专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US09096495B2 Process for the preparation of triiodinated carboxylic aromatic derivatives 有权
标题翻译：三碘化羧酸衍生物的制备方法
公开(公告)号：US09096495B2
公开(公告)日：2015-08-04
申请号：US13143225
申请日：2010-03-12
申请人： Pier Lucio Anelli , Marino Brocchetta , Roberta Fretta , Luciano Lattuada , Armando Mortillaro
发明人： Pier Lucio Anelli , Marino Brocchetta , Roberta Fretta , Luciano Lattuada , Armando Mortillaro
IPC分类号： C07C233/06 , C07C237/46 , C07C231/02 , C07C231/10
CPC分类号： C07C237/46 , C07C231/02 , C07C231/10 , C07C235/16
摘要： The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof.
摘要翻译：本发明涉及制备给定的甲酰氨基化合物，特别是2,4,6-三碘代邻苯二甲酸衍生物的方法，作为制备X射线造影剂的有用中间体，其中碘帕醇。所述方法包括使合适的N-亚磺酰基中间体化合物与市售的α-羟基酸或其盐反应。

12. 发明申请

US20110275850A1 Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives 有权
标题翻译：三碘化羧基芳族衍生物的制备方法
公开(公告)号：US20110275850A1
公开(公告)日：2011-11-10
申请号：US13143225
申请日：2010-03-12
申请人： Pier Lucio Anelli , Marino Brocchetta , Roberta Fretta , Luciano Lattuada , Armando Mortillaro
发明人： Pier Lucio Anelli , Marino Brocchetta , Roberta Fretta , Luciano Lattuada , Armando Mortillaro
IPC分类号： C07C231/10 , C07C231/02
CPC分类号： C07C237/46 , C07C231/02 , C07C231/10 , C07C235/16
摘要： The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof.
摘要翻译：本发明涉及制备给定的甲酰氨基化合物，特别是2,4,6-三碘代邻苯二甲酸衍生物的方法，作为制备X射线造影剂的有用中间体，其中碘帕醇。所述方法包括使合适的N-亚磺酰基中间体化合物与市售的α-羟基酸或其盐反应。

13. 发明授权

US06307074B1 Process for the preparation of bile acid derivatives 有权
标题翻译：制备胆汁酸衍生物的方法
公开(公告)号：US06307074B1
公开(公告)日：2001-10-23
申请号：US09449998
申请日：1999-11-26
申请人： Marino Brocchetta , Chiara Gallotti , Massimo Visigalli , Pier Lucio Anelli
发明人： Marino Brocchetta , Chiara Gallotti , Massimo Visigalli , Pier Lucio Anelli
IPC分类号： C07J4100
CPC分类号： C07J9/00
摘要： A process for the preparation of the compounds of general formula (I) in which R1 is H or OH; R2 is H, &agr;-OH, or &bgr;-OH; and R3 is a straight or branched C1-C4 alkyl group or a benzyl group, comprising the reduction of compounds of formula (III) wherein R1, R2 and R3 have the same meanings as in formula I, in the presence of sodium borohydride.
摘要翻译：制备通式（I）的化合物的方法，其中R 1为H或OH; R 2为H，α-OH或β-OH; 和R 3是直链或支链C 1 -C 4烷基或苄基，包括在硼氢化钠存在下还原其中R 1，R 2和R 3具有与式I中相同含义的式（III）化合物。

14. 发明授权

US5649537A Paramagnetic metal icon chelates and use thereof as contrast agents in magnetic resonance imaging 失效
标题翻译：顺磁性金属图标螯合物及其在磁共振成像中作为造影剂的用途
公开(公告)号：US5649537A
公开(公告)日：1997-07-22
申请号：US443342
申请日：1995-05-17
申请人： Pier Lucio Anelli , Christoph De Haen , Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri
发明人： Pier Lucio Anelli , Christoph De Haen , Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K51/04 , A61B5/055
CPC分类号： A61K49/10 , A61K49/085 , A61K51/0493 , A61K51/0497 , A61K2123/00
摘要： Novel paramagnetic metal ion chelates and their use as contrast agents in the diagnostic technique known as "magnetic resonance imaging" (M.R.I.) of the gastrointestinal tract and particularly of the liver, are described. The novel compounds result from the conjugation of a bile acid with a chelating agent and are capable of chelating the ions of bivalent and trivalent metals. The compounds have formula A-L-B in which A is the residue of a bile acid and derivatives of a bile acid, B is the residue of a chelating agent of a bivalent or trivalent metal ion having an atomic number of 20 to 31, 39, 42, 43, 44, 49, 57 to 83, L is a ligand between A and B.
摘要翻译：描述了新型顺磁性金属离子螯合物及其在称为“磁共振成像”（M.R.I.）的胃肠道特别是肝脏的诊断技术中作为造影剂的用途。新型化合物由胆汁酸与螯合剂结合而产生，并能螯合二价和三价金属的离子。所述化合物具有式ALB，其中A是胆汁酸的残基和胆汁酸的衍生物，B是二价或三价金属离子的螯合剂的残基，其原子序数为20至31,39,42， 43，44，49，57至83，L是A和B之间的配体。

15. 发明授权

US06342598B1 Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents 有权
标题翻译：两性多羧酸螯合物和与顺磁金属的复合物作为MRI造影剂
公开(公告)号：US06342598B1
公开(公告)日：2002-01-29
申请号：US09448289
申请日：1999-11-24
申请人： Pier Lucio Anelli , Luciano Lattuada , Fulvio Uggeri , Giovanna Lux , Michele Serleti , Milena Gabellini , Hervé Tournier
发明人： Pier Lucio Anelli , Luciano Lattuada , Fulvio Uggeri , Giovanna Lux , Michele Serleti , Milena Gabellini , Hervé Tournier
IPC分类号： C07D25702
CPC分类号： C07J41/0055 , A61K49/06 , A61K49/1812 , C07C229/16 , C07C229/76 , C07C233/47 , C07C237/08 , C07C237/10 , C07C237/12 , C07F9/091 , Y10S977/896 , Y10S977/927 , Y10S977/93
摘要： Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.
摘要翻译：取代的多羧酸配体分子和所述配体的相应金属配合物，优选顺磁性金属配合物，用于在磁共振成像（MRI）领域中产生应答。多羧酸配体的顺磁配合物具有有利的张力活性，并且可用作用于调查血液池的制剂中的MRI造影剂。

16. 发明申请

US20120232151A1 Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form 审中-公开
标题翻译：以固体形式制备钆酸二甲酚复合物的方法
公开(公告)号：US20120232151A1
公开(公告)日：2012-09-13
申请号：US13510409
申请日：2010-11-23
申请人： Pier Lucio Anelli , Pierfrancesco Morisini , Silvia Ceragioli , Fulvio Uggeri , Luciano Lattuada , Roberta Fretta , Aurelia Ferrigato
发明人： Pier Lucio Anelli , Pierfrancesco Morisini , Silvia Ceragioli , Fulvio Uggeri , Luciano Lattuada , Roberta Fretta , Aurelia Ferrigato
IPC分类号： C07C227/00 , A61K31/197 , C07C229/36
CPC分类号： A61K49/1887 , A61K9/0019 , B29C67/24 , C07C213/10 , C07C227/38 , C07C227/40 , Y10T428/2982 , C07C229/22
摘要： The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
摘要翻译：本发明公开了一种以固体形式制备钆酸二甲酚络合物的方法。特别地，所述固体形式通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地得到。本发明对于工业规模是特别有利的，因为固体形式可以通过使用水作为溶剂，其是无毒溶剂，易于处理并且基本上不需要麻烦的健康或安全预防措施来获得。

17. 发明授权

US5660814A Iodinated paramagnetic chelates, and their use as contrast agents 失效
标题翻译：碘化顺磁螯合物，以及它们作为造影剂的用途
公开(公告)号：US5660814A
公开(公告)日：1997-08-26
申请号：US448476
申请日：1995-05-30
申请人： Fulvio Uggeri , Pier Lucio Anelli , Franco Fedeli , Marcella Murru , Christoph De Haen
发明人： Fulvio Uggeri , Pier Lucio Anelli , Franco Fedeli , Marcella Murru , Christoph De Haen
IPC分类号： C07D257/02 , A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/04 , C07C237/04 , C07C237/10 , G01N31/00 , G01N33/48
CPC分类号： A61K49/10 , A61K49/0438 , A61K49/085 , A61K51/0497
摘要： Novel compounds containing a polyiodinated aromatic or heteroaromatic residue and their chelate complexes with ions of metal elements with atomic number from 20 to 31, 39, from 42 to 44, 49 and from 57 to 83, and their salts with physiologically tolerable organic and inorganic bases are useful contrast agents for preparation of diagnostic formulations to obtain images of organs and/or tissues of human and animal body through the use of nuclear magnetic resonance or X-rays or the combination of both nuclear magnetic resonance and X-rays.
摘要翻译： PCT No.PCT / EP94 / 01677 Sec。 371日期：1995年5月30日 102（e）日期1995年5月30日PCT 1994年5月25日PCT公布。公开号WO94 / 27644 日期1994年12月8日含有多碘化芳族或杂芳族残基的新型化合物及其与原子序数为20〜31,39,42,49和57〜83的金属元素离子的螯合络合物及其与生理盐可耐受的有机和无机碱是用于制备诊断制剂的有用的造影剂，以通过使用核磁共振或X射线或核磁共振和X-射线的组合来获得人体和动物的器官和/或组织的图像，射线

18. 发明授权

US6099824A Benzyloxy derivatives of DTPA for MRI 失效
标题翻译：用于MRI的DTPA的苄氧基衍生物
公开(公告)号：US6099824A
公开(公告)日：2000-08-08
申请号：US904646
申请日：1997-08-01
申请人： Pier Lucio Anelli , Andrea Beltrami , Fulvio Uggeri , Mario Virtuani
发明人： Pier Lucio Anelli , Andrea Beltrami , Fulvio Uggeri , Mario Virtuani
IPC分类号： A61K49/06 , C07C229/16 , C07C229/22 , C07C229/76 , A61B5/055
CPC分类号： C07C229/76 , A61K49/06 , C07C229/16 , C07C229/22 , Y10S514/836
摘要： Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.10) alkyl, linear or branched, which can be substituted by 1-6 hydroxyl and/or alkoxyl groups,m is between 1 and 5.
摘要翻译：可以螯合顺磁性双金属和三价金属离子的化合物，它们与所述金属离子的螯合物以及它们在磁共振成像（MRI）中作为造影剂的用途，具有式（I）的化合物其中R是 - （CH 2）m O-R 2 基团或氢，R2是（C6-C10）芳基或（C1-C5） - 芳基（C6-C10）烷基，被对应于OH基团或OR3基团的基团L取代或不被取代，其中R3 是直链或支链（C1-C5）烷基; 或L是NH 2，卤素，COOH或CONR 4 R 5，其中R 4和R 5独立地是氢，或可被1-6个羟基和/或1-6个烷氧基取代的直链或支链（C1-C5）烷基，R1可以具有与R独立的含义，除氢外，Z独立地为OH或OR 6，或NR 4 R 5，其中R 4和R 5如前所定义，R 6为直链或支链的（C1-C10）烷基，其可以是被1-6个羟基和/或烷氧基取代，m在1和5之间。

19. 发明授权

US07368101B2 Process for the preparation of iopamidol and the new intermediates therein 有权
标题翻译：碘帕醇及其中间体的制备方法
公开(公告)号：US07368101B2
公开(公告)日：2008-05-06
申请号：US11316559
申请日：2005-12-21
申请人： Pier Lucio Anelli , Marino Brocchetta , Giovanna Lux , Enrico Cappelletti
发明人： Pier Lucio Anelli , Marino Brocchetta , Giovanna Lux , Enrico Cappelletti
IPC分类号： A61K49/04 , C07C233/00 , C07D407/00
CPC分类号： C07C231/02 , C07C237/46
摘要： A process for the preparation of (S)-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide (II) which process comprises a) reacting the compound of formula (II) with a suitable protecting agent, to give a compound of formula (III) wherein R is a group of formula A or B wherein R1 is a hydrogen atom, a C1÷C4 straight or branched alkoxy group, R2 is hydrogen, a C1÷C4 straight or branched alkoy group and R3 ?is a C1÷C4 straight or branched alkyl group, a trifuoromethyl or a trichloromethyl group; b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula (IV) wherein R is as defined above; and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formula A carboxamido hydroxy groups under acidic conditions. The invention also refers to the new intermediates of formula (III) and (IV) wherein —R is a group A.
摘要翻译：制备（S）-N，N'-双[2-羟基-1-（羟甲基）乙基] -5 - [（2-羟基-1-氧代 - 丙基）氨基] -2,4， 5-氨基-N，N'-双[2-羟基-1-（羟甲基）乙基] -2,4,6-三碘-1,3-苯二甲酰胺的6-三碘-1,3-苯二甲酰胺（碘帕醇）（II）所述方法包括a）使式（II）化合物与合适的保护剂反应，得到其中R为式A或B的基团的式（III）化合物，其中R 1 >是氢原子，C 1或C 4直链或支链烷氧基，R 2是氢，C 1 直线或支链烷基，R 3？是C / C 直链或支链烷基，三氟甲基或三氯甲基; b）通过与（S）-2-（乙酰氧基）丙酰氯反应，酰化式（III）中间体化合物的第5位的氨基，得到其中R如上定义的式（Ⅳ）化合物; 和c）在碱性条件下除去存在于式（Ⅳ）化合物中的所有酰基，在R是式A的基团时，先前在酸性条件下，在甲酰氨基取代基中羟基的环保保护被切割。在酸性条件下。本发明还涉及式（III）和（IV）的新中间体，其中-R是基团A.

20. 发明授权

US06479681B2 Bile acid salts 失效
标题翻译：胆酸盐
公开(公告)号：US06479681B2
公开(公告)日：2002-11-12
申请号：US09934603
申请日：2001-08-23
申请人： Marino Brocchetta , Chiara Gallotti , Massimo Visigalli , Pier Lucio Anelli
发明人： Marino Brocchetta , Chiara Gallotti , Massimo Visigalli , Pier Lucio Anelli
IPC分类号： C07J4100
CPC分类号： C07J9/00
摘要： A process for the preparation of the compounds of general formula (I) in which R1 is H or OH; R2 is H, &agr;-OH, or &bgr;-OH; and R3 is a straight or branched C1-C4 alkyl group or a benzyl group, comprising the reduction of compounds of formula (III) wherein R1, R2 and R3 have the same meanings as in formula I, in the presence of sodium borohydride.
摘要翻译：制备通式（I）的化合物的方法，其中R 1为H或OH; R 2为H，α-OH或β-OH; 和R 3是直链或支链C 1 -C 4烷基或苄基，包括在硼氢化钠存在下还原其中R 1，R 2和R 3具有与式I中相同含义的式（III）化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式