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11. 发明授权

US07879115B2 Method for using a static electric field to induce crystallization and to control crystal form 失效
标题翻译：使用静电场诱导结晶和控制晶体形式的方法
公开(公告)号：US07879115B2
公开(公告)日：2011-02-01
申请号：US11104714
申请日：2005-04-13
申请人： Bruce A. Garetz , Allan S. Myerson , Stephen Arnold , Janice E. Aber
发明人： Bruce A. Garetz , Allan S. Myerson , Stephen Arnold , Janice E. Aber
IPC分类号： B01D9/02
CPC分类号： C30B29/58 , B01D9/005 , C07K1/306 , C12N13/00 , C30B7/00 , C30B29/54 , C30B30/02
摘要： Applying a strong static DC electric field to supersaturated aqueous glycine solutions resulted in the nucleation of the γ polymorph attributed to the electric-field induced orientation of the highly polar glycine molecules in large preexisting solute clusters, helping them organize into a crystalline structure. A method to induce crystallization and to prepare polymorphs and/or morphologies of materials by using a static electric field to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure that would not normally appear without the use of the static electric field. Aqueous glycine solutions were prepared by combining solid glycine and water. Supersaturated solutions were generated by heating the tubes to 62-64° C. and holding them at that temperature in an ultrasonicator overnight. Once the glycine was completely dissolved, the solutions were slowly cooled to room temperature. A chamber was constructed consisting of two brass electrodes separated by a 5 mm insulating gap, with a hole drilled down through the center, parallel to the gap-electrode interface, with a diameter large enough to accommodate the test tube. A DC voltage was applied across the electrodes, large enough to produce electric fields in the range of 400,000 to 800,000 V/m. Tests tubes containing the aged solutions were placed in the high-voltage chamber. Exposure of the aged solutions to fields of 600,000 V/m resulted in crystallization typically within 30-90 min. The onset of nucleation was observed visually by the formation of a needle-shaped crystallite.
摘要翻译：将强静态DC电场应用于过饱和甘氨酸水溶液，导致γ大多数晶核的成核归因于大容量预先存在的溶质簇中高极性甘氨酸分子的电场诱导取向，有助于它们组织成晶体结构。通过使用静电场引起结晶并制备材料的多晶型物和/或形态的方法，以使得在过饱和溶液中发生成核和晶体生长，以获得通常不会出现的晶体结构使用静电场。通过将固体甘氨酸和水混合制备甘氨酸水溶液。通过将管加热至62-64℃并将其在超声波隔离器中保持在该温度下来产生过饱和溶液。一旦甘氨酸完全溶解，将溶液缓慢冷却至室温。由两个黄铜电极构成的腔体由两个黄铜电极隔开，绝缘间隔为5mm，孔穿过中心平行于间隙 - 电极界面钻出，直径足够大以容纳试管。在电极之间施加直流电压，其足够大以产生在400,000至800,000V / m的范围内的电场。将含有老化溶液的试管置于高压室中。将老化溶液暴露于600,000V / m的场中，结晶通常在30-90分钟内。通过形成针状微晶目测观察成核的开始。

12. 发明申请

US20090093375A1 DNA or RNA detection and/or quantification using spectroscopic shifts or two or more optical cavities 审中-公开
标题翻译： DNA或RNA检测和/或使用光谱偏移或两个或更多个光学腔的定量
公开(公告)号：US20090093375A1
公开(公告)日：2009-04-09
申请号：US10768977
申请日：2004-01-30
申请人： Stephen Arnold , Iwao Teraoka , Frank Vollmer
发明人： Stephen Arnold , Iwao Teraoka , Frank Vollmer
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： C12Q1/6816 , B01J2219/005 , B01J2219/00511 , B01J2219/00529 , B01J2219/00648 , B01J2219/00704 , B01J2219/00722 , C12Q1/6825 , C12Q2565/628
摘要： A spectroscopic technique for high-sensitivity, label free DNA quantification uses a shift in an optical resonance (whispering gallery mode, WGM) excited in a micron-sized optical cavity (e.g., a silica sphere) to detect and measure nucleic acids. The surface of the silica sphere is chemically modified with oligonucleotides. Hybridization to the target DNA leads to a red-shift of the optical resonance wavelength. The sensitivity of this resonance technique is higher than most optical single-pass devices such as surface plasmon resonance biosensors. Each microsphere can be identified by its unique resonance wavelength. Specific, multiplexed DNA detection may be provided by using two or more microspheres. The multiplexed signal from two or more microspheres illustrates that a single nucleotide mismatch in an 11-mer oligonucleotide can be discriminated with a high signal-to-noise of 54. This all-photonic WGM biosensor can be integrated on a chip, such as a semiconductor chip, which makes it an easy to manufacture, analytic component for a portable, robust lab-on-a-chip device.
摘要翻译：用于高灵敏度，无标记DNA定量的光谱技术使用在微米尺寸的光学腔（例如，二氧化硅球体）中激发的光学共振（耳语画廊模式，WGM）中的移动来检测和测量核酸。二氧化硅球体的表面用寡核苷酸进行化学修饰。与目标DNA的杂交导致光学共振波长的红移。这种共振技术的灵敏度高于大多数光学单通道器件，如表面等离子体共振生物传感器。每个微球可以通过其独特的共振波长来识别。可以通过使用两个或更多个微球来提供特异性的多重DNA检测。来自两个或更多个微球的多路复用信号表明，11聚体寡核苷酸中的单核苷酸不匹配可以用54的高信噪比来鉴别。该全光子WGM生物传感器可以集成在芯片上，例如半导体芯片，使其成为易于制造的便携式，强大的实验室芯片设备的分析组件。

13. 发明申请

US20060072069A1 Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents 有权
标题翻译：可湿性水凝胶包括反应性，亲水性，聚合物内部润湿剂
公开(公告)号：US20060072069A1
公开(公告)日：2006-04-06
申请号：US10954559
申请日：2004-09-30
申请人： Walter Laredo , Stephen Arnold , Kevin McCabe , Susan Orr , Azaam Alli
发明人： Walter Laredo , Stephen Arnold , Kevin McCabe , Susan Orr , Azaam Alli
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/52 , C08F226/10 , C08F265/10 , C08F271/02 , C08F283/00 , C08F283/12 , C08F290/00 , C08F290/06 , C08F290/068 , C08F290/148 , C08F293/005 , C08F297/00 , C08L53/00 , C08L39/06 , C08L83/04 , C08L33/12 , C08L33/26 , C08L2666/02 , C08L51/085
摘要： The present invention relates to wettable silicone hydrogels comprising the reaction product of at least one siloxane containing component and at least one reactive, hydrophilic polymeric internal wetting agent. The present invention further relates to silicone hydrogel contact lenses comprising at least one oxygen permeable component, and an amount of reactive, hydrophilic polymeric internal wetting agent sufficient to impart wettability to said device.
摘要翻译：本发明涉及可湿性硅氧烷水凝胶，其包含至少一种含硅氧烷的组分和至少一种反应性亲水性聚合物内润湿剂的反应产物。本发明还涉及包含至少一种透氧组分的硅酮水凝胶隐形眼镜，以及足以赋予所述装置润湿性的一定量的反应性亲水性聚合内部润湿剂。

14. 发明申请

US20110306854A1 SYRINGE-BASED WHISPERING GALLERY MODE MICRORESONATOR MICROFLUIDIC BIOCHEM SENSOR 有权
标题翻译：以SYRINGE为基础的画廊模式微型微型流感传感器
公开(公告)号：US20110306854A1
公开(公告)日：2011-12-15
申请号：US13090836
申请日：2011-04-20
申请人： Stephen Arnold , Slyka Shopova , Ying Chen , William Chin , Guyu Liu , Raaj Haresh Rajmangal
发明人： Stephen Arnold , Slyka Shopova , Ying Chen , William Chin , Guyu Liu , Raaj Haresh Rajmangal
IPC分类号： A61B5/1468 , G01N21/55
CPC分类号： G01N21/77 , A61B5/1459 , A61B5/1473 , A61B5/6848 , A61M5/178 , G01N33/54366 , G01N2021/7789 , G02B6/29341 , G02B6/29356
摘要： A syringe-based whispering gallery mode sensor includes a syringe including an assembly provided its needle, the assembly including (1) an optical carrier having a reflective distal end, and (2) at least one resonator coupled with the optical carrier. This sensor may be provided in a system including a light source, a light detector, and a data analysis component. A method for determining the presence or concentration of a target substance in body fluid may be performed using such a system.
摘要翻译：基于注射器的耳语画廊模式传感器包括一个注射器，其包括提供其针的组件，该组件包括（1）具有反射远端的光学载体，和（2）至少一个与光学载体耦合的谐振器。该传感器可以设置在包括光源，光检测器和数据分析部件的系统中。可以使用这样的系统来执行用于确定体液中目标物质的存在或浓度的方法。

15. 发明申请

US20070290174A1 LACTAM POLYMER DERIVATIVES 审中-公开
标题翻译： LACTAM聚合物衍生物
公开(公告)号：US20070290174A1
公开(公告)日：2007-12-20
申请号：US11780175
申请日：2007-07-19
申请人： Stephen Arnold , Walter Laredo
发明人： Stephen Arnold , Walter Laredo
IPC分类号： C08G63/08
CPC分类号： C08F8/04 , C08F8/14 , C08F283/124 , C08G18/6283 , C08G18/71 , C08G18/8108 , C08G18/8116 , Y10S525/937 , C08F26/06 , C08F126/10 , C08F26/10 , C08F220/28 , C08F220/56 , C08F222/1006
摘要： Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.
摘要翻译：内酰胺聚合物已经用硼氢化钠（NaBH 4 H 4）进行了改性，得到含有羟基官能团的内酰胺聚合物。这些官能团可用于共价连接反应性基团，荧光探针，抗微生物剂，生物活性因子和药物。作为医疗装置的组件，特别是眼科装置，更具体地说是隐形眼镜。基于这些聚合物的水凝胶也可用于药物递送，组织工程和可植入装置领域的生物医学应用。

16. 发明申请

US20070114477A1 ENHANCED SENSITIVITY OF A WHISPERING GALLERY MODE MICROSPHERE SENSOR BY A HIGH-REFRACTIVE INDEX SURFACE LAYER 审中-公开
标题翻译：通过高折射率表面层增强图像模式微波传感器的灵敏度
公开(公告)号：US20070114477A1
公开(公告)日：2007-05-24
申请号：US11561087
申请日：2006-11-17
申请人： Iwao Teraoka , Stephen Arnold
发明人： Iwao Teraoka , Stephen Arnold
IPC分类号： G03C5/16 , G01N23/04
CPC分类号： G01N21/552 , G01N21/7746
摘要： The use of whispering gallery mode (WGM) evanescent waves to detect adsorption of molecules to the surface of microsphere sensors and more particularly to the utilization of a high refractive index surface layer to increase the sensitivity thereof. The present invention examines the sensor capability of WGM in a dielectric sphere coated with a thin uniform dielectric layer of a high refractive index. Among the utilities of such a modified resonator for the sensing are to have an evanescent field of a different penetration depth without using a non-silica based microsphere or changing the laser wavelength, to further enhance the sensitivity by drawing the optical field of WGM into the coating layer, and to realize the same relative shifts for WGM of different radial modes, thus eliminating ambiguities in the measurement of a refractive index change in the surrounding medium.
摘要翻译：使用耳语画廊模式（WGM）ev逝波来检测分子到微球传感器表面的吸附，更具体地说是利用高折射率表面层来增加其敏感性。本发明考察了涂覆有高折射率薄均匀介电层的电介质球体中WGM的传感器能力。在这种用于感测的改进的谐振器的用途中，具有不使用非二氧化硅基微球体或改变激光波长的不同穿透深度的渐逝场，以通过将WGM的光学场拉入到并且对于不同径向模式的WGM实现相同的相对偏移，从而消除了测量周围介质中折射率变化的模糊性。

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