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11. 发明授权

US6060239A Cellubrevin homologs 失效
公开(公告)号：US6060239A
公开(公告)日：2000-05-09
申请号：US621018
申请日：1996-03-22
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C07H21/04 , C12N15/00 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

12. 发明授权

US5633149A Polynucleotide encoding novel chemokine expressed in inflamed adenoid 失效
标题翻译：编码在发炎腺样体中表达的新趋化因子的多核苷酸
公开(公告)号：US5633149A
公开(公告)日：1997-05-27
申请号：US352324
申请日：1994-12-07
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P43/00 , C07K14/52 , C07K14/54 , C07K16/24 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/522 , C12Q1/6883 , A61K38/00 , C12Q2600/158 , Y10S514/885 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

13. 发明授权

US06692920B1 Antibodies to a chemokine expressed in inflamed adenoid 失效
标题翻译：在发炎腺样体中表达的趋化因子的抗体
公开(公告)号：US06692920B1
公开(公告)日：2004-02-17
申请号：US09588044
申请日：2000-06-05
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： A61K39395
CPC分类号： C07K14/522 , A61K38/00 , C12Q1/6883 , C12Q2600/158
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

14. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

15. 发明授权

US5843719A Cellubrevin homolog 失效
标题翻译： Cellubrevin同系物
公开(公告)号：US5843719A
公开(公告)日：1998-12-01
申请号：US897429
申请日：1997-07-21
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12P21/06 , C07H21/04 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (CB). The present invention also provides for antisense molecules to the nucleotide sequences which encode CB, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.
摘要翻译：本发明提供了鉴定和编码新型纤维连翘蛋白（CB）的核苷酸和氨基酸序列。本发明还提供编码CB的核苷酸序列的反义分子，用于产生纯化的CB的表达载体，能够特异性结合CB的抗体，用于检测CB编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主用于表达CB的细胞，基于编码CB的核酸分子和能够特异性结合CB的抗体的活化，发炎或患病细胞和/或组织的诊断测试。

16. 发明授权

US5783669A Hyaluronan receptor expressed in human umbilical vein endothelial 失效
标题翻译：透明质酸受体在人脐静脉内皮中表达
公开(公告)号：US5783669A
公开(公告)日：1998-07-21
申请号：US700178
申请日：1996-08-20
申请人： Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/705
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.
摘要翻译：本发明提供鉴定和编码人脐静脉内皮细胞的透明质酸受体（hr）的核苷酸和氨基酸序列。本发明还提供编码hr的核苷酸序列的反义分子，用于产生纯化的HR的表达载体，能够特异性结合HR的抗体，用于检测HR编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主用于表达HR的细胞，基于编码HR的核酸分子和能够特异性结合受体的抗体的活化的，血管生成的，发炎的或转移性细胞和/或组织的诊断测试。

17. 发明授权

US5587306A Phospholipase C homolog 失效
标题翻译：磷脂酶C同系物
公开(公告)号：US5587306A
公开(公告)日：1996-12-24
申请号：US419078
申请日：1995-04-10
申请人： Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12P21/08 , C12N9/20 , C12N15/70
CPC分类号： C12N9/16 , A61K38/52 , C12Y503/04001
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for the detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.
摘要翻译：本发明提供鉴定和编码新型磷脂酶C同源物（plch和PLCH）的核苷酸和氨基酸序列。本发明还提供了针对ch核苷酸序列的反义分子，用于产生纯化的PLCH的表达载体，能够特异性结合PLCH的抗体，用于检测过量PLCH编码核苷酸序列的杂交探针或寡核苷酸，用于 PLCH的表达，基于编码PLCH的核酸分子和能够特异性结合PLCH的抗体的活化，发炎，患病和羟基脲抗性细胞和/或组织的诊断测试。

18. 发明授权

US07708984B2 Methods of treatment with anitbodies to a chemokine expressed in inflamed adenoid 失效
标题翻译：在发炎腺样体中表达的趋化因子的治疗方法
公开(公告)号：US07708984B2
公开(公告)日：2010-05-04
申请号：US11806846
申请日：2007-06-04
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： A61K38/19
CPC分类号： C07K14/522 , A61K38/00 , C12Q1/6883 , C12Q2600/158 , Y10S514/885 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

19. 发明授权

US5676946A Phospholipase C homolog 失效
标题翻译：磷脂酶C同系物
公开(公告)号：US5676946A
公开(公告)日：1997-10-14
申请号：US726883
申请日：1996-10-04
申请人： Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12P21/08 , C12N9/20 , C12N15/70
CPC分类号： C12N9/16 , A61K38/52 , C12Y503/04001
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.
摘要翻译：本发明提供鉴定和编码新型磷脂酶C同源物（plch和PLCH）的核苷酸和氨基酸序列。本发明还提供了针对ch核苷酸序列的反义分子，用于产生纯化的PLCH的表达载体，能够特异性结合PLCH的抗体，用于检测过量PLCH编码核苷酸序列的杂交探针或寡核苷酸，用于 PLCH的表达，基于编码PLCH的核酸分子和能够特异性结合PLCH的抗体的活化，发炎，患病和羟基脲抗性细胞和/或组织的诊断试验。

20. 发明授权

US06913891B1 Human myeloid terminal differentiation response gene 失效
标题翻译：人骨髓末端分化反应基因
公开(公告)号：US06913891B1
公开(公告)日：2005-07-05
申请号：US09208206
申请日：1998-12-09
申请人： Benjamin Graeme Cocks , Janice Au-Young , Jeffrey J. Seilhamer
发明人： Benjamin Graeme Cocks , Janice Au-Young , Jeffrey J. Seilhamer
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/12 , C12N15/19 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for myd118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 and MYD118 polypeptide. The invention specifically provides for use of the myd118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for myd118. The invention further provides antibodies which specifically bind to MYD118.
摘要翻译：本发明提供编码和鉴定指定为MYD118的新型人骨髓末端分化应答基因的多核苷酸和氨基酸序列。本发明还提供了myd118反义分子。本发明进一步提供用于产生纯化的MYD118多肽的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和MYD118多肽的抑制剂; 以及基于编码MYD118和MYD118多肽的多核苷酸序列的药物组合物和治疗方法。本发明特别提供了myd118多核苷酸序列用作检测骨髓增生性疾病和白血病的诊断组合物。本发明还涉及基于myd118的核苷酸序列的治疗方法和组合物。本发明进一步提供特异性结合MYD118的抗体。

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