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11. 发明授权

US10894132B2 Auto-injector 有权
公开(公告)号：US10894132B2
公开(公告)日：2021-01-19
申请号：US15897872
申请日：2018-02-15
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/46 , A61M5/20 , A61M5/32 , A61M5/315
摘要： An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

12. 发明授权

US10556064B2 Auto-injector 有权
公开(公告)号：US10556064B2
公开(公告)日：2020-02-11
申请号：US15480026
申请日：2017-04-05
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/32 , A61M5/46 , A61M5/50 , A61M5/20
摘要： An auto-injector for administering a dose of a liquid medicament has a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. There is also a trigger button arranged distally or laterally in or on the case, a control spring arranged around the carrier, and a needle extension control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle extension or to the chassis for needle retraction depending on the relative axial position of the carrier and the chassis.

13. 发明授权

US10518041B2 Injection device 有权
公开(公告)号：US10518041B2
公开(公告)日：2019-12-31
申请号：US14879805
申请日：2015-10-09
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/20 , A61M5/32 , A61M5/50 , A61M5/46
摘要： An Injection device for administering a dose of liquid medicament to patient comprises—a syringe containing the dose of medicament—a hollow injection needle adapted to penetrate skin of the patient,—a stopper translatably disposed within syringe,—a plunger connectable to stopper and translatable in at least a proximal direction to displace stopper in the proximal direction and—a releasable noise component capable of, upon release, generating an audible and/or tactile feedback. The proximal displacement of stopper causes the dose of the medicament to be expelled through the hollow injection needle. The noise component is released when the plunger reaches a position relative to the syringe in which stopper is located in proximity of a proximal end of the syringe. The released noise component impacts on at least one component of the injection device to generate the audible and/or tactile feedback indicating the end of the injection.

14. 发明授权

US09950123B2 Detent mechanism 有权
公开(公告)号：US09950123B2
公开(公告)日：2018-04-24
申请号：US14982555
申请日：2015-12-29
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/20 , A61M5/32 , A61M5/46 , A61M5/50
CPC分类号： A61M5/3158 , A61M5/2033 , A61M5/31501 , A61M5/31511 , A61M5/3157 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , F04C2270/0421 , Y10T403/32501
摘要： A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. Each ramp is on one longitudinal side of the rhomboid ramp member such that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction and such that application of a translative force between the components in the other longitudinal direction with the first beam head engaged to the other one of the ramps deflects the resilient beam in the other transversal direction.

15. 发明申请

US20160106923A1 Injection Device 审中-公开
标题翻译：注射装置
公开(公告)号：US20160106923A1
公开(公告)日：2016-04-21
申请号：US14879805
申请日：2015-10-09
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315
摘要： An Injection device for administering a dose of liquid medicament to patient comprises—a syringe containing the dose of medicament—a hollow injection needle adapted to penetrate skin of the patient, —a stopper translatably disposed within syringe, —a plunger connectable to stopper and translatable in at least a proximal direction to displace stopper in the proximal direction and—a releasable noise component capable of, upon release, generating an audible and/or tactile feedback. The proximal displacement of stopper causes the dose of the medicament to be expelled through the hollow injection needle. The noise component is released when the plunger reaches a position relative to the syringe in which stopper is located in proximity of a proximal end of the syringe. The released noise component impacts on at least one component of the injection device to generate the audible and/or tactile feedback indicating the end of the injection.
摘要翻译：一种用于向患者施用一定剂量的液体药物的注射装置包括：包含剂量的药物的注射器 - 适于穿透患者皮肤的中空注射针，可平移地设置在注射器内的塞子， - 可连接到塞子和可平移的柱塞在至少近端方向上沿着近端方向移动止动件;以及 - 释放的噪声部件，其能够在释放时产生可听见的和/或触觉的反馈。塞子的近端位移导致药物的剂量通过中空注射针排出。当柱塞到达相对于注射器的位置时，噪声分量被释放，止动器位于注射器的近端附近。释放的噪声分量影响注射装置的至少一个部件以产生表示注射结束的声音和/或触觉反馈。

16. 发明申请

US20140336590A1 AUTOINJECTOR 有权
公开(公告)号：US20140336590A1
公开(公告)日：2014-11-13
申请号：US14364242
申请日：2012-12-19
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： Yannick Hourmand , Simon Brereton , Thomas Mark Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/32 , A61M5/315
CPC分类号： A61M5/3204 , A61M5/2033 , A61M5/31511 , A61M5/326 , A61M2005/206
摘要： Described is an autoinjector comprising a case, a needle shroud slidably arranged in the case, a chassis slidably arranged in the case and rotatably coupled to the needle shroud, an outer plunger selectively engaged to the chassis, an inner plunger selectively engaged to the outer plunger, and a drive spring applying a biasing force to the outer plunger. The biasing force is applied to the inner plunger when the inner plunger is engaged to the outer plunger. Axial movement of the needle shroud relative to the case causes rotation of the chassis relative to the needle shroud. The rotation of the chassis causes the inner plunger to rotate relative to the outer plunger and disengage the outer plunger to remove the biasing force from the drive spring on the inner plunger.
摘要翻译：描述了一种自动注射器，其包括壳体，可滑动地布置在壳体中的针罩，可滑动地布置在壳体中并可旋转地联接到针罩的底架，选择性地接合到底架的外柱塞，选择性地接合到外柱塞的内柱塞以及向外柱塞施加偏置力的驱动弹簧。当内柱塞接合到外柱塞时，偏置力被施加到内柱塞。针罩相对于壳体的轴向运动导致底盘相对于针罩旋转。底盘的旋转使得内柱塞相对于外柱塞旋转，并使外柱塞脱离，以消除来自内柱塞上的驱动弹簧的偏压力。

17. 发明授权

US12005240B2 Auto-injector 有权
公开(公告)号：US12005240B2
公开(公告)日：2024-06-11
申请号：US18413900
申请日：2024-01-16
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/20 , A61M5/32 , A61M5/46
CPC分类号： A61M5/3157 , A61M5/20 , A61M5/2033 , A61M5/326 , A61M5/46 , A61M2005/206 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

18. 发明授权

US11819670B2 Auto-injector 有权
公开(公告)号：US11819670B2
公开(公告)日：2023-11-21
申请号：US17126962
申请日：2020-12-18
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/20 , A61M5/32 , A61M5/46
CPC分类号： A61M5/3157 , A61M5/20 , A61M5/2033 , A61M5/326 , A61M5/46 , A61M2005/206 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

19. 发明申请

US20230082328A1 AUTO-INJECTOR 有权
公开(公告)号：US20230082328A1
公开(公告)日：2023-03-16
申请号：US17935237
申请日：2022-09-26
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/32 , A61M5/46 , A61M5/50 , A61M5/20
摘要： An auto-injector for administering a dose of a liquid medicament includes an elongate tubular case and a carrier subassembly including a tubular carrier slidably arranged inside the case. The carrier is adapted to contain a syringe with a hollow injection needle, a drive spring, and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier, wherein the drive spring acts between the carrier and the plunger, wherein the plunger, in an initial state, is locked to the carrier by a ramped engagement to the carrier and by being prevented from rotating out of this ramped engagement, depending on a relative longitudinal position of the carrier in the case, and wherein the plunger is arranged to be released for rotating out of the ramped engagement.

20. 发明申请

US20210213206A1 Autoinjector 有权
公开(公告)号：US20210213206A1
公开(公告)日：2021-07-15
申请号：US17213115
申请日：2021-03-25
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/32 , A61M5/50 , A61M5/20
摘要： A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. Each ramp is on one longitudinal side of the rhomboid ramp member such that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction and such that application of a translative force between the components in the other longitudinal direction with the first beam head engaged to the other one of the ramps deflects the resilient beam in the other transversal direction.

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