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11. 发明授权

US09097376B2 Spherical annular seal member and method of manufacturing the same 有权
标题翻译：球形环形密封件及其制造方法
公开(公告)号：US09097376B2
公开(公告)日：2015-08-04
申请号：US14110809
申请日：2012-04-09
申请人： Osamu Miyashita , Eiji Satou , Koichi Ishida , Toshikazu Takasago , Satoshi Matsunaga
发明人： Osamu Miyashita , Eiji Satou , Koichi Ishida , Toshikazu Takasago , Satoshi Matsunaga
IPC分类号： F16J15/12 , F16L23/22 , F01N13/18 , F16L27/073 , B29C70/02 , F16J15/08
CPC分类号： F16L23/22 , B29C70/028 , F01N13/1827 , F16J15/0812 , F16L27/073
摘要： A spherical annular seal member 46 includes a spherical annular base member 42 defined by a cylindrical inner surface 38, a partially convex spherical surface 39, and large- and small-diameter side annular end faces 40 and 41 of the partially convex spherical surface 39; a plurality of partially convex spherical intermediate layers 43 formed integrally on the partially convex spherical surface 39 of the spherical annular base member 42 and laminated in a radial direction; and an outer layer 45 formed integrally on a partially convex spherical surface 44 of the outermost partially convex spherical intermediate layer 43 of these partially convex spherical intermediate layers 43.
摘要翻译：球形环形密封件46包括由圆柱形内表面38，部分凸出的球形表面39和部分凸出的球形表面39的大直径和小直径的侧面环形端面40和41限定的球形环形底座件42; 多个部分凸出的球形中间层43整体地形成在球形环形基底构件42的部分凸起的球形表面39上并沿径向方向层叠; 以及整体形成在这些部分凸出的球状中间层43的最外部部分球形中间层43的部分凸出的球面44上的外层45。

12. 发明授权

US4308268A Maytansinoids, pharmaceutical compositions thereof and method of use thereof 失效
标题翻译：美登木素生物碱，其药物组合物及其使用方法
公开(公告)号：US4308268A
公开(公告)日：1981-12-29
申请号：US153905
申请日：1980-05-28
申请人： Osamu Miyashita , Hiroshi Akimoto
发明人： Osamu Miyashita , Hiroshi Akimoto
IPC分类号： A61K31/535 , A61P35/00 , C07D498/18 , C07D521/00
CPC分类号： C07D498/18 , Y10S514/908
摘要： Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and Y is Cl, OH, SH, CN, NO.sub.2, --OR or --S(O).sub.n R wherein R is slkyl, aryl, aralkyl or azaheterocyclic group which may be substituted, and n is 0, 1 or 2, have antimitotic, antitumor and antimicrobial activities.
摘要翻译：新型美登木素素，其分子式如下：其中X为H或Cl，Y为Cl，OH，SH，CN，NO 2，-OR或-S（O）n R，其中R为烷基，芳基，芳烷基或氮杂环基可以被取代，并且n为0,1或2，具有抗有丝分裂，抗肿瘤和抗微生物活性。

13. 发明授权

US4264596A Maytansinoids, pharmaceutical compositions thereof and method of use thereof 失效
标题翻译：美登木素生物碱，其药物组合物及其使用方法
公开(公告)号：US4264596A
公开(公告)日：1981-04-28
申请号：US171460
申请日：1980-07-23
申请人： Osamu Miyashita , Hiroshi Akimoto
发明人： Osamu Miyashita , Hiroshi Akimoto
IPC分类号： A61K31/535 , A61P35/00 , C07D498/16 , C07D498/18 , C12P17/18 , A61K31/395
CPC分类号： C07D498/16 , C07D498/18 , C12P17/188 , C12R1/04 , C12R1/11 , C12R1/465 , C12R1/585
摘要： Novel maytansinoid compounds of the formula: ##STR1## wherein X is H or Cl, R.sup.1 is an alkyl group of 2 to 4 carbon atoms and R.sup.2 is a lower alkyl group or an unsubstituted or substituted phenyl or aralkyl group, have antimitotic, antitumor and antimicrobial activities.
摘要翻译：新颖的美登木素生物化合物：其中X为H或Cl，R 1为2至4个碳原子的烷基，R 2为低级烷基或未取代或取代的苯基或芳烷基，具有抗有丝分裂，抗肿瘤和抗菌活性。

14. 发明授权

US4263294A Maytansinoids, pharmaceutical compositions thereof and method of use thereof 失效
标题翻译：美登木素生物碱，其药物组合物及其使用方法
公开(公告)号：US4263294A
公开(公告)日：1981-04-21
申请号：US93742
申请日：1979-11-13
申请人： Osamu Miyashita , Hiroshi Akimoto
发明人： Osamu Miyashita , Hiroshi Akimoto
IPC分类号： C07D498/18 , A61K31/535 , C07D498/16 , C07D521/00
CPC分类号： C07D498/18 , Y10S148/131
摘要： Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and R is ##STR2## wherein R.sup.1 and R.sup.2 may be the same or different, and each is H or a substituted or unsubstituted hydrocarbon residue or heterocyclic group, or R.sup.1 and R.sup.2 may, taken together with the adjacent N atom, form a heterocyclic group, andR.sup.3 is a substituted or unsubstituted hydrocarbon residue, have antimitotic, antitumor and antimicrobial activities.
摘要翻译：新型美登木素生物碱，其分子式为：其中X为H或Cl，R为R，其中R 1和R 2可以相同或不同，并且各自为H或取代或未取代的烃基或杂环基，或R 1 并且R 2可以与相邻的N原子一起形成杂环基，并且R 3是取代或未取代的烃残基，具有抗有丝分裂，抗肿瘤和抗微生物活性。

15. 发明申请

US20140027986A1 SPHERICAL ANNULAR SEAL MEMBER AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：球形密封件密封件及其制造方法
公开(公告)号：US20140027986A1
公开(公告)日：2014-01-30
申请号：US14110809
申请日：2012-04-09
申请人： Osamu Miyashita , Eiji Satou , Koichi Ishida , Toshikazu Takasago , Satoshi Mitsunaga
发明人： Osamu Miyashita , Eiji Satou , Koichi Ishida , Toshikazu Takasago , Satoshi Mitsunaga
IPC分类号： F16L23/22 , B29C70/02
CPC分类号： F16L23/22 , B29C70/028 , F01N13/1827 , F16J15/0812 , F16L27/073
摘要： A spherical annular seal member 46 includes a spherical annular base member 42 defined by a cylindrical inner surface 38, a partially convex spherical surface 39, and large- and small-diameter side annular end faces 40 and 41 of the partially convex spherical surface 39; a plurality of partially convex spherical intermediate layers 43 formed integrally on the partially convex spherical surface 39 of the spherical annular base member 42 and laminated in a radial direction; and an outer layer 45 formed integrally on a partially convex spherical surface 44 of the outermost partially convex spherical intermediate layer 43 of these partially convex spherical intermediate layers 43.
摘要翻译：球形环形密封件46包括由圆柱形内表面38，部分凸出的球形表面39和部分凸出的球形表面39的大直径和小直径的侧面环形端面40和41限定的球形环形底座件42; 多个部分凸出的球形中间层43整体地形成在球形环形基底构件42的部分凸起的球形表面39上并沿径向方向层叠; 以及整体形成在这些部分凸出的球状中间层43的最外部部分球形中间层43的部分凸出的球面44上的外层45。

16. 发明授权

US4260608A Maytansinoids, pharmaceutical compositions thereof and methods of use thereof 失效
标题翻译：美登木素生物碱，其药物组合物及其使用方法
公开(公告)号：US4260608A
公开(公告)日：1981-04-07
申请号：US92953
申请日：1979-11-09
申请人： Osamu Miyashita , Hiroshi Akimoto
发明人： Osamu Miyashita , Hiroshi Akimoto
IPC分类号： A61K31/535 , A61P35/00 , C07D498/18 , C07D498/16
CPC分类号： C07D498/18
摘要： Novel maytansinoids of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group which may optionally be substituted or a group of the formula: --A.sup.1 --Y.sup.1 wherein A.sup.1 is an alkylene group or a bond, and Y.sup.1 is a cycloalkyl, phenyl, indolyl or imidazolyl group which may optionally be substituted,R.sup.2 is hydrogen atom, an alkyl, cycloalkyl or benzyl group,R.sup.3 is hydrogen atom, an alkyl group which may optionally be substituted, alkoxy, bornyloxy, isobornyloxy, benzyloxy group or a group of the formula: --A.sup.2 --Y.sup.2 wherein A.sup.2 is an alkylene group or a bond, and Y.sup.2 is an alicyclic hydrocarbon, phenyl or heterocyclic group which may optionally be substituted,provided that R.sup.3 is not an unsubstituted C.sub.1-4 alkyl group when both R.sup.1 and R.sup.2 are methyl groups, have antimicrobial antimitotic and antitumor activities.
摘要翻译：新型美登木素素，其分子式如下：其中R 1为氢原子，可任意取代的烷基或下式基团-A1-Y1其中A1为亚烷基或键，Y1为环烷基，苯基，吲哚基或咪唑基，其可以任选被取代，R 2是氢原子，烷基，环烷基或苄基，R 3是氢原子，可任意被取代的烷基，烷氧基，苄氧基，其中A2是亚烷基或键，Y2是可任选被取代的脂环烃，苯基或杂环基，条件是当R 3不是未取代的C 1-4烷基时，和R2是甲基，具有抗微生物抗生素和抗肿瘤活性。

17. 发明授权

US4248870A Maytansinoids and use 失效
标题翻译：美登木素和使用
公开(公告)号：US4248870A
公开(公告)日：1981-02-03
申请号：US85880
申请日：1979-10-18
申请人： Osamu Miyashita , Hiroshi Akimoto
发明人： Osamu Miyashita , Hiroshi Akimoto
IPC分类号： A61K31/395 , A61P35/00 , C07D498/18 , A61K31/535 , C07D498/16
CPC分类号： C07D498/18
摘要： Novel maytansinoids of the formula: ##STR1## wherein R is an alicyclic hydrocarbon group of 3 to 10 carbon atoms, phenyl or heterocyclic group, which may optionally be substituted, andA is an alkylene group of 1 to 4 carbon atoms or a bond, provided that A means said alkylene group when attached to a N atom in said heterocyclic group R,have antimicrobial, antimitotic and antitumor activities.
摘要翻译：新颖的美登木素生物质，其结构式如下：其中R为3至10个碳原子的脂环族烃基，苯基或杂环基，可任意取代，A为1至4个碳原子的亚烷基或键，条件是当连接到所述杂环基团R中的N原子时，A表示亚烷基，具有抗微生物，抗有丝分裂和抗肿瘤活性。

18. 发明授权

US4190656A Uracil derivatives and production thereof 失效
标题翻译：尿嘧啶衍生物及其生产
公开(公告)号：US4190656A
公开(公告)日：1980-02-26
申请号：US944769
申请日：1978-09-22
申请人： Koichi Matsumura , Osamu Miyashita , Hiroshi Shimadzu , Naoto Hashimoto
发明人： Koichi Matsumura , Osamu Miyashita , Hiroshi Shimadzu , Naoto Hashimoto
IPC分类号： A61K31/505 , A61P31/12 , A61P35/00 , A61P35/02 , C07D233/90 , C07D239/22 , C07D333/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D239/10
CPC分类号： C07D239/22 , Y10S514/908
摘要： New compounds of the formula ##STR1## (wherein R.sub.1 represents a lower alkyl group: and ##STR2## represents an alkylidene radical in which at least one of R.sub.2 and R.sub.3 is a lower alkyl which may optionally be substituted by phenyl, phenyl or a 5- or 6-membered aromatic ring including S, N or O, and the remainder, if any, is hydrogen; ora cycloalkylidene radical of up to six carbon atoms, to which a benzene ring may optionally be fused).These compounds are produced by reacting the corresponding 6-acyloxy compounds with a compound of the formula ##STR3## The new compounds have antiviral activity and are useful to prolong the life spans of tumor-bearing animals.
摘要翻译：式（IMAGE）的新化合物（其中R 1表示低级烷基：＆lt; IMAGE＆gt;代表亚烷基，其中R 2和R 3中的至少一个为可任意被苯基，苯基或5 - 或6元芳环，其余的（如果有的话）是氢;或至多6个碳原子的亚环烷基，苯环可以任选地被稠合）。这些化合物通过使相应的6-酰氧基化合物与下式化合物反应来制备。新化合物具有抗病毒活性并且可用于延长荷瘤动物的寿命。

19. 发明授权

US3959280A 3-(Disubstituted)aminoisothiazolo[3,4-d]pyrimidines 失效
标题翻译： 3-（二取代）氨基异噻唑{8,3-d {9嘧啶
公开(公告)号：US3959280A
公开(公告)日：1976-05-25
申请号：US522863
申请日：1974-11-11
申请人： Yoshiyasu Furukawa , Osamu Miyashita
发明人： Yoshiyasu Furukawa , Osamu Miyashita
IPC分类号： A61K31/505 , A61P7/10 , A61P25/20 , A61P29/00 , C07D239/48 , C07D239/56 , C07D513/04 , C07D239/00
CPC分类号： C07D239/48 , C07D239/56 , C07D513/04
摘要： Novel 3-(disubstituted)aminoisothiazolo[3,4-d]-pyrimidines of the formula ##SPC1##Wherein R.sup.1, R.sup.2 and R.sup.3 are respectively alkyl, alkenyl, aryl, aralkyl or aralkenyl, each of which may be substituted, or R.sup.1 and R.sup.2 form together with the adjacent nitrogen a heterocyclic ring which may be substituted, R.sup.4 is hydrogen or alkyl and X is oxygen or imino with a proviso that when X is imino R.sup.4 is hydrogen, show an eminent adenosine-3',5'-cyclic phosphate phosphodiesterase-inhibitory activity, and exhibit excellent pharmacological actions such as antiinflammatory and sedative activities.
摘要翻译：式WHEREIN R1，R2和R3的新型3-（二取代的）氨基异噻唑并[3,4-d] - 嘧啶分别是烷基，烯基，芳基，芳烷基或芳烯基，其各自可以被取代，或者R 1和R 2一起形成相邻的氮是可以被取代的杂环，R4是氢或烷基，X是氧或亚氨基，条件是当X是亚氨基R4是氢时，显示出显着的腺苷-3'，5'-磷酸磷酸二酯酶 - 并具有优异的药理作用，如抗炎和镇静作用。

20. 发明授权

US4961692A Oscillating vessel pump 失效
标题翻译：振荡容器泵
公开(公告)号：US4961692A
公开(公告)日：1990-10-09
申请号：US352344
申请日：1989-05-16
申请人： Yasuhiro Fukui , Osamu Miyashita
发明人： Yasuhiro Fukui , Osamu Miyashita
IPC分类号： F04D1/00 , A61M1/10 , F04D11/00 , F04D33/00
CPC分类号： F04D33/00 , A61M1/101
摘要： The present invention provides a pump by vessel oscillation including a vessel having an inlet for liquid and an outlet opening in a specific tangential direction of an outer peripheral portion thereof. The vessel is oscillated in a specific direction to outflow the liquid through the outlet opening. Accordingly, the liquid in the interior of the vessel undergoes a simple centrifugal motion and when the pump is used for a blood circulation device such as an artificial heart or assisted circulation device, the blood is completely shut off from outside and isolated from entry of various germs, air, foreign matter, etc. The pump is simple is construction and excellent in reliability and durability.

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