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11. 发明授权

US06381496B1 Parameter context switching for an implanted device 有权
标题翻译：植入设备的参数上下文切换
公开(公告)号：US06381496B1
公开(公告)日：2002-04-30
申请号：US09668925
申请日：2000-09-25
申请人： Paul M. Meadows , Carla M. Mann
发明人： Paul M. Meadows , Carla M. Mann
IPC分类号： A61N108
CPC分类号： A61N1/08
摘要： An implant device provides context switching, meaning the ability to change one set of operational parameters for another. The implant device is controlled by a set of operational parameters. The patient may swap the current set of operational parameters with another set of operational parameters. Further, the implant device may include a time-of-day clock, and/or a sensor, and is configured to automatically change its operational parameters from one set of operational parameters to another at certain times of the day, week, or month, or upon the occurrence of certain prescribed events. In one embodiment, the patient may define selected operational parameters within a new set of operational parameters for use with the implant device, providing such patient-defined parameters remain within set limits. The ability to change the current operational parameter set (OPS) is achieved, in a first embodiment, by including memory circuitry within the implant device wherein a plurality of OPS's are stored. Upon receipt of an appropriate command, manually provided by the patient user through a hand-help programmer, or automatically generated by time-of-day or sensor circuits within the implant device, the current OPS is exchanged by another OPS. In a second embodiment, a plurality of OPS's are externally stored, e.g., in a hand-held programming device, and only the currently-used OPS is stored in the implant device. Changes to the OPS are made by transmitting the replacement OPS to the implant device through a telemetry link established with the implant device from the hand-held programming device. When the patient wishes to change the OPS, he manually activates the appropriate controls on the hand-held programming device, and such activation causes the new OPS to be telemetered to the implant device, where it replaces the current OPS.
摘要翻译：植入装置提供上下文切换，意味着改变另一组操作参数的能力。植入装置由一组操作参数控制。患者可以用另一组操作参数来交换当前的一组操作参数。此外，植入装置可以包括日时钟和/或传感器，并且被配置为在白天，周或月的某些时间自动地将其操作参数从一组操作参数改变到另一组，或发生某些规定事件时。在一个实施例中，患者可以在新的一组操作参数内定义所选择的操作参数，以便与植入装置一起使用，从而提供这样的患者定义的参数保持在设定的限度内。在第一实施例中，通过在存储多个OPS的植入装置内包括存储器电路来实现改变当前操作参数集（OPS）的能力。当接收到由患者用户通过手助程序员手动提供或由植入装置内的时间或传感器电路自动产生的适当命令时，当前OPS由另一OPS交换。在第二实施例中，多个OPS被外部存储在例如手持编程设备中，并且只有当前使用的OPS被存储在植入装置中。通过从手持编程设备通过植入装置建立的遥测链路将替换OPS发送到植入装置来进行对OPS的改变。当患者希望改变OPS时，他手动激活手持编程设备上的适当控制，并且这种激活使得新的OPS被遥测到植入装置，其中它替代当前的OPS。

12. 发明授权

US08600518B2 Electrodes for stimulation leads and methods of manufacture and use 失效
标题翻译：刺激电极用电极及制造及使用方法
公开(公告)号：US08600518B2
公开(公告)日：2013-12-03
申请号：US12427935
申请日：2009-04-22
申请人： Paul M. Meadows , Randall Lee Brase
发明人： Paul M. Meadows , Randall Lee Brase
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/3605 , A61N1/37223 , H01R43/00
摘要： An electrode has a unitary ring with an exterior surface, an interior surface, and at least two edges. The electrode also includes a seat formed in at least the exterior surface of the unitary ring. The seat is configured and arranged for attachment of a terminal end of a lead wire, disposed in the seat, to the electrode. A lead includes a lead body; a plurality of electrodes disposed at the distal end of the lead body; and a plurality of lead wires. Each electrode includes a unitary ring and a seat in the unitary ring. The unitary ring has an exterior surface and an interior surface and defines a hollow center region. The seat is formed as a depression of a portion of the unitary ring. Each of the lead wires extends along the lead body and is attached to a corresponding electrode at the seat of the corresponding electrode.
摘要翻译：电极具有整体环，其具有外表面，内表面和至少两个边缘。电极还包括形成在整体环的至少外表面中的座。座椅被构造和布置成用于将设置在座椅中的引线的终端连接到电极。铅包括铅体; 设置在所述引线体的前端的多个电极; 和多根引线。每个电极包括单一环和单一环中的座。整体环具有外表面和内表面并且限定中空中心区域。座椅形成为整体环的一部分的凹陷。每个引线沿着引线主体延伸并且附接到相应电极的座处的对应的电极。

13. 发明申请

US20120130448A1 SYSTEM AND METHOD FOR DISPLAYING STIMULATION FIELD GENERATED BY ELECTRODE ARRAY 有权
标题翻译：用于显示由电极阵列产生的刺激场的系统和方法
公开(公告)号：US20120130448A1
公开(公告)日：2012-05-24
申请号：US13361669
申请日：2012-01-30
申请人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/34
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

14. 发明申请

US20100280572A1 OPEN LOOP DEEP BRAIN STIMULATION SYSTEM FOR THE TREATMENT OF PARKINSON'S DISEASE OR OTHER DISORDERS 审中-公开
标题翻译：用于治疗帕金森病或其他疾病的开环循环脑刺激系统
公开(公告)号：US20100280572A1
公开(公告)日：2010-11-04
申请号：US12839046
申请日：2010-07-19
申请人： Paul M. Meadows , Carla Mann Woods
发明人： Paul M. Meadows , Carla Mann Woods
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/0534 , A61N1/0539
摘要： A deep brain stimulation (DBS) system (10) provides a multiplicity of stimulation channels through which electrical stimuli may be delivered deep within the brain of a patient. The DBS system is powered by a rechargeable battery (27) . In one embodiment, the system has four channels driving sixteen electrodes (32). The DBS system is easily programmed for use by a clinician using a clinician programming system (60), and further affords a simple but highly advanced hand held programmer (50) control interface through which the patient may easily change stimulation parameters within acceptable limits. The DBS system (10) includes a small, implantable pulse generator (20) that is small enough to be implanted directly in the cranium of the patient, thereby eliminating the long lead wires and tunneling procedures that have been used in the past. The implantable pulse generator provides electrical stimuli in an open-loop fashion as defined by the stimulation parameters. Further, the DBS system allows up to two electrode arrays (30, 30′) to be attached to the implantable pulse generator (20), thereby eliminating the requirement for implanting two independent implantable pulse generators for bilateral stimulation of deep brain structures.
摘要翻译：深部脑刺激（DBS）系统（10）提供了多个刺激通道，通过电刺激通道，电刺激可以在患者的脑部内深深地传递。 DBS系统由可充电电池（27）供电。在一个实施例中，系统具有驱动十六个电极（32）的四个通道。 DBS系统易于编程以供临床医生使用临床医师编程系统（60）使用，并进一步提供简单但高度先进的手持编程器（50）控制接口，通过该控制接口，患者可以容易地将刺激参数改变到可接受的限度内。 DBS系统（10）包括小到可植入的脉冲发生器（20），该脉冲发生器（20）足够小以直接植入患者的颅骨中，从而消除过去已经使用的长引线和隧道过程。可植入脉冲发生器以由刺激参数定义的开环方式提供电刺激。此外，DBS系统允许多达两个电极阵列（30,30'）附接到可植入脉冲发生器（20），从而消除了植入两个独立的可植入脉冲发生器用于双侧刺激深部脑结构的要求。

15. 发明申请

US20090234427A1 SYSTEMS, APPARATUSES, AND METHODS FOR DIFFERENTIATING BETWEEN MULTIPLE LEADS IMPLANTED WITHIN A PATIENT 有权
标题翻译：用于在患者中植入的多个引线之间进行分化的系统，装置和方法
公开(公告)号：US20090234427A1
公开(公告)日：2009-09-17
申请号：US12400260
申请日：2009-03-09
申请人： Kenny Kinyen Chinn , Michael A. Moffitt , Paul M. Meadows
发明人： Kenny Kinyen Chinn , Michael A. Moffitt , Paul M. Meadows
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61B2017/320056 , A61N1/372 , A61N1/3752
摘要： Systems, apparatuses, and methods for differentiating between multiple leads that are implanted within a patient include a stimulator configured to be implanted at an implant site within the patient and generate electrical stimulation current, a plurality of leads each comprising one or more electrodes configured to deliver the electrical stimulation current at a stimulation site within the patient, and a shuttle assembly having a plurality of receiving ports each configured to receive a proximal portion of one of the leads and guide the leads from the stimulation site to the implant site of the stimulator. The shuttle assembly is configured to enable a user to differentiate between each of the leads after the leads are guided to the implant site of the stimulator.
摘要翻译：用于区分植入患者体内的多个引线之间的系统，装置和方法包括：被配置为植入患者内的植入部位并产生电刺激电流的刺激器，多个引线，每个引线包括一个或多个电极，在患者内的刺激部位处的电刺激电流以及具有多个接收端口的梭组件，每个接收端口被配置为接收一个引线的近端部分并将引线从刺激部位引导到刺激器的植入部位。穿梭组件被配置成使得使用者能够在引线被引导到刺激器的植入部位之后区分每个引线。

16. 发明授权

US07013177B1 Treatment of pain by brain stimulation 失效
公开(公告)号：US07013177B1
公开(公告)日：2006-03-14
申请号：US10188582
申请日：2002-07-03
申请人： Todd K. Whitehurst , Carla Mann Woods , Paul M. Meadows
发明人： Todd K. Whitehurst , Carla Mann Woods , Paul M. Meadows
IPC分类号： A61N1/34 , A61N1/32
CPC分类号： A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to alleviate pain use at least one implantable system control unit (SCU), producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulation is delivered to targeted areas in the brain. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.

17. 发明授权

US06741892B1 Movable contact locking mechanism for spinal cord stimulator lead connector 失效
标题翻译：用于脊髓刺激器导线连接器的可动触点锁定机构
公开(公告)号：US06741892B1
公开(公告)日：2004-05-25
申请号：US09799214
申请日：2001-03-05
申请人： Paul M. Meadows , Larry D. Devor , Stephen L. Goldman
发明人： Paul M. Meadows , Larry D. Devor , Stephen L. Goldman
IPC分类号： A61N1375
CPC分类号： A61N1/3752
摘要： A moveable contact connector system provides easy lead insertion, lead retention, and reliable electrical connection for implantable devices. The connector system may be used with in-line leads commonly found in such applications. Moveable contacts are provided in the connector, which contacts are placed in a first position for easy lead insertion, and in a second position for lead retention. The second position also provides a good electrical connection between the moveable connector contacts and the lead contacts. Multiple means for moving said at least one moveable contact between the first and second positions are described. A first embodiment uses a rotatable cam which is rotated to align the cam lodes with said at least one moveable contact, pushing the movable contacts against the lead contacts. The second and third embodiments use a sliding key to force said at least one moveable contact against the lead contacts.
摘要翻译：可移动接触连接器系统为可植入设备提供简单的引线插入，引线保持和可靠的电连接。连接器系统可以与在这样的应用中通常发现的在线引线一起使用。连接器中提供可移动的触点，该触点被放置在第一位置以便于引线插入，并且在第二位置用于引线保持。第二位置还提供可移动的连接器触点和引线触点之间良好的电连接。描述用于在第一和第二位置之间移动所述至少一个可动触点的多个装置。第一实施例使用旋转的凸轮，其旋转以将凸轮凸台与所述至少一个可移动接触件对准，将可动触头推靠在引线触头上。第二和第三实施例使用滑动键来迫使所述至少一个可动触头抵靠引线触点。

18. 发明授权

US06622048B1 Implantable device programmer 有权
标题翻译：可植入器件编程器
公开(公告)号：US06622048B1
公开(公告)日：2003-09-16
申请号：US09718648
申请日：2000-11-21
申请人： Carla M. Mann , Paul M. Meadows
发明人： Carla M. Mann , Paul M. Meadows
IPC分类号： A61N102
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185
摘要： A patient and/or a clinician may program an implant device, e.g., an implanted spinal cord stimulator (SCS), through the use of a programming computer, or clinician programmer, linked with the implant device so that the paresthesia resulting from an applied electrical stimulus pattern is adjusted or programmed so as to match the area of perceived pain or other need. Data is initially stored in the computer that relates to known information regarding the anatomical relationships between the spine and the body. The body is divided into dermatomes and/or subdivisions of dermatomes, and a representation of the body, including its dermatomes and/or subdivisions of dermatomes are displayed on the screen (or other display device) associated with the computer. The patient moves a cursor over the regions of the body displayed on the computer screen to select the region of pain, or a region of paresthesia, by a click of a mouse or the press of a button. The patient may select as many dermatomes or body segments/regions/subdivisions as necessary to communicate the area of pain or paresthesia to the computer. The computer uses the patient-provided information, as well as the pre-programmed data therein, to quickly zero in on an electrode combination and appropriate stimulus parameters that create a match (or as close of a match as is possible) between the pain region and the paresthesia region.
摘要翻译：患者和/或临床医生可以通过使用与植入装置连接的编程计算机或临床医师编程器来编程植入装置，例如植入的脊髓刺激器（SCS），使得由施加的电气产生的感觉异常刺激模式被调整或编程，以便匹配感觉到的疼痛或其他需要的面积。数据最初存储在计算机中，其涉及关于脊柱和身体之间的解剖关系的已知信息。身体分为皮肌和（或）皮肌的细分，并且与计算机相关联的屏幕（或其他显示装置）上显示身体的表示，包括其皮肌和/或皮肤细分。患者将光标移动到计算机屏幕上显示的身体区域上，通过点击鼠标或按下按钮来选择疼痛区域或感觉异常区域。患者可根据需要选择尽可能多的皮肤或身体部位/区域/细分，将疼痛或感觉异常区域传达给计算机。计算机使用患者提供的信息以及其中的预先编程的数据来快速地将电极组合置零，并且在疼痛区域之间产生匹配（或尽可能接近匹配）的合适的刺激参数和感觉异常区域。

19. 发明授权

US08428725B2 Method of stimulating a Hypoglossal nerve for controlling the position of a patient's tongue 有权
标题翻译：刺激舌下神经以控制患者舌头位置的方法
公开(公告)号：US08428725B2
公开(公告)日：2013-04-23
申请号：US12572758
申请日：2009-10-02
申请人： Paul M. Meadows , Marcelo G. Lima , Faisal N. Zaidi
发明人： Paul M. Meadows , Marcelo G. Lima , Faisal N. Zaidi
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/08 , A61B5/4818 , A61N1/0551 , A61N1/0556 , A61N1/36003 , A61N1/3601 , A61N1/3606 , A61N1/3615 , A61N1/37264
摘要： A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.
摘要翻译：用于控制患者舌头的位置的方法包括将至少一个电极附接到患者的下咽神经，并将电信号通过电极施加到位于舌下神经内的至少一个目标运动传递部分以刺激至少一个舌头的肌肉。方法还可以包括使用多于一个接触器来靶向多于一个的马达输出并刺激多于一个的肌肉。保持舌头位置的刺激负荷可以由每只肌肉共享。可以控制患者舌头的位置，以防止阻塞性睡眠呼吸暂停。

20. 发明授权

US07798864B2 Low-profile connector for a neurostimulation lead 有权
标题翻译：用于神经刺激导联的低调连接器
公开(公告)号：US07798864B2
公开(公告)日：2010-09-21
申请号：US12402007
申请日：2009-03-11
申请人： John M. Barker , Matthew B. Flowers , Paul M. Meadows , Randy L. Brase , Robert Tong
发明人： John M. Barker , Matthew B. Flowers , Paul M. Meadows , Randy L. Brase , Robert Tong
IPC分类号： H01R24/04
CPC分类号： H01R24/58 , A61N1/3752 , H01R13/193 , H01R43/26 , H01R2107/00 , H01R2201/12
摘要： An implantable connector, implantable lead assemblies, and implantable lead assembly kits are provided. The connector comprises an electrically insulative receptacle having a port configured for receiving an electrical lead body portion that carries an electrical terminal, and an electrical spring clip contact mounted within the receptacle. The electrical contact includes a collar and opposing lever arms. The collar is configured for being placed between an expanded state for receiving the terminal therein when the lead body portion is received within the port, and a collapsed state to firmly engage the terminal. The opposing lever arms are configured for being displaced using a tool to correspondingly place the collar between the expanded state and the collapsed state. The implantable connector can be incorporated into a lead and used to receive another lead to form the lead assembly. A tool can be provided with the connector to provide the lead assembly kit.
摘要翻译：提供可植入连接器，可植入引线组件和可植入导线组件套件。连接器包括电绝缘插座，其具有构造成用于容纳承载电端子的电引线主体部分的端口，以及安装在插座内的电弹簧夹接头。电触点包括一个套环和相对的杠杆臂。轴环被构造成当引线主体部分被接收在端口内时被放置在用于接收其中的端子的扩展状态之间，以及用于牢固地接合端子的折叠状态。相对的杆臂被构造成使用工具移位，以相应地将套环放置在膨胀状态和折叠状态之间。可植入式连接器可以结合到引线中并用于接收另一引线以形成引线组件。可以为连接器提供工具以提供导线组件套件。

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