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11. 发明申请

US20110218644A1 DRUG DELIVERY AND DIAGNOSTIC SYSTEM FOR ORTHOPEDIC IMPLANTS 有权
标题翻译：用于正交植入物的药物递送和诊断系统
公开(公告)号：US20110218644A1
公开(公告)日：2011-09-08
申请号：US13039362
申请日：2011-03-03
申请人： Jason Meridew , Mukesh Kumar , Tayler E. Kreider
发明人： Jason Meridew , Mukesh Kumar , Tayler E. Kreider
IPC分类号： A61M25/04 , A61F2/36
CPC分类号： A61M5/14 , A61F2/34 , A61F2/3662 , A61F2/389 , A61F2002/3068 , A61F2002/368 , A61F2002/3694 , A61M5/14276 , A61M39/0208 , A61M2205/3523 , A61M2210/086
摘要： A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
摘要翻译：药物递送和诊断系统可以包括具有外部附接表面的矫形植入物。管道可以联接到外部附接表面。导管可以具有沿其长度形成的入口和多个穿孔。导管可适于在入口和穿孔之间传递流体。皮下端口可以流体地联接到入口，并且适于沿着导管和通过整形外科植入物的外部附接表面的穿孔穿过入口传送流体。

12. 发明申请

US20110052601A1 COMPOSITIONS COMPRISING ANTI-ICAM-1 ANTIBODIES 审中-公开
标题翻译：包含抗ICAM-1抗体的组合物
公开(公告)号：US20110052601A1
公开(公告)日：2011-03-03
申请号：US12390246
申请日：2009-02-20
申请人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
发明人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
IPC分类号： A61K39/42 , A61P11/00 , A61P31/12
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2320/32
摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.
摘要翻译：提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

13. 发明申请

US20100100191A1 Tibial Tray Having a Reinforcing Member 审中-公开
标题翻译：胫骨托具有加强构件
公开(公告)号：US20100100191A1
公开(公告)日：2010-04-22
申请号：US12579479
申请日：2009-10-15
申请人： Brian M. May , Mukesh Kumar
发明人： Brian M. May , Mukesh Kumar
IPC分类号： A61F2/38 , A61B17/56
CPC分类号： A61F2/389 , A61F2/30767 , A61F2/30965 , A61F2002/30769 , A61F2002/30879 , A61F2002/30881 , A61F2002/30883 , A61F2002/30884 , A61F2002/3092 , A61F2240/001 , A61F2310/00023 , A61F2310/00179
摘要： A knee joint prosthesis can include a tibial component that can have a tibial tray. The tibial tray can include a platform-like tray that defines a superior surface and an inferior surface. The platform-like tray can have a tray perimeter and a raised wall formed on the inferior surface. The raised wall can be offset inboard relative to the tray perimeter. Porous material can be disposed on the inferior surface of the platform-like tray at a location generally between the raised wall and the tray perimeter.
摘要翻译：膝关节假体可以包括可具有胫骨托的胫骨部件。胫骨托可包括限定上表面和下表面的平台状托盘。平台状托盘可以具有托盘周边和形成在下表面上的凸起壁。凸起的壁可以相对于托盘周边在内侧偏移。多孔材料可以在通常在凸起壁和托盘周边之间的位置处设置在平台状托盘的下表面上。

14. 发明授权

US07699987B2 Stabilized formulation 失效
标题翻译：稳定配方
公开(公告)号：US07699987B2
公开(公告)日：2010-04-20
申请号：US11449476
申请日：2006-06-08
申请人： Anand C. Burman , Rama Mukherjee , Dinesh Kumar , Dhiraj Khattar , Mukesh Kumar , Praveen Khullar , Perundurai S. Srinivasan , Rajesh Srivastava
发明人： Anand C. Burman , Rama Mukherjee , Dinesh Kumar , Dhiraj Khattar , Mukesh Kumar , Praveen Khullar , Perundurai S. Srinivasan , Rajesh Srivastava
IPC分类号： B01D15/08
CPC分类号： C07D305/14 , A61K47/44 , B01D15/325 , B01J20/287
摘要： A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.
摘要翻译：公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其也含有适于人类给药的任何其它合适的增溶剂如脱水醇。使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

15. 发明申请

US20070196230A1 Method and apparatus for forming porous metal implants 有权
标题翻译：用于形成多孔金属植入物的方法和设备
公开(公告)号：US20070196230A1
公开(公告)日：2007-08-23
申请号：US11357929
申请日：2006-02-17
申请人： Ned Hamman , J. Fleming , Elizabeth Schleuter , Isaac Janson , Jason Meridew , Mukesh Kumar
发明人： Ned Hamman , J. Fleming , Elizabeth Schleuter , Isaac Janson , Jason Meridew , Mukesh Kumar
IPC分类号： B22F3/11
CPC分类号： C09C1/00 , A61F2/30767 , A61F2/30907 , A61F2/34 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2002/30011 , A61F2002/30064 , A61F2002/30166 , A61F2002/30169 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30383 , A61F2002/30451 , A61F2002/30454 , A61F2002/30604 , A61F2002/30736 , A61F2002/30827 , A61F2002/30878 , A61F2002/3092 , A61F2002/30968 , A61F2002/3411 , A61F2220/0025 , A61F2220/0058 , A61F2230/0028 , A61F2230/0047 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0023 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00131 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097 , A61F2310/00976 , A61K35/12 , A61L27/04 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/406 , A61L2300/414 , A61L2300/428 , A61L2300/606 , A61L2300/64 , B22F3/1125 , B22F2001/0066 , B22F2998/10 , C01P2004/61 , B22F1/0059 , B22F3/04 , B22F3/02 , B22F3/1021 , B22F3/1216
摘要： A method for providing a porous metal implant. A mixture of a biocompatible metal, a spacing agent, and a binder is provided. The mixture is formed into a shaped the spacing agent is removed to form a plurality of pores in the implant. A shaped porous metal implant is also provided.
摘要翻译：一种用于提供多孔金属植入物的方法。提供生物相容性金属，间隔剂和粘合剂的混合物。将混合物形成为成形物，去除间隔剂以在植入物中形成多个孔。还提供了一种成形的多孔金属植入物。

16. 发明申请

US20060280803A1 Method and apparatus for repairing bone 有权
标题翻译：骨修复方法及装置
公开(公告)号：US20060280803A1
公开(公告)日：2006-12-14
申请号：US11407409
申请日：2006-04-19
申请人： Mukesh Kumar , Ned Hamman , Michael Leach , John Manocchio , Paul D'Antonio , Daryl Carter
发明人： Mukesh Kumar , Ned Hamman , Michael Leach , John Manocchio , Paul D'Antonio , Daryl Carter
IPC分类号： A61K35/32
CPC分类号： A61L27/365 , A61L27/3608 , A61L27/3683 , A61L27/3691 , A61L2430/02 , A61M5/204 , A61M5/3129
摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.
摘要翻译：用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。提供了几种用于水合形成的骨组合物的装置。还提供了水合形成的骨组合物的方法。

17. 发明申请

US20060037894A1 Particle filter for fuel cell coolant 有权
标题翻译：燃料电池冷却液颗粒过滤器
公开(公告)号：US20060037894A1
公开(公告)日：2006-02-23
申请号：US10922610
申请日：2004-08-19
申请人： Mukesh Kumar , Stephen Fan , George Shih
发明人： Mukesh Kumar , Stephen Fan , George Shih
IPC分类号： B01D35/143
CPC分类号： B01D46/2411 , B01D39/12 , B01D46/0086 , B01D2275/201 , H01M8/04044
摘要： A particle filter for a fuel cell coolant is disclosed. The particle filter includes a filter housing having an upstream end for receiving the coolant and a downstream end for discharging the coolant. A filter element is provided in the filter housing. A pressure gauge is operably connected to the upstream end of the filter housing for measuring and indicating a pressure of the coolant corresponding to a degree of blockage of the filter element.
摘要翻译：公开了一种用于燃料电池冷却剂的颗粒过滤器。颗粒过滤器包括具有用于接收冷却剂的上游端和用于排出冷却剂的下游端的过滤器壳体。过滤器壳体中设置过滤元件。压力计可操作地连接到过滤器壳体的上游端，用于测量和指示对应于过滤元件的堵塞程度的冷却剂的压力。

18. 发明申请

US20050141537A1 Auto-learning of MAC addresses and lexicographic lookup of hardware database 审中-公开
标题翻译： MAC地址的自学习和硬件数据库的词典查询
公开(公告)号：US20050141537A1
公开(公告)日：2005-06-30
申请号：US10747332
申请日：2003-12-29
申请人： Mukesh Kumar , Kavitha Prasad
发明人： Mukesh Kumar , Kavitha Prasad
IPC分类号： H04L12/24 , H04L12/28 , H04L12/46 , H04L29/12
CPC分类号： H04L29/12839 , H04L12/4641 , H04L29/12009 , H04L41/12 , H04L45/7453 , H04L61/6022
摘要： Ethernet systems and methods for auto-learning of MAC addresses and lexicographic lookup of hardware databases are disclosed. An Ethernet network device generally includes a hardware MAC address database containing MAC address entries and a hardware MAC address learning engine in communication with the hardware MAC address database and configured to receive an unresolved source MAC address to be learned and to record the unresolved source MAC address in the hardware MAC address database in a corresponding MAC address entry. The Ethernet network device may also include a hardware lexicographic lookup engine configured to perform hardware lookups of MAC address entries in the hardware MAC address database and to interface with a management application program interface (API) for management of the Ethernet network device.
摘要翻译：公开了用于MAC地址的自学习和硬件数据库的字典查询的以太网系统和方法。以太网网络设备通常包括包含MAC地址条目的硬件MAC地址数据库和与硬件MAC地址数据库通信的硬件MAC地址学习引擎，并被配置为接收待解析的源MAC地址并记录未解决的源MAC地址在硬件MAC地址数据库中相应的MAC地址表项。以太网网络设备还可以包括配置为执行硬件MAC地址数据库中的MAC地址条目的硬件查找并与用于管理以太网网络设备的管理应用程序接口（API）的接口的硬件词典查找引擎。

19. 发明申请

US20050049291A1 Process for the preparation of pharmaceutical compositions for topical delivery of cyclooxygenase-2-enzyme inhibitors 审中-公开
标题翻译：用于制备用于局部递送环加氧酶-2-酶抑制剂的药物组合物的方法
公开(公告)号：US20050049291A1
公开(公告)日：2005-03-03
申请号：US10493457
申请日：2002-10-23
申请人： Mukesh Kumar , Ajay Singla , Shirumalla Kumar , Vinod Arora , Rajiy Malik
发明人： Mukesh Kumar , Ajay Singla , Shirumalla Kumar , Vinod Arora , Rajiy Malik
IPC分类号： A61K9/00 , A61K31/00 , A61K31/365 , A61K31/635 , A61K47/00 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , A61K31/415 , A61K9/14
CPC分类号： A61K9/0014 , A61K31/00 , A61K31/365 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44
摘要： A present invention relates to a pharmaceutical composition for topical delivery comprising a pharmaceutically effective amount of drug(s), that acts selectively as a cyclooxygenase-2 enzyme inhibitor. The composition provides better percutaneous absorption and enhanced efficacy.
摘要翻译：本发明涉及用于局部递送的药物组合物，其包含药学上有效量的药物，其选择性地作为环加氧酶-2酶抑制剂起作用。该组合物提供更好的经皮吸收和增强的功效。

20. 发明申请

US20050016926A1 Stabilized formulation 审中-公开
标题翻译：稳定配方
公开(公告)号：US20050016926A1
公开(公告)日：2005-01-27
申请号：US10626501
申请日：2003-07-24
申请人： Anand Burman , Rama Mukherjee , Dinesh Kumar , Dhiraj Khattar , Mukesh Kumar , Praveen Khullar , Perundurai Srinivasan , Rajesh Srivastava
发明人： Anand Burman , Rama Mukherjee , Dinesh Kumar , Dhiraj Khattar , Mukesh Kumar , Praveen Khullar , Perundurai Srinivasan , Rajesh Srivastava
IPC分类号： A61K47/44 , B01D15/08 , B01D15/32
CPC分类号： C07D305/14 , A61K47/44 , B01D15/325 , B01J20/287
摘要： A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.
摘要翻译：公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其也含有适于人类给药的任何其它合适的增溶剂如脱水醇。使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

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