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11. 发明申请

US20150216942A1 NANOPARTICLE-INSULIN AND INSULIN ANALOGUE COMPOSITIONS 有权
标题翻译：纳米胰岛素和胰岛素类似物组合物
公开(公告)号：US20150216942A1
公开(公告)日：2015-08-06
申请号：US14608343
申请日：2015-01-29
申请人： Midatech Limited
发明人： Thomas Rademacher , Jan Mous
IPC分类号： A61K38/28 , B65D25/20 , A61J1/00 , A61K9/14
CPC分类号： A61K38/28 , A61J1/00 , A61K9/143 , A61K9/146 , A61K47/26 , A61K47/48861 , A61K47/48884 , A61K47/6923 , A61K47/6929 , B65D25/205
摘要： The present invention relates to insulin- and insulin analogue-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analogue, such as a rapidly-acting insulin analogue. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analogue, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analogue peptide that is non-covalently bound to the corona.
摘要翻译：本发明涉及与游离胰岛素或胰岛素类似物如快速作用的胰岛素类似物一起配制或用于胰岛素和胰岛素类似物的纳米颗粒。本发明的组合物可用于药物中，特别是在血糖控制中。用于控制糖尿病患者的血糖水平。与游离胰岛素或胰岛素类似物一起配制或与胰岛素类似物一起使用的本发明的纳米颗粒组合物包含包含金属和/或半导体的芯的纳米颗粒; 和包含共价连接到所述核的多个配体的电晕，其中所述多个配体包含至少一个碳水化合物部分; 和至少一种与电晕非共价结合的胰岛素肽和/或胰岛素类似物肽。

12. 发明申请

US20140248365A1 NANOPARTICLE PEPTIDE COMPOSITIONS 审中-公开
标题翻译：纳米胶囊组合物
公开(公告)号：US20140248365A1
公开(公告)日：2014-09-04
申请号：US14174221
申请日：2014-02-06
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： A61K9/14 , A61K38/29
CPC分类号： A61K9/146 , A61K38/29 , A61K47/6923 , A61K47/6929
摘要： The present invention relates to teriparatide peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of bone density. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one glutathione; and at least one teriparatide peptide that is non-covalently bound to the corona.
摘要翻译：本发明涉及特异性肽载带的纳米颗粒，特别是用于医学中，并且包括用于治疗诸如骨密度的病症的方法。纳米颗粒组合物包含纳米颗粒，其包含包含金属和/或半导体的芯; 和包含共价连接到所述核的多个配体的电晕，其中所述多个配体包含至少一种谷胱甘肽; 和至少一种与电晕非共价结合的特立帕肽肽。

13. 发明申请

US20140227186A1 NANOPARTICLE DELIVERY COMPOSITIONS 审中-公开
标题翻译：纳米粒子输送组合物
公开(公告)号：US20140227186A1
公开(公告)日：2014-08-14
申请号：US14175422
申请日：2014-02-07
申请人： Midatech Limited
发明人： Thomas Rademacher , David K. Male
IPC分类号： A61K9/51 , A61K38/17 , A61K39/395 , A61K49/18
CPC分类号： A61K9/5123 , A61K9/0009 , A61K9/5115 , A61K9/5192 , A61K38/1709 , A61K39/3955 , A61K49/1824 , B82Y5/00 , Y10S977/773 , Y10S977/788 , Y10S977/81 , Y10S977/906 , Y10S977/93
摘要： Nanoparticle delivery systems for use in targeting biologically active agents to the central nervous system comprise a composition comprising (a) a nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise a carbohydrate, insulin and/or a glutathione; and (b) the at least one agent to be delivered to the CNS. Methods of treatment and diagnosing CNS disorders utilising the nanoparticle delivery systems and related screening methods are also disclosed.
摘要翻译：用于将生物活性剂靶向中枢神经系统的纳米颗粒递送系统包括组合物，其包含（a）纳米颗粒，其包含：（i）包含金属和/或半导体的芯; 和（ii）包含多个与核共价连接的配体的电晕，其中所述配体包含碳水化合物，胰岛素和/或谷胱甘肽; 和（b）至少一个待递送至CNS的药剂。还公开了使用纳米颗粒递送系统和相关筛选方法治疗和诊断中枢神经系统疾病的方法。

14. 发明申请

US20140220135A1 PERMEATION ENHANCED ACTIVE-CARRYING NANOPARTICLES 审中-公开
标题翻译：渗透增强活性载体纳米颗粒
公开(公告)号：US20140220135A1
公开(公告)日：2014-08-07
申请号：US14172165
申请日：2014-02-04
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： A61K47/48
CPC分类号： A61K47/549 , A61K9/143 , A61K9/145 , A61K9/5115 , A61K47/6923 , B82Y5/00
摘要： Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein an active agent and a permeation enhancer are bound to or associated with the nanoparticles.
摘要翻译：纳米颗粒具有与芯共价连接的配体的核心和电晕，其中活性剂和渗透增强剂与纳米颗粒结合或结合。

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