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11. 发明授权

US5201383A Ignition timing control system for internal combustion engines 失效
标题翻译：用于内燃机的点火时序控制系统
公开(公告)号：US5201383A
公开(公告)日：1993-04-13
申请号：US813632
申请日：1991-12-26
申请人： Hiroshi Kitagawa , Shunji Takahashi , Sachito Fujimoto
发明人： Hiroshi Kitagawa , Shunji Takahashi , Sachito Fujimoto
IPC分类号： F02D45/00 , B60K28/16 , F02D29/02 , F02P5/15
CPC分类号： F02P5/1502 , B60K28/16 , F02P5/1504 , Y02T10/46
摘要： An ignition timing control system for an internal combustion engine in which an ECU sets a basic spark advance value in response to operating condition of the engine, corrects the set basic spark advance value, and delimits the corrected spark advance value in a spark retarding direction by means of a retard limiting value. The ECU further detects operation of a slip control system which detects a predetermined slip state of driving wheels of the vehicle and controls the engine so as to reduce output thereof upon detection of the predetermined slip state. When the slip control system is operative, the ECU changes the retard limiting value toward an advanced side relative to a value set when the slip control system is inoperative.
摘要翻译：一种用于内燃机的点火正时控制系统，其中ECU根据发动机的运行状态设定基本火花提前值，校正设定的基本火花提前值，并且通过在火花熄火方向上界定校正的火花提前值延迟限制值的手段。 ECU还检测检测车辆的驱动轮的预定滑动状态的滑动控制系统的操作，并且控制发动机，以便在检测到预定滑动状态时减小其输出。当滑差控制系统工作时，ECU相对于滑差控制系统不工作时设定的值，将延迟限制值向先进侧改变。

12. 发明授权

US5158063A Air-fuel ratio control method for internal combustion engines 失效
标题翻译：用于内燃机的空燃比比控制方法
公开(公告)号：US5158063A
公开(公告)日：1992-10-27
申请号：US812705
申请日：1991-12-23
申请人： Fumio Hosoda , Sachito Fujimoto , Hiroshi Ito , Shunji Takahashi
发明人： Fumio Hosoda , Sachito Fujimoto , Hiroshi Ito , Shunji Takahashi
IPC分类号： F02D41/02 , F02D41/14 , F02D45/00
CPC分类号： F02D41/1488 , F02D41/0235 , F02D41/1446 , F02D41/1486 , F02D2200/0406 , F02D2200/0414 , F02D2200/0804
摘要： An air-fuel ratio control method for an internal combustion engine. The air-fuel ratio of an air-fuel mixture supplied to the engine is feedback-controlled to a predetermined value in response to an output from the exhaust gas ingredient concentration sensor. The temperature of at least one component part of the engine, which should be controlled, is estimated based on the detected temperature of exhaust gases, engine rotational speed, and engine load. The air-fuel ratio of the air-fuel mixture is inhibited from being feedback-controlled but enriched, when the estimated temperature of any one of the at least one component part of the engine is higher than a corresponding predetermined value.
摘要翻译：一种用于内燃机的空燃比控制方法。供应到发动机的空气燃料混合物的空燃比响应于来自排气成分浓度传感器的输出被反馈控制到预定值。基于检测到的排气温度，发动机转速和发动机负荷来估计发动机的至少一个组成部分的温度，其应该被控制。当发动机的至少一个部件中的任何一个的估计温度高于相应的预定值时，空气燃料混合物的空燃比被禁止反馈控制但是富集。

13. 发明授权

US4566418A Electronically controlled internal combustion engine provided with an accelerator position sensor 失效
标题翻译：设有加速器位置传感器的电控内燃机
公开(公告)号：US4566418A
公开(公告)日：1986-01-28
申请号：US645766
申请日：1984-08-30
申请人： Minato Yamamoto , Shunji Takahashi
发明人： Minato Yamamoto , Shunji Takahashi
IPC分类号： F02D11/10 , F02D41/22
CPC分类号： F02D11/106 , F02D41/22 , Y02T10/40
摘要： An electronically controlled internal combustion engine provided with an accelerator position sensor wherein, in order to positively prevent violent running and make some degree of running possible, an idling switch, intermediate switch and fully opening switch issuing signals when a wiper crosses them are provided within the accelerator position sensor, in case the magnitude of the output from the accelerator position sensor when any of the above mentioned respective switches issues signal during the operation of the accelerator position sensor is not in a normal range memorized in advance, the accelerator position sensor will be judged to fail and, when the accelerator position sensor is judged to fail, signals from the accelerator position sensor will not be accepted, a desirable running state will be judged on the basis of a combination of the signals from the respective switched and an injector will be controlled.
摘要翻译：一种具有加速器位置传感器的电子控制内燃机，其特征在于，为了可靠地防止剧烈的行驶并且使一些程度的行驶成为可能，当刮水器穿过它们时，提供空转开关，中间开关和完全打开的开关信号加速器位置传感器在加速器位置传感器的操作期间发生信号的情况下来自加速器位置传感器的输出的大小不在预先存储的正常范围内的情况下，加速器位置传感器将为判断为失败，并且当加速器位置传感器被判定为失败时，来自加速器位置传感器的信号将不被接受，则将基于来自各个切换器和喷射器的信号的组合来判断期望的运行状态被控制。

14. 发明申请

US20130177950A1 PROCESS FOR PRODUCING REVEROMYCIN A OR A SYNTHETIC INTERMEDIATE THEREOF, PROCESS FOR PRODUCING COMPOUNDS CONTAINING A SPIROKETAL RING AND NOVEL ANTINEOPLASTICS, FUNGICIDES AND THERAPEUTIC AGENTS FOR BONE DISORDERS 有权
标题翻译：用于生产复方素或其合成中间体的方法，用于生产含有螺旋环和新型抗原蛋白的化合物的方法，用于骨骼疾病的杀真菌剂和治疗剂
公开(公告)号：US20130177950A1
公开(公告)日：2013-07-11
申请号：US13819959
申请日：2011-08-30
申请人： Hiroyuki Osada , Shunji Takahashi , Makoto Kawatani , Yoshiyuki Sakaki , Atsushi Toyoda
发明人： Hiroyuki Osada , Shunji Takahashi , Makoto Kawatani , Yoshiyuki Sakaki , Atsushi Toyoda
IPC分类号： C07D493/10 , C12P17/06 , C12N1/20
CPC分类号： C07D493/10 , A61K31/351 , C07K14/36 , C12N1/20 , C12N15/52 , C12P17/06 , C12P17/181
摘要： A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
摘要翻译：属于属于链霉菌属的细菌，其具有产生还原霉素A或其合成中间体的能力，所述细菌被修饰以增加编码SEQ ID NO：36的氨基酸序列的revQ基因的表达或具有SEQ ID NO：36的氨基酸序列的表达，与亲本菌株相比，与SEQ ID NO：36不小于80％的身份，因此与亲本菌株相比上述生产能力增加。

15. 发明授权

US07632486B1 Method for diagnosing bone metastasis of malignant tumor 失效
标题翻译：诊断恶性肿瘤骨转移的方法
公开(公告)号：US07632486B1
公开(公告)日：2009-12-15
申请号：US09763370
申请日：1999-08-20
申请人： Etsuro Ogata , Mitsuru Koizumi , Shunji Takahashi
发明人： Etsuro Ogata , Mitsuru Koizumi , Shunji Takahashi
IPC分类号： A61K49/00 , C12Q1/00 , G01N31/00 , G01N1/00 , A01N61/00
CPC分类号： G01N33/574 , G01N33/57488 , G01N33/6887 , G01N2333/47 , Y10T436/10 , Y10T436/25
摘要： Bone metastasis and the efficacy of drugs in the treatment of malignant tumors such as breast cancer, prostatic cancer and lung cancer that cause the bone metastasis are diagnosed using a marker that reflects the activity of osteoblasts and a marker that reflects the action of osteoclasts.
摘要翻译：使用反映成骨细胞的活性的标记物和反映破骨细胞作用的标记物诊断骨转移和药物治疗引起骨转移的乳腺癌，前列腺癌和肺癌等恶性肿瘤的功效。

16. 发明申请

US20070269857A1 A PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY MICROORGANISMS AND A METHOD FOR SCREENING COMPOUNDS WITH ANTIBIOTIC OR WEEDING ACTIVITY 失效
标题翻译：通过微生物生产异噻菌根化合物的方法和用抗生素或加强活性筛选化合物的方法
公开(公告)号：US20070269857A1
公开(公告)日：2007-11-22
申请号：US11695320
申请日：2007-04-02
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P23/00 , C12P5/02 , C12P7/66
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

17. 发明授权

US08980587B2 Process for producing reveromycin A or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders 有权
标题翻译：生产瑞维霉素A或其合成中间体的方法，用于生产含有螺旋酮环的化合物的方法和新型抗肿瘤剂，杀真菌剂和骨疾病治疗剂
公开(公告)号：US08980587B2
公开(公告)日：2015-03-17
申请号：US13819959
申请日：2011-08-30
申请人： Hiroyuki Osada , Shunji Takahashi , Makoto Kawatani , Yoshiyuki Sakaki , Atsushi Toyoda
发明人： Hiroyuki Osada , Shunji Takahashi , Makoto Kawatani , Yoshiyuki Sakaki , Atsushi Toyoda
IPC分类号： C12N1/21 , C12P17/06 , C12P17/16 , C07K14/36 , C07D493/10 , C12N15/52 , C12P17/18 , C12N1/20 , A61K31/351
CPC分类号： C07D493/10 , A61K31/351 , C07K14/36 , C12N1/20 , C12N15/52 , C12P17/06 , C12P17/181
摘要： A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
摘要翻译：属于属于链霉菌属的细菌，其具有产生还原霉素A或其合成中间体的能力，所述细菌被修饰以增加编码SEQ ID NO：36的氨基酸序列的revQ基因的表达或具有SEQ ID NO：36的氨基酸序列的表达，与亲本菌株相比，与SEQ ID NO：36不小于80％的身份，因此与亲本菌株相比上述生产能力增加。

18. 发明授权

US07531333B2 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 失效
标题翻译：通过微生物生产类异戊二烯化合物的方法和用抗生素或除草活性筛选化合物的方法
公开(公告)号：US07531333B2
公开(公告)日：2009-05-12
申请号：US11837645
申请日：2007-08-13
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P5/00
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译：本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

19. 发明申请

US20080227141A1 PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY MICROORGANISMS AND A METHOD FOR SCREENING COMPOUNDS WITH ANTIBIOTIC OR WEEDING ACTIVITY 审中-公开
公开(公告)号：US20080227141A1
公开(公告)日：2008-09-18
申请号：US12045792
申请日：2008-03-11
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12Q1/18
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

20. 发明授权

US07132268B2 Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity 有权
公开(公告)号：US07132268B2
公开(公告)日：2006-11-07
申请号：US10938613
申请日：2004-09-13
申请人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
发明人： Koichiro Miyake , Shinichi Hashimoto , Hiroaki Motoyama , Akio Ozaki , Haruo Seto , Tomohisa Kuzuyama , Shunji Takahashi
IPC分类号： C12P5/00 , C12N9/02
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

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