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11. 发明授权

US6060239A Cellubrevin homologs 失效
公开(公告)号：US6060239A
公开(公告)日：2000-05-09
申请号：US621018
申请日：1996-03-22
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C07H21/04 , C12N15/00 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

12. 发明授权

US5633149A Polynucleotide encoding novel chemokine expressed in inflamed adenoid 失效
标题翻译：编码在发炎腺样体中表达的新趋化因子的多核苷酸
公开(公告)号：US5633149A
公开(公告)日：1997-05-27
申请号：US352324
申请日：1994-12-07
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P43/00 , C07K14/52 , C07K14/54 , C07K16/24 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/522 , C12Q1/6883 , A61K38/00 , C12Q2600/158 , Y10S514/885 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

13. 发明授权

US06692920B1 Antibodies to a chemokine expressed in inflamed adenoid 失效
标题翻译：在发炎腺样体中表达的趋化因子的抗体
公开(公告)号：US06692920B1
公开(公告)日：2004-02-17
申请号：US09588044
申请日：2000-06-05
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： A61K39395
CPC分类号： C07K14/522 , A61K38/00 , C12Q1/6883 , C12Q2600/158
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

14. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

15. 发明授权

US5843719A Cellubrevin homolog 失效
标题翻译： Cellubrevin同系物
公开(公告)号：US5843719A
公开(公告)日：1998-12-01
申请号：US897429
申请日：1997-07-21
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12P21/06 , C07H21/04 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (CB). The present invention also provides for antisense molecules to the nucleotide sequences which encode CB, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.
摘要翻译：本发明提供了鉴定和编码新型纤维连翘蛋白（CB）的核苷酸和氨基酸序列。本发明还提供编码CB的核苷酸序列的反义分子，用于产生纯化的CB的表达载体，能够特异性结合CB的抗体，用于检测CB编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主用于表达CB的细胞，基于编码CB的核酸分子和能够特异性结合CB的抗体的活化，发炎或患病细胞和/或组织的诊断测试。

16. 发明授权

US5783669A Hyaluronan receptor expressed in human umbilical vein endothelial 失效
标题翻译：透明质酸受体在人脐静脉内皮中表达
公开(公告)号：US5783669A
公开(公告)日：1998-07-21
申请号：US700178
申请日：1996-08-20
申请人： Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/705
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.
摘要翻译：本发明提供鉴定和编码人脐静脉内皮细胞的透明质酸受体（hr）的核苷酸和氨基酸序列。本发明还提供编码hr的核苷酸序列的反义分子，用于产生纯化的HR的表达载体，能够特异性结合HR的抗体，用于检测HR编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主用于表达HR的细胞，基于编码HR的核酸分子和能够特异性结合受体的抗体的活化的，血管生成的，发炎的或转移性细胞和/或组织的诊断测试。

17. 发明授权

US5587306A Phospholipase C homolog 失效
标题翻译：磷脂酶C同系物
公开(公告)号：US5587306A
公开(公告)日：1996-12-24
申请号：US419078
申请日：1995-04-10
申请人： Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12P21/08 , C12N9/20 , C12N15/70
CPC分类号： C12N9/16 , A61K38/52 , C12Y503/04001
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for the detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.
摘要翻译：本发明提供鉴定和编码新型磷脂酶C同源物（plch和PLCH）的核苷酸和氨基酸序列。本发明还提供了针对ch核苷酸序列的反义分子，用于产生纯化的PLCH的表达载体，能够特异性结合PLCH的抗体，用于检测过量PLCH编码核苷酸序列的杂交探针或寡核苷酸，用于 PLCH的表达，基于编码PLCH的核酸分子和能够特异性结合PLCH的抗体的活化，发炎，患病和羟基脲抗性细胞和/或组织的诊断测试。

18. 发明授权

US07708984B2 Methods of treatment with anitbodies to a chemokine expressed in inflamed adenoid 失效
标题翻译：在发炎腺样体中表达的趋化因子的治疗方法
公开(公告)号：US07708984B2
公开(公告)日：2010-05-04
申请号：US11806846
申请日：2007-06-04
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： A61K38/19
CPC分类号： C07K14/522 , A61K38/00 , C12Q1/6883 , C12Q2600/158 , Y10S514/885 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

19. 发明授权

US5676946A Phospholipase C homolog 失效
标题翻译：磷脂酶C同系物
公开(公告)号：US5676946A
公开(公告)日：1997-10-14
申请号：US726883
申请日：1996-10-04
申请人： Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12P21/08 , C12N9/20 , C12N15/70
CPC分类号： C12N9/16 , A61K38/52 , C12Y503/04001
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.
摘要翻译：本发明提供鉴定和编码新型磷脂酶C同源物（plch和PLCH）的核苷酸和氨基酸序列。本发明还提供了针对ch核苷酸序列的反义分子，用于产生纯化的PLCH的表达载体，能够特异性结合PLCH的抗体，用于检测过量PLCH编码核苷酸序列的杂交探针或寡核苷酸，用于 PLCH的表达，基于编码PLCH的核酸分子和能够特异性结合PLCH的抗体的活化，发炎，患病和羟基脲抗性细胞和/或组织的诊断试验。

20. 发明授权

US06352849B1 Mammalian phospholipase A2 nucleotide sequences, low molecular weight amino acid sequences encoded thereby, antisense sequences and nucleotide sequences having internal ribosome binding sites 失效
标题翻译：哺乳动物磷脂酶A2核苷酸序列，由此编码的低分子量氨基酸序列，具有内部核糖体结合位点的反义序列和核苷酸序列
公开(公告)号：US06352849B1
公开(公告)日：2002-03-05
申请号：US09362230
申请日：1999-07-28
申请人： Jay A. Tischfield , Jeffrey J. Seilhamer
发明人： Jay A. Tischfield , Jeffrey J. Seilhamer
IPC分类号： C12N1555
CPC分类号： C12N9/16 , C07K2319/00
摘要： Novel mammalian phospholipase (PLA2) nucleotide sequences and low molecular weight (about 14 KD) amino acid sequences encoded thereby are disclosed. More particularly, a cloned human HPLA2 cDNA expressing HPLA2-10 and its cloned rat RPLA2 cDNA counterpart, expressing RPLA2-10, which are characterized as PLA2 Type IV, are disclosed. A second type of PLA2 cDNA, characterized as PLA2 Type III and exemplified by a rat PLA2 cDNA encoding RPLA2-8 and a partial human PLA2 nucleotide sequence encoding HPLA2-8, is disclosed. Expression of the cDNAs encode the two new types of PLA2 enzymes which have phospholipase activity. The novel PLA2s do not include disulfide bridges between cysteine amino acids 11 and 77 or elapid loops. However, the novel PLA2s may include amino acid COOH-terminal extensions which can vary in length. Seventeen of the eighteen absolutely conserved amino acids in all active 14 KD PLA2s are believed to be conserved in RPLA2-8 and HPLA2-8, whereas all eighteen are believed to be conserved in RPLA2-10 and HPLA2-10. Because the encoded sequences of RPLA2-8 and HPLA2-8 include only 16 cysteine amino acids, they have been designated as Type III. RPLA2-10 and HPLA2-10 are designated as Type IV since their encoded sequences include only 12 cysteine amino acids.
摘要翻译：公开了由此编码的新型哺乳动物磷脂酶（PLA2）核苷酸序列和低分子量（约14KD）氨基酸序列。更具体地，公开了表达为PLA2 IV型的克隆的表达HPLA2-10的人HPLA2 cDNA及其克隆的大鼠RPLA2 cDNA对应物，表达RPLA2-10。公开了第二种类型的PLA2，其特征为PLA2型III，并且由编码RPLA2-8的大鼠PLA2 cDNA和编码HPLA2-8的部分人PLA2核苷酸序列示例。 cDNA的表达编码了具有磷脂酶活性的两种新型PLA2酶。新型PLA2不包括半胱氨酸氨基酸11和77之间的二硫键或elapid环。然而，新颖的PLA2可以包括可以在长度上变化的氨基酸COOH-末端延伸。所有活性14 KD PLA2中十八个绝对保守氨基酸中的17个被认为在RPLA2-8和HPLA2-8中保守，而所有十八个被认为在RPLA2-10和HPLA2-10中保守。由于RPLA2-8和HPLA2-8的编码序列仅包含16个半胱氨酸氨基酸，因此已被指定为III型。 RPLA2-10和HPLA2-10被命名为IV型，因为它们的编码序列仅包括12个半胱氨酸氨基酸。

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