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11. 发明申请

US20050158449A1 Method and apparatus for coating of substrates 有权
标题翻译：用于涂布基材的方法和装置
公开(公告)号：US20050158449A1
公开(公告)日：2005-07-21
申请号：US10976348
申请日：2004-10-27
申请人： Ralph Chappa
发明人： Ralph Chappa
IPC分类号： B05B13/02 , B05B13/04 , B05D3/00 , B05C5/00
CPC分类号： B05D1/02 , B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05C13/025 , B05D1/002 , Y10S118/11
摘要： The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.
摘要翻译：本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。在一个实施例中，本发明包括一种包括双向旋转构件的装置。在一个实施例中，本发明包括具有双向分度运动的方法。在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。在一个实施例中，本发明包括装置保持构件。在一个实施例中，本发明包括空气喷嘴或气刀。在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。

12. 发明申请

US20050281858A1 Devices, articles, coatings, and methods for controlled active agent release 审中-公开
标题翻译：用于控制活性剂释放的装置，制品，涂料和方法
公开(公告)号：US20050281858A1
公开(公告)日：2005-12-22
申请号：US11156245
申请日：2005-06-17
申请人： Tim Kloke , Ralph Chappa
发明人： Tim Kloke , Ralph Chappa
IPC分类号： A61K9/46 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/40 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/12 , A61L31/16 , A61L2300/608 , A61L2420/08
摘要： The present invention relates to multi-layer coatings and device, articles, and methods regarding the same, for controlled active agent release. Embodiments of the present invention include devices, articles, coatings, and methods relating to an composition including an active agent, a first layer disposed on the composition, and a second layer disposed on the first layer, wherein the second layer is configured to provide controlled release of the active agent through the second layer and the second layer has release characteristics that are distinct from the first layer.
摘要翻译：本发明涉及用于受控活性剂释放的多层涂层及其相关的装置，制品和方法。本发明的实施方案包括与包含活性剂的组合物，设置在组合物上的第一层和设置在第一层上的第二层相关的装置，制品，涂层和方法，其中第二层被配置为提供受控的活性剂通过第二层和第二层的释放具有与第一层不同的释放特性。

13. 发明申请

US20050260246A1 Bioactive agent release coating 审中-公开
标题翻译：生物活性剂释放涂层
公开(公告)号：US20050260246A1
公开(公告)日：2005-11-24
申请号：US11123835
申请日：2005-05-06
申请人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke , Laurie Lawin , Klaus Wormuth
发明人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke , Laurie Lawin , Klaus Wormuth
IPC分类号： A61F2/02 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/606 , C08L33/06
摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译：用于涂覆可植入医疗装置以提高其在体内释放生物活性剂的能力的涂料组合物。涂料组合物特别适用于在其输送和/或使用过程（例如支架和导管）中经历显着弯曲和/或膨胀的装置。组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。

14. 发明申请

US20060067968A1 Bioactive agent release coating 有权
公开(公告)号：US20060067968A1
公开(公告)日：2006-03-30
申请号：US11281845
申请日：2005-11-17
申请人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
发明人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
IPC分类号： A61F13/00 , B05D3/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606 , C08L33/06
摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

15. 发明申请

US20060057277A1 Methods, devices, and coatings for controlled active agent release 有权
标题翻译：用于控制活性剂释放的方法，装置和涂层
公开(公告)号：US20060057277A1
公开(公告)日：2006-03-16
申请号：US11223811
申请日：2005-09-09
申请人： Ralph Chappa
发明人： Ralph Chappa
IPC分类号： A61K6/083 , A61L33/00
CPC分类号： A61L27/54 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/602
摘要： The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.
摘要翻译：本发明涉及方法，装置和涂层，其中通过涂层或材料的沉积速率确定活性剂释放。在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括鉴定以多种涂布沉积速率施加到基材上的涂料组合物的活性剂洗脱速率，选择一种涂布沉积速率，以及将涂料组合物施用于医疗器械以选定的沉积速率。在一个实施方案中，本发明包括一种组合，其包括医疗装置和用于用活性剂涂覆医疗装置的表面的组合物，使得当植入体内时涂覆表面随时间推移释放活性剂。

16. 发明申请

US20050281863A1 Controlled release bioactive agent delivery device 审中-公开
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US20050281863A1
公开(公告)日：2005-12-22
申请号：US11203931
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
IPC分类号： A61K9/00 , A61K31/58 , A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.
摘要翻译：本发明提供控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物和所述第二聚合物是疏水性的。本发明还提供了以受控释放方式将生物活性剂递送至患者的方法，以及制备控制释放的生物活性剂递送装置的方法。

17. 发明申请

US20070101933A1 Method and Apparatus for Coating of Substrates 有权
标题翻译：基材涂层方法及装置
公开(公告)号：US20070101933A1
公开(公告)日：2007-05-10
申请号：US11539443
申请日：2006-10-06
申请人： Ralph Chappa
发明人： Ralph Chappa
IPC分类号： B05B5/025
CPC分类号： B05D1/02 , B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05C13/025 , B05D1/002 , Y10S118/11
摘要： The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bidirectional rotation member. In an embodiment, the invention includes a method with a bidirectional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.
摘要翻译：本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。在一个实施例中，本发明包括一种包括双向旋转构件的装置。在一个实施例中，本发明包括具有双向分度运动的方法。在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。在一个实施例中，本发明包括装置保持构件。在一个实施例中，本发明包括空气喷嘴或气刀。在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。

18. 发明申请

US20060210701A1 Linear Rail Coating Apparatus and Method 有权
标题翻译：直线导轨涂布装置及方法
公开(公告)号：US20060210701A1
公开(公告)日：2006-09-21
申请号：US11421637
申请日：2006-06-01
申请人： Ralph Chappa , Steven Porter
发明人： Ralph Chappa , Steven Porter
IPC分类号： A61L33/00 , B05B13/02
CPC分类号： B05D1/002 , A61L31/10 , B05B13/0242 , B05B13/0442 , B05B16/40
摘要： The invention provides an apparatus for coating a device comprising a coating chamber and a device rotator having at least one device mount wherein the apparatus allows insertion and retraction of the device on the device mount into and out of the coating chamber. In another aspect, the invention provides a method of applying a substantially uniform coating on a device comprising the steps of providing an apparatus for coating a device, mounting the device onto the device mount, purging the coating chamber to reduce humidity in the coating chamber, maintaining a reduced humidity content in the coating chamber, inserting the device into the coating chamber, disposing a coating material on the device and rotating the device mounts about the device axis.
摘要翻译：本发明提供了一种用于涂覆装置的装置，该装置包括涂覆室和具有至少一个装置安装件的装置旋转器，其中装置允许装置在装置安装件上进出涂层室的插入和缩回。另一方面，本发明提供了一种在装置上施加基本上均匀的涂层的方法，包括以下步骤：提供用于涂覆装置的装置，将装置安装到装置安装件上，清洗涂布室以减少涂覆室中的湿度，保持涂布室中的湿度降低，将装置插入涂覆室中，将涂层材料设置在装置上并使装置围绕装置轴线旋转。

19. 发明申请

US20050287188A1 Controlled release bioactive agent delivery device 失效
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US20050287188A1
公开(公告)日：2005-12-29
申请号：US11203981
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
IPC分类号： A61K9/00 , A61K31/58 , A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
摘要翻译：本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

20. 发明申请

US20050271706A1 Controlled release bioactive agent delivery device 审中-公开
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US20050271706A1
公开(公告)日：2005-12-08
申请号：US11204271
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
IPC分类号： A61K9/00 , A61K31/58 , A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.
摘要翻译：本发明提供了将生物活性剂递送到眼睛的方法，所述方法包括以下步骤：在眼睛内的植入部位提供装置，并将装置保持在植入部位以向眼睛提供治疗有效量的生物活性剂。该装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中主体构件的至少一部分偏离延伸方向。提供与主体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。本发明还提供了将治疗有效量的生物活性剂施用于眼后段的方法。

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