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11. 发明授权

US4692148A Intra-aortic balloon pump apparatus and method of using same 失效
标题翻译：主动脉内球囊泵装置及其使用方法
公开(公告)号：US4692148A
公开(公告)日：1987-09-08
申请号：US845557
申请日：1986-03-28
申请人： Adrian Kantrowitz , Paul S. Freed , Hiroyuki Tachi , Akira Suzuki
发明人： Adrian Kantrowitz , Paul S. Freed , Hiroyuki Tachi , Akira Suzuki
IPC分类号： A61B5/0408 , A61B5/0215 , A61B5/042 , A61B5/0472 , A61B5/0478 , A61B5/0492 , A61M1/10 , A61M25/00 , A61M29/00
CPC分类号： A61B5/6853 , A61B5/0215 , A61B5/042 , A61M1/1072
摘要： An apparatus and method for placing an aortic balloon catheter is provided wherein a pair of spaced electrodes on the distal end of the catheter assembly are disposed inside a thoracic aorta near a patient's heart and are used to sense R-waves and P-waves in an ECG signal. The electrodes are moved to an ideal intra-aortic position where the R-waves and P-waves are sensed to have the same magnitude. The P-wave, occurring earlier than the R-wave, serves to accurately predict theoccurrence of the R-wave. The balloon of the catheter is deflated upon sensing the R-wave.
摘要翻译：提供一种用于放置主动脉球囊导管的装置和方法，其中在导管组件的远端上的一对间隔开的电极设置在患者心脏附近的胸主动脉内部，并且用于在一个心电信号。将电极移动到理想的主动脉内部位置，其中R波和P波被感测为具有相同的量值。发生在R波之前的P波用于准确预测R波的发生。在感测R波时导管的气囊放气。

12. 发明授权

US4051840A Dynamic aortic patch 失效
标题翻译：动态游乐设备
公开(公告)号：US4051840A
公开(公告)日：1977-10-04
申请号：US645735
申请日：1976-01-05
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/10 , A61M1/03 , A61F1/24
CPC分类号： A61M1/1072
摘要： An improved dynamic aortic patch is surgically implanted in the thoracic aorta and is systematically inflated and deflated to generate pressure waves in the bloodstream. The pressure waves assist the heart by augmenting the circulation of the blood through the body. The patch includes a flexible inflatable bladder and an independent envelope. The envelope has a reinforced surface for limiting and directing inflation of the bladder inwardly toward the lumen of the aorta.

13. 发明授权

US6132363A Cardiovascular support control system 有权
公开(公告)号：US6132363A
公开(公告)日：2000-10-17
申请号：US164513
申请日：1998-09-30
申请人： Paul S. Freed , Michael Psakhis , Paul G. DeDecker , Adrian Kantrowitz
发明人： Paul S. Freed , Michael Psakhis , Paul G. DeDecker , Adrian Kantrowitz
IPC分类号： A61M1/12 , A61M1/00 , A61M1/10 , A61M5/00
CPC分类号： A61M39/0247 , A61M1/1072 , A61M1/122 , A61M1/125 , A61M1/106 , A61M2205/52 , A61M2230/04 , A61M2230/30
摘要： An apparatus for assisting cardiac function of a patient includes an inflatable chamber operably positionable with respect to an aorta of the patient, a percutaneous access device implantable with respect to a hypogastric region of the patient and connectible in fluid communication with the inflatable chamber, and a drive unit connectible through the percutaneous access device for selectively inflating and deflating the inflatable chamber in accordance with a control program stored in memory. The control program controls the drive unit in response to a periodically scheduled patient monitoring routine for measuring values of the physiology of the patient. The control program uses measured values as modified in accordance with the control program and physician programmable parameters for assisting cardiac function of the patient. The program includes the steps of automatically controlling the drive unit in response to a periodically scheduled patient monitoring routine for measuring values of physiology of the patient, and using measured values as modified in accordance with physician programmable parameters for assisting cardiac function of the patient. A software program is connectible in electronic communication with the control program for adjusting settings of the drive unit. The software program is capable of one or more of the following functions: retrieving current values of physician programmable parameters, selectively retrieving a history of the drive unit operation including error detection records, displaying a continuous ECG, and/or displaying a single-beat sample of aortic pressure waveform obtained in real time from the patient.

14. 发明授权

US6048353A Trephine device for locating and cutting a cylindrical or reverse tapered aperture in flexible material 失效
标题翻译： Trephine装置用于定位和切割柔性材料中的圆柱形或反向锥形孔
公开(公告)号：US6048353A
公开(公告)日：2000-04-11
申请号：US262192
申请日：1999-03-04
申请人： Paul S. Freed , Adrian Kantrowitz , Seymour Mermelstein
发明人： Paul S. Freed , Adrian Kantrowitz , Seymour Mermelstein
IPC分类号： A61B17/16 , A61B17/32 , A61F5/445 , A61B17/14
CPC分类号： A61B17/32053 , A61B17/1695 , A61F5/445
摘要： A trephine device for preparing apertures through a flexible material, such as skin of a patient, including a base plate having an upper surface and an opposed lower surface, where the upper surface has at least one upwardly protruding skin deforming contoured surface. The base plate is adapted to be removably inserted into a pocket surgically prepared in tissue of the patient. The device can include a handle member mounted on and projecting upwardly from the upper surface of the base plate. A clamping member is connected to the trephine device in overlying relationship to the upper surface of the base plate. The clamping member facilitates deformable, clamping, sandwiched engagement of the flexible material between the upper surface of the base plate and the clamping member. When the base plate is inserted into the pocket surgically prepared in the tissue of the patient, the skin of the patient is engageable between the base plate and the clamping member. The trephine device includes a cutter positionable relative to the handle member. The cutter is movable relative to the clamping member into cutting engagement with the flexible material deformably engaged by the clamping member to form an aperture having a cylindrical wall or a reverse tapered wall in the flexible material.
摘要翻译：用于通过诸如患者皮肤的柔性材料制备孔的环钻设备，包括具有上表面和相对的下表面的基板，其中上表面具有至少一个向上突出的皮肤变形的轮廓表面。基板适于可拆卸地插入到手术组织制备在患者组织中的口袋中。该装置可以包括安装在基板的上表面上并从基板的上表面向上突出的把手件。夹紧构件以与基板的上表面重叠的关系连接到环钻装置。夹紧构件促进柔性材料在基板的上表面和夹紧构件之间的可变形，夹紧，夹紧接合。当基板插入到手术组织在患者组织中的口袋中时，患者的皮肤可接合在基板和夹紧构件之间。环钻设备包括可相对于手柄构件定位的刀具。切割器相对于夹紧构件可移动，与由可夹紧构件可变形地接合的柔性材料切割接合以形成在柔性材料中具有圆柱形壁或倒锥形壁的孔。

15. 发明授权

US5833619A External blood pressure sensor apparatus and method 失效
标题翻译：外部血压传感器装置及方法
公开(公告)号：US5833619A
公开(公告)日：1998-11-10
申请号：US856904
申请日：1997-05-15
申请人： Paul S. Freed , Adrian Kantrowitz
发明人： Paul S. Freed , Adrian Kantrowitz
IPC分类号： A61B5/0215 , A61B5/0456 , A61M1/10 , A61M1/12 , A61B5/00
CPC分类号： A61M1/1072 , A61B5/0215 , A61B5/0456
摘要： An apparatus and method for measuring the blood pressure of a patient with a permanent or temporary cardiac assist device throughout an entire cardiac cycle by partially filling the inflatable chamber of the cardiac assist device operatively disposed with respect to an aorta with pressurized fluid and using the partially filled chamber as a transducer. An external pressure sensor is located in a drive unit connected to the inflatable chamber. The drive unit controls, monitors and stores the fluid pressure with respect to the inflatable chamber. When isolated from a pressurized fluid reservoir, the pressure within the inflatable chamber corresponds to the current blood pressure of the patient throughout the cardiac cycle. The inflatable chamber preferably is defined at least in part by a flexible membrane. The inflatable chamber is partially inflated with a predetermined volume of pressurized fluid from the reservoir. The partially inflated chamber is then isolated from the reservoir for at least one complete cardiac cycle, and preferably two complete cardiac cycles. The blood pressure wave form of the patient is continuously monitored and stored by measuring the pressure variations in the isolated, partially filled, chamber. A control program evaluates the stored pressure data and updates a patient parameter table with current heart function parameters for subsequent use during the next series of diastolic augmentation, inflation/deflation cycles of the inflatable chamber.
摘要翻译：一种用于通过部分地填充相对于主动脉与加压流体可操作地设置的心脏辅助装置的可充气室来测量具有永久或临时心脏辅助装置的患者在整个心动周期中的血压的装置和方法，填充室作为传感器。外部压力传感器位于连接到可充气室的驱动单元中。驱动单元控制，监视和存储相对于可充气室的流体压力。当从加压流体储存器隔离时，可充气室内的压力对应于整个心脏周期中患者的当前血压。充气室优选至少部分地由柔性膜限定。充气室部分地从储存器中预定体积的加压流体充气。然后将部分充气的腔室与储器隔离至少一个完整的心动周期，优选两个完整心脏周期。通过测量隔离的，部分填充的腔室中的压力变化来连续监测和存储患者的血压波形。控制程序评估所存储的压力数据，并用当前的心脏功能参数来更新患者参数表，以便在下一系列舒张增压，充气室的充气/放气循环期间随后使用。

16. 发明授权

US4809681A Electrocardiographic measurement method for controlling an intra-aortic balloon pump 失效
标题翻译：用于控制主动脉内球囊泵的心电图测量方法
公开(公告)号：US4809681A
公开(公告)日：1989-03-07
申请号：US31137
申请日：1987-03-30
申请人： Adrian Kantrowitz , Paul S. Freed , Hiroyuki Tachi , Akira Suzuki
发明人： Adrian Kantrowitz , Paul S. Freed , Hiroyuki Tachi , Akira Suzuki
IPC分类号： A61B5/0215 , A61B5/042 , A61M1/10 , A61M29/02 , A61M1/00
CPC分类号： A61B5/6853 , A61B5/0215 , A61B5/042 , A61M1/1072 , A61M29/02
摘要： A pair of spaced electrodes are disposed inside the thoracic aorta near the heart and are used to sense R- and P-waves in an ECG signal. The electrodes are moved to an ideal intra-aortic position, which is that where R- and P-waves are sensed to have the same magnitude, the P-wave, which occurs earlier than the R-wave, serving as means for accurately predicting the occurrence of the R-wave. The electrodes are affixed to the distal end of an intra-aortic balloon, which is capable of being disposed at the ideal position by monitoring of the R- and P-waves sensed by the electrodes. The balloon is deflated at the occurrence of the R-wave, which has been correctly predicted by the earlier P-wave.
摘要翻译：一对间隔的电极设置在靠近心脏的胸主动脉内部，并用于感测ECG信号中的R波和P波。将电极移动到理想的主动脉内部位置，这是R和P波被感测到具有相同幅度的位置，P波早于R波发生，作为准确预测的手段发生R波。电极固定在主动脉内球囊的远端，该主动脉球囊能够通过监测由电极感测到的R-波和P波来放置在理想位置。在R波发生时气球被放气，这已经被较早的P波正确预测。

17. 发明授权

US4733652A Intra-aortic balloon 失效
标题翻译：主动脉内气囊
公开(公告)号：US4733652A
公开(公告)日：1988-03-29
申请号：US73843
申请日：1987-07-15
申请人： Adrian Kantrowitz , Paul S. Freed , Avi Bar-Lev , Sadahiko Mushika , Akira Suzuki
发明人： Adrian Kantrowitz , Paul S. Freed , Avi Bar-Lev , Sadahiko Mushika , Akira Suzuki
IPC分类号： A61M1/10 , A61B19/00
CPC分类号： A61M1/1072
摘要： An intra-aortic balloon pump apparatus includes a first catheter one end of which is secured to a connector having a gas supply port, a balloon one end of which is secured to the distal end of the first catheter, a central tubular member the distal end of which projects from the distal end of the first catheter and to which the distal end of the balloon is fixedly secured, a second catheter freely insertable into the central tubular member and having a distal end provided with an arterial pressure transduceer, and a second connector to which the other end of the second catheter is secured for feeding a signal from the pressure transducer to the outside of the apparatus. After the balloon, central tubular member and first catheter are placed into the aorta, the second catheter having the pressure transducer at its distal end is inserted through the interior of the central tubular member into the aorta.
摘要翻译：主动脉内球囊泵装置包括第一导管，其一端固定到具有气体供给口的连接器，其一端固定到第一导管的远端，中心管状构件的远端其中第一导管从第一导管的远端突出并且气囊的远端固定地固定到其上，第二导管可自由地插入中心管状构件中，并且具有设置有动脉压力变送器的远端，以及第二连接器固定第二导管的另一端用于将来自压力传感器的信号输送到装置的外部。在气囊之后，将中央管状构件和第一导管置于主动脉中，将具有其远端处的压力换能器的第二导管穿过中心管状构件的内部插入主动脉。

18. 发明授权

US06735532B2 Cardiovascular support control system 有权
标题翻译：心血管支持控制系统
公开(公告)号：US06735532B2
公开(公告)日：2004-05-11
申请号：US10298502
申请日：2002-11-18
申请人： Paul S. Freed , Michael Psakhis , Paul G. DeDecker
发明人： Paul S. Freed , Michael Psakhis , Paul G. DeDecker
IPC分类号： G01L700
CPC分类号： A61M1/1072 , A61M1/1037 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/125
摘要： An apparatus and method for assisting cardiac function of a patient includes a flaccid inflatable chamber held at a predetermined volume generally midway between fully inflated and fully deflated for performing a periodically scheduled patient monitoring routine for measuring values of the physiology of the patient, and reinflating the chamber after either detecting a dicrotic notch or expiration of a measurement time period window, whichever occurs first. A software program is connectible in electronic communication with the control program for adjusting settings of the drive unit. The software program is capable of one or more of the following functions: retrieving current values of physician programmable parameters, selectively retrieving a history of the drive unit operation including error detection records, displaying a continuous ECG, and/or displaying a single-beat sample of aortic pressure waveform obtained in real time from the patient.
摘要翻译：用于辅助患者的心脏功能的装置和方法包括一个松弛充气室，其保持在一个预定的体积，通常在完全膨胀和完全放气之间的中间，以执行周期性地安排的患者监测程序，用于测量患者的生理学值，在检测到重新开口或测量时间段窗口到期后，以先到者为准。软件程序可与用于调整驱动单元的设置的控制程序进行电子通信。该软件程序能够具有以下功能中的一个或多个：检索医师可编程参数的当前值，选择性地检索包括错误检测记录，显示连续ECG的驱动单元操作的历史和/或显示单拍样本的主动脉压力波形从患者实时获得。

19. 发明授权

US08721515B2 Rigid body aortic blood pump implant 有权
标题翻译：刚体主动脉血泵植入物
公开(公告)号：US08721515B2
公开(公告)日：2014-05-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed , Jean Kantrowitz
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

20. 发明申请

US20100111715A1 AIR SUPPLY MECHANISM FOR VENTRICULAR ASSIST SYSTEM 有权
标题翻译：空气辅助系统的空气供应机构
公开(公告)号：US20100111715A1
公开(公告)日：2010-05-06
申请号：US12310257
申请日：2007-08-17
申请人： Paul G. DeDecker , Paul S. Freed
发明人： Paul G. DeDecker , Paul S. Freed
IPC分类号： F04B23/04
CPC分类号： F04B45/043 , F04B27/053 , F04B27/0536 , F04B27/0538 , F04B45/04 , F04B45/047
摘要： A pump system has a rotatory shaft and a rotatory drive arrangement coupled to the rotatory shaft for applying rotatory energy thereto. First through fourth pump arrangements are coupled to the rotatory shaft, each pump arrangement pumping a pulse of air during each rotation of the rotatory shaft, the first, second, third, and fourth pump arrangements pumping a corresponding pulse of air sequentially during each rotation of the rotatory shaft. The rotatory shaft has a first and second ends, and a central region therebetween where an electric motor is coaxially arranged. The first and third pump arrangements are coupled to the first end of the rotatory shaft, and the second and fourth pump arrangements are coupled to the second end of the rotatory shaft. Angularly displaced eccentric couplers couple the pump arrangements to the respective ends of the rotatory shaft.
摘要翻译：泵系统具有旋转轴和连接到旋转轴的旋转驱动装置，用于向其提供旋转能量。第一至第四泵装置联接到旋转轴，每个泵装置在旋转轴的每次旋转期间泵送空气脉冲，第一，第二，第三和第四泵装置在每次旋转期间顺序地泵送对应的空气脉冲旋转轴。旋转轴具有第一和第二端，以及其间电机同轴布置的中间区域。第一和第三泵装置联接到旋转轴的第一端，并且第二和第四泵装置联接到旋转轴的第二端。倾斜偏心联轴器将泵装置连接到旋转轴的相应端部。

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