会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 12. 发明申请
    • Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof
    • 工程I-ONUI核酸内切酶及其同源物及其用途的生成与表达
    • US20140148361A1
    • 2014-05-29
    • US13702972
    • 2011-06-07
    • Barry L. StoddardAbigail Rose LambertRyo TakeuchiAndrew M. ScharenbergSarah Katherine Baxter
    • Barry L. StoddardAbigail Rose LambertRyo TakeuchiAndrew M. ScharenbergSarah Katherine Baxter
    • C12N15/10
    • C12N15/1037C07K2319/00C12N9/22C12N15/1034C12Q1/44G01N2333/922
    • The present disclosure provides compositions and methods for producing and expressing variant or engineered I-OnuI endonucleases, variant or engineered I-OnuI homologues, and hybrids of two I-OnuI or I-OnuI homologue domains that have a target site altered from the wild-type. A method for selecting a variant or engineered I-OnuI endonuclease, I-OnuI endonuclease homologue, and a hybrid of two I-OnuI or I-OnuI homologue domains that have a target site altered from the wild-type and directed to a site within a gene of interest is also provided. In addition, the present disclosure provides the crystal structure of the I-OnuI and I-LtrI endonucleases; the specificity profiles for both endonuclease for DNA binding and cleavage; the identity of amino acid residue positions in the I-OnuI and I-LtrI protein scaffold that determine DNA recognition specificity; methods for determining amino acid substitutions at those positions that alter DNA cleavage specificity; methods for the complete redesign of the DNA cleavage specificity of I-OnuI and its homologues for recognition and cleavage of a human gene of interest; and the relationship of the amino acid sequence, structure and specificity of I-OnuI to a collection of identifiable I-OnuI endonuclease homologues.
    • 本公开提供了用于产生和表达变体或工程化I-OnuI内切核酸酶,变体或工程化I-OnuI同源物的组合物和方法,以及两个I-OnuI或I-OnuI同系物结构域的杂交体,其具有从野生型 类型。 用于选择变体或工程化的I-OnuI核酸内切核酸酶,I-OnuI核酸内切酶同源物的方法,以及两个I-OnuI或I-OnuI同源结构域的杂交体,其具有从野生型改变的靶位点并引导至野生型 还提供了感兴趣的基因。 此外,本公开提供了I-OnuI和I-LtrI内切核酸酶的晶体结构; 核酸内切酶用于DNA结合和切割的特异性谱; 确定DNA识别特异性的I-OnuI和I-LtrI蛋白质支架中的氨基酸残基位置的身份; 在改变DNA裂解特异性的那些位置处测定氨基酸取代的方法; 完全重新设计I-OnuI及其同源物的DNA切割特异性的方法,用于识别和切割感兴趣的人类基因; 以及I-OnuI的氨基酸序列,结构和特异性与可鉴定的I-OnuI核酸内切酶同源物的集合的关系。
    • 13. 发明申请
    • Display driving semiconductor device
    • 显示驱动半导体器件
    • US20100194730A1
    • 2010-08-05
    • US12654247
    • 2009-12-15
    • Ryo Takeuchi
    • Ryo Takeuchi
    • G06F3/038
    • H01L23/4985H01L23/50H01L2924/0002H01L2924/00
    • In order to decrease the length of a semiconductor element in a long side direction taking into consideration a disposition of electrodes and circuits, center portions (30a-3, 30a-4, and 30a-5) of a long side portion (30a) of the semiconductor element (30) include the plurality of display input electrodes (34) arranged in the long side direction (X). A center portion (30b-3) of a long side portion (30b) includes the plurality of power supply input electrodes (41) arranged in the long side direction (X). The center portions (30a-3, 30a-4, and 30a-5) of the long side portion (30a) further include space or an electrode for routing the conductor wiring (51) from the substrate (32) to the plurality of power supply input electrodes (41).
    • 考虑到电极和电路的布置,为了在长边方向上减小半导体元件的长度,将长边部分(30a)的中心部分(30a-3,30a-4和30a-5) 半导体元件(30)包括沿长边方向(X)配置的多个显示用输入电极(34)。 长侧部(30b)的中心部(30b-3)包括沿长边方向(X)配置的多个电源输入电极(41)。 长侧部分(30a)的中心部分(30a-3,30a-4和30a-5)还包括用于将导体布线(51)从基板(32)路由到多个功率的空间或电极 供给输入电极(41)。
    • 16. 发明申请
    • Level shifter circuit and display driver circuit
    • 电平移位电路和显示驱动电路
    • US20120038611A1
    • 2012-02-16
    • US13137057
    • 2011-07-18
    • Keigo OtaniRyo Takeuchi
    • Keigo OtaniRyo Takeuchi
    • G09G5/00H03L5/00
    • H03K3/356165G09G2310/027
    • A level shifter circuit according to the present invention includes a first voltage conversion circuit and a second voltage conversion circuit. The first voltage conversion circuit receives an input signal having an amplitude ranging between a power supply potential GND and a power supply potential VDDL, a power supply potential VDDH which is higher than the power supply potential VDDL is supplied. Further, a current limiting circuit is provided that limits a current supplied from a power supply line of the power supply potential VDDH, and outputs a voltage signal with a larger amplitude than that of the input signal according to the input signal. The second voltage conversion circuit is supplied with the power supply potential VDDH, and outputs an output signal with an amplitude ranging between the power supply potential GND and the power supply potential VDDH.
    • 根据本发明的电平移位器电路包括第一电压转换电路和第二电压转换电路。 第一电压转换电路接收具有在电源电位GND和电源电位VDDL之间的幅度范围的输入信号,提供高于电源电位VDDL的电源电位VDDH。 此外,提供了限制从电源电位VDDH的电源线提供的电流的限流电路,并根据输入信号输出具有比输入信号的幅度大的振幅的电压信号。 第二电压转换电路被提供有电源电位VDDH,并输出幅度在电源电位GND和电源电位VDDH之间的输出信号。