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11. 发明授权

US09804089B2 Sensing device for detecting a target substance 有权
公开(公告)号：US09804089B2
公开(公告)日：2017-10-31
申请号：US13201927
申请日：2010-02-08
申请人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N33/543 , G01N21/27
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).

12. 发明申请

US20080112304A1 Spot Alignment For Parrallel Read-Out Of Two-Dimensional Encoded Optical Storage Media 审中-公开
标题翻译：用于二维编码光存储介质的Parrallel读出的点对齐
公开(公告)号：US20080112304A1
公开(公告)日：2008-05-15
申请号：US11568116
申请日：2005-04-14
申请人： Alexander Marc Van Der Lee , Christopher Busch , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Christopher Busch , Dominique Maria Bruls
IPC分类号： G11B7/00 , G11B7/24
CPC分类号： G11B7/0938 , G11B7/14 , G11B7/24085
摘要： The present invention provides a two-dimensional encoded optical storage medium (12) comprising at least one alignment pattern (14) for aligning a spot array (16) intended to read out the optical storage medium (12). Furthermore, the present invention is directed to a method and a device for reading out a two-dimensional encoded optical storage medium (12) having at least one alignment pattern (14) comprising a plurality of bit rows (R1, R2, R3, R4, R5, R6, R7, R8), wherein at least one bit row (R2, R3, R4, R6, R7, R8) of said alignment pattern (14) is empty.
摘要翻译：本发明提供了一种二维编码光学存储介质（12），其包括用于对准用于读出光学存储介质（12）的光点阵列（16）的至少一个对准图案（14）。此外，本发明涉及一种用于读出具有至少一个对齐图案（14）的二维编码光学存储介质（12）的方法和装置，所述对准图案包括多个位行（R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8），其中所述对准图案（14）的至少一个位列（R 2，R 3，R 4，R 6，R 7，R 8）是空的。

13. 发明授权

US08670123B2 Optical biosensor with focusing optics 有权
标题翻译：带聚焦光学的光学生物传感器
公开(公告)号：US08670123B2
公开(公告)日：2014-03-11
申请号：US13379721
申请日：2010-06-21
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
IPC分类号： G01N21/55 , G02B3/00
CPC分类号： G02B3/0068 , G01N21/552 , G01N21/648 , G01N2201/0638 , G02B27/1066 , G02B27/126
摘要： The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.
摘要翻译：本发明涉及用于生物传感器（10）的聚焦光学器件（100），其允许以简单的方式将扩展的检测区域（13）精确地成像到检测器平面（P）上。为此，聚焦光学器件（100）包括彼此相邻布置的至少两个聚焦小透镜（LL），使得它们将沿着主光轴（MOA）定向的入射平行光束（L2）成像到一个共同的平面（P）。由聚焦光学器件（100）接收的输出光束（L2）可以优选地源于透明载体的调查区域（13）处的平行输入光束（L1）的全内反射。

14. 发明授权

US08520211B2 Carrier for optical detection in small sample volumes 有权
标题翻译：小样本量的光学检测载体
公开(公告)号：US08520211B2
公开(公告)日：2013-08-27
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： A carrier and an apparatus for optical detection of a sample in a sample chamber includes en optical structure for refracting an input light beam into the adjacent sample chamber and for collecting an output light beam from light that originates in the sample chamber from the input light beam. The optical structure includes grooves in the surface of the carrier in which the Input light beam is transmitted Over a short distance through a sample. The optical structure can also be used for a wetting detection.
摘要翻译：用于样品室中的样品的光学检测的载体和设备包括用于将输入光束折射到相邻样品室中的光学结构，并且用于从输入光束收集来自样品室的光的输出光束。光学结构包括在载体的表面中的凹槽，其中输入光束在短距离内透射通过样品。光学结构也可用于润湿检测。

15. 发明授权

US08486689B2 Microelectronic sensor device for the detection of target particles 有权
标题翻译：用于检测目标颗粒的微电子传感器装置
公开(公告)号：US08486689B2
公开(公告)日：2013-07-16
申请号：US12747529
申请日：2008-10-31
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
IPC分类号： C12M1/00
CPC分类号： G01N21/1717 , G01N21/552 , G01N21/648 , G01N2021/1721 , G01N2021/1727 , G01N2201/0691
摘要： The invention relates to a microelectronic sensor device for the examination of target particles (1) that are bound to binding sites (3) at the binding surface (12) of a carrier (11). In a preferred embodiment, an input light beam (L1) is transmitted into the carrier (11), where a frustrated total internal reflection (FTIR) takes place at the binding surface (12). The amount of light in a resulting output light beam (L2) is detected by a light detector (31) and provides information about the presence of target particles at the binding surface. Moreover, an actuation unit (50) induces movements of the bound target particles (1) by an interaction with a magnetic field (B) or an electric field, particularly with a given modulation frequency (COIn), such that by a demodulation of the detector signal (S) effects of the target particles can be distinguished from background.
摘要翻译：本发明涉及一种用于检查在载体（11）的结合表面（12）处结合到结合位点（3）的靶颗粒（1）的微电子传感器装置。在优选实施例中，输入光束（L1）被传输到载体（11）中，其中在结合表面（12）处发生挫败的全内反射（FTIR）。通过光检测器（31）检测所得到的输出光束（L2）中的光量，并提供关于在结合表面处存在目标颗粒的信息。此外，致动单元（50）通过与磁场（B）或电场的相互作用（特别是给定的调制频率（COIn））的相互作用来诱导结合的目标颗粒（1）的运动，使得通过解调目标颗粒的检测器信号（S）效应可以与背景区分开。

16. 发明申请

US20120147377A1 OPTICAL BIOSENSOR WITH FOCUSING OPTICS 有权
标题翻译：光学生物传感器与聚焦光学
公开(公告)号：US20120147377A1
公开(公告)日：2012-06-14
申请号：US13379721
申请日：2010-06-21
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
IPC分类号： G01N21/55 , G02B3/00
CPC分类号： G02B3/0068 , G01N21/552 , G01N21/648 , G01N2201/0638 , G02B27/1066 , G02B27/126
摘要： The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.
摘要翻译：本发明涉及用于生物传感器（10）的聚焦光学器件（100），其允许以简单的方式将扩展的检测区域（13）精确地成像到检测器平面（P）上。为此，聚焦光学器件（100）包括彼此相邻布置的至少两个聚焦小透镜（LL），使得它们将沿着主光轴（MOA）定向的入射平行光束（L2）成像到一个共同的平面（P）。由聚焦光学器件（100）接收的输出光束（L2）可以优选地源于透明载体的调查区域（13）处的平行输入光束（L1）的全内反射。

17. 发明申请

US20110026030A1 CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 有权
标题翻译：用于小样品中光学检测的载体
公开(公告)号：US20110026030A1
公开(公告)日：2011-02-03
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (L1) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及一种用于在样品室（2）中的样品（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻的样品室（2）中并用于从源于样品室（2）的光收集输出光束（L2）的光学结构（50）从输入光束。优选地，光学结构（50）包括在载体（11）的表面（12）中的凹槽，其中输入光束通过样品在短距离上传播。光学结构（50）也可用于润湿检测。

18. 发明申请

US20100267165A1 MICROELECTRONIC SENSOR DEVICE FOR THE DETECTION OF TARGET PARTICLES 有权
标题翻译：用于检测目标颗粒的微电子传感器装置
公开(公告)号：US20100267165A1
公开(公告)日：2010-10-21
申请号：US12747529
申请日：2008-10-31
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
IPC分类号： G01N33/53
CPC分类号： G01N21/1717 , G01N21/552 , G01N21/648 , G01N2021/1721 , G01N2021/1727 , G01N2201/0691
摘要： The invention relates to a microelectronic sensor device for the examination of target particles (1) that are bound to binding sites (3) at the binding surface (12) of a carrier (11). In a preferred embodiment, an input light beam (L1) is transmitted into the carrier (11), where a frustrated total internal reflection (FTIR) takes place at the binding surface (12). The amount of light in a resulting output light beam (L2) is detected by a light detector (31) and provides information about the presence of target particles at the binding surface. Moreover, an actuation unit (50) induces movements of the bound target particles (1) by an interaction with a magnetic field (B) or an electric field, particularly with a given modulation frequency (COIn), such that by a demodulation of the detector signal (S) effects of the target particles can be distinguished from background.
摘要翻译：本发明涉及一种用于检查在载体（11）的结合表面（12）处结合到结合位点（3）的靶颗粒（1）的微电子传感器装置。在优选实施例中，输入光束（L1）被传输到载体（11）中，其中在结合表面（12）处发生挫败的全内反射（FTIR）。通过光检测器（31）检测所得到的输出光束（L2）中的光量，并提供关于在结合表面处存在目标颗粒的信息。此外，致动单元（50）通过与磁场（B）或电场的相互作用（特别是给定的调制频率（COIn））的相互作用来诱导结合的目标颗粒（1）的运动，使得通过解调目标颗粒的检测器信号（S）效应可以与背景区分开。

19. 发明申请

US20100165345A1 MICROELECTRONIC SENSOR DEVICE WITH A MODULATED LIGHT SOURCE 有权
标题翻译：具有调制光源的微电子传感器装置
公开(公告)号：US20100165345A1
公开(公告)日：2010-07-01
申请号：US12670148
申请日：2008-07-17
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/59
CPC分类号： G01N21/552 , G01N21/648 , G01N27/745 , G01N2201/064 , G01N2201/0691 , G01N2201/0696
摘要： The invention relates to a microelectronic sensor device and a method for making optical examinations at a carrier (11), e.g. for the detection of magnetic particles (1) at a contact surface (12) of the carrier (11) by frustrated total internal reflection (FTIR). A light source (21), particularly a laser light source, with a laser modulator (22) are used for emitting an input light beam (L1) into the carrier (11) which is modulated such that optical interferences with reflections (L1′) of the input light beam (L1) from the entrance window (14) or other components of the carrier (11) are reduced/minimized. This can for example be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source (21) with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are e.g. induced by thermal extension.
摘要翻译：本发明涉及一种微电子传感器装置和一种用于在载体（11）上进行光学检查的方法。用于通过沮丧的全内反射（FTIR）检测载体（11）的接触表面（12）处的磁性颗粒（1）。使用具有激光调制器（22）的光源（21），特别是具有激光光源的光源（21）将输入光束（L1）发射到被调制的载波（11）中，使得与反射（L1'）的光学干涉（14）的输入光束（L1）或载体（11）的其他部件的距离减小/最小化。这可以例如通过脉冲开/关调制实现，其中当前发射的脉冲（PN）的第一弛豫最小值与光源（21）中的第一弛豫最小值与反射脉冲（PN-1'）的第一弛豫最大值一致，。通过减少干扰的影响，该装置不容易受到尺寸变化的干扰。由热延伸引起。

20. 发明授权

US08228506B2 Microelectronic sensor device with a modulated light source 有权
标题翻译：具有调制光源的微电子传感器装置
公开(公告)号：US08228506B2
公开(公告)日：2012-07-24
申请号：US12670148
申请日：2008-07-17
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01B9/02 , G01N21/00 , G01N21/55
CPC分类号： G01N21/552 , G01N21/648 , G01N27/745 , G01N2201/064 , G01N2201/0691 , G01N2201/0696
摘要： A microelectronic sensor device and a method for making optical examinations at a carrier for the detection of magnetic particles, for example, at a contact surface of the carrier by frustrated total internal reflection (FTIR), include a light source with a laser modulator for emitting an input light beam into the carrier. The input light beam is modulated such that optical interferences with reflections of the input light beam from the entrance window, or from other components of the carrier, are reduced or minimized. This can be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are induced by thermal extension, for example.
摘要翻译：微电子传感器装置和用于在载体处用于检测磁性颗粒的光学检查的方法，例如通过沮丧的全内反射（FTIR）在载体的接触表面处，包括具有用于发射的激光调制器的光源输入光束进入载体。输入光束被调制成使得来自入口窗口的输入光束或者来自载体的其它部件的反射的光学干涉被减小或最小化。这可以通过脉冲开/关调制来实现，其中当前发射的脉冲（PN）的第一弛豫最小值在光源中与反射脉冲（PN-1'）的第一弛豫最大值重合。通过减少干扰的影响，例如，该设置不容易受到由热延伸引起的尺寸变化的干扰。

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