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11. 发明授权

US6106505A Triclosan-containing medical devices 失效
标题翻译：含三氯生的医疗器械
公开(公告)号：US6106505A
公开(公告)日：2000-08-22
申请号：US101129
申请日：1998-06-30
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352
摘要： The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.
摘要翻译： PCT No.PCT / US96 / 20932 Sec。 371日期1998年6月30日第 102（e）日期1998年6月30日PCT 1996年12月23日PCT PCT。公开号WO97 / 25085 日期1997年7月17日本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

12. 发明申请

US20080075761A1 Antimicrobial Medical Devices Containing Chlorhexidine Free Base And Salt 有权
标题翻译：含有洗必太碱和盐的抗菌药物
公开(公告)号：US20080075761A1
公开(公告)日：2008-03-27
申请号：US11946622
申请日：2007-11-28
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N25/34 , A01N25/00 , A01N37/52 , A01P1/00 , A61F2/02
CPC分类号： A61K9/7023 , A61K31/155 , A61K47/32 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/206 , A61L2300/404
摘要： The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.
摘要翻译：本发明涉及用包含一种或多种溶剂和洗脱剂游离碱和水溶性氯己定盐的组合的溶液处理的医疗装置，其重量/重量比为约1:1至约1:5，优选为约1：1。

13. 发明授权

US06843784B2 Triclosan and silver compound containing medical devices 失效
标题翻译：三氯生和含银化合物的医疗器械
公开(公告)号：US06843784B2
公开(公告)日：2005-01-18
申请号：US09777121
申请日：2001-02-05
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N59/16 , A61L2/18 , A61L15/44 , A61L17/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A01N59/16 , A61L2/18 , A61L15/44 , A61L17/005 , A61L27/54 , A61L29/16 , A61L2300/104 , A61L2300/202 , A61L2300/21 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/45 , D06M11/83 , D06M13/432 , D06M16/00 , Y10T428/1352 , A01N31/16 , A01N31/12 , A01N31/08 , A01N25/34 , A01N2300/00
摘要： The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.
摘要翻译：本发明涉及包含三氯生和含银化合物的组合的聚合物医疗制品。至少部分地是基于发现这些试剂协同作用，从而允许使用相对较低水平的两种试剂。虽然以前已经发现三氯生与氯己定联合使用时可能特别有用，但是已经进一步发现，根据本发明，可以制备具有合适的抗微生物性质的医药制品，其含有不含氯己定的三氯生。这样的医疗制品具有预防或抑制感染的优点，同时避免对氯己定具有敏感性的个体对氯己定的不良不良反应。

14. 发明授权

US06503952B2 Triple antimicrobial composition 失效
标题翻译：三重抗菌组成
公开(公告)号：US06503952B2
公开(公告)日：2003-01-07
申请号：US09758930
申请日：2001-01-11
申请人： Shanta Modak , Lester Sampath , Lauserpina A. Caraos
发明人： Shanta Modak , Lester Sampath , Lauserpina A. Caraos
IPC分类号： A61K31155
CPC分类号： A01N47/44 , A01N2300/00
摘要： An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.
摘要翻译：一种抗微生物组合物，其包含（i）0.025％至2％的选自氯己定游离碱，氯己定盐，聚六亚甲基双胍和脒基的抗微生物剂; （ii）0.005〜0.1％的季铵化合物; 和（iii）0.025％至2％的氯化酚化合物。

15. 发明授权

US5772640A Triclosan-containing medical devices 失效
标题翻译：含三氯生的医疗器械
公开(公告)号：US5772640A
公开(公告)日：1998-06-30
申请号：US583239
申请日：1996-01-05
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352
摘要： The present invention relates to polymeric medical articles contained the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are contained in either hydrophilic or hydrophobic polymers.
摘要翻译：本发明涉及含有抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包含在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。

16. 发明授权

US06872195B2 Chlorhexidine-containing medical devices 失效
标题翻译：含洗必泰的医疗器械
公开(公告)号：US06872195B2
公开(公告)日：2005-03-29
申请号：US10647740
申请日：2003-08-25
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352 , A61L29/06 , C08L83/04 , C08L75/04 , A61L27/507
摘要： The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.
摘要翻译：本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

17. 发明授权

US5985931A Triple antimicrobial composition 失效
标题翻译：三重抗菌组成
公开(公告)号：US5985931A
公开(公告)日：1999-11-16
申请号：US11841
申请日：1998-06-02
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N47/44 , A61K31/155
CPC分类号： A01N47/44
摘要： The present invention relates to antimicrobial compositons comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 1 percent by weight of a quaternary ammonium compound, such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial deterents, soaps, creams rinses, and emulsions for use in the medical community as well as general public use.
摘要翻译： PCT No.PCT / US96 / 18104 Sec。 371日期1998年6月2日 102（e）1998年6月2日PCT PCT 1996年11月12日PCT公布。出版物WO97 / 17849 日期1997年5月22日本发明涉及抗微生物组合物，其包含（i）小于或等于2重量％的氯己定或氯己定盐; （ii）小于或等于1重量％的季铵化合物，例如苯扎氯铵; 和（iii）小于或等于2％（重量）的对氯甲ax en酚。本发明的抗微生物组合物可用于抗菌消毒剂，肥皂，乳膏漂洗剂和用于医学界的乳剂以及一般公众使用。

18. 发明授权

US5705532A Triple antimicrobial composition 失效
标题翻译：三重抗菌组成
公开(公告)号：US5705532A
公开(公告)日：1998-01-06
申请号：US556256
申请日：1995-11-13
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N47/44 , A01N31/08 , A01N33/12 , A01N37/52
CPC分类号： A01N47/44
摘要： The present invention relates to antimicrobial compositions comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 0.1 percent by weight of a quaternary ammonium compound such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial detergents, soaps, creams, rinses, and emulsions for use in the medical community as well as general public use.
摘要翻译：本发明涉及抗微生物组合物，其包含（i）小于或等于2重量％的氯己定或氯己定盐; （ii）小于或等于0.1重量％的季铵化合物如苯扎氯铵; 和（iii）小于或等于2％（重量）的对氯甲ax en酚。本发明的抗微生物组合物可以用于医学界中使用的抗微生物洗涤剂，肥皂，乳膏，漂洗剂和乳剂，以及一般公众使用。

19. 发明授权

US5567495A Infection resistant medical devices 失效
标题翻译：感染的医疗设备
公开(公告)号：US5567495A
公开(公告)日：1996-10-22
申请号：US273329
申请日：1994-07-11
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L29/16 , A61M25/00 , B29D22/00
CPC分类号： A61L29/16 , A61M25/0017 , A61L2300/104 , A61L2300/206 , A61L2300/404 , Y10T428/139 , Y10T428/1393 , Y10T428/1397
摘要： The present invention provides for medical devices which are antiinfective as a result of antiinfective agents impregnated onto their surfaces and/or antiinfective activity incorporated into their access sites. It is based, at least in part, on the discovery that certain combinations of antimicrobial agents and solvents change the surface characteristics of polymeric medical devices, thereby facilitating the retention of antimicrobial agents. It is further based on the discovery that the incorporation of antiinfective polymeric inserts into the access site of a medical device provides substantially improved antiinfective activity.
摘要翻译：本发明提供了由于浸渍在其表面上的抗感染剂和/或并入其进入部位的抗感染活性而具有抗感染性的医疗器械。至少部分地基于以下发现：抗微生物剂和溶剂的某些组合改变聚合物医疗装置的表面特性，从而有助于抗微生物剂的保留。进一步基于以下发现：将抗感染聚合物插入物并入医疗装置的进入部位提供了显着改善的抗感染活性。

20. 发明授权

US5133090A Antiviral glove 失效
标题翻译：抗病毒手套
公开(公告)号：US5133090A
公开(公告)日：1992-07-28
申请号：US555093
申请日：1990-07-18
申请人： Shanta M. Modak , Lester Sampath
发明人： Shanta M. Modak , Lester Sampath
IPC分类号： A01N25/24 , A01N47/44 , A01N59/16 , A41D19/00 , A61B19/04 , A61K31/155 , A61L2/16 , A61L15/46 , A61L17/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/00 , A61P31/12
CPC分类号： A01N25/24 , A01N47/44 , A01N59/16 , A41D19/0055 , A61B42/00 , A61L2/16 , A61L31/10 , A61L31/16 , A41D2400/34 , A61L2300/206 , A61L2300/408 , A61L2300/606
摘要： An antiviral surgical or examination glove is obtained by blocking adsorption sites for the antiinfective agent which may exist in the lubricating agent, e.g., cross-linked corn starch, or in the material of the glove itself. The glove of the invention comprises an elastomeric hand-shaped body having interior and exterior surfaces and an inner coating disposed on the interior surface of the elastomeric body. The inner coating comprises (a) an antiinfective agent selected from the group consisting of chlorhexidine and pharmaceutically acceptable salts of chlorhexidine and (b) a lubricating agent which does not significantly adsorb the antiinfective agent. The inner coating is effective to deliver an antivirally effective amount of the antiinfective agent within ten minutes of exposure to a liquid.
摘要翻译：通过阻止可能存在于润滑剂例如交联玉米淀粉中或在手套本身的材料中的抗感染剂的吸附部位来获得抗病毒手术或检查手套。本发明的手套包括具有内表面和外表面的弹性手形体，以及设置在弹性体本体的内表面上的内涂层。内涂层包含（a）选自氯己定和氯己定的药学上可接受的盐的抗感染剂和（b）不显着吸附抗感染剂的润滑剂。内涂层有效地在暴露于液体的十分钟内递送抗病毒有效量的抗感染剂。

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