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11. 发明授权

US4710554A Polybutadiene and process for preparing the same 失效
标题翻译：聚丁二烯及其制备方法
公开(公告)号：US4710554A
公开(公告)日：1987-12-01
申请号：US829846
申请日：1986-02-14
申请人： Akio Imai , Yasushi Okamoto , Masatoshi Saito
发明人： Akio Imai , Yasushi Okamoto , Masatoshi Saito
IPC分类号： C08F4/00 , C08C19/30 , C08F4/42 , C08F4/48 , C08F8/00 , C08F8/18 , C08F8/20 , C08F36/00 , C08F136/06
CPC分类号： C08F136/06
摘要： A polybutadiene having an average 1,2-bond content of 18 to 32% by mole, a branched polymer chain content of 60% by weight or more and a Mooney viscosity at 100.degree. C. of 40 to 90, the viscosity of a 5% by weight concentration solution of this polybutadiene in styrene at 25.degree. C. being 60 to 90 cps, and a process for preparing the polybutadiene comprising starting the polymerization of 1,3-butadiene in an inert hydrocarbon solvent in the presence of a Lewis basic compound and an organolithium compound, the latter compound being in an amount of 0.5 to 3 millimoles per 100 g of 1,3-butadiene, at a temperature selected from the range of 30.degree. to 80.degree. C., carrying out the polymerization by controlling the temperature so that the temperature at the end of polymerization may be 5.degree. to 40.degree. higher than the temperature at the start of polymerization, and adding to the resulting polymer solution a polyfunctional halogen compound in an amount of 0.6 to 1 equivalent per equivalent of the organolithium compound to further react the polymer with the polyfunctional halogen compound.
摘要翻译：平均1,2-键含量为18〜32摩尔％，支链聚合物链含量为60重量％以上，100℃下门尼粘度为40〜90的聚丁二烯，粘度为5〜该聚丁二烯在25℃下在苯乙烯中的重量浓度溶液为60至90cps，以及制备聚丁二烯的方法，包括在路易斯碱的存在下在惰性烃溶剂中开始1,3-丁二烯的聚合化合物和有机锂化合物，后一化合物的量为0.5-3毫摩尔/ 100g 1,3-丁二烯，温度选自30-80℃，通过控制进行聚合使聚合结束时的温度比聚合开始时的温度高5〜40℃，向所得聚合物溶液中加入0.6〜1当量的多官能卤素化合物，的有机锂化合物进一步使聚合物与多官能卤素化合物反应。

12. 发明申请

US20070117846A1 Processes for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine and hydrochloride thereof 有权
标题翻译： 1-苄基-4 - [（5,6-二甲氧基-1茚满酮）-2-基]甲基哌啶及其盐酸盐的制备方法
公开(公告)号：US20070117846A1
公开(公告)日：2007-05-24
申请号：US10580908
申请日：2005-04-27
申请人： Akio Imai , Hiroshi Nishimura
发明人： Akio Imai , Hiroshi Nishimura
IPC分类号： C07D211/06 , A61K31/445
CPC分类号： C07D211/32 , B01J25/02
摘要： Processes for preparing 1-benzyl-4-[(5,6-dimethoxy-lindanon)-2-yl]methylpiperidine (donepezil), which is useful as an intermediate for medicines, and for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (donepezil hydrochloride), which is useful as a medicine. The process for donepezil hydrochloride production comprises catalytically hydrogenating the compound represented by the structural formula (III) [1-benzyl-4-[(5,6-dimethoxy-lindanon)-2-ylidene]methylpiperidine] with a Raney nickel catalyst under mild conditions and subsequently treating it with hydrochloric acid. Thus, impurities are further diminished. The operations are simple and the process is suitable for industrial production.
摘要翻译：用于制备1-苄基-4 - [（5,6-二甲氧基 - 茚满酮）-2-基]甲基哌啶（多奈哌齐）的方法，其可用作药物的中间体，并用于制备1-苄基-4 - [（5 ，6-二甲氧基-1-茚满酮）-2-基]甲基哌啶盐酸盐（盐酸多奈哌齐），其可用作药物。盐酸多奈哌齐的方法包括用温和的阮内镍催化剂催化氢化由结构式（III）[1-苄基-4 - [（5,6-二甲氧基 - 茚满酮）-2-亚基]甲基哌啶]代表的化合物然后用盐酸处理。因此，杂质进一步减少。操作简单，适用于工业生产。

13. 发明申请

US20050059542A1 Alpha-olefin polymerization catalyst and process for producing alpha-olefin polymer 审中-公开
标题翻译： α-烯烃聚合催化剂和α-烯烃聚合物的制备方法
公开(公告)号：US20050059542A1
公开(公告)日：2005-03-17
申请号：US10975814
申请日：2004-10-29
申请人： Makoto Satoh , Yasuki Fujiwara , Akio Imai
发明人： Makoto Satoh , Yasuki Fujiwara , Akio Imai
IPC分类号： C08F4/658 , C08F4/60 , C08F4/642 , C08F10/00 , B01J31/00 , C08F4/44
CPC分类号： C08F10/00 , C08F4/6565
摘要： An α-olefin polymerization catalyst comprising (A) a solid catalyst component containing a titanium compound obtained by treating a solid product having a titanium content of 1.5% by weight or less obtained by reducing Ti(OR1)aX4-a (R1 represents a hydrocarbon group having 1 to 20 carbon atoms, X represents a halogen atom and a represents a number satisfying 0
摘要翻译：一种α-烯烃聚合催化剂，其包含（A）含有钛化合物的固体催化剂组分，所述钛化合物通过将通过还原Ti（OR 1）aX 4-a（R 2）获得的钛含量为1.5重量％以下的固体产物在具有Si-O键的有机硅化合物的存在下，使用有机镁化合物与式（1）表示碳原子数1〜20的烃基，X表示卤素原子，a表示满足0

14. 发明授权

US06331501B1 Catalyst for &agr;-olefin polymerization and process for producing &agr;-olefin polymer 有权
标题翻译：用于α-烯烃聚合的催化剂和用于生产α-烯烃聚合物的方法
公开(公告)号：US06331501B1
公开(公告)日：2001-12-18
申请号：US09250286
申请日：1999-02-16
申请人： Makoto Satoh , Yasuki Fujiwara , Akio Imai
发明人： Makoto Satoh , Yasuki Fujiwara , Akio Imai
IPC分类号： B01J3100
CPC分类号： C08F10/00 , C08F4/651 , C08F4/6565
摘要： A catalyst for &agr;-olefin polymerization obtained by contacting (A) a solid catalyst component containing a titanium compound which is obtained by treating a solid product obtained by contacting an organosilicon compound having an Si—O bond, an ester compound and an organomagnesium compound, with an ether compound, titanium tetrachloride and an acyl halide, and successively treating said treated solid with an mixture of an ether compound and titanium tetrachloride, or a mixture of an ether compound, titanium tetrachloride and an ester compound, (B) an organoaluminum compound and (C) an electron-donative compound, and a process for producing an &agr;-olefin polymer with the catalyst.
摘要翻译：通过使（A）含有钛化合物的固体催化剂成分与通过使通过使具有Si-O键的有机硅化合物接触而得到的固体产物，酯化合物和有机镁化合物接触而获得的α-烯烃聚合反应，与醚化合物，四氯化钛和酰基卤反应，并用醚化合物和四氯化钛的混合物或醚化合物，四氯化钛和酯化合物的混合物连续处理所述处理的固体，（B）有机铝化合物和（C）电子给体化合物，以及使用该催化剂生产α-烯烃聚合物的方法。

15. 发明授权

US6140321A Polymorphs of donepezil hydrochloride and process for production 失效
标题翻译：盐酸多奈哌齐的多晶型物及其制备方法
公开(公告)号：US6140321A
公开(公告)日：2000-10-31
申请号：US774802
申请日：1996-12-30
申请人： Akio Imai , Hideaki Watanabe , Takashi Kajima , Yasushi Ishihama , Akiyo Ohtsuka , Tomohide Tanaka
发明人： Akio Imai , Hideaki Watanabe , Takashi Kajima , Yasushi Ishihama , Akiyo Ohtsuka , Tomohide Tanaka
IPC分类号： C07D211/32 , A61K31/445 , A61P25/28 , A61P43/00 , B01D9/02 , A01N43/46 , A01N43/36 , C07D211/20 , C07D223/00
CPC分类号： C07D211/32
摘要： Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.
摘要翻译：盐酸多奈哌齐，1-苄基-4 - [（5,6-二甲氧基-1-茚满酮）-2-基]甲基哌啶盐酸盐，以药物用途中耐热和湿气稳定的四种多晶型物的形式提供。他们可以在工业上生产。它们由X射线粉末衍射图中的峰和溴化钾红外吸收光谱中的吸收峰指定。

16. 发明授权

US6066704A Transition metal complex, catalyst for olefin polymerization, and process for producing olefin polymers 失效
标题翻译：过渡金属络合物，用于烯烃聚合的催化剂，以及用于生产烯烃聚合物的方法
公开(公告)号：US6066704A
公开(公告)日：2000-05-23
申请号：US29887
申请日：1998-06-26
申请人： Hiroaki Katayama , Akio Imai , Hidenori Hanaoka , Norio Kawamura , Akira Miyashita
发明人： Hiroaki Katayama , Akio Imai , Hidenori Hanaoka , Norio Kawamura , Akira Miyashita
IPC分类号： C07F9/53 , C07F17/00 , C08F4/642 , C08F4/646 , C08F4/659 , C08F4/6592 , C08F10/00 , C08F210/16 , C08F4/44 , B01J31/00 , B01J37/00 , C07F7/00 , C07F7/28
CPC分类号： C07F17/00 , C07F9/532 , C08F10/00 , C08F210/16 , C08F4/65908 , C08F4/65912 , C08F4/6592 , Y10S526/943
摘要： A transition metal complex represented by the formula [1] ##STR1## wherein M is a transition metal atom of the group 4 of the periodic table of elements; Cp is a group having a cyclopentadiene type anionic skeleton; A and G are each a divalent residue containing an atom of the group 15 or 16 of the periodic table of elements and may be the same with or different from each other; X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently a hydrogen atom, halogen atom, alkyl group with the number of carbon atoms of 1-20 optionally substituted with at least one halogen atom, aralkyl group with the number of carbon atoms of 7-20 optionally substituted with at least one halogen atom, aryl group with the number of carbon atoms of 6-20 optionally substituted with at least one halogen atom, substituted silyl group with the number of carbon atoms of 1-20 optionally substituted with at least one halogen atom, alkoxy group with the number of carbon atoms of 1-20 optionally substituted with at least one halogen atom, aralkyloxy group with the number of carbon atoms of 7-20 optionally substituted with at least one halogen atom, aryloxy group with the number of carbon atoms of 6-20 optionally substituted with at least one halogen atom or a di-substituted amino group with the number of carbon atoms of 2-20, provided that R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may optionally combine with each other to form a ring; L is a Lewis base and w is an integer of 0-2, an olefin polymerization catalyst and a process for producing olefin polymers which uses the catalyst.
摘要翻译： PCT No.PCT / JP96 / 02439 Sec。 371日期：1998年6月26日 102（e）日期1998年6月26日PCT 1996年8月30日PCT PCT。公开号WO97 / 08179 日期：1997年3月6日由式[1]表示的过渡金属络合物，其中M是元素周期表第4族的过渡金属原子; Cp是具有环戊二烯型阴离子骨架的基团; A和G各自是含有元素周期表第15或16族的原子的二价残基，并且可以彼此相同或不同; X1，X2，R1，R2，R3和R4各自独立地为氢原子，卤素原子，任选被至少一个卤素原子取代的碳原子数为1-20的烷基，具有碳原子数的芳烷基任选被至少一个卤素原子取代的，任选被至少一个卤素原子取代的碳原子数为6-20的芳基，任选被至少一个卤素原子取代的碳原子数为1-20的取代甲硅烷基，任选被至少一个卤素原子，任选被至少一个卤素原子取代的碳原子数为1-20的烷氧基，任选被至少一个卤素原子取代的碳原子数为7-20的芳烷氧基，芳氧基碳原子数为6-20个，任选被至少一个卤素原子取代或碳原子数为2-20的二取代氨基，条件是R1，R2，R3和R4可以任选地与每个其他形式戒指; L是路易斯碱，w是0-2的整数，烯烃聚合催化剂和使用该催化剂的烯烃聚合物的制造方法。

17. 发明授权

US5985864A Polymorphs of donepezil hydrochloride and process for production 失效
公开(公告)号：US5985864A
公开(公告)日：1999-11-16
申请号：US870394
申请日：1997-06-06
申请人： Akio Imai , Hideaki Watanabe , Takashi Kajima , Yasushi Ishihama , Akiyo Ohtsuka , Tomohide Tanaka , Yukio Narabu
发明人： Akio Imai , Hideaki Watanabe , Takashi Kajima , Yasushi Ishihama , Akiyo Ohtsuka , Tomohide Tanaka , Yukio Narabu
IPC分类号： C07D211/32 , A01N43/40 , A01N43/46 , C07D207/00 , C07D211/20
CPC分类号： C07D211/32
摘要： Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.

18. 发明授权

US5608018A .alpha.-olefin polymerization catalyst system and process for producing .alpha.-olefin catalyst 失效
标题翻译： α-烯烃聚合催化剂体系和α-烯烃催化剂生产方法
公开(公告)号：US5608018A
公开(公告)日：1997-03-04
申请号：US350158
申请日：1994-11-30
申请人： Takeshi Ebara , Teruyosi Kiyota , Akio Imai
发明人： Takeshi Ebara , Teruyosi Kiyota , Akio Imai
IPC分类号： C08F4/654 , C08F4/656 , C08F10/00 , C08F4/651
CPC分类号： C08F10/00
摘要： An .alpha.-olefin polymerization catalyst system having so high a catalytic activity and stereoregularity that the catalyst residue and amorphous polymer need not be removed and a process for producing an.alpha.-olefin polymer using the catalyst system, said catalyst system consisting essentially of:(A) a trivalent titanium compound-containing solid catalyst component prepared by reducing a titanium compound, represented by the general formula Ti(OR.sup.1).sub.a X.sub.4-a in which R.sup.1 represents a hydrocarbon group having 1 to 20 carbon atoms; X represents a halogen atom; and a represents a numeral satisfying 0
摘要翻译：具有如此高的催化活性和立构规整性的催化剂残余物和无定形聚合物不需要除去的α-烯烃聚合催化剂体系和使用该催化剂体系生产α-烯烃聚合物的方法，所述催化剂体系基本上由以下组成：（A ）通过还原由通式Ti（OR 1）a X 4-a表示的钛化合物制备的含三价钛化合物的固体催化剂组分，其中R 1表示具有1至20个碳原子的烃基; X表示卤原子; 和a表示满足0

19. 发明授权

US5191041A Catalyst for olefinic hydrocarbon polymerization and process and producing olefinic hydrocarbon polymer 失效
标题翻译：用于烯烃聚合的催化剂和制备和生产烯烃聚合物
公开(公告)号：US5191041A
公开(公告)日：1993-03-02
申请号：US821037
申请日：1992-01-16
申请人： Hayato Saba , Keisaku Yamamoto , Akio Imai , Kiyoyuki Sugimori , Kizuku Wakatsuki
发明人： Hayato Saba , Keisaku Yamamoto , Akio Imai , Kiyoyuki Sugimori , Kizuku Wakatsuki
IPC分类号： C08F10/00
CPC分类号： C08F10/00
摘要： An inert hydrocarbon solvent-soluble catalyst for polymerization of olefinic hydrocarbons and a process for producing an olefinic polymer using the same are disclosed, the catalyst being composed of (A) a reaction product obtained by reacting (a) at least one vanadium compound represented by formula:VO(OR).sub.m X.sub.3-mwherein R represents a hydrocarbon group; X represents a halogen atom; and m represents a real number of from 0 to 3, and (b) a dihydroxy hydrocarbon compound constituted of a straight chain hydrocarbon skeleton containing from 2 to 12 carbon atoms and having a hydroxyl group at each of both terminals thereof and at least one hydrocarbon branch bonded to said hydrocarbon skeleton in an inert hydrocarbon solvent at an (a) to (b) molar ratio of from 1:0.5 to 1:1.4 and (B) at least one organoaluminum compound represented by formula:R'.sub.n AlX'.sub.3-nwherein R' represents a hydrocarbon group; X' represents a halogen atom; and n represents a real number more than 0 and less than 3. Olefinic hydrocarbon polymers having narrow distributions of molecular weight and composition can be produced with high efficiency and high polymerization activity without being accompanied by obstruction or contamination of equipment due to precipitation of a catalyst.
摘要翻译：公开了一种用于烯烃聚合的惰性烃溶剂可溶性催化剂和使用其的制备烯烃聚合物的方法，该催化剂由（A）通过使（a）至少一种钒化合物式：VO（OR）mX3-m其中R表示烃基; X表示卤原子; m表示0〜3的实数，（b）由含有2〜12个碳原子的直链烃骨架构成的二羟基烃化合物，其两末端具有羟基，至少一个烃在（a）至（b）摩尔比为1:0.5至1:1.4的惰性烃溶剂中与所述烃骨架键合的至少一种有机铝化合物，和（B）至少一种由式：R'nAlX'3- n其中R'表示烃基; X'表示卤原子; 并且n表示大于0且小于3的实数。可以以高效率和高聚合活性生产具有窄分子量和组成分布的烯属烃聚合物，而不伴随催化剂沉淀引起的设备阻塞或污染。

20. 发明授权

US5037891A Modified ethylene-.alpha.-olefin copolymer rubber and a process for producing the same 失效
标题翻译：改性乙烯-α-烯烃共聚橡胶及其制备方法
公开(公告)号：US5037891A
公开(公告)日：1991-08-06
申请号：US353756
申请日：1989-05-18
申请人： Hiroyoshi Takao , Akio Imai , Mitsuji Tsuji
发明人： Hiroyoshi Takao , Akio Imai , Mitsuji Tsuji
IPC分类号： C08F255/04 , C08F255/02 , C08F255/06
CPC分类号： C08F255/02
摘要： A modified copolymer rubber obtained by kneading at 200.degree.-280.degree. C.(A) at least one copolymer rubber material selected from the group consisting of an ethylene-.alpha.-olefin copolymer rubber having a number-average molecular weight of 10,000-100,000 and an ethylene content of 15-85% by weight and an ethylene-.alpha.-olefin-nonconjugated diene copolymer rubber having a number-average molecular weight of 10,000-100,000, an ethylene content of 15-85% by weight and a nonconjugated diene content of 3.0% by weight or less,(B) a free-radical initiator,(C) at least one vinyl aromatic monomer and(D) an unsaturated dicarboxylic anhydride, wherein the weight ratios of (B):(A), (C):(A), (D):(A) and (C):(D) are 0.005-1.0:100, 0.2-20:100, 0.5-15:100 and 0.1-3:1, respectively.The process is suited for industrially producing a modified copolymer rubber having a high bound unsaturated dicarboxylic anhydride content, a low tendency of increase of the Mooney viscosity [ML.sub.1+4 (121.degree. C.)], and an excellent moldability and storage stability without being obstructed by gel formation during the kneading. The modified copolymer rubber thus obtained can be advantageously used for thermoplastic elastomer, blending polymer adhesive etc.
摘要翻译：通过在200〜280℃下捏合得到的改性共聚物橡胶（A）至少一种选自数均分子量为10,000-100,000的乙烯-α-烯烃共聚物橡胶和乙烯含量为15-85％（重量），乙烯-α-烯烃 - 非共轭二烯共聚物橡胶的数均分子量为10,000-100,000，乙烯含量为15-85％（重量），非共轭二烯含量为 3.0重量％以下，（B）自由基引发剂，（C）至少一种乙烯基芳族单体和（D）不饱和二羧酸酐，其中（B）:( A），（C）：（A），（D）：（A）和（C）:( D）分别为0.005-1.0:100,0.2-20:100,0.5-15:100和0.1-3:1。该方法适用于工业生产具有高结合不饱和二羧酸酐含量的改性共聚物橡胶，门尼粘度[ML1 + 4（121℃）]增加的趋势低，并且具有优异的成型性和储存稳定性，而不会在捏合期间被凝胶形成阻碍。由此获得的改性共聚物橡胶可有利地用于热塑性弹性体，共混聚合物粘合剂等。

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