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11. 发明申请

US20140200330A1 Isolation of Phosphoproteins, Glycoproteins and Fragments thereof 审中-公开
标题翻译：磷蛋白，糖蛋白及其片段的分离
公开(公告)号：US20140200330A1
公开(公告)日：2014-07-17
申请号：US13744305
申请日：2013-01-17
申请人： Matthias Rainer , Fabio Polato , Douglas T. Gjerde , Guenther Bonn
发明人： Matthias Rainer , Fabio Polato , Douglas T. Gjerde , Guenther Bonn
IPC分类号： C07K1/30
CPC分类号： C07K1/303
摘要： The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for many types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics.
摘要翻译：本发明提供了选择性分离磷酸化和糖基化蛋白质及其片段的方法和装置。镧系金属阳离子用于沉淀含有磷酸基团和/或糖基团的蛋白质或蛋白质片段。样品制备方法可用于许多类型的生物样品，包括HeLa细胞，食物和人脑脊液。蛋白质被分离，回收并准备好通过质谱法或其他分析方法进行分析，允许检测限降低到飞甲的水平。该方法和装置是蛋白质分析和诊断领域的宝贵工具。

12. 发明申请

US20120088906A1 Isolation of Phosphoproteins, Glycoproteins and Fragments thereof 有权
标题翻译：磷蛋白，糖蛋白及其片段的分离
公开(公告)号：US20120088906A1
公开(公告)日：2012-04-12
申请号：US13270148
申请日：2011-10-10
申请人： Fabio Polato , Mathias Rainer , Douglas T. Gjerde , Guenther Bonn
发明人： Fabio Polato , Mathias Rainer , Douglas T. Gjerde , Guenther Bonn
IPC分类号： C07K1/30 , C07K1/36
CPC分类号： C07K1/32
摘要： The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. Metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for several types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics.
摘要翻译：本发明提供了选择性分离磷酸化和糖基化蛋白质及其片段的方法和装置。金属阳离子用于沉淀含有磷酸基团和/或糖基团的蛋白质或蛋白质片段。样品制备方法可用于几种类型的生物样品，包括HeLa细胞，食物和人脑脊液。蛋白质被分离，回收并准备好通过质谱法或其他分析方法进行分析，允许检测限降低到飞甲的水平。该方法和装置是蛋白质分析和诊断领域的宝贵工具。

13. 发明授权

US08105513B2 Pipette tip containing particle-filled polymer monolith 有权
标题翻译：移液管尖端含有颗粒填充聚合物整料
公开(公告)号：US08105513B2
公开(公告)日：2012-01-31
申请号：US12479676
申请日：2009-06-05
申请人： Alexander Bonn , Guenther Bonn , Christian Huck , Bernhard Maerk , Harald Sonderegger , Mathias Rainer , Douglas T. Gjerde
发明人： Alexander Bonn , Guenther Bonn , Christian Huck , Bernhard Maerk , Harald Sonderegger , Mathias Rainer , Douglas T. Gjerde
IPC分类号： B05D7/22 , B01L3/02 , B01D35/02
CPC分类号： B01J20/28042 , B01J20/02 , B01J20/0211 , B01J20/0237 , B01J20/0281 , B01J20/043 , B01J20/048 , B01J20/06 , B01J20/08 , B01J20/103 , B01J20/20 , B01J20/205 , B01J20/26 , B01J20/28007 , B01J20/28026 , B01J2220/64 , B82Y30/00 , G01N2035/1053
摘要： The present invention relates to a pipette tip which is fitted with a porous organic monolith which is doped with active particles. Due to a unique polymerization method, the extraction tips stay highly permeable which allows sample to pass through the monolithic bed. The extraction tip represents an ideal tool for solid phase extraction, especially for desalting, isolating and purifying biomolecules such as peptides and proteins.
摘要翻译：吸液头技术领域本发明涉及一种移液管吸头，其配有掺有活性颗粒的多孔有机整料。由于独特的聚合方法，萃取尖端保持高渗透性，允许样品通过整体床。提取尖端代表固相萃取的理想工具，特别是用于脱盐，分离和纯化生物分子如肽和蛋白质。

14. 发明授权

US08734857B2 Hydrolysates made of plant extracts and antibacterial agent containing the same 有权
标题翻译：由植物提取物制成的水解物和含有它的抗菌剂
公开(公告)号：US08734857B2
公开(公告)日：2014-05-27
申请号：US12740396
申请日：2008-10-30
申请人： Guenther Bonn , Guenther Stecher , Michael A. Popp , Robert Mayer
发明人： Guenther Bonn , Guenther Stecher , Michael A. Popp , Robert Mayer
IPC分类号： A61K36/00
CPC分类号： A61K36/85 , A61K8/97 , A61K36/185 , A61K36/35 , A61K36/51 , A61K36/515 , A61K36/70 , A61Q11/00 , A61Q19/00 , Y02A50/473
摘要： The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Primula elatior (L.) Hill, and Gentiana lutea L.; and a mixture thereof; or b) a mixture of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Gentiana lutea L., and Rumicis herba; and subsequent removal of the ethanol/water extraction agent, wherein the hydrolysate can be obtained from the extract via hydrolytic treatment using a mineral acid. The hydrolyzates according to the invention show a pronounced antibacterial effect against germs relevant to the skin, ears, nose, and throat and respiratory systems.
摘要翻译：本发明涉及由至少一种提取物制成的抗菌剂和水解产物，所述提取物通过使用来自干燥植物材料的乙醇/水提取而制备，所述提取物为：a）至少一种选自以下的植物：马鞭草 L.，Sambucus nigra L.，Primula veris L.，Primula elatior（L.）Hill和Gentiana lutea L. 和它们的混合物; 或b）混合物：马鞭草（L.），接骨木（Sambucus nigra L.），樱草属（Primula veris L.），龙胆（Gentiana lutea L.）和罗米and（Rumicis herba）随后除去乙醇/水提取剂，其中可以通过使用无机酸的水解处理从提取物中获得水解产物。根据本发明的水解产物显示出对皮肤，耳朵，鼻子，喉咙和呼吸系统相关细菌的显着的抗菌作用。

15. 发明申请

US20120255894A1 METHOD FOR COVALENTLY ATTACHING POLYMERIC MONOLITHS TO POLYETHER ETHER KETONE (PEEK) SURFACES 审中-公开
标题翻译：将聚合物单体与聚醚醚酮（PEEK）表面共价连接的方法
公开(公告)号：US20120255894A1
公开(公告)日：2012-10-11
申请号：US13516810
申请日：2010-12-20
申请人： Guenther Bonn , Samuel Clark Ligon
发明人： Guenther Bonn , Samuel Clark Ligon
IPC分类号： C08G8/02 , B01D15/20
CPC分类号： B01J20/285 , B01D15/206 , B01D15/22 , B01J20/261 , B01J20/30 , B01J20/3092 , B01J2220/82 , B01J2220/86 , G01N30/6052 , G01N30/6078 , G01N2030/528 , G01N2030/567
摘要： Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces The present invention provides a method of covalently attaching a polymeric monolith to the internal surface of polyether ether ketone (PEEK) tubing and column housings, comprising the steps of: (a) reducing the ketone group of the PEEK to a hydroxyl group to obtain a modified PEEK, (b) optionally reacting the hydroxyl group obtained in step (a) with a compound having an active vinyl group to form a modified PEEK selected from the group of acrylate modified PEEK, methacrylate modified PEEK, styrene modified PEEK and epoxy modified PEEK, and (c) reacting the modified PEEK obtained in step (a) or (b) with a polymer or polymerization mixture for forming the polymeric monolith. Hereby, the mechanical stability and solvent durability of larger diameter monolithic columns as well as their overall performance are improved.
摘要翻译：将聚合物整料共价连接到聚醚醚酮（PEEK）表面上的方法本发明提供了一种将聚合物整料共价连接到聚醚醚酮（PEEK）管和柱壳体的内表面上的方法，包括以下步骤：（a）将PEEK的酮基还原为羟基以获得改性的PEEK，（b）任选地使步骤（a）中获得的羟基与具有活性乙烯基的化合物反应以形成选自丙烯酸酯的改性PEEK 改性PEEK，甲基丙烯酸酯改性PEEK，苯乙烯改性PEEK和环氧改性PEEK，和（c）使步骤（a）或（b）中获得的改性PEEK与形成聚合物整料的聚合物或聚合混合物反应。因此，改善了较大直径单块柱的机械稳定性和溶剂耐久性以及其整体性能。

16. 发明申请

US20100323013A1 HYDROLYSATES MADE OF PLANT EXTRACTS AND ANTIBACTERIAL AGENT CONTAINING THE SAME 有权
标题翻译：植物提取物和含有其的抗菌剂的水解产物
公开(公告)号：US20100323013A1
公开(公告)日：2010-12-23
申请号：US12740396
申请日：2008-10-30
申请人： Guenther Bonn , Guenther Stecher , Michael A. Popp , Robert Mayer
发明人： Guenther Bonn , Guenther Stecher , Michael A. Popp , Robert Mayer
IPC分类号： A61K9/36 , A61K36/85 , A61K9/28 , A61P31/04
CPC分类号： A61K36/85 , A61K8/97 , A61K36/185 , A61K36/35 , A61K36/51 , A61K36/515 , A61K36/70 , A61Q11/00 , A61Q19/00 , Y02A50/473
摘要： The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Primula elatior (L.) Hill, and Gentiana lutea L.; and a mixture thereof; or b) a mixture of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Gentiana lutea L., and Rumicis herba; and subsequent removal of the ethanol/water extraction agent, wherein the hydrolysate can be obtained from the extract via hydrolytic treatment using a mineral acid. The hydrolyzates according to the invention show a pronounced antibacterial effect against germs relevant to the skin, ears, nose, and throat and respiratory systems.
摘要翻译：本发明涉及由至少一种提取物制成的抗菌剂和水解产物，所述提取物通过使用来自干燥植物材料的乙醇/水提取而制备，所述提取物为：a）至少一种选自以下的植物：马鞭草 L.，Sambucus nigra L.，Primula veris L.，Primula elatior（L.）Hill和Gentiana lutea L. 和它们的混合物; 或b）混合物：马鞭草（L.），接骨木（Sambucus nigra L.），樱草属（Primula veris L.），龙胆（Gentiana lutea L.）和罗米and（Rumicis herba）随后除去乙醇/水提取剂，其中可以通过使用无机酸的水解处理从提取物中获得水解产物。根据本发明的水解产物显示出对皮肤，耳朵，鼻子，喉咙和呼吸系统相关细菌的显着的抗菌作用。

17. 发明授权

US07715002B2 Method for classifying scientific materials such as silicate materials, polymer materials and/or nanomaterials 有权
标题翻译：用于分类硅酸盐材料，聚合物材料和/或纳米材料等科学材料的方法
公开(公告)号：US07715002B2
公开(公告)日：2010-05-11
申请号：US11626321
申请日：2007-01-23
申请人： Michael A. Popp , Guenther Bonn , Christian W. Huck
发明人： Michael A. Popp , Guenther Bonn , Christian W. Huck
IPC分类号： G01J3/42 , G01N21/35
CPC分类号： G01N21/359 , G01N21/3563 , G01N2201/1293
摘要： A method is provided for characterizing a scientific material, such as a silicate material, a polymer material and/or nanomaterial. The method can include the steps of irradiating a measuring light of a predetermined wavelength range into material specimens, recording the measuring light reflected and/or reemitted by the material specimens, determining a ratio depending on the wave lengths of irradiated to detected measuring light (spectrum), and numerical-mathematical processing of spectral data of single material specimens for determining the characteristic features of the material specimens.
摘要翻译：提供了用于表征科学材料的方法，例如硅酸盐材料，聚合物材料和/或纳米材料。该方法可以包括以下步骤：将预定波长范围的测量光照射到材料样品中，记录由材料样品反射和/或重新发射的测量光，确定根据照射到检测到的测量光的波长），以及用于确定材料样品的特征的单一材料样品的光谱数据的数学数学处理。

18. 发明申请

US20100078572A1 ANALYSIS OF LOW MOLECULAR WEIGHT MOLECULES BY MALDI-MS 审中-公开
标题翻译：通过MALDI-MS分析低分子量分子
公开(公告)号：US20100078572A1
公开(公告)日：2010-04-01
申请号：US12531832
申请日：2008-03-19
申请人： Guenther Bonn , Rania Bakry , Christian W. Huck , Rainer Vallant , Zoltan Szabo
发明人： Guenther Bonn , Rania Bakry , Christian W. Huck , Rainer Vallant , Zoltan Szabo
IPC分类号： B01D59/44
CPC分类号： H01J49/0418
摘要： The invention relates to a process for the analysis of molecules having a molecular weight of
摘要翻译：本发明涉及通过基质辅助激光解吸/电离质谱法（MALDI-MS）分析分子量为<1500Da的分子的方法，其中将含有低分子量分子的分析物施加到基质材料上，其特征在于基质材料包括富勒烯衍生的二氧化硅。该过程允许通过密集的信号清楚地识别小分子而不与基质相关的背景扰动。

19. 发明申请

US20080177481A1 METHOD FOR CLASSIFYING SCIENTIFIC MATERIALS SUCH AS SILICATE MATERIALS, POLYMER MATERIALS AND/OR NANOMATERIALS 有权
标题翻译：用于分类诸如硅酸盐材料，聚合物材料和/或纳米材料的科学材料的方法
公开(公告)号：US20080177481A1
公开(公告)日：2008-07-24
申请号：US11626321
申请日：2007-01-23
申请人： Michael A. Popp , Guenther Bonn , Christian W. Huck
发明人： Michael A. Popp , Guenther Bonn , Christian W. Huck
IPC分类号： G01N21/00 , G01N15/02
CPC分类号： G01N21/359 , G01N21/3563 , G01N2201/1293
摘要： A method is provided for characterizing a scientific material, such as a silicate material, a polymer material and/or nanomaterial. The method can include the steps of irradiating a measuring light of a predetermined wavelength range into material specimens, recording the measuring light reflected and/or reemitted by the material specimens, determining a ratio depending on the wave lengths of irradiated to detected measuring light (spectrum), and numerical-mathematical processing of spectral data of single material specimens for determining the characteristic features of the material specimens.
摘要翻译：提供了用于表征科学材料的方法，例如硅酸盐材料，聚合物材料和/或纳米材料。该方法可以包括以下步骤：将预定波长范围的测量光照射到材料样品中，记录由材料样品反射和/或重新发射的测量光，确定根据照射到检测到的测量光的波长），以及用于确定材料样品的特征的单一材料样品的光谱数据的数学数学处理。

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