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11. 发明授权

US06656927B1 Ip3 receptor ligands 失效
标题翻译： Ip3受体配体
公开(公告)号：US06656927B1
公开(公告)日：2003-12-02
申请号：US09926664
申请日：2001-11-30
申请人： Tetsuo Nagano , Kazuya Kikuchi , Takanari Inoue , Masamitsu Iino , Kenzo Hirose
发明人： Tetsuo Nagano , Kazuya Kikuchi , Takanari Inoue , Masamitsu Iino , Kenzo Hirose
IPC分类号： A61K3800
CPC分类号： C07F9/6561 , C07F9/117 , C07F9/65522
摘要： A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R1 and R2 independently represent a C1-6 alkyl group, R3 represents an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group or a C1-6 alkoxy group and X-represents an anion, and n represents an integer of 2 to 5. The compound or a salt is useful as a ligand of inositol-1,4,5-trisphosphate (IP3) receptor.
摘要翻译：由通式（I）表示的化合物或其盐，其中R表示由下式（A），（B）或（C）表示的基团，其中R 1和R 2独立地表示C1 -6烷基，R 3表示氨基，单（C 1-6烷基）氨基，二（C 1-6烷基）氨基或C 1-6烷氧基，X代表阴离子，和 n表示2〜5的整数。化合物或其盐可用作肌醇-1,4,5-三磷酸（IP3）受体的配体。

12. 发明授权

US07939330B2 Fluorescent probe 失效
标题翻译：荧光探针
公开(公告)号：US07939330B2
公开(公告)日：2011-05-10
申请号：US12911348
申请日：2010-10-25
申请人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
发明人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
IPC分类号： G01N21/78 , G01N31/00 , G01N31/22 , C07D209/08 , C07D249/18
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided.A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R1和R2表示氢原子或由下式（A）表示的基团：（其中X1至X4表示氢原子，烷基或保护基氨基，m和n表示0或1）; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基; R5至R12表示氢原子，磺基，磷基，卤素原子或C1-6烷基; R13和R14表示C1-18烷基; Z1表示氧原子，硫原子或-N（R15） - （其中R15表示氢原子或C1-6烷基）; Y1和Y2表示-C（= O） - ， - C（= S） - 或-C（R16）（R17）（其中R16和R17表示C1-6烷基）。和M-表示中和电荷所需数量的抗衡离子]。

13. 发明申请

US20100330685A1 DIAMINORHODAMINE DERIVATIVE 审中-公开
公开(公告)号：US20100330685A1
公开(公告)日：2010-12-30
申请号：US12826291
申请日：2010-06-29
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N33/00 , C07D493/10 , C07D491/20
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X表示阴离子，和含有所述化合物的一氧化氮测定用试剂。

14. 发明授权

US07297690B2 Fluorescent lanthadine complex 失效
标题翻译：荧光素配子
公开(公告)号：US07297690B2
公开(公告)日：2007-11-20
申请号：US10536382
申请日：2004-02-17
申请人： Kazuya Kikuchi , Shinya Iwasawa , Tetsuo Nagano
发明人： Kazuya Kikuchi , Shinya Iwasawa , Tetsuo Nagano
IPC分类号： C07F7/00 , C07F9/00
CPC分类号： C07D215/38 , C09K11/06 , C09K2211/1029
摘要： A luminescent lanthanide complex using a photo induced electron transfer as the luminescence controlling principle is presented. The complex comprises a substituted 2-quinolinol containing a sensor group and a complex group and lanthanide ion (Ln3+). This complex is allowed to be co-present in a liquid phase with a material to be measured, and the luminescence of said complex is measured.
摘要翻译：提出了使用光诱导电子转移作为发光控制原理的发光镧系元素络合物。络合物包含含有传感器基团和络合基团和镧系元素离子（Ln 3+ +）的取代的2-羟基喹啉。允许该络合物与待测量的材料在液相中共存，并测量所述络合物的发光。

15. 发明申请

US20050037332A1 Fluorescent probe for zinc 失效
标题翻译：锌荧光探针
公开(公告)号：US20050037332A1
公开(公告)日：2005-02-17
申请号：US10767334
申请日：2004-01-30
申请人： Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
发明人： Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
IPC分类号： C07D405/12 , C07D405/14 , C07D493/10 , G01N33/58 , G01N33/84 , C12Q1/00 , C07D311/88 , C07D45/02
CPC分类号： C07D405/12 , C07D405/14 , C07D493/10 , G01N33/582 , G01N33/84
摘要： A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.
摘要翻译：由以下通式（IA）或（IB）表示的化合物或其盐特异性捕获锌离子并发射荧光，并且可用作锌的荧光探针：其中R 1和R 2表示氢原子或下述式（A）表示的基团：其中X 1〜X 4表示氢原子，2-吡啶基甲基，2-吡啶基乙基，2-甲基-6-吡啶基甲基基团或2-甲基-6-吡啶基乙基，条件是至少一个是除2-吡啶基甲基之外的基团，m和n表示0或1，条件是它们不同时为0; 条件是R 1和R 2不同时为氢原子; R 3和R 4代表氢原子或卤素原子; R 5和R 6代表氢原子，烷基羰基或烷基羰氧基甲基; R 7表示氢原子或烷基。

16. 发明申请

US20070298507A1 Fluorescent Probe 审中-公开
标题翻译：荧光探针
公开(公告)号：US20070298507A1
公开(公告)日：2007-12-27
申请号：US10598250
申请日：2005-02-22
申请人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
发明人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
IPC分类号： G01N21/78 , C07D209/08 , G01N31/00 , G01N31/22 , C07D249/18
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided. A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R 1和R 2表示氢原子或由下式（A）表示的基团：（其中X 1至X 4表示氢原子，烷基或氨基的保护基，m和n表示0或1）; R 3和R 4代表氢原子，C 1-6烷基或C 1-6 - 烷基烷氧基 R 5至R 12代表氢原子，磺基，磷酸基，卤素原子或C 1-6烷基; R 13和R 14代表C 1-18烷基; Z 1表示氧原子，硫原子或-N（R 15） - （其中R 15表示氢原子或C 1〜烷基）; Y - （O） - ， - （-S） - 或-C（R 16）（R 17）（其中R 16和R 17代表C 1-6烷基）; 和 - 表示中和电荷所需的数字的抗衡离子]。

17. 发明授权

US06328602B1 Connector with less crosstalk 失效
标题翻译：串扰少的连接器
公开(公告)号：US06328602B1
公开(公告)日：2001-12-11
申请号：US09593790
申请日：2000-06-13
申请人： Shuji Yamasaki , Kazuya Kikuchi
发明人： Shuji Yamasaki , Kazuya Kikuchi
IPC分类号： H01R13648
CPC分类号： H01R13/6585 , H01R13/6471
摘要： A connector includes signal sockets, and ground sockets. The signal sockets and the ground sockets are made of electrically conductive material and alternately arranged in a column direction and a row direction. Each of the signal sockets includes a contact lead section for an external signal lead to be connected, and a base section connected to the contact lead section of the signal socket. Also, each of the ground sockets includes a contact lead section for an external ground lead to be connected, a first extending section extending between one of the signal sockets which is arranged adjacent to the ground socket and one of two of the signal sockets which are arranged adjacent to the ground socket obliquely from the one signal socket, and a base section connected to the contact lead section of the ground socket and the first extending section. Here, the first extending section of the ground socket shields electromagnetic wave from the one signal socket to the one of the two signal sockets.
摘要翻译：一个连接器包括信号插座和接地插座。信号插座和接地插座由导电材料制成，并且在列方向和行方向上交替布置。每个信号插座包括用于连接外部信号引线的接触引线部分和连接到信号插座的接触引线部分的基部。此外，每个接地插座包括用于连接外部接地引线的接触引线部分，在与接地插座相邻布置的信号插座中的一个之间延伸的第一延伸部分和两个信号插座之一从所述一个信号插座倾斜地布置成与所述接地插座相邻，以及与所述接地插座的接触引线部和所述第一延伸部连接的基部。这里，接地插座的第一延伸部分将电磁波从一个信号插座屏蔽到两个信号插座中的一个。

18. 发明授权

US6048230A Contact and high-density connector using the same 失效
标题翻译：接触和高密度连接器使用相同
公开(公告)号：US6048230A
公开(公告)日：2000-04-11
申请号：US966037
申请日：1997-11-07
申请人： Kazuya Kikuchi
发明人： Kazuya Kikuchi
IPC分类号： H01R13/11 , H01R13/10
CPC分类号： H01R13/11 , H01R12/724 , H01R2107/00
摘要： In a connector, distal end portions of a pair of elastic tongue pieces are formed with beveling tapered-extension portions such that, when the elastic tongue pieces are displaced substantially perpendicularly to an inserting direction of a rod-like male terminal upon insertion and fitting of the rod-like male terminal between the elastic tongue pieces of a bifoliate female terminal, distal-end outer-side surfaces of the elastic tongue pieces become parallel to an inner wall of a female terminal insertion window with an angle determined by considering an angle of deflection of the elastic tongue pieces. A high-density connector using this contact is also disclosed.
摘要翻译：在一个连接器中，一对弹性舌片的远端部分形成有斜切锥形延伸部分，使得弹性舌片在插入和装配时基本上垂直于杆状阳端子的插入方向移位双极母端子的弹性舌片之间的杆状阳端子，弹性舌片的前端外侧表面平行于阴端子插入窗口的内壁，其角度通过考虑角度弹性舌片的偏转。还公开了使用该接触件的高密度连接器。

19. 发明授权

US5369642A Switcher for redundant signal transmission system 失效
标题翻译：冗余信号传输系统切换器
公开(公告)号：US5369642A
公开(公告)日：1994-11-29
申请号：US892249
申请日：1992-06-02
申请人： Masashi Shioka , Kazuya Kikuchi
发明人： Masashi Shioka , Kazuya Kikuchi
IPC分类号： H04B1/74 , G06F11/00
CPC分类号： H04B1/74
摘要： A switcher applicable to a redundant signal transmission system and capable of maintaining impedance matching when an input line associated with a faulty active transmitter is connected to a standby transmitter. The switcher may have first switching circuit assigned to the standby transmitter, a plurality of second switching circuits associated one-to-one with a plurality of active transmitters, and a pair of connection lines cascading the first and second switching circuits. When a faulty active transmitter is replaced with the standby transmitter, relay switches constituting the first and second switching circuits disconnect portions of the connection lines which are more remote, from the first switching circuit than the second switching circuit means associated with the faulty active transmitter.
摘要翻译：适用于冗余信号传输系统的切换器，并且当与故障有源发射机相关联的输入线路连接到备用发射机时能够维持阻抗匹配。切换器可以具有分配给备用发射机的第一切换电路，与多个有源发射机一对一关联的多个第二切换电路以及级联第一和第二开关电路的一对连接线。当故障有源发射机被替换为备用发射机时，构成第一和第二开关电路的继电器开关从与第一开关电路相比远离与第二有源变送器有关的第二开关电路装置的连接线的部分更远。

20. 发明授权

US08940906B2 Nonlinear luminescent molecule, fluorescent stain, and observation method 有权
标题翻译：非线性发光分子，荧光染料和观察方法
公开(公告)号：US08940906B2
公开(公告)日：2015-01-27
申请号：US13380749
申请日：2010-06-21
申请人： Katsumasa Fujita , Shin Mizukami , Kazuya Kikuchi , Satoshi Kawata , Shogo Kawano
发明人： Katsumasa Fujita , Shin Mizukami , Kazuya Kikuchi , Satoshi Kawata , Shogo Kawano
IPC分类号： C07F5/02 , G01N21/64 , C09B23/04 , C09B57/10
CPC分类号： C07F5/022 , C09B23/04 , C09B57/10 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to a nonlinear fluorescent molecule that generates a nonlinear fluorescence reaction by incidence of excitation light. This nonlinear fluorescence molecule includes donors and, and an acceptor that is coupled to the donors and. As the donor is excited by the incidence of the excitation light, electric charge moves from the donor to the acceptor. Then, the donor and the acceptor form a charge separated state. In a state in which the charge separated state is maintained, the donor fluoresces when transiting from an excited state to a ground state.
摘要翻译：本发明涉及通过激发光的入射产生非线性荧光反应的非线性荧光分子。这种非线性荧光分子包括供体和与供体偶联的受体。当供体被激发光的发生激发时，电荷从供体移动到受体。然后，供体和受体形成电荷分离状态。在保持电荷分离状态的状态下，当从激发态转变为基态时，供体发荧光。

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