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11. 发明申请

US20140154725A1 INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO NANOPARTICLES 有权
标题翻译：用于测试血脑屏障穿刺的基于INSECT的VIVO模型和将脑膜暴露于纳米颗粒的方法
公开(公告)号：US20140154725A1
公开(公告)日：2014-06-05
申请号：US13881566
申请日：2011-09-30
申请人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
IPC分类号： G01N33/50
CPC分类号： G01N33/5058 , G01N33/5085
摘要： There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.
摘要翻译：提供了一种离体昆虫筛选模型，以准确地确定不同纳米颗粒的血脑屏障穿透，以改善早期药物发现过程中的复合筛选程序/过程。与现有技术相比，该目标提供了许多优点，因为昆虫模型是决策过程中比现有体外模型更可靠的工具，并且将加速药物筛选过程并减少后期磨耗率。此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

12. 发明申请

US20120122145A1 INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO CHEMICAL COMPOUNDS 有权
标题翻译：用于测试血脑屏障穿刺的基于INSECT的VIVO模型和将化学物质暴露于化学化合物的方法
公开(公告)号：US20120122145A1
公开(公告)日：2012-05-17
申请号：US13387088
申请日：2010-08-10
申请人： Peter Aadal , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal , Gunnar Andersson , Olga Andersson
IPC分类号： C12Q1/02 , A01K67/00
CPC分类号： G01N33/5085
摘要： There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.
摘要翻译：提供了一种离体昆虫筛选模型，以准确确定不同化合物的血脑屏障渗透，以改善早期药物发现过程中的复合筛选程序/过程。与现有技术相比，该目标提供了许多优点，因为昆虫模型是决策过程中比现有体外模型更可靠的工具，并且将加速药物筛选过程并减少后期磨耗率。此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

13. 发明授权

US07444266B2 Control system for a transformer or reactor 有权
标题翻译：变压器或电抗器的控制系统
公开(公告)号：US07444266B2
公开(公告)日：2008-10-28
申请号：US11385434
申请日：2006-03-21
申请人： Bengt-Olof Stenestam , Gunnar Andersson
发明人： Bengt-Olof Stenestam , Gunnar Andersson
IPC分类号： G06F11/30 , G06F15/00 , G21C17/00
CPC分类号： G01R31/3274 , G01R31/027 , H01F29/04 , H01H2009/0061 , H02H7/055
摘要： A universal control and diagnostic system for a transformer that may be retrofit with existing control and tap-changer equipment, the system providing for remote monitoring and control of the equipment and for measuring various criteria associated with the tap-changer to substantially minimize damage to the equipment during a maneuver and for substantially avoiding carbonization of a connected contact.
摘要翻译：用于变压器的通用控制和诊断系统，可以使用现有的控制和分接开关设备进行改造，该系统提供对设备的远程监控和控制，并用于测量与分接开关相关的各种标准，从而大大减少对在机动操作期间设备，并大大避免连接的接触件的碳化。

14. 发明申请

US20050187297A1 New compounds, methods for their preparation and use thereof 失效
标题翻译：新化合物，其制备方法和用途
公开(公告)号：US20050187297A1
公开(公告)日：2005-08-25
申请号：US11050430
申请日：2005-02-04
申请人： Stig Jonsson , Gunnar Andersson , Ulf Wellmar , Ingela Fritzson
发明人： Stig Jonsson , Gunnar Andersson , Ulf Wellmar , Ingela Fritzson
IPC分类号： A61K31/195 , C07C233/54 , C07C233/63 , C07C233/75 , C07C233/88 , C07C235/56 , C07C275/36 , C07C321/28 , C07C321/30 , C07C323/59 , C07C323/63 , C07D207/06 , C07D211/14 , C07D295/096 , C07D295/155
CPC分类号： C07C233/54 , C07C233/63 , C07C233/75 , C07C235/56 , C07C275/36 , C07C323/59 , C07C323/63 , C07C2601/02 , C07D207/06 , C07D211/14 , C07D295/096 , C07D295/155
摘要： Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.
摘要翻译：用于临床治疗自身免疫疾病，炎性疾病，器官移植排斥和恶性肿瘤的式（I）化合物。一种药物组合物，其包含给予每日剂量为0.005mg / kg至10mg / kg体重，特别是0.025mg / kg至2mg / kg体重的式（I）化合物。

15. 发明申请

US20050099741A1 Tap changer monitoring 有权
标题翻译：分接开关监控
公开(公告)号：US20050099741A1
公开(公告)日：2005-05-12
申请号：US10450579
申请日：2001-12-14
申请人： Bengt-Olof Stenestam , Gunnar Andersson
发明人： Bengt-Olof Stenestam , Gunnar Andersson
IPC分类号： G01R31/327 , G01R31/333 , H01F29/04 , H02H3/00
CPC分类号： G01R31/3274 , G01R31/333 , H01F29/04 , H01H2009/0061
摘要： A method and means for diagnosing transformer tap changers is provided. Pressure is monitored in an insulating liquid of a tap changer for a period of time in which switching of the tap changer is carried through. Switching-related information is then extracted from the pressure diagram. The method, preferably used for single-phase tap changers, comprises the step of relating quantities from pressure peaks to specific arcings of the switching sequence. Early error detection is achieved, whereby transformed failures may be avoided. Repeated measurements ae followed by trend evaluation. If a trend indicating tap changer problems is detected, an alarm signal is triggered. The invention may include switching off the transformer if the pressure exceeds a predetermined emergency value as well as extracting information of the base pressure in the tap changer and converting it to level of insulating liquid.
摘要翻译：提供了用于诊断变压器抽头变换器的方法和装置。在分接开关的绝缘液体中监测压力，持续一段时间，分接开关切换进行。然后从压力图中提取开关相关信息。优选用于单相抽头变换器的方法包括将来自压力峰值的数量与切换序列的特定弧形相关联的步骤。实现早期错误检测，从而可以避免变形的故障。重复测量，然后进行趋势评估。如果检测到指示分接开关故障的趋势，则触发报警信号。如果压力超过预定的紧急值，本发明可以包括关闭变压器，以及提取分接开关中的基础压力的信息并将其转换成绝缘液体的水平。

16. 发明授权

US06322739B1 Method of manufacturing pharmaceutical articles 有权
标题翻译：药品的制造方法
公开(公告)号：US06322739B1
公开(公告)日：2001-11-27
申请号：US09372006
申请日：1999-08-11
申请人： Gunnar Andersson , Des Mulligan
发明人： Gunnar Andersson , Des Mulligan
IPC分类号： B29C4514
CPC分类号： B65D51/002 , B29C35/16 , B29C37/005 , B29C45/00 , B29C45/0053 , B29C45/14 , B29C45/16 , B29C71/0072 , B29K2023/12 , B29L2031/565 , Y10S425/812 , Y10T428/1352
摘要： The invention relates to a process of preparing pharmaceutical closures for containers made of flexible polymeric materials which are suitable to be filled with parenterally administerable fluids prior to their sealing and sterilization. The process involves a specific relaxation period for the elastomer material of the closure which thereby can settle and develop resealing characteristics. The closures will have an excellent resealing capacity after being penetrated by a piercing device for establishing fluid communication with the container, even after multiple entries into the container.
摘要翻译：本发明涉及一种制备用于由柔性聚合物材料制成的容器的药物封闭物的方法，其适合于在其密封和灭菌之前装有肠胃外施用的流体。该方法涉及封闭件的弹性体材料的特定松弛期，从而可以沉降并形成再密封特性。即使在多次进入容器之后，这些封闭件在被穿孔装置穿透以与容器形成流体连通之后将具有优异的再密封能力。

17. 发明授权

US09513279B2 Insect-based ex vivo model for testing blood-brain barrier penetration and method for exposing insect brain to nanoparticles 有权
标题翻译：用于测试血脑屏障渗透的基于昆虫的离体模型和将昆虫脑暴露于纳米颗粒的方法
公开(公告)号：US09513279B2
公开(公告)日：2016-12-06
申请号：US13881566
申请日：2011-09-30
申请人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
IPC分类号： G01N33/50
CPC分类号： G01N33/5058 , G01N33/5085
摘要： There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.
摘要翻译：提供了一种离体昆虫筛选模型，以准确地确定不同纳米颗粒的血脑屏障穿透，以改进早期药物发现过程中的复合筛选程序/过程。与现有技术相比，该目标提供了许多优点，因为昆虫模型是决策过程中比现有体外模型更可靠的工具，并且将加速药物筛选过程并减少后期磨耗率。此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

18. 发明授权

US09194864B2 Screening methods employing insects with blood brain barrier 有权
标题翻译：使用具有血脑屏障的昆虫的筛选方法
公开(公告)号：US09194864B2
公开(公告)日：2015-11-24
申请号：US13060619
申请日：2009-09-16
申请人： Peter Aadal Nielsen , Gunnar Andersson
发明人： Peter Aadal Nielsen , Gunnar Andersson
IPC分类号： G01N33/50
CPC分类号： G01N33/5085
摘要： There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier.
摘要翻译：提供旨在反映脊椎动物血脑屏障（BBB）渗透的昆虫模型。 BBB穿透的调查在药物发现中是非常重要的; 成功的CNS药物必须穿过BBB，而BBB渗透可能会对外周作用药物造成不良副作用。具体地，本发明涉及昆虫在对脑或中枢神经系统具有生物学作用的物质的筛选和/或对脑或中枢神经系统疾病或病症的影响中的应用。它进一步涉及这种昆虫在筛选具有所需生物学活性并且不会穿过血脑屏障的物质的用途。

19. 发明授权

US09176118B2 Methods employing insect models for determining intestinal absorption of chemical compounds 有权
标题翻译：采用昆虫模型测定化学化合物肠道吸收的方法
公开(公告)号：US09176118B2
公开(公告)日：2015-11-03
申请号：US13387083
申请日：2010-08-10
申请人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
IPC分类号： C12Q1/00 , G01N33/50
CPC分类号： G01N33/5085
摘要： There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.
摘要翻译：为了改善早期药物发现过程中的化合物筛选程序/过程，提供了用于确定脊椎动物，特别是人类中不同化合物的胃肠道吸收的昆虫筛选模型。与现有技术相比，昆虫模型是决策过程的可靠工具，而不仅仅是现有的体外模型，因此与现有技术相比具有很多优势，并且将加速药物筛选过程并降低后期的磨耗率。此外，它将减少在药物发现阶段牺牲的哺乳动物的数量。

20. 发明申请

US20120122146A1 NANOPARTICLE SCREENING METHODS EMPLOYING INSECTS WITH BLOOD BRAIN BARRIER 审中-公开
标题翻译：使用血液屏障的纳米技术筛选方法
公开(公告)号：US20120122146A1
公开(公告)日：2012-05-17
申请号：US13387094
申请日：2010-08-10
申请人： Peter Aadal , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal , Gunnar Andersson , Olga Andersson
IPC分类号： C12Q1/02 , B82Y5/00
CPC分类号： G01N33/5085 , G01N2333/43552
摘要： There is provided an insect model for determining the penetration of nanoparticles through the BBB. The model is also directed to the use of insects for studying the environmental safety of nanoparticles. The particles are administered into the hemolymf of an insect having a BBB, such as the locust, and the uptake into the brain is analysed. Thus, in this model it is possible to investigate the potential up-take into the brain of nanoparticles circulating in the blood.
摘要翻译：提供了用于确定纳米颗粒穿过BBB的穿透性的昆虫模型。该模型还针对使用昆虫研究纳米颗粒的环境安全性。将颗粒施用于具有BBB的昆虫的血淋巴，例如蝗虫，并分析对大脑的摄取。因此，在该模型中，可以研究在血液中循环的纳米颗粒的脑中的潜在上升。

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