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11. 发明授权

US6148266A Data processing apparatus for chromatograph 失效
公开(公告)号：US6148266A
公开(公告)日：2000-11-14
申请号：US605416
申请日：1996-02-22
申请人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
发明人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
IPC分类号： G01N30/86 , G06F17/10 , G06F19/00
CPC分类号： G06F17/10 , G01N30/8641
摘要： A method of properly correcting a base line. A concept of flexibility of a base line is introduced as an input index and a gravitation is presumed between the base line and signal data which is measured, thereby constructing a method of correcting the base line which changes gentler than a change in signal with respect to time in a peak area and which is sensitive to an area where a value of the signal data is small. A base line like a natural and smooth curve which isn't easily influenced by a local change in signal such as noise or the like can be set by an input of the flexibility.

12. 发明授权

US5644503A Methods and apparatuses for analyzing multichannel chromatogram 失效
标题翻译：分析多通道色谱图的方法和装置
公开(公告)号：US5644503A
公开(公告)日：1997-07-01
申请号：US409986
申请日：1995-03-24
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N27/447 , G01N30/86 , G01N31/00 , G01N30/00 , G06F17/16
CPC分类号： G01N30/8624 , G01N2201/1293 , G01N30/8631 , G01N30/8679
摘要： A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. By compressing three-dimensional data in the wavelength direction, noise components cancel with each other to obtain noise free two-dimensional data Di.beta.. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. The quantified data is displayed on a screen. Since noise components cancel with each other, it is possible to realize an analyzing method which is capable of accurately resolving and analyzing the components. Also, overlapping peaks are specified, and a data matrix D is determined. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.
摘要翻译：实现了用于分析多通道色谱图的方法，用于准确地分辨多通道色谱图上的重叠峰，以允许分析样品的组成。首先，指定重叠峰的分量。确定数据矩阵Dij，并在波长方向上压缩以获得数据矩阵向量Di。通过在波长方向压缩三维数据，噪声分量彼此抵消，以获得无噪声的二维数据Diβ。接下来，对二维数据进行解卷积，记录最终标准偏差s0，并将解卷积的二维数据重新卷积到保留强度矩阵。计算定量光谱强度矩阵，识别组件，并对所识别的组分进行量化。量化的数据显示在屏幕上。由于噪声分量彼此抵消，因此可以实现能够精确地分析和分析组件的分析方法。此外，指定重叠的峰值，并且确定数据矩阵D. 随后，解决了特征值问题，估计了组件的数量+ E，uns n + EE。迭代执行反褶积和特征值问题的计算，直到峰被隔离。然后，计算洗脱曲线，识别组分，并对所鉴定的组分进行定量。

13. 发明授权

US08232079B2 Oligosaccharide synthesizer 失效
标题翻译：寡糖合成仪
公开(公告)号：US08232079B2
公开(公告)日：2012-07-31
申请号：US11197335
申请日：2005-08-05
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/00 , C12P19/18
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.
摘要翻译：在各种糖核苷酸溶液和糖基转移酶（或引物）已被混合之后，将它们引入固定在其上的引物（或糖基转移酶）的反应罐（柱）中。然后将从反应槽出来的溶液引入超滤柱。根据本发明的寡糖合成仪配备有用于确保由超滤塔分离的糖基转移酶或引物返回到用于将每种溶液存储在样品注射器中的容器中的流动路径。

14. 发明授权

US07699990B2 Separation analyzer 失效
标题翻译：分离分析仪
公开(公告)号：US07699990B2
公开(公告)日：2010-04-20
申请号：US11581147
申请日：2006-10-16
申请人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
发明人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
IPC分类号： B01D15/08
CPC分类号： G01N35/1097 , G01N1/38 , G01N30/20 , G01N30/34 , G01N2030/027 , Y10T436/2575
摘要： A separation analyzer for transferring solutions, while changing mixing ratios of the solutions, wherein a flow passage from a first pump, a flow passage from a second pump, and a passage for sample introduction section, the flow passages being connected, which further comprises a flow switching means for temporarily storing the solutions, whereby the flow switching means alternatively makes a first state for pushing out the solutions in a second sampling loop to the sample introduction section by the second pump, while transferring the solutions to the first sampling loop; and a second state for pushing out the solutions in the first sampling loop by the second pump, while transferring the solutions from the first pump to the second sampling loop.
摘要翻译：一种用于输送溶液的分离器，同时改变溶液的混合比，其中来自第一泵的流动通道，来自第二泵的流动通道和用于样品引入部分的通道，流动通道连接，还包括流动切换装置，用于临时存储溶液，由此流动切换装置交替地将第二状态用于将第二取样回路中的溶液推出到第二泵的样品引入部分，同时将溶液转移到第一取样回路; 以及第二状态，用于在将所述解决方案从所述第一泵传送到所述第二采样回路的同时，通过所述第二泵推出所述第一采样回路中的所述解。

15. 发明申请

US20080172186A1 Method and apparatus for analyzing multi-channel chromatogram 失效
标题翻译：用于分析多通道色谱图的方法和装置
公开(公告)号：US20080172186A1
公开(公告)日：2008-07-17
申请号：US12073964
申请日：2008-03-12
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N31/00 , G06F19/00
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8679 , G01N2201/1293
摘要： A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.
摘要翻译：实现了分析多通道色谱图的方法，用于准确地分辨多通道色谱图上的重叠峰，以便分析样品的组成。首先，指定重叠峰的分量。确定数据矩阵Dij，并在波长方向上压缩以获得数据矩阵向量Di。接下来，对二维数据进行解卷积，记录最终标准偏差s 0，并将去卷积的二维数据重新卷积到保留强度矩阵。计算定量光谱强度矩阵，识别组件，并对所识别的组分进行量化。随后，解决了特征值问题，并且估计了分量的数量n。迭代执行反褶积和特征值问题的计算，直到峰被隔离。然后，计算洗脱曲线，识别组分，并对所鉴定的组分进行定量。

16. 发明授权

US07070988B2 Oligosaccharide synthesizer 失效
公开(公告)号：US07070988B2
公开(公告)日：2006-07-04
申请号：US10715385
申请日：2003-11-19
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/34
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.

17. 发明申请

US20060024817A1 Oligosaccharide synthesizer 失效
标题翻译：寡糖合成仪
公开(公告)号：US20060024817A1
公开(公告)日：2006-02-02
申请号：US11197335
申请日：2005-08-05
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/34 , C40B60/14
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.
摘要翻译：在各种糖核苷酸溶液和糖基转移酶（或引物）已被混合之后，将它们引入固定在其上的引物（或糖基转移酶）的反应罐（柱）中。然后将从反应槽出来的溶液引入超滤柱。根据本发明的寡糖合成仪配备有用于确保由超滤塔分离的糖基转移酶或引物返回到用于将每种溶液存储在样品注射器中的容器中的流动路径。

18. 发明申请

US20050251349A1 Method and apparatus for analyzing multi-channel chromatogram 有权
标题翻译：用于分析多通道色谱图的方法和装置
公开(公告)号：US20050251349A1
公开(公告)日：2005-11-10
申请号：US11182855
申请日：2005-07-18
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N27/447 , G01N30/86 , G01N31/00
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8679 , G01N2201/1293
摘要： A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.
摘要翻译：实现了分析多通道色谱图的方法，用于准确地分辨多通道色谱图上的重叠峰，以便分析样品的组成。首先，指定重叠峰的分量。确定数据矩阵Dij，并在波长方向上压缩以获得数据矩阵向量Di。接下来，对二维数据进行解卷积，记录最终标准偏差s0，并将解卷积的二维数据重新卷积到保留强度矩阵。计算定量光谱强度矩阵，识别组件，并对所识别的组分进行量化。随后，解决了特征值问题，估计了组件的数量

19. 发明授权

US06962809B1 Sugar chain synthesizer 失效
标题翻译：糖链合成器
公开(公告)号：US06962809B1
公开(公告)日：2005-11-08
申请号：US10482626
申请日：2002-07-01
申请人： Kisaburo Deguchi , Genzo Hirata , Junkichi Miura , Masahito Ito , Shinichiro Nishimura , Susumu Nishiguchi , Atsushi Toda , Hiroaki Nakagawa , Kuriko Yamada
发明人： Kisaburo Deguchi , Genzo Hirata , Junkichi Miura , Masahito Ito , Shinichiro Nishimura , Susumu Nishiguchi , Atsushi Toda , Hiroaki Nakagawa , Kuriko Yamada
IPC分类号： C12P19/14 , C12P19/18 , C12M1/34
CPC分类号： C12P19/18 , C12P19/14
摘要： A sugar chain synthesizer comprising one or more reaction columns packed with immobilized glycosyltransferase and/or glycosidase; one or more separation means, arranged downstream from the reaction columns, for separating reaction products, unreaction products and byproducts contained in the solution eluted from the reaction columns; a first pump for feeding a primer of water soluble polymer and buffer solution to the reaction columns through a first selector valve; a second pump for feeding a buffer solution and sugar nucleotide solution to any one of the reaction columns through a second selector valve; one or more circulation flow paths connecting between a flow path downstream from the separation means and a flow path upstream from each of the reaction columns; and a third selector valve, arranged between the separation means and one or more circulation flow paths, for selective connection between the separation means and a desired circulation flow path. This synthesizer ensures continuous and automatic synthesis of sugar chains even if complicated.
摘要翻译：一种糖链合成仪，其包含一个或多个填充有固定的糖基转移酶和/或糖苷酶的反应柱; 一个或多个分离装置，布置在反应塔的下游，用于分离从反应塔洗脱的溶液中所含的反应产物，未反应产物和副产物; 第一泵，用于通过第一选择阀向反应塔供给水溶性聚合物和缓冲溶液的底漆; 第二泵，其通过第二选择阀将缓冲溶液和糖核苷酸溶液供给到任一反应塔; 连接在分离装置下游的流动路径和每个反应塔上游的流动路径之间的一个或多个循环流动路径; 以及第三选择阀，布置在所述分离装置和一个或多个循环流动路径之间，用于分离装置和期望的循环流动路径之间的选择性连接。这种合成器即使复杂，也能确保糖链的连续和自动合成。

20. 发明授权

US06675107B2 Data processing apparatus for chromatograph 失效
标题翻译：色谱数据处理装置
公开(公告)号：US06675107B2
公开(公告)日：2004-01-06
申请号：US10319692
申请日：2002-12-16
申请人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
发明人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
IPC分类号： G06F1900
CPC分类号： G06F17/10 , G01N30/8641
摘要： A method of properly correcting a base line. A concept of flexibility of a base line is introduced as an input index and a gravitation is presumed between the base line and signal data which is measured, thereby constructing a method of correcting the base line which changes gentler than a change in signal with respect to time in a peak area and which is sensitive to an area where a value of the signal data is small. A base line like a natural and smooth curve which isn't easily influenced by a local change in signal such as noise or the like can be set by an input of the flexibility.
摘要翻译：一种正确校正基线的方法。引入基线的灵活性的概念作为输入索引，并且在基线和被测量的信号数据之间推测引力，由此构建校正基线相对于相对于信号的信号变化更为温和的方法在峰值区域中的时间，并且其对信号数据的值较小的区域敏感。可以通过输入灵活性来设定像自然平滑曲线的基线，其不容易受诸如噪声等信号的局部变化的影响。

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