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11. 发明授权

US4572446A Process for making a fiber bundle 失效
标题翻译：制造纤维束的方法
公开(公告)号：US4572446A
公开(公告)日：1986-02-25
申请号：US592835
申请日：1984-03-23
申请人： Ronald J. Leonard , Kenneth M. Johnson
发明人： Ronald J. Leonard , Kenneth M. Johnson
IPC分类号： A61M1/00 , A61M1/18 , B01D63/02 , B29C53/80 , B65H81/00 , B65H81/08
CPC分类号： B65H81/00 , B01D63/021 , B29C53/8016
摘要： A bundle (12) of hollow fiber (34) is formed by winding a length of hollow fiber around a core (38) from an arm (20) that is in a plane at an acute angle with respect to the longitudinal axis of the core and is between opposite ends of the core. Relative rotation is provided between the longitudinal axis of the core and the position of the winding arm. During winding of the hollow fiber around the core, there is an increase in the ratio of (a) the angular velocity of the wind and (b) the relative rotational velocity between the longitudinal axis of the core and the position of the winding arm. In this manner, the void fraction of radially-outward annuli of the wound bundle is less than the void fraction would be if the ratio remained constant.
摘要翻译：通过将一定长度的中空纤维从围绕芯（38）的臂（20）缠绕成一束中空纤维（34），所述臂（20）相对于芯的纵向轴线处于锐角的平面并且在芯的相对端之间。在芯的纵向轴线和绕组臂的位置之间提供相对旋转。在围绕芯部缠绕中空纤维期间，（a）风的角速度和（b）芯的纵向轴线与绕组臂的位置之间的相对旋转速度的比率增加。以这种方式，如果该比例保持恒定，则伤口束的径向向外的空隙的空隙率小于空隙率。

12. 发明授权

US4062773A High surface to volume structure and method of generating same 失效
标题翻译：高表面积体积结构及其生成方法
公开(公告)号：US4062773A
公开(公告)日：1977-12-13
申请号：US609312
申请日：1975-09-02
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/36 , B01D29/00 , B01D29/02
CPC分类号： A61M1/3627 , B01D29/111 , B01D29/213
摘要： A filter assembly and element are disclosed herein for use in filtering biological fluids. The assembly includes a variable volume housing within which is positioned a cylindrically-shaped, high surface area filter. During operation, the housing volume is changed, but the surface area available for filtration remains substantially constant. This permits the filter to be operated with low priming volumes and also to effectively reduce gas bubble entrapment in the filter.A method of making the element and a method for operating the filter assembly are also disclosed.
摘要翻译：本文公开了用于过滤生物流体的过滤器组件和元件。组件包括可变容积的壳体，其中定位有圆柱形的高表面积过滤器。在操作期间，壳体容积改变，但可用于过滤的表面积保持基本恒定。这允许过滤器以低启动体积操作，并且还有效地减少过滤器中的气泡滞留。

13. 发明授权

US4883455A Cardioplegia administration set 失效
标题翻译：心麻痹管理套
公开(公告)号：US4883455A
公开(公告)日：1989-11-28
申请号：US243896
申请日：1988-09-13
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M5/44 , A61M1/36 , A61M39/22
CPC分类号： A61M1/3621 , A61M1/3627 , A61M1/3643 , A61M1/369 , A61M2205/3337 , A61M2205/366 , A61M39/228 , Y10S128/03
摘要： A cardioplegia administration set including a heat exchanger, a bubble trap, a three-end connector, a normally-closed, pressure-responsive valve and interconnecting tubing. A first tubing means having an inlet adapted to be connected to a source of cardioplegia solution and an outlet connected to an inlet of the three-end connector interconnects inlets and outlets of the heat exchanger and the bubble trap therebetween so that a solution passageway is established from the source of cardioplegia solution through the heat exchanger and the bubble trap to an end of the three-end connector adapted to connect to an injection catheter. A second tubing means has an inlet connected to a recirculation outlet of the three-end connector and an outlet adapted to be connected to the source of cardioplegia solution so that a solution passageway is established from the three-end connector through the normally-closed valve back to the source of cardioplegia solution when the valve is open. The second tubing means and the normally-closed, pressure-responsive valve together comprise a recirculation loop.

14. 发明授权

US4800022A Platelet collection system 失效
标题翻译：血小板收集系统
公开(公告)号：US4800022A
公开(公告)日：1989-01-24
申请号：US926865
申请日：1986-11-04
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/00 , A61M1/02 , A61M1/34 , A61M1/38 , B01D61/14 , B01D61/22 , B01D13/00
CPC分类号： A61M1/3496
摘要： A system is provided for collecting platelets. Whole blood is removed from a patient 10 and directed to a hemoconcentrator 22 having a blood inlet 24, a blood outlet 26, a blood passage communicating with the blood inlet and blood outlet, an ultrafiltrate outlet 28 and a membrane separating the blood passage from the ultrafiltrate outlet. The blood is passed through the blood passage of the hemoconcentrator while a negative pressure is adapted to the ultrafiltrate outlet. In this manner, the platelets concentrate on the membrane wall. After a selected period of time, the application of the negative pressure is terminated to the ultrafiltrate outlet, and the concentrated platelets from the hemoconcentrator are flushed and directed to a platelet collection container 44. In one embodiment, the flushing solution comprises the patient's blood that is directed via the blood inlet through the blood passage while in another embodiment, the patient's blood is diverted and a saline solution is used as the flush. During the flush, a positive pressure may be applied to the ultrafiltrate outlet of the hemoconcentrator.
摘要翻译：提供一种用于收集血小板的系统。将全血从患者10取出并且被引导到具有血液入口24，血液出口26，与血液入口和血液出口连通的血液通道的血液浓缩器22，超滤液出口28和将血液通道从超滤出口血液通过血液浓缩器的血液通道，而负压适应于超滤液出口。以这种方式，血小板集中在膜壁上。在选定的时间段之后，将负压施加终止于超滤液出口，并且来自血液浓缩器的浓缩血小板被冲洗并引导至血小板收集容器44.在一个实施方案中，冲洗溶液包含患者的血液，通过血液入口穿过血液通道，而在另一个实施方案中，患者的血液被转移并且盐水溶液被用作冲洗液。在冲洗期间，正压力可以施加到血液浓缩器的超滤液出口。

15. 发明授权

US4715953A Hollow fiber separation device manifold 失效
标题翻译：中空纤维分离装置歧管
公开(公告)号：US4715953A
公开(公告)日：1987-12-29
申请号：US481439
申请日：1983-04-01
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： B01D63/02 , B01D13/00
CPC分类号： B01D63/022 , B01D63/02 , B01D63/021
摘要： A hollow fiber separation device such as an oxygenator for blood which comprises a core having a bundle of hollow tubular fibers circumferentially wrapped around the core for separation of materials. A housing encloses the bundle and first and second manifold systems respectively provide separated flow through the bundle in contact with exterior surfaces of the hollow fibers and the bores of the hollow fibers in first and second flow paths. A space extends longitudinally through the bundle exposing open ends of the fibers at opposed sides of the space, regions of the bundle are adjacent to the space being potted to prevent leakage around to the fibers. The second manifold system includes an inlet and outlet conduit, each being in flow communication with the space. Partition means in the space isolates fluid flow between the inlet conduit in one of the opposed sides from fluid flow between the outlet conduit in the other of opposed sides.
摘要翻译：一种中空纤维分离装置，例如用于血液的氧合器，其包括具有围绕芯部周向缠绕的用于分离材料的中空管状纤维束的芯。壳体包围束，第一和第二歧管系统分别提供与中空纤维的外表面和第一和第二流动路径中的中空纤维的孔接触的束的分离流。空间纵向延伸穿过该纤维的相对侧的纤维的开口端，该束的区域与被封装的空间相邻以防止在纤维周围的泄漏。第二歧管系统包括入口和出口管道，每个管道与空间流动连通。隔离装置在空间中分离流体之间的流体流动，其中一个相对侧的入口导管之间的流体在另一个相对侧的出口导管之间流动。

16. 发明授权

US5888611A Multilayer hollow fiber body and method of making 失效
标题翻译：多层中空纤维体及其制造方法
公开(公告)号：US5888611A
公开(公告)日：1999-03-30
申请号：US70711
申请日：1998-04-30
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/18 , A61M1/16 , B01D63/02 , B32B5/12
CPC分类号： B01D63/026 , A61M1/1625 , B01D63/02 , B01D63/021 , A61M1/1698 , B01D2313/025 , Y10T428/24124 , Y10T428/24215 , Y10T428/24231
摘要： A multilayer hollow fiber body useful, for example, in a blood oxygenator. The multilayer hollow fiber body comprises a single hollow fiber mat arranged in the form of a body comprising a plurality of hollow fiber plies. The mat comprises a plurality of generally parallel hollow fibers disposed at regular intervals, and a plurality of connecting fibers holding the connecting fibers. The mat is repeatedly folded over on itself along fold lines, each of which is at an oblique angle to the hollow fibers, to form a multilayer hollow fiber body in which the hollow fibers of any ply of the multilayer hollow fiber body are disposed so as to cross the hollow fibers of an adjacent successive ply of the multilayer hollow fiber body. Also disclosed is a method of making the multilayer hollow fiber body.
摘要翻译：可用于例如在血液充氧器中的多层中空纤维体。多层中空纤维体包括以包括多个中空纤维层的主体的形式布置的单个中空纤维垫。垫包括以规则间隔布置的多个大致平行的中空纤维，以及多个连接纤维，其保持连接纤维。该折叠线沿着与中空纤维成倾斜角的折叠线重复折叠，形成多层中空纤维体，多层中空纤维体的任何层的中空纤维被设置为以交叉多层中空纤维体的相邻连续层的中空纤维。还公开了制造多层中空纤维体的方法。

17. 发明授权

US4670152A Priming system for ultrafiltration unit 失效
标题翻译：超滤装置启动系统
公开(公告)号：US4670152A
公开(公告)日：1987-06-02
申请号：US851288
申请日：1986-04-10
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/36 , B01D13/00
CPC分类号： A61M1/3643 , A61M2205/366
摘要： A system is disclosed for priming an ultrafiltration unit (10) connected to a blood source, without requiring a pump in the blood line. An ultrafiltration unit (10) is provided having an ultrafiltration membrane which separates a blood compartment from an ultrafiltrate compartment, a blood inlet port (12), a blood outlet port (14), a second inlet port (16) communicating with the ultrafiltrate compartment, and an ultrafiltrate outlet port (18). A feedback tube (38) connects the blood outlet port (14) to the second input port (16). Priming solution (36) is introduced to the blood inlet port (12) and a vacuum is applied to the ultrafiltrate outlet port (18). The priming solution (36) is drawn through the blood compartment, through the ultrafiltrate compartment, out the ultrafiltrate outlet port, and to drain.
摘要翻译：公开了一种用于启动连接到血液源的超滤单元（10）的系统，而不需要血液管线中的泵。提供超滤单元（10），其具有将血液隔室与超滤室隔离的超滤膜，血液入口（12），血液出口（14），与超滤室隔开的第二入口（16）和超滤出口（18）。反馈管（38）将血液出口（14）连接到第二输入端口（16）。将引发溶液（36）引入血液入口（12），并向超滤出口（18）施加真空。引发溶液（36）通过血液隔室，通过超滤室隔离出超滤出口，并排出。

18. 发明授权

US4061470A Blood oxygenator utilizing a removable membrane oxygenator unit 失效
标题翻译：使用可移除膜氧合器单元的血液充氧器
公开(公告)号：US4061470A
公开(公告)日：1977-12-06
申请号：US735863
申请日：1976-10-27
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/03
CPC分类号： A61M1/1698 , A61M1/26 , A61M2209/082 , A61M2209/084 , Y10S128/03
摘要： An oxygenator for blood which comprises means for removably holding a membrane oxygenator unit, means for conveying blood to a patient through the oxygenator unit in a first flow path and back to the patient, and means for supplying oxygen gas through the oxygenator unit in a second flow path separated from the first flow path in the unit by a semi-permeable membrane. The oxygenator unit holding means carries a plate which has an oxygen inlet manifold port positioned to communicate with a mounted oxygenated unit, to provide a sealed oxygen flow path through the plate into the oxygenator unit and to provide for dispersal of effluent oxygen in a plurality of directions, thereby preventing the accidental obstruction of the oxygen outlet of the unit.
摘要翻译：一种用于血液的氧合器，包括用于可移除地保持膜氧合器单元的装置，用于通过第一流动路径中的氧合器单元向患者输送血液并返回到患者的装置，以及用于在第二流体中通过氧合器单元供应氧气的装置流动路径通过半透膜与单元中的第一流动路径分离。氧合器单元保持装置承载一个板，其具有定位成与所安装的氧化单元连通的氧气进口歧管端口，以提供通过该板进入氧合器单元的密封的氧气流动路径，并提供在多个方向，从而防止意外堵塞设备的氧气出口。

19. 发明授权

US3985135A Dual chamber reservoir 失效
标题翻译：双室水箱
公开(公告)号：US3985135A
公开(公告)日：1976-10-12
申请号：US563861
申请日：1975-03-31
申请人： Walter L. Carpenter , Ronald J. Leonard
发明人： Walter L. Carpenter , Ronald J. Leonard
IPC分类号： B65D33/38 , A61J1/00 , A61J1/05 , A61M1/02 , B65D30/22 , A61M5/14
CPC分类号： A61J1/10
摘要： A reservoir for use with blood oxygenation apparatus is described herein. A chamber separator within said reservoir defines, in the interior thereof, a primary chamber and a secondary chamber, with a flow channel, connecting the primary and secondary chambers. A plurality of intake and outlet ports communicate with the primary chamber. The reservoir may be connected to blood oxygenation apparatus via the intake and outlet ports, while the flow channel may be clamped to prevent fluid flow between the primary and the secondary chambers, when it is desired to reduce the blood volume in the reservoir.
摘要翻译：本文描述了用于血氧仪的储存器。所述储存器内的室分离器在其内部限定了具有连接初级室和次室的流动通道的初级室和次级室。多个进出口与主室连通。储存器可以经由进出口连接到血氧装置，同时当期望减少储存器中的血液体积时，流动通道可以被夹紧以防止主要和次要室之间的流体流动。

20. 发明授权

US6113782A Potting of tubular bundles in housing 失效
标题翻译：在管壳中灌装管状束
公开(公告)号：US6113782A
公开(公告)日：2000-09-05
申请号：US123696
申请日：1998-07-28
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/18 , A61M1/16 , B01D53/22 , B01D61/28 , B01D63/00 , B01D63/02 , B29C33/12 , B29C39/10 , B01D63/06 , B01D67/00 , A61M1/20
CPC分类号： B01D63/04 , B01D63/022 , B29C33/12 , B29C39/10 , F28F21/062 , F28F21/067 , A61M1/1698
摘要： Tubular bundles are potted in a housing, such as in an oxygenator or a pheresis unit. Spacer material is placed into the housing to cover the first ends of the tubular elements. A layer of potting material is placed into the housing covering the spacer material, and then solidified in place to seal between each of the tubular elements and the housing. The spacer material is then removed from the housing to expose the first ends of the tubular elements. In the oxygenator, at least some of the tubes are gas exchange tubes having an interior lumen and a tube wall which is permeable for oxygen and carbon dioxide flow through the tube wall. The potting separates the housing into manifold chambers communicating with the interior of the tubes and a blood flow chamber sealed from the manifold chambers. Blood flows over the exterior surface of the tubes. Other tubes may be heat transfer tubes, such as for carrying a heat transfer fluid to control the temperature of the blood. Multiple pottings may be performed to provide separate sealed manifold chambers for each set of tubes.
摘要翻译：管状束被封装在壳体中，例如在氧合器或排气单元中。间隔材料被放置在壳体中以覆盖管状元件的第一端。将一层灌封材料放置在覆盖间隔物材料的壳体中，然后固化就位以在每个管状元件和壳体之间密封。然后将间隔材料从壳体移除以露出管状元件的第一端。在氧合器中，至少一些管是具有内腔和管壁的气体交换管，其可渗透通过管壁的氧气和二氧化碳。灌封器将壳体分隔成与管内部连通的歧管室以及与歧管腔密封的血流室。血液流过管的外表面。其他管可以是传热管，例如用于承载传热流体以控制血液的温度。可以执行多个灌封，以为每组管提供单独的密封歧管腔。

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