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11. 发明授权

US3952094A Antibacterial compositions 失效
公开(公告)号：US3952094A
公开(公告)日：1976-04-20
申请号：US541845
申请日：1975-01-17
申请人： Martin Cole , Robert Sutherland
发明人： Martin Cole , Robert Sutherland
IPC分类号： A61K31/43 , A61K31/545 , A61K35/00
CPC分类号： A61K31/43 , A61K31/545
摘要： Compositions containing a mixture of 2-isopropoxynaphth-1-yl penicillin and cephaloridine or cephalothin have been found to show enhanced activity against certain clinically important bacteria.

12. 发明申请

US20080001767A1 PARTICLE MONITORS AND METHOD(S) THEREFOR 有权
公开(公告)号：US20080001767A1
公开(公告)日：2008-01-03
申请号：US11778685
申请日：2007-07-17
申请人： Martin Cole
发明人： Martin Cole
IPC分类号： G08B21/00
CPC分类号： G08B17/107 , G01F1/6842 , G01N21/53 , G01P5/10 , G08B17/10 , G08B17/113 , G08B17/12
摘要： The present invention relates to the field of the detection, analysis and/or determination of matter or particles suspended in fluid. In one particular form, the present invention relates to smoke detectors, which detect unwanted pyrolysis or combustion of material. In another form, the present invention relates to smoke detectors of the early detection type, and which may be applied to ventilation, air-conditioning or duct monitoring of a particular area. In yet another form, the present invention relates to surveillance monitoring, such as building, fire or security monitoring. In still another form, the present invention relates to environment monitoring, such as monitoring, detection and/or analysis of a fluid, zone, area and/or ambient environment, including commercial and industrial environments.

13. 发明申请

US20070285264A1 SMOKE DETECTORS PARTICULARLY DUCTED SMOKE DETECTORS 审中-公开
标题翻译：烟雾探测器特别吸引烟雾探测器
公开(公告)号：US20070285264A1
公开(公告)日：2007-12-13
申请号：US11843859
申请日：2007-08-23
申请人： Martin Cole
发明人： Martin Cole
IPC分类号： G08B17/107
CPC分类号： G08B17/107 , G01N21/53 , G01N2021/4711 , G01N2021/4733 , G01N2021/4792 , G08B17/113
摘要： The present invention relates to the detection of particles suspended in fluid particularly smoke detectors suitable for mounting on ducting for the early detection of smoke created by unwanted pyrolysis or combustion of materials in a protected area or fire zone to which the duct is connected. The present invention provides alternately illuminating a detection zone with one of either a first or a second illumination. The improvement embodied in the current invention is the ability to retain sensitivity to a wide range of particle sizes and also to discriminate between different kinds of smoke or dust according to particle size, whilst also achieving relatively long service life, small size, light weight and low cost.
摘要翻译：本发明涉及悬浮在流体中的颗粒特别是烟雾探测器的检测器，特别是烟雾探测器，其适于安装在管道上，以便早期检测由管道连接到的保护区域或防火区中的材料的不希望的热解或燃烧产生的烟雾。本发明提供交替地照射具有第一或第二照明中的一个的检测区域。本发明所体现的改进是保持对各种粒度的灵敏度的能力，并且还能够根据粒度来区别不同种类的烟雾或粉尘，同时还实现相对较长的使用寿命，小尺寸，轻质量和低成本。

14. 发明授权

US06813079B2 Fabricating optical waveguide gratings 有权
标题翻译：制造光波导光栅
公开(公告)号：US06813079B2
公开(公告)日：2004-11-02
申请号：US10109639
申请日：2002-04-01
申请人： Richard Ian Laming , Martin Cole
发明人： Richard Ian Laming , Martin Cole
IPC分类号： G02B2742
CPC分类号： G02B6/02152 , G02B6/02138 , Y10S359/90
摘要： A method of fabricating an optical waveguide grating having a plurality of grating lines of refractive index variation comprises the steps of: (i) repeatedly exposing a spatially periodic writing pattern onto a photosensitive optical waveguide: and (ii) moving the writing light pattern and/or the waveguide between successive exposures of the writing light pattern, so that each of at least a majority of the grating lines is generated by at least two exposures to different respective regions of the writing light pattern.
摘要翻译：一种制造具有多个折射率变化的光栅线的光波导光栅的方法包括以下步骤：（i）将空间周期性写入光图案重复地曝光到光敏光波导上;和（ii）移动书写光图案和 /或写入光图案的连续曝光之间的波导，使得至少大部分的光栅线中的每一个通过对写入光图案的不同相应区域的至少两次曝光来产生。

15. 发明授权

US06349157B1 Dispersion compensation optical fibre transmission 有权
标题翻译：色散补偿光纤传输
公开(公告)号：US06349157B1
公开(公告)日：2002-02-19
申请号：US09571739
申请日：2000-05-15
申请人： Richard Ian Laming , Martin Cole , Laurence Reekie
发明人： Richard Ian Laming , Martin Cole , Laurence Reekie
IPC分类号： G02B628
CPC分类号： H04B10/2519 , G02B6/29317 , G02B6/2932 , G02B6/29394 , H04B2210/254
摘要： A method of forming a chirped fiber grating having the steps of providing an optical fiber, impressing a non-linear grating onto a portion of the optical fiber to define a non-linear variation in the refractive index. The method further comprising applying a temperature gradient to a portion of the optical fiber to provide a variation that acts against the non-linear variation in the refractive index.
摘要翻译：一种形成啁啾光纤光栅的方法，具有提供光纤的步骤，将非线性光栅施加在光纤的一部分上以限定折射率的非线性变化。该方法还包括向光纤的一部分施加温度梯度以提供抵抗折射率的非线性变化的变化。

16. 发明授权

US4529720A Antibiotic from Streptomyces clavulicerus 失效
标题翻译：来自链球菌的抗生素
公开(公告)号：US4529720A
公开(公告)日：1985-07-16
申请号：US305337
申请日：1981-09-24
申请人： Martin Cole , Thomas T. Howarth , Christopher Reading
发明人： Martin Cole , Thomas T. Howarth , Christopher Reading
IPC分类号： A61K31/42 , A61K31/43 , C07D503/00 , C12P17/18
CPC分类号： C12P17/188 , A61K31/42 , A61K31/43 , C07D503/00
摘要： A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulonic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potancy, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta. lactam antibiotics against many .beta.-lactamase producing bacteria.
摘要翻译：已经从Streptomyces clavuligerus中分离出一种新的抗菌活性剂。这种被称为克拉维酸的新化合物具有式（I）：除了广谱抗生素的中等耐药性之外，克拉维酸及其盐和酯具有增强β-内酰胺的有效性的能力针对许多β-内酰胺酶生产细菌的抗生素。

17. 发明授权

US4346168A Process for the preparation of penicillin derivatives 失效
标题翻译：制备青霉素衍生物的方法
公开(公告)号：US4346168A
公开(公告)日：1982-08-24
申请号：US149343
申请日：1980-05-13
申请人： Martin Cole , Robert A. Edmondson
发明人： Martin Cole , Robert A. Edmondson
IPC分类号： C07D499/00 , C07D499/72 , C12N9/18 , C12P37/00
CPC分类号： C07D499/00 , C12N9/18 , C12P37/00
摘要： A process for the preparation of .alpha.-carboxy, 6, .alpha.-methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative.The process is for the preparation of a compound of formula (I): ##STR1## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): ##STR2## wherein R.sup.1 is an ester-forming radical, to the action of the enzyme .alpha.-chymotrypsin or an esterase-producing strain of Streptomyces sp.
摘要翻译：通过酯化衍生物的酶水解制备α-羧基，6α-甲氧基青霉素衍生物的方法。该方法用于制备式（I）化合物：其中R表示苯基或2-或3-噻吩基，该方法包括使式（IV）化合物：（IV）化合物）其中R1是成酯基团，涉及酶α-酶胰蛋白酶或链霉菌属的酯酶产生菌株的作用。

18. 发明授权

US4203973A Antibiotics 失效
标题翻译：抗生素
公开(公告)号：US4203973A
公开(公告)日：1980-05-20
申请号：US913304
申请日：1978-06-07
申请人： Martin Cole , John D. Hood , Dennis Butterworth
发明人： Martin Cole , John D. Hood , Dennis Butterworth
IPC分类号： C07D477/20 , A61K35/00
CPC分类号： C07D477/20
摘要： It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.
摘要翻译：已经发现，通过某些菌株的橄榄油链霉菌和相关生物体的发酵可以获得抗生素，当纯的这种抗生素是许多β-内酰胺酶的非常有效的抑制剂时。我们指定MM 4550A的抗生素可以通过从培养基中获得的粗抗菌复合物的色谱纯化以基本上纯的形式获得。

19. 发明授权

US06218380B1 Pharmaceutical compositions 失效
标题翻译：药物组合物
公开(公告)号：US06218380B1
公开(公告)日：2001-04-17
申请号：US07749482
申请日：1991-08-15
申请人： Martin Cole , Thomas Trevor Howarth , Christopher Reading
发明人： Martin Cole , Thomas Trevor Howarth , Christopher Reading
IPC分类号： C07D50318
CPC分类号： A61K31/42 , A61K31/424 , C07D498/04
摘要： A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of &bgr; lactam antibiotics against many &bgr;-lactamase producing bacteria.
摘要翻译：已经从Streptomyces clavuligerus中分离出一种新的抗菌活性剂。这种被称为克拉维酸的新化合物具有式（I）：除了广谱抗生素的中等效力之外，克拉维酸及其盐和酯还具有增强β-内酰胺抗生素对许多β-内酰胺酶的有效性的能力产生细菌。

20. 发明授权

US6072926A Optical waveguide grating 失效
标题翻译：光波导光栅
公开(公告)号：US6072926A
公开(公告)日：2000-06-06
申请号：US952303
申请日：1998-04-16
申请人： Martin Cole , Wei-Hung Loh , Richard Ian Laming , Michael Nickolaos Zervas
发明人： Martin Cole , Wei-Hung Loh , Richard Ian Laming , Michael Nickolaos Zervas
IPC分类号： G02B5/18 , G02B5/26 , G02B6/02 , G02B6/10 , G02B6/136 , G02B6/34
CPC分类号： G02B6/02152 , G02B6/02138 , G02B6/02085
摘要： A method of forming optical waveguide gratings, such as in-fiber gratings, is described. The gratings are formed optically, with a phase mask being scanned by a writing laser beam to generate the grating pattern. The waveguide and phase mask are moved with respect to one another during the writing process, to vary the grating properties along the length of the grating. Relative movement in a single direction provides a chance of grating pitch, and so can be used to fabricate chirped or multi-wavelength gratings. Bi-directional dither alters the strength of the grating, and so can be used to fabricate apodised gratings.
摘要翻译： PCT No.PCT / GB96 / 01154 Sec。 371日期：1998年4月16日 102（e）日期1998年4月16日PCT提交1996年5月14日PCT公布。第WO96 / 36895号公报日期：1996年11月21日描述了一种形成诸如光纤内光栅的光波导光栅的方法。光栅被光学地形成，相位掩模被写入激光束扫描以产生光栅图案。波导和相位掩模在写入过程中相对于彼此移动，以沿着光栅的长度改变光栅特性。在单个方向上的相对运动提供光栅间距的机会，因此可用于制造啁啾或多波长光栅。双向抖动改变光栅的强度，因此可用于制造变迹光栅。

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