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11. 发明申请

US20180127703A1 MEDICAL SAMPLE TRANSPORTATION CONTAINER 审中-公开
公开(公告)号：US20180127703A1
公开(公告)日：2018-05-10
申请号：US15569036
申请日：2016-04-21
申请人： Q-LINEA AB
发明人： Jonas Jarvius , Anders Lind , Henrik Soderstrom , Jan Grawe , Ian Fitzpatrick , Jurg Bartholdi
IPC分类号： C12M1/00 , A01N1/02 , C12M3/06 , C12M1/02 , C12Q1/04
CPC分类号： C12M41/14 , A01N1/0252 , A01N1/0273 , C12M27/16 , C12M41/24 , C12Q1/04
摘要： A portable apparatus for transport and incubation of a medical sample in a blood culture flask includes a sealable container having a thermally insulated compartment for receiving the blood culture flask and a heater for heating the medical sample to a temperature suitable for pre-culturing of the sample. An agitator is provided for agitating the sample in the blood culture flask.

12. 发明申请

US20170121759A1 METHOD FOR DETECTING AND CHARACTERISING A MICROORGANISM 审中-公开
公开(公告)号：US20170121759A1
公开(公告)日：2017-05-04
申请号：US15318261
申请日：2015-06-12
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： C12Q1/68 , C12Q1/18
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q1/18
摘要： A method for detecting and characterizing a microorganism in a clinical sample includes introducing a clinical sample to a first culture vessel containing the culture medium; removing a test aliquot; separating DNA from the test aliquot; and performing nucleic acid tests on the DNA to identify the microorganism and to detect the presence or absence of one or more genetic antimicrobial resistance markers in the microorganism. If a microorganism is identified, an antimicrobial susceptibility test is performed wherein microbial growth in the antimicrobial susceptibility test is monitored by accessing growth or markers for growth and wherein the type and concentration of antimicrobial agents used in the antimicrobial susceptibility test is determined by the identity of the microorganism and the antimicrobial resistance markers detected. A device for performing the method is also provided.

13. 发明授权

US11505835B2 Method for determining the identity and antimicrobial susceptibility of a microorganism 有权
公开(公告)号：US11505835B2
公开(公告)日：2022-11-22
申请号：US16844240
申请日：2020-04-09
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： C12P19/34 , C12Q1/689 , C12Q1/18 , C12Q1/04
摘要： A method for detecting and characterizing a microorganism in a clinical sample includes introducing a clinical sample to a first culture vessel containing the culture medium; removing a test aliquot; separating DNA from the test aliquot; and performing nucleic acid tests on the DNA to identify the microorganism and to detect the presence or absence of one or more genetic antimicrobial resistance markers in the microorganism. If a microorganism is identified, an antimicrobial susceptibility test is performed wherein microbial growth in the antimicrobial susceptibility test is monitored by accessing growth or markers for growth and wherein the type and concentration of antimicrobial agents used in the antimicrobial susceptibility test is determined by the identity of the microorganism and the antimicrobial resistance markers detected. A device for performing the method is also provided.

14. 发明申请

US20210246410A1 MEDICAL SAMPLE TRANSPORTATION CONTAINER 有权
公开(公告)号：US20210246410A1
公开(公告)日：2021-08-12
申请号：US17214192
申请日：2021-03-26
申请人： Q-linea AB
发明人： Jonas Jarvius , Anders Lind , Henrik Soderstrom , Jan Grawe , Ian Fitzpatrick , Jurg Bartholdi
IPC分类号： C12M1/00 , A01N1/02 , C12M3/06 , C12M1/02 , C12Q1/04
摘要： A portable apparatus and method for transport and incubation of a medical sample in a blood culture flask includes a sealable container having a thermally insulated compartment for receiving the blood culture flask and a heater for heating the medical sample to a temperature suitable for pre-culturing of the sample. An agitator is provided for agitating the sample in the blood culture flask.

15. 发明申请

US20210017568A1 DEVICE FOR DETERMINING ANTIMICROBIAL SUSCEPTIBILITY OF A MICROORGANISM 有权
公开(公告)号：US20210017568A1
公开(公告)日：2021-01-21
申请号：US17061291
申请日：2020-10-01
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe , Ylva Molin , Markus Klintstedt , Mats Gullberg
IPC分类号： C12Q1/18 , C12M1/26 , C12M1/34
摘要： The present invention provides methods for determining the antimicrobial susceptibility of a microorganism in a clinical sample said method comprising removing a test aliquot from a clinical sample culture before the culture reaches 0.5 McFarland units, isolating the microbial cells and transferring the cells into a suitable culture medium for microbial growth, and performing an AST assay using the isolated microbes, wherein the concentration of microbial cells in the microbial cells used to set up the AST assay is measured before the degree of microbial growth in the different growth conditions of the AST assay is measured. Devices for determining the antimicrobial susceptibility of a microorganism in a clinical sample are also provided.

16. 发明授权

US10831011B2 Sample holder for image based analysis of samples 有权
公开(公告)号：US10831011B2
公开(公告)日：2020-11-10
申请号：US16310187
申请日：2017-06-15
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： G02B21/24 , G02B21/34 , G02B27/40 , G01N21/64 , B01L3/00
摘要： A sample holder 100 for use in a device for image-based analysis of multiple samples, the sample holder comprising: an optically flat surface 10; multiple locations of interest 16, 18 dispersed across the optically flat surface 10 that each, in use, correspond to locations of a sample of the multiple samples; and multiple focal structures 12 associated with the multiple locations of interest 16, 18; wherein the focal structures 12 each comprise at least one pyramid shaped indentation 30 in the optically flat surface 10.

17. 发明授权

US10655188B2 Method for determining the identity and antimicrobial susceptibility of a microorganism 有权
公开(公告)号：US10655188B2
公开(公告)日：2020-05-19
申请号：US15318261
申请日：2015-06-12
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： C12P19/34 , C12Q1/689 , C12Q1/18 , C12Q1/04
摘要： A method for detecting and characterizing a microorganism in a clinical sample includes introducing a clinical sample to a first culture vessel containing the culture medium; removing a test aliquot; separating DNA from the test aliquot; and performing nucleic acid tests on the DNA to identify the microorganism and to detect the presence or absence of one or more genetic antimicrobial resistance markers in the microorganism. If a microorganism is identified, an antimicrobial susceptibility test is performed wherein microbial growth in the antimicrobial susceptibility test is monitored by accessing growth or markers for growth and wherein the type and concentration of antimicrobial agents used in the antimicrobial susceptibility test is determined by the identity of the microorganism and the antimicrobial resistance markers detected. A device for performing the method is also provided.

18. 发明申请

US20190119724A1 DETECTING AND CHARACTERISING A MICROORGANISM 审中-公开
公开(公告)号：US20190119724A1
公开(公告)日：2019-04-25
申请号：US16094699
申请日：2017-04-21
申请人： Q-LINEA AB
发明人： Jonas Jarvius , Anders Lind , Henrik Soderstrom , Jan Grawe
IPC分类号： C12Q1/6806 , C12Q1/686 , C12Q1/6837 , A01N1/02
摘要： A method for detecting and characterising a microorganism in a clinical sample includes introducing a clinical sample to a first culture vessel and then simultaneously transporting and incubating the clinical sample in a thermally insulated compartment of a sealable container. A test aliquot is removed from the sample and the remainder of the sample is cultured further. The method further includes removing DNA from said test aliquot and performing nucleic acid tests on said DNA to identify the microorganism and to detect the presence or absence of one or more genetic antimicrobial resistance markers in said microorganism. The nucleic acid tests are performed using: i) one or more nucleic acid probes and/or primers for microbial identification, a said probe or primer being capable of hybridising specifically to, or a said primer being capable of selectively amplifying, a nucleotide sequence which is identificatory of a given microorganism; and ii) one or more nucleic acid probes and/or primers for antimicrobial resistance marker detection, a said probe or primer being capable of hybridising specifically to, or a said primer being capable of selectively amplifying, a nucleotide sequence representing a genetic antimicrobial resistance marker. It is detected whether or not said probes and/or primers have hybridised to said DNA and/or said primers have been extended (e.g. an amplification reaction has taken place) and if a microorganism is identified in step then an antimicrobial susceptibility test is performed on said cultured clinical sample.

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