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11. 发明申请

US20080183273A1 Stented heart valve devices and methods for atrioventricular valve replacement 有权
标题翻译：心脏瓣膜瓣膜置换装置及房室瓣置换方法
公开(公告)号：US20080183273A1
公开(公告)日：2008-07-31
申请号：US12009323
申请日：2008-01-17
申请人： Thierry Mesana , Timothy G. Laske , Allen Tower , Alexander J. Hill , Timothy R. Ryan
发明人： Thierry Mesana , Timothy G. Laske , Allen Tower , Alexander J. Hill , Timothy R. Ryan
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/82 , A61F2/852 , A61F2/958 , A61F2002/065 , A61F2002/8486 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/005 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0037 , A61F2250/0039 , A61F2250/0064 , A61F2250/0069
摘要： A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.
摘要翻译：一种用于植入体腔（例如二尖瓣）的可压缩和可扩展的支架组件，所述支架组件包括至少一个成形和尺寸使其允许相邻心脏结构的正常操作的支架筒。一个或多个支架套筒可以包括在支架组件中，其中一个或多个支架套筒可以包括具有锥形边缘的圆柱体。

12. 发明授权

US09610423B2 Sleeve valve catheters 有权
公开(公告)号：US09610423B2
公开(公告)日：2017-04-04
申请号：US13486523
申请日：2012-06-01
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
IPC分类号： A61M1/00 , A61M25/00
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body.

13. 发明授权

US09352121B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09352121B2
公开(公告)日：2016-05-31
申请号：US13409646
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

14. 发明授权

US09345528B2 Large area cryoablation catheter with multi-geometry tip ECG/CRYO mapping capabilities 有权
标题翻译：大面积冷冻消融导管具有多重几何尖端ECG / CRYO映射功能
公开(公告)号：US09345528B2
公开(公告)日：2016-05-24
申请号：US13360379
申请日：2012-01-27
申请人： Timothy G. Laske , Claudia Lueckge , Réal Ste-Marie
发明人： Timothy G. Laske , Claudia Lueckge , Réal Ste-Marie
IPC分类号： A61B18/04 , A61B18/02 , A61B18/14 , A61B17/32 , A61B18/18 , A61B18/00
CPC分类号： A61B18/02 , A61B17/320068 , A61B18/1492 , A61B18/1815 , A61B2018/00101 , A61B2018/00196 , A61B2018/00357 , A61B2018/00577 , A61B2018/00613 , A61B2018/0212 , A61B2018/0262 , A61B2018/1407 , A61B2090/0463 , F04C2270/041
摘要： A medical device including an ablation element. A thermally insulative sheath is included disposed within the ablation element. A fluid injection tube is disposed within a portion of the thermally insulative sheath. The ablation element passively transitions from a substantially linear geometric configuration to a substantially circular geometric configuration as the sheath is retracted proximally from a first position in which the sheath substantially encloses the fluid injection tube to a second position in which a portion of the fluid injection tube extends a distance away from the sheath.
摘要翻译：包括消融元件的医疗装置。包括设置在消融元件内的绝热护套。流体注入管设置在绝热护套的一部分内。当护套从第一位置向近侧缩回时，消融元件从基本线性的几何构型被无源地过渡到基本上圆形的几何构型，其中鞘基本上包围流体注入管到第二位置，在第二位置，一部分流体注入管距离护套延伸一段距离。

15. 发明申请

US20120238964A1 SLEEVE VALVE CATHETERS 审中-公开
标题翻译：套管阀
公开(公告)号：US20120238964A1
公开(公告)日：2012-09-20
申请号：US13486611
申请日：2012-06-01
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
IPC分类号： A61M25/14
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body.
摘要翻译：导管主体包括出口，在该出口处形成压力响应套筒，其允许材料在给定压力下离开导管体的内腔。在一个实施例中，套筒的表面与导管主体的表面大致齐平。

16. 发明授权

US07187982B2 Medical electrical lead anchoring 有权
标题翻译：医用电气导线锚定
公开(公告)号：US07187982B2
公开(公告)日：2007-03-06
申请号：US10637160
申请日：2003-08-08
申请人： Kevin R. Seifert , Timothy G. Laske
发明人： Kevin R. Seifert , Timothy G. Laske
IPC分类号： A61N1/00
CPC分类号： A61N1/0587 , A61N1/059 , A61N2001/0578
摘要： A non-rigid tether extends distally from an electrode of a medical electrical lead body coupling a tissue anchor to the lead body. The tissue anchor includes a surface to receive a push force from an insertion tool adapted to insert the anchor within a segment of tissue so that the electrode is held in close proximity to the tissue.
摘要翻译：非刚性系绳从连接组织锚固体到引线体的医用电引线体的电极向远侧延伸。组织锚固件包括接收来自插入工具的推动力的表面，所述插入工具适于将锚固件插入组织段内，使得电极保持紧靠组织。

17. 发明授权

US06939338B2 Methods and apparatus for imparting curves in elongated medical catheters 失效
标题翻译：在细长的医用导管中赋予曲线的方法和装置
公开(公告)号：US06939338B2
公开(公告)日：2005-09-06
申请号：US10125365
申请日：2002-04-19
申请人： Steven L. Waldhauser , Timothy G. Laske , James F. Kelley , Kenneth C. Gardeski , Gregory P. Shipe
发明人： Steven L. Waldhauser , Timothy G. Laske , James F. Kelley , Kenneth C. Gardeski , Gregory P. Shipe
IPC分类号： A61B1/005 , A61M25/00 , A61M25/01 , A61M25/092
CPC分类号： A61M25/0158 , A61B1/0058 , A61M25/0041 , A61M25/0054 , A61M2025/0064
摘要： Curves and dynamic shapes are imparted in distal segments of medical instruments e.g., catheters, through use of a temperature-activated actuator coupled to distal segment of the instrument body. The actuator comprises includes members extending side-by-side in substantially a common plane and configured to move in opposite directions when independently activated. A first heating device is coupled to a first actuator member and configured to deliver thermal energy to the first actuator member to activate the first actuator member and cause the first actuator member to move the distal segment in a first direction. A second heating device is coupled to a second actuator member and configured to deliver thermal energy to the second actuator member to activate the second actuator member and cause the second actuator member to move the distal segment in a second direction opposed to the first direction.
摘要翻译：曲线和动态形状通过使用耦合到仪器主体的远端部分的温度激活的致动器，在医疗器械的远端部分（例如导管）中被施加。致动器包括在基本上共同的平面中并排延伸的构件，并且构造成当独立地启动时沿相反的方向移动。第一加热装置联接到第一致动器构件并且构造成将热能传递到第一致动器构件以启动第一致动器构件并使第一致动器构件沿第一方向移动远侧段。第二加热装置联接到第二致动器构件并且被配置为将热能传递到第二致动器构件以致动第二致动器构件并使第二致动器构件沿与第一方向相反的第二方向移动远侧段。

18. 发明授权

US06801809B2 Extractable implantable medical lead 有权
标题翻译：可提取植入式医用铅
公开(公告)号：US06801809B2
公开(公告)日：2004-10-05
申请号：US09854999
申请日：2001-05-14
申请人： Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
发明人： Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N2001/0578
摘要： A medical electrical lead with a tip-ring assembly optimized to resist damage during extraction. The lead includes an elongated plastic tube and at least two elongated conductors mounted in the plastic tube. A tip-ring assembly is mounted to the distal end of the tube, the tip-ring assembly including a ring electrode coupled to one of the conductors, a tip electrode located distal to the ring electrode and coupled to another of the conductors and two molded plastic components separately fabricated of a plastic harder than the plastic tube, adhered to one another and together defining a circumferential groove in which the ring electrode is located and mechanically coupled to the tip electrode. The tip electrode may be provided with a proximally extending electrode shank covered by a tine sleeve which is fabricated of a plastic softer than the molded plastic components and is adhered to more distally located molded plastic component. The more distally located molded plastic component preferably overlaps the electrode shank to provide a stronger structure.
摘要翻译：具有尖端环组件的医疗电气引线，优化以防止在提取期间的损坏。引线包括细长塑料管和安装在塑料管中的至少两根细长导体。尖端环组件安装到管的远端，尖端环组件包括耦合到一个导体的环形电极，位于环形电极远侧并连接到另一个导体的尖端电极，以及两个模制分别由比塑料管更硬的塑料制成的塑料部件彼此粘合在一起并且一起形成环形电极所在的并且机械地联接到尖端电极的周向槽。尖端电极可以设置有由齿形套筒覆盖的近端延伸的电极柄，其由比模制的塑料部件更软的塑料制成并且被粘附到更远端定位的模制塑料部件上。更远端定位的模制塑料部件优选地与电极柄重叠以提供更强的结构。

19. 发明授权

US06256542B1 Extractable implantable medical lead 有权
公开(公告)号：US06256542B1
公开(公告)日：2001-07-03
申请号：US09507960
申请日：2000-02-22
申请人： Mark T. Marshall , Bret R. Shoberg , Clare E. Padgett , Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
发明人： Mark T. Marshall , Bret R. Shoberg , Clare E. Padgett , Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N1/056
摘要： A medical electrical lead with a tip-ring assembly optimized to resist damage during extraction. The lead includes an elongated plastic tube and at least two elongated conductors mounted in the plastic tube. A tip-ring assembly is mounted to the distal end of the tube, the tip-ring assembly including a ring electrode coupled to one of the conductors, a tip electrode located distal to the ring electrode and coupled to another of the conductors and two molded plastic components separately fabricated of a plastic harder than the plastic tube, adhered to one another and together defining a circumferential groove in which the ring electrode is located and mechanically coupled to the tip electrode. The tip electrode may be provided with a proximally extending electrode shank covered by a tine sleeve which is fabricated of a plastic softer than the molded plastic components and is adhered to more distally located molded plastic component. The more distally located molded plastic component preferably overlaps the electrode shank to provide a stronger structure.

20. 发明授权

US06185464B2 Arrangement for planting an endocardial cardiac lead 失效
标题翻译：种植心内膜心脏铅的安排
公开(公告)号：US06185464B2
公开(公告)日：2001-02-06
申请号：US09262387
申请日：1999-03-04
申请人： Matthew D. Bonner , Timothy G. Laske
发明人： Matthew D. Bonner , Timothy G. Laske
IPC分类号： A61N100
CPC分类号： A61N1/056 , A61M25/0043 , A61M25/01 , A61N2001/0578
摘要： An arrangement for introducing and implanting the electrode(s) of an endocardial implantable cardiac lead at a cardiac implantation site within a heart chamber or vessel. An elongated guide body formed of flexible material and extending between a guide body proximal end and a guide body distal end is advanced transvenously to position the guide body distal end in relation to the cardiac implantation site. A guide body tracking mechanism is coupled with the lead distal end for receiving and slidingly engaging the guide body to allow the cardiac lead to be advanced along the guide body until the electrode is positioned at the cardiac implantation site. A pusher mechanism formed of an elongated pusher body of flexible material extends between a pusher body proximal end and a pusher body distal end and has a cardiac lead engaging mechanism for engaging the cardiac lead at or adjacent the distal lead end. The pusher body has sufficient column strength to be advanced alongside the guide body and lead body with the cardiac lead engaging mechanism engaging and slidingly advancing the guide body tracking mechanism and the cardiac lead distally along the guide body to thereby allow the cardiac lead to be advanced along the guide body until the electrode is positioned at the cardiac implantation site. The lead body is released from the lead engaging mechanism and fixed, if the lead includes a fixation mechanism. The pusher mechanism is retracted by retraction of the pusher body.
摘要翻译：用于在心室或血管内的心脏植入部位处引入和植入心内可植入心脏引线的电极的装置。由柔性材料形成并在引导体近端和引导体远端之间延伸的细长引导体相对于心脏植入部位传递推进以引导体远端。引导体跟踪机构与引线远端联接，用于接收和滑动地接合引导体，以允许心脏引线沿引导体前进，直到电极定位在心脏植入部位。由细长的柔性材料推动器构成的推动机构在推动体本体近端和推动体本体远端之间延伸，并且具有心脏引线接合机构，用于在远侧引线端处或与其相邻的心脏引线接合。推动器主体具有足够的柱强度，使引导体和引线体沿着引导体接合并使引导体跟踪机构和心引导体沿引导体向远侧滑动地前进，从而允许心导线前进沿着引导体直到电极位于心脏植入部位。如果引线包括固定机构，则引线体从引线接合机构释放并固定。推动器机构通过推动器主体的缩回缩回。

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