cross section chamber receives an ejection plate pivoted near one end to a first leg of the ring housing and having a resilient lost motion connection with a second leg of the ring housing near its other end. A compressible sac or pouch extends through said chamber and is fitted at its opposite ends with porcine valves and has conduit extensions outwardly of said valves for connection with the left atrium and the descending thoracic aorta, respectively. During use, the sac or pouch is cyclically compressed by the ejection plate, initially at the end of the ejection plate having the lost motion yielding connection with the follower ring housing, and subsequently at both ends of the ejection plate so that a predetermined volume of blood is delivered on each stroke of the ejection plate to the thoracic aorta.
摘要翻译：具有合适的减速装置的植入式无系绳外部动力电动机驱动具有用于轴从动销的环形壳体的螺旋槽式轴。矩形横截面腔室容纳一个靠近一端枢转到环形壳体的第一支腿的弹出板，并且具有与其另一端附近的环形壳体的第二支腿弹性的空动连接。可压缩的囊或袋延伸穿过所述腔室并且在其相对端与猪阀配合，并且在所述阀门的外侧分别具有与左心房和下胸主动脉连接的导管延伸部。在使用过程中，囊或袋被排出板循环地压缩，最初在具有空转运动的排出板的端部产生与从动环壳体的连接，并且随后在排出板的两端处，血液在排出板的每个行程上被递送到胸主动脉。

12. 发明授权

US4058857A Cardiac replacement pumping devices 失效
标题翻译：心脏置换泵装置
公开(公告)号：US4058857A
公开(公告)日：1977-11-22
申请号：US657702
申请日：1976-02-12
申请人： Thomas M. Runge , John E. Burkhalter , Spiros George Pallas
发明人： Thomas M. Runge , John E. Burkhalter , Spiros George Pallas
IPC分类号： A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1046 , A61M1/1049 , A61M1/12
摘要： A pumping device whose functioning resembles the action of the natural four chambered heart is constructed as a total cardiac replacement unit. An internal electrical drive motor adapted to be powered by radio frequency induction across intact skin drives an eccentric rotary element which in turn causes oscillation of pivoted vanes whose movements cyclically compress a pair of blood compatible sacs which simulate the left ventricle and right ventricle of the natural heart by pumping blood through the aorta and pulmonary artery, respectively. As in the natural heart, stroke volume of each ventricle is independent of the other and is a function of right atrial and left atrial pressure and volume. Additional embodiments of the invention feature modified driving means for the pumping vanes.
摘要翻译：其功能类似于天然四腔心脏的作用的泵送装置被构造为总心脏置换装置。适用于通过完整皮肤的射频感应供电的内部电驱动马达驱动偏心旋转元件，偏心旋转元件又引起枢转叶片的振荡，其运动循环地压缩一对血液相容的囊，模拟左心室和右心室的自然心脏通过分别通过主动脉和肺动脉抽血。如同天然心脏一样，每个心室的搏动体积都是独立的，并且是右心房和左心房压力和体积的函数。本发明的另外的实施例具有用于泵送叶片的改进的驱动装置。

13. 发明授权

US5785686A Cannula system for a biventricular cardiac support system or a cardiopulmonary bypass system 失效
标题翻译：用于双心室心脏支持系统或体外循环系统的插管系统
公开(公告)号：US5785686A
公开(公告)日：1998-07-28
申请号：US892910
申请日：1997-07-15
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61F2/958 , A61M1/12 , A61M1/36 , A61M25/00 , A61M29/00
CPC分类号： A61M25/10 , A61M1/3659 , A61M25/0021 , A61M1/12 , A61M1/3666 , A61M2025/0037 , A61M2025/1052 , A61M2202/0472 , A61M2210/127 , A61M25/007
摘要： A cannula system for a biventricular cardiac support system or a cardiopulmonary bypass system wherein a first cannula having a pair of side-by-side lumens is adapted to be positioned within the left atrium and left ventricle and aorta of a patient. Blood from the left atrium and left ventricle drains into one of the lumens in the first cannula and is conveyed to the inlet of a pulsatile flow cardiopulmonary bypass pump from where it is pumped through the other lumen into the aorta of the patient. An inflatable balloon is provided at the distal end of the first cannula for holding the distal end of the cannula in the aorta above the aortic valve. The first cannula includes an axially extending bore communicating with a space in the aorta between the inflated balloon and the aortic valve for conveying cardioplegic solution to the space communicating with the left and right arteries of the patient. A second cannula having a pair of side-by-side lumens is adapted to be positioned within the right atrium and right ventricle and pulmonary artery of the patient. Blood from the right atrium and right ventricle flows into one of the lumens in the second cannula and is conveyed to the pulsatile flow cardiopulmonary bypass pump from where it is pumped through the other lumen into the pulmonary artery of the patient.
摘要翻译：用于双心室心脏支持系统或体外循环系统的插管系统，其中具有一对并排腔的第一套管适于定位在患者的左心房和左心室和主动脉内。来自左心房和左心室的血液排入第一套管中的一个管腔中，并被输送到脉动流动心肺旁路泵的入口，从那里泵入另一内腔进入患者的主动脉。在第一插管的远端设置有可膨胀的气囊，用于将套管的远端保持在主动脉瓣上方的主动脉中。第一插管包括与充气球囊和主动脉瓣之间的主动脉中的空间连通的轴向延伸的孔，用于将心脏停跳液转移到与患者的左和右动脉连通的空间。具有一对并排腔的第二套管适于定位在患者的右心房和右心室和肺动脉内。来自右心房和右心室的血液流入第二套管中的一个管腔，并被传送到脉动流心肺旁路泵，从那里泵送通过另一内腔进入患者的肺动脉。

14. 发明授权

US5743845A Biventricular pulsatile cardiac support system having a mechanically balanced stroke volume 失效
标题翻译：具有机械平衡的行程体积的双心搏脉动心脏支持系统
公开(公告)号：US5743845A
公开(公告)日：1998-04-28
申请号：US371964
申请日：1995-01-12
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10
CPC分类号： A61M1/1037 , A61M1/1096 , A61M1/1046
摘要： A biventricular pulsatile cardiac support system having a mechanically balanced stroke volume wherein a pair of side-by-side, valveless, compressible conduits extend through the compression chamber of a pulsatile flow cardiopulmonary bypass pump and a passive exterior valve positioned at the inlet and the outlet of the pump. The inlets of the conduits communicate with the right and left atria of the patient's heart and the outlets of the conduits communicate with the pulmonary artery and aorta so that the volume of blood passing from the right atrium, through the right ventricle, to the pulmonary artery, is substantially balanced with the volume of blood passing from the left atrium through the left ventricle to the aorta. The support system can be operated in single or biventricular support mode and in partial or total cardiopulmonary bypass mode, omitting the oxygenator used in conventional cardiopulmonary bypass, and in so doing, rely on the patient's own lungs rather than artificial oxygenator. This variant of cardiopulmonary support for cardiac surgery should reduce cost and complications associated with conventional cardiopulmonary bypass.
摘要翻译：具有机械平衡的行程体积的双心搏脉动心脏支持系统，其中一对并排的无阀可压缩导管延伸穿过脉动流心肺旁路泵的压缩室和位于入口和出口处的被动外部阀的泵。导管的入口与患者心脏的右心房和左心房连通，并且导管的出口与肺动脉和主动脉连通，使得从右心室通过右心室到达肺动脉的血液体积，与从左心房通过左心室到主动脉的血液体积基本平衡。支持系统可以在单心或双心支持模式和部分或全部心肺旁路模式下运行，省略常规体外循环中使用的氧合器，并且这样做依赖于患者自己的肺而不是人工充氧器。心脏手术的心肺支持的这种变体应该降低与常规体外循环相关的成本和并发症。

15. 发明授权

US5688245A Cannula system for a biventricular cardiac support system or a cardiopulmonary bypass system 失效
标题翻译：用于双心室心脏支持系统或体外循环系统的插管系统
公开(公告)号：US5688245A
公开(公告)日：1997-11-18
申请号：US641756
申请日：1996-05-02
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61F2/958 , A61M1/12 , A61M1/36 , A61M25/00 , A61M1/00
CPC分类号： A61M25/10 , A61M1/3659 , A61M25/0021 , A61M1/12 , A61M1/3666 , A61M2025/0037 , A61M2025/1052 , A61M2202/0472 , A61M2210/127 , A61M25/007
摘要： A cannula system for a biventricular cardiac support system or a cardiopulmonary bypass system wherein a first cannula having a pair of side-by-side lumens is adapted to be positioned within the left atrium and left ventricle and aorta of a patient. Blood from the left atrium and left ventricle drains into one of the lumens in the first cannula and is conveyed to the inlet of a pulsatile flow cardiopulmonary bypass pump from where it is pumped through the other lumen into the aorta of the patient. An inflatable balloon is provided at the distal end of the first cannula for holding the distal end of the cannula in the aorta above the aortic valve. The first cannula includes an axially extending bore communicating with a space in the aorta between the inflated balloon and the aortic valve for conveying cardioplegic solution to the space communicating with the left and right arteries of the patient. A second cannula having a pair of side-by-side lumens is adapted to be positioned within the right atrium and right ventricle and pulmonary artery of the patient. Blood from the right atrium and right ventricle flows into one of the lumens in the second cannula and is conveyed to the pulsatile flow cardiopulmonary bypass pump from where it is pumped through the other lumen into the pulmonary artery of the patient.
摘要翻译：用于双心室心脏支持系统或体外循环系统的插管系统，其中具有一对并排腔的第一套管适于定位在患者的左心房和左心室和主动脉内。来自左心房和左心室的血液排入第一套管中的一个管腔中，并被输送到脉动流动心肺旁路泵的入口，从那里泵入另一内腔进入患者的主动脉。在第一插管的远端设置有可膨胀的气囊，用于将套管的远端保持在主动脉瓣上方的主动脉中。第一插管包括与充气球囊和主动脉瓣之间的主动脉中的空间连通的轴向延伸的孔，用于将心脏停跳液转移到与患者的左和右动脉连通的空间。具有一对并排腔的第二套管适于定位在患者的右心房和右心室和肺动脉内。来自右心房和右心室的血液流入第二套管中的一个管腔，并被传送到脉动流心肺旁路泵，从那里泵送通过另一内腔进入患者的肺动脉。

16. 发明授权

US5114932A Hyperosmolar oxyreplete hemosubstitute 失效
标题翻译：高渗氧饱和血液发育
公开(公告)号：US5114932A
公开(公告)日：1992-05-19
申请号：US620539
申请日：1990-11-30
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61K9/00 , A61K31/025 , A61K31/13 , A61K33/00 , A61K33/42 , A61K38/42
CPC分类号： A61K9/0026 , A61K31/025 , A61K31/13 , A61K33/00 , A61K33/42 , A61K38/42 , Y10S514/832 , Y10S514/833
摘要： New blood substitutes are described having osmolarities greater than normal blood. The new blood substitues typically comprise a physiologically acceptable fluid electrolyte solution, a physiologically acceptable agent capable of increasing the osmolarity of the blood substitute to a value greater than normal blood, an oxygen carrying substance, and a sufficient amount of water to achieve the desired osmolarity. The blood substitutes of the present invention have osmolarities in the range of 500-800 milliosmoles per liter.
摘要翻译：描述了新的血液代用品具有大于正常血液的渗透压。新的血液替代物通常包括生理上可接受的流体电解质溶液，能够将血液替代物的渗透压增加到大于正常血液的值的生理学上可接受的试剂，携氧物质和足够量的水以达到所需的渗透压浓度。本发明的血液代用品的渗透压在500-800毫摩尔/升的范围内。

17. 发明授权

US4176411A Cardiac assist device employing electrically stimulated artificial muscle 失效
标题翻译：使用电刺激人造肌肉的心脏辅助装置
公开(公告)号：US4176411A
公开(公告)日：1979-12-04
申请号：US855219
申请日：1977-11-28
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61F2/72 , A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1053 , A61F2/72 , A61M1/1048 , A61M1/1055 , A61M1/122
摘要： A left atrial to descending thoracic aorta shunt is encircled by an artificial muscle sheath consisting of a multiplicity of connected rod-like segments formed of an elastomer. Each segment contains a series of embedded electromagnets and surrounding dispersed fragments of magnetically attractable material. The electromagnets are energized across intact skin of a recipient of the device by state of the art induction means to cause contraction of the individual artificial muscle segments with resulting contraction of the muscle sheath to thereby squeeze cyclically a predetermined volume of blood through the flexible shunt which is equipped at opposite ends of the muscle sheath with check valves.
摘要翻译：下降胸主动脉分流的左心房被包括由弹性体形成的多个连接的棒状节段组成的人造肌鞘包围。每段包含一系列嵌入式电磁铁，并包含磁吸引材料的分散碎片。电磁体通过现有技术的感应装置通过现有技术的诱导装置通过装置的受体的完整皮肤通电，从而引起各个人造肌肉段的收缩，从而导致肌肉鞘的收缩，从而通过柔性分流器循环地挤压预定体积的血液，在肌肉鞘的两端装有止回阀。

18. 发明授权

US4058855A Cardiac pumping device 失效
标题翻译：心脏泵送装置
公开(公告)号：US4058855A
公开(公告)日：1977-11-22
申请号：US760322
申请日：1977-01-18
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1046 , A61M1/1051 , Y10S128/03 , Y10T74/18312
摘要： A pulsatile flow pumping unit adapted to serve as a total cardiac replacement device, a cardiac assist pump for orthotopic placement, for extracorporeal application in conjunction with a membrane oxygenator for cardiopulmonary support during surgery or critical illnesses, for pulsatile flow coronary artery perfusion, and for filling and emptying of an aortic diastolic augmentation balloon for cardiac assist is provided. The pumping unit features simplicity of construction, comparative economy and reliability by utilizing a minimum number of working parts including a large diameter slitted rotary driver and cam operated follower means which avoids close machining tolerances and attendant high cost of manufacturing. The device automatically adjusts its rate of pumping in accordance with both preload (filling pressure) and afterload (pulmonic and systemic pressure) and in addition modifies its stroke volume in a downward direction when confronted with high afterload. The automatic adjustment of the device during operation depending on several variables is accomplished without electronic control or monitoring.
摘要翻译：一种脉动流动泵送装置，适用于全心脏置换装置，用于原位放置的心脏辅助泵，用于体外应用，用于在手术或关键疾病期间用于心肺支持的膜氧合器，用于脉动流动冠状动脉灌注，以及用于提供用于心脏辅助的主动脉舒张增压气囊的填充和排空。泵送单元具有简单的结构，比较经济性和可靠性，通过使用最小数量的工作部件，包括大直径切割旋转驱动器和凸轮操作的随动装置，其避免了紧密的加工公差和伴随的高制造成本。该装置根据预压（填充压力）和后负荷（肺气和全身压力）自动调节其泵送速率，此外，当面对高后负荷时，该装置还向下调整其行程体积。在运行期间根据多个变量的装置自动调整是在没有电子控制或监控的情况下完成的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式