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11. 发明授权

US08574253B2 Method, system and device for tissue removal 有权
标题翻译：用于组织去除的方法，系统和装置
公开(公告)号：US08574253B2
公开(公告)日：2013-11-05
申请号：US12098250
申请日：2008-04-04
申请人： William Harwick Gruber , Ronald David Adams , Albert Chun-Chi Chin , Eric Karl Litscher , Roy Hewitt Sullivan , Paul DiCesare , Jeffrey Radziunas , Daniel Vigliotti , Bryan Dale Knodel , Chris Scott Daniels , Kevin J. Vititoe , Michael Anthony Lorenz , Paul P. Kolada , Ryan Scott Crisp , Chris William Cicenas , Ludwin M. Mora , Brent Lee Burchfield
发明人： William Harwick Gruber , Ronald David Adams , Albert Chun-Chi Chin , Eric Karl Litscher , Roy Hewitt Sullivan , Paul DiCesare , Jeffrey Radziunas , Daniel Vigliotti , Bryan Dale Knodel , Chris Scott Daniels , Kevin J. Vititoe , Michael Anthony Lorenz , Paul P. Kolada , Ryan Scott Crisp , Chris William Cicenas , Ludwin M. Mora , Brent Lee Burchfield
IPC分类号： A61B17/32
CPC分类号： A61B17/32002 , A61B17/29 , A61B17/3201 , A61B17/32053 , A61B17/32056 , A61B17/320725 , A61B17/320783 , A61B17/42 , A61B2017/00685 , A61B2017/2905 , A61B2017/320004 , A61B2017/320064 , A61B2017/320775 , A61B2017/4216 , A61B2018/1407 , A61B2217/005 , A61M1/0082
摘要： A method and device for tissue removal. The device may be used to remove uterine fibroids and other abnormal gynecological tissue. According to one embodiment, the device includes a housing, an outer tube, and an inner tube. The outer tube is fixed to the housing and includes a side window proximate to its distal end. The side window may have sloped proximal and distal ends. The inner tube has a distal end positioned within the outer tube, the distal end being adapted to rotate and, at the same time, to move back and forth past the side window, with the rotational and translational movement of the inner tube being independently controllable. The distal end of the inner tube may have an external bevel. Suction is applied to the proximal end of the inner tube to draw tissue into the side window and to remove resected tissue through the inner tube.
摘要翻译：一种用于组织去除的方法和装置。该装置可用于去除子宫肌瘤和其他异常妇科组织。根据一个实施例，该装置包括外壳，外管和内管。外管固定在壳体上并且包括靠近其远端的侧窗。侧窗可能具有倾斜的近端和远端。内管具有定位在外管内的远端，远端适于旋转，并且同时来回移动经过侧窗，内管的旋转和平移运动可独立控制。内管的远端可以具有外部斜面。将吸力施加到内管的近端以将组织拉入侧窗并通过内管去除切除的组织。

12. 发明申请

US20130131637A1 IMPLANTABLE DRUG DELIVERY DEVICES FOR GENITOURINARY SITES 有权
标题翻译：用于生殖部位的可植入药物递送装置
公开(公告)号：US20130131637A1
公开(公告)日：2013-05-23
申请号：US13813745
申请日：2011-08-03
申请人： Paul DiCesare , Jeffrey Radziunas , Andrew Barnes , Eric Britschock , David Sutton
发明人： Paul DiCesare , Jeffrey Radziunas , Andrew Barnes , Eric Britschock , David Sutton
IPC分类号： A61M31/00
CPC分类号： A61M31/002
摘要： Implantable drug delivery devices are provided lo have a deployment shape for implantation in the body and a retention shape for retention in the body. The device may have one or more elongated drug reservoirs containing a drug, mid the drug reservoir may be formed from a deformable material. In one case, a first filament is attached to the first end of the drug reservoir and second filament is attached to the second end of the drug reservoir, wherein a fastener is positioned about the first and second filaments to permit shortening and prevent lengthening of the filaments with reference to the ends of the daig reservoir, as a means for transforming the device from the implantation shape to the retention shape.
摘要翻译：可植入药物递送装置具有用于植入体内的展开形状和用于保持在体内的保持形状。该装置可以具有包含药物的一个或多个细长的药物储存器，药物储存器的中部可以由可变形材料形成。在一种情况下，第一丝被附着到药物储存器的第一端并且第二丝连接到药物储存器的第二端，其中紧固件围绕第一和第二长丝定位以允许缩短和防止延长参考daig储存器的端部的细丝作为将装置从植入形状转换成保持形状的手段。

13. 发明授权

US09060760B2 Tissue removal system 有权
标题翻译：组织清除系统
公开(公告)号：US09060760B2
公开(公告)日：2015-06-23
申请号：US13589003
申请日：2012-08-17
申请人： Roy H. Sullivan , Ronald D. Adams , Andrew Barnes , Jeffrey Radziunas , Joe Paul , Paul DiCesare
发明人： Roy H. Sullivan , Ronald D. Adams , Andrew Barnes , Jeffrey Radziunas , Joe Paul , Paul DiCesare
IPC分类号： A61B17/32 , A61B10/02 , A61M1/00 , A61B10/04 , A61B17/00 , A61B19/00 , A61B17/42
CPC分类号： A61B10/0291 , A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/320016 , A61B17/42 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00389 , A61B2017/00685 , A61B2017/320028 , A61B2017/32004 , A61B2017/320064 , A61B2017/4216 , A61B2217/005 , A61B2217/007 , A61M1/0047
摘要： A tissue removal device includes an outer tubular member coupled to a housing and a having a tissue resection window, an inner tubular member slidably disposed within the outer tubular member, a tissue trap having a sealed interior in fluid communication with a vacuum chamber, an open proximal end of the inner tubular member being disposed within the tissue trap interior, and an actuator moveably coupled to the housing and operatively connected to a movable piston in the vacuum chamber, such that movement of the actuator relative to the housing generates a vacuum in the tissue trap.
摘要翻译：组织去除装置包括联接到壳体并具有组织切除窗口的外部管状构件，可滑动地设置在外部管状构件内部的内部管状构件，具有与真空室流体连通的密封内部的组织阱，内部管状构件的近端设置在组织捕获器内部，以及可移动地联接到壳体并且可操作地连接到真空室中的可移动活塞的致动器，使得致动器相对于壳体的运动在组织陷阱

14. 发明授权

US08105355B2 Suture lock fastening device 有权
标题翻译：缝合锁紧固装置
公开(公告)号：US08105355B2
公开(公告)日：2012-01-31
申请号：US11436398
申请日：2006-05-18
申请人： Edward C. Page , Patrick Gutelius , Danial Ferreira , Jeffrey Radziunas , Paul Dicesare
发明人： Edward C. Page , Patrick Gutelius , Danial Ferreira , Jeffrey Radziunas , Paul Dicesare
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B2017/045 , A61B2017/0488
摘要： A suture lock fastening device to cinch a suture in a suture lock, cut the suture end, and deploy the suture lock in response to a single movement of a user. The fastening device includes a fastening head with a retainer that is configured to hold a suture lock in the fastening head. To release the suture lock from the fastening head, the retainer is irreversibly deformed. The fastening device may include an axially movable cutter with a cutting edge to sever the ends of the suture close to the suture lock. A threading device may be preloaded into the fastening device to facilitate threading the suture through the fastening device.
摘要翻译：一种缝合线锁紧装置，用于将缝合线缝合在缝合线锁中，切割缝合线端部，并且响应于使用者的单次运动而部署缝合线锁。紧固装置包括具有保持器的紧固头部，该保持器构造成将缝合线锁定在紧固头部中。为了从紧固头释放缝合线锁，保持架不可逆地变形。紧固装置可以包括具有切割刃的可轴向移动的切割器，以将缝合线的端部切割成靠近缝合线锁定。穿线装置可以被预加载到紧固装置中以便于缝合线穿过紧固装置。

15. 发明申请

US20080249534A1 METHOD AND DEVICE FOR DISTENDING A GYNECOLOGICAL CAVITY 有权
标题翻译：用于抑制心脏病的方法和装置
公开(公告)号：US20080249534A1
公开(公告)日：2008-10-09
申请号：US11951853
申请日：2007-12-06
申请人： William H. Gruber , Ronald D. Adams , Michael A. Lorenz , Ryan S. Crisp , Chris W. Clcenas , Brent L. Burchfield , Paul DiCesare , Jeffrey Radziunas , Daniel Vigliotti
发明人： William H. Gruber , Ronald D. Adams , Michael A. Lorenz , Ryan S. Crisp , Chris W. Clcenas , Brent L. Burchfield , Paul DiCesare , Jeffrey Radziunas , Daniel Vigliotti
IPC分类号： A61B17/42 , A61M29/02
CPC分类号： A61B17/4241 , A61B1/0615 , A61B1/0661 , A61B1/303 , A61B5/6875 , A61B17/02 , A61B17/0218 , A61B17/12013 , A61B17/12045 , A61B17/12099 , A61B17/12136 , A61B17/22 , A61B17/30 , A61B17/32002 , A61B17/320068 , A61B17/320783 , A61B17/42 , A61B2017/00084 , A61B2017/00278 , A61B2017/00557 , A61B2017/00862 , A61B2017/00876 , A61B2017/00893 , A61B2017/12018 , A61B2017/12127 , A61B2017/22038 , A61B2017/306 , A61B2090/064 , A61B2090/306 , A61F6/20 , A61F6/225 , A61M25/0026 , A61M25/09 , A61M25/1002 , A61M25/1011 , A61M29/02 , A61M31/002 , A61M37/0092 , A61M2025/1047 , A61M2025/105 , A61N5/0603 , A61N5/062 , A61N7/022
摘要： Method and device for distending a gynecological cavity. According to one embodiment, a mechanical, non-fluid device is used to distend the gynecological cavity. Such devices include, for example, self-expanding members, such as resilient baskets, coils, whisks, prongs, and loops, or mechanically expanded members, such as inflatable balloons, mechanically-expanded cages and loops, and scissor jacks. The device may serve a purpose in addition to distension, such as illumination, imaging, irrigation, drug delivery, resection and cauterization.
摘要翻译：扩大妇科腔的方法和装置。根据一个实施例，使用机械非流体装置来扩张妇科腔。这样的装置包括例如自膨胀构件，例如弹性篮，线圈，拂子，插脚和环，或机械膨胀构件，例如可充气气球，机械扩展的笼和环和剪刀千斤顶。除了照明，成像，灌溉，药物递送，切除和烧灼之外，该装置还可以用于扩张的目的。

16. 发明申请

US20080234729A1 Suture lock fastening device 有权
标题翻译：缝合锁紧固装置
公开(公告)号：US20080234729A1
公开(公告)日：2008-09-25
申请号：US11436398
申请日：2006-05-18
申请人： Edward C. Page , Patrick Gutelius , Danial Ferreira , Jeffrey Radziunas , Paul Dicesare
发明人： Edward C. Page , Patrick Gutelius , Danial Ferreira , Jeffrey Radziunas , Paul Dicesare
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B2017/045 , A61B2017/0488
摘要： A suture lock fastening device to cinch a suture in a suture lock, cut the suture end, and deploy the suture lock in response to a single movement of a user. The fastening device includes a fastening head with a retainer that is configured to hold a suture lock in the fastening head. To release the suture lock from the fastening head, the retainer is irreversibly deformed. The fastening device may include an axially movable cutter with a cutting edge to sever the ends of the suture close to the suture lock. A threading device may be preloaded into the fastening device to facilitate threading the suture through the fastening device.
摘要翻译：一种缝合线锁紧装置，用于将缝合线缝合在缝合线锁中，切割缝合线端部，并且响应于使用者的单次运动而部署缝合线锁。紧固装置包括具有保持器的紧固头部，该保持器构造成将缝合线锁定在紧固头部中。为了从紧固头释放缝合锁，保持器不可逆地变形。紧固装置可以包括具有切割刃的可轴向移动的切割器，以将缝合线的端部切割成靠近缝合线锁定。穿线装置可以被预加载到紧固装置中以便于缝合线穿过紧固装置。

17. 发明申请

US20050059163A1 Device and methods for collection of biological fluid sample and treatment of selected components 有权
标题翻译：用于收集生物流体样品和处理所选组分的装置和方法
公开(公告)号：US20050059163A1
公开(公告)日：2005-03-17
申请号：US10912263
申请日：2004-08-05
申请人： Ajit Dastane , Dimitrios Manoussakis , Christopher Battles , Paul DiCesare , Jeffrey Radziunas
发明人： Ajit Dastane , Dimitrios Manoussakis , Christopher Battles , Paul DiCesare , Jeffrey Radziunas
IPC分类号： A61B5/15 , A61B10/00 , B01F13/00 , B01L3/14 , G01N33/49 , G01N1/18
CPC分类号： B01L3/50825 , A61B5/15003 , A61B5/150236 , A61B5/150251 , A61B5/150351 , A61B5/150755 , A61B5/154 , A61B5/417 , A61B10/0045 , B01F13/002 , B01F15/00512 , B01L3/50215 , B01L2200/16 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2400/0683 , G01N33/491 , Y10T428/13 , Y10T436/25375 , Y10T436/255
摘要： A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.
摘要翻译：收集装置和用于收集生物样品，特别是全血的收集装置和方法包括分离构件，以将全血分离成其组分，并且至少包含试剂，定位成选择性地与分离的样品的组分相互作用。试剂能够选择性地与血浆/血清相互作用，并且被阻止与全血接触或相互作用。

18. 发明授权

US06821282B2 Full thickness resection device control handle 有权
标题翻译：全厚度切除装置控制手柄
公开(公告)号：US06821282B2
公开(公告)日：2004-11-23
申请号：US09957901
申请日：2001-09-20
申请人： Stephen J. Perry , Paul DiCesare , Patrick Gutelius , Mark Monroe , Jeffrey Radziunas , Roy H. Sullivan
发明人： Stephen J. Perry , Paul DiCesare , Patrick Gutelius , Mark Monroe , Jeffrey Radziunas , Roy H. Sullivan
IPC分类号： A61B1704
CPC分类号： A61B17/11 , A61B17/07207 , A61B17/115 , A61B17/2909 , A61B17/320016 , A61B2017/0725 , A61B2017/2905 , A61B2017/2923 , A61B2017/320032
摘要： A control mechanism for a resectioning device, comprises a first actuator coupled to a flexible drive shaft for actuating a first mechanism when operated in a first direction and for actuating, when operated in a second direction, a second mechanism and a first lockout mechanism coupled to the first actuator for preventing actuation of the first actuator in the second direction before a predetermined amount of actuation in the first direction has been completed. Furthermore, mechanisms are provided to control the release during operation in a second direction of torsional energy stored in a flexible drive shaft during operation in a first direction.
摘要翻译：一种用于切除装置的控制机构，包括联接到柔性驱动轴的第一致动器，用于当沿第一方向操作时用于致动第一机构，并且当在第二方向上操作时，致动第二机构和第一闭锁机构，在第一方向上的预定的致动量已经完成之前用于防止第一致动器在第二方向上的致动的第一致动器。此外，提供机构以在第一方向的操作期间在存储在柔性驱动轴中的扭转能的第二方向上操作期间的释放。

19. 发明授权

US06520971B1 Full thickness resection device control handle 有权
标题翻译：全厚度切除装置控制手柄
公开(公告)号：US06520971B1
公开(公告)日：2003-02-18
申请号：US09722026
申请日：2000-11-27
申请人： Stephen J. Perry , Paul DiCesare , Patrick Gutelius , Mark Monroe , Jeffrey Radziunas
发明人： Stephen J. Perry , Paul DiCesare , Patrick Gutelius , Mark Monroe , Jeffrey Radziunas
IPC分类号： A61B1710
CPC分类号： A61B17/2909 , A61B17/07207 , A61B17/320016 , A61B2017/0725 , A61B2017/2905 , A61B2017/2923 , A61B2017/320032
摘要： A control handle for a full thickness resection device is disclosed. In an embodiment for the control handle of the present invention, the control handle includes a body and a staple firing assembly coupled to the body. The staple firing assembly includes a rotatable staple firing ring, a worm gear assembly rotatably engaged with the staple firing ring, and a flexible drive shaft coupled to the worm gear assembly. In an embodiment for a method of the present invention, a method for actuating a full thickness resection device is provided. The method includes the steps of rotating a staple firing ring in a first direction and actuating a worm gear assembly in a first operative mode in response to the rotation of the staple firing ring in the first direction, the worm gear assembly is coupled to the staple firing ring. A flexible drive shaft is rotated in the first direction, the flexible drive shaft being coupled to the worm gear assembly, and torsional energy is stored in the flexible drive shaft during rotation of the flexible drive shaft in the first direction. The worm gear assembly is actuated in a second operative mode and a release rate of the stored torsional energy in the flexible drive shaft is controlled by the worm gear assembly. The flexible drive shaft is rotated in a second direction.
摘要翻译：公开了一种全厚度切除装置的控制手柄。在本发明的控制手柄的一个实施例中，控制手柄包括主体和联接到主体的订书钉组件。订书钉组装包括可转动的订书钉预制环，可旋转地与订书钉发射环接合的蜗轮组件和联接到蜗轮组件的柔性驱动轴。在本发明的方法的实施例中，提供了一种用于致动全厚度切除装置的方法。该方法包括以下步骤：响应于第一方向上的订书钉击发环的旋转，以第一方向旋转订书钉击发环并以第一操作模式致动蜗轮组件，蜗轮组件联接到订书钉射击戒指柔性驱动轴沿着第一方向旋转，柔性驱动轴联接到蜗轮组件，并且扭转能量在柔性驱动轴沿第一方向旋转期间被存储在柔性驱动轴中。蜗轮组件以第二操作模式致动，并且柔性驱动轴中存储的扭转能量的释放速率由蜗轮组件控制。柔性驱动轴沿第二方向旋转。

20. 发明申请

US20130046316A1 TISSUE REMOVAL SYSTEM 有权
公开(公告)号：US20130046316A1
公开(公告)日：2013-02-21
申请号：US13589003
申请日：2012-08-17
申请人： Roy H. Sullivan , Ronald D. Adams , Andrew Barnes , Jeffrey Radziunas , Jo Paul , Paul DiCesare
发明人： Roy H. Sullivan , Ronald D. Adams , Andrew Barnes , Jeffrey Radziunas , Jo Paul , Paul DiCesare
IPC分类号： A61B17/42
CPC分类号： A61B10/0291 , A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/320016 , A61B17/42 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00389 , A61B2017/00685 , A61B2017/320028 , A61B2017/32004 , A61B2017/320064 , A61B2017/4216 , A61B2217/005 , A61B2217/007 , A61M1/0047
摘要： A tissue removal device includes an outer tubular member coupled to a housing and a having a tissue resection window, an inner tubular member slidably disposed within the outer tubular member, a tissue trap having a sealed interior in fluid communication with a vacuum chamber, an open proximal end of the inner tubular member being disposed within the tissue trap interior, and an actuator moveably coupled to the housing and operatively connected to a movable piston in the vacuum chamber, such that movement of the actuator relative to the housing generates a vacuum in the tissue trap.

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