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11. 发明授权

US07569544B2 Methods of increasing delivery of active agents to brain comprising administering receptor associated protein (RAP) fragments conjugated to active agents 有权
标题翻译：增加活性剂向脑的递送的方法，包括施用与活性剂缀合的受体相关蛋白（RAP）片段
公开(公告)号：US07569544B2
公开(公告)日：2009-08-04
申请号：US10812849
申请日：2004-03-30
申请人： Todd Zankel , Christopher M. Starr
发明人： Todd Zankel , Christopher M. Starr
IPC分类号： A61K38/18 , C07K19/00 , C07K14/435 , C07K14/48 , C07K14/485 , C07K14/50
CPC分类号： C07K14/705 , A61K38/00 , A61K47/64 , C07K2319/00 , C07K2319/22 , C07K2319/23
摘要： The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
摘要翻译：本发明涉及受体介导的药物递送的方法和组合物，特别是跨血脑屏障。

12. 发明授权

US5672881A Charge-coupled device imaging apparatus 失效
标题翻译：电荷耦合器件成像装置
公开(公告)号：US5672881A
公开(公告)日：1997-09-30
申请号：US612195
申请日：1996-03-06
申请人： Steven K. Striepeke , Peter Edridge , Christopher M. Starr , John C. Klock
发明人： Steven K. Striepeke , Peter Edridge , Christopher M. Starr , John C. Klock
IPC分类号： G01N21/64
CPC分类号： G01N21/6456
摘要： An apparatus for fluorescence of a biological sample includes a light illumination source, an ambient light-excluding optical chamber, a sample holder, a two-dimensional array charge coupled device ("CCD") sensor providing for on-chip signal integration of each pixel of the array, and an analog/digital converter for digitizing the CCD signal. Signal acquisition time from the array is varied so that the integrated signal from each pixel is below its saturation level. A darkfield value for each pixel is acquired and subtracted from the illuminated signal from that pixel so as to yield a darkfield corrected signal. The fluorescence value for each pixel can be compensated for variations in excitation energy reaching different sample areas. Image readout is through a single channel output.
摘要翻译：用于生物样品的荧光的装置包括光照射源，环境光排除光学室，样品架，二维阵列电荷耦合器件（“CCD”）传感器，用于提供每个像素的片上信号积分的阵列，以及用于数字化CCD信号的模拟/数字转换器。来自阵列的信号采集时间是变化的，使得来自每个像素的积分信号低于其饱和水平。获取每个像素的暗场值，并从该像素的照明信号中减去暗场值，以产生暗场校正信号。每个像素的荧光值可以补偿到不同样品区域的激发能量的变化。图像读出是通过单通道输出。

13. 发明授权

US08546319B2 Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes 有权
标题翻译：使用p97作为递送治疗性溶酶体酶的酶递送系统
公开(公告)号：US08546319B2
公开(公告)日：2013-10-01
申请号：US12729792
申请日：2010-03-23
申请人： Christopher M. Starr , Todd Zankel
发明人： Christopher M. Starr , Todd Zankel
IPC分类号： C07K14/00 , C12N9/00
CPC分类号： A61K47/64 , A61K38/465 , A61K38/47 , C12Y302/01076 , G01N33/5008 , G01N33/5035 , G01N33/5058 , G01N33/566 , A61K2300/00
摘要： The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
摘要翻译：本发明提供了通过向患有溶酶体储存疾病的患者施用与能够转运到细胞的溶酶体中的P97缀合的P97来治疗，改善或预防溶酶体贮积病的组合物和方法血脑屏障。

14. 发明授权

US08440629B2 Cyclic receptor-associated protein (RAP) peptides 有权
标题翻译：环状受体相关蛋白（RAP）肽
公开(公告)号：US08440629B2
公开(公告)日：2013-05-14
申请号：US12600786
申请日：2008-03-21
申请人： Christopher M. Starr , Todd C. Zankel
发明人： Christopher M. Starr , Todd C. Zankel
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes.
摘要翻译：本发明一般涉及低密度脂蛋白受体相关蛋白（RAP）的受体选择性变体及其组合物，产生这种变体的方法和使用这种受体选择性RAP变体组合物用于治疗目的的方法。

15. 发明申请

US20100303797A1 Use of p97 As An Enzyme Delivery System For The Delivery of Therapeutic Lysosomal Enzymes 有权
标题翻译：使用p97作为递送治疗性溶酶体酶的酶递送系统
公开(公告)号：US20100303797A1
公开(公告)日：2010-12-02
申请号：US12729792
申请日：2010-03-23
申请人： Christopher M. Starr , Todd Zankel
发明人： Christopher M. Starr , Todd Zankel
IPC分类号： A61K38/47 , A61K38/46 , A61P3/00 , C12Q1/02 , C12N9/96 , A61K38/00 , C07K14/00
CPC分类号： A61K47/64 , A61K38/465 , A61K38/47 , C12Y302/01076 , G01N33/5008 , G01N33/5035 , G01N33/5058 , G01N33/566 , A61K2300/00
摘要： The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
摘要翻译：本发明提供了通过向患有溶酶体储存疾病的患者施用与能够转运到细胞的溶酶体中的P97缀合的P97来治疗，改善或预防溶酶体贮积病的组合物和方法血脑屏障。

16. 发明申请

US20100210517A1 CYCLIC RECEPTOR-ASSOCIATED PROTEIN (RAP) PEPTIDES 有权
标题翻译：周期性受体相关蛋白（RAP）PEPTIDES
公开(公告)号：US20100210517A1
公开(公告)日：2010-08-19
申请号：US12600786
申请日：2008-03-21
申请人： Christopher M. Starr , Todd C. Zankel
发明人： Christopher M. Starr , Todd C. Zankel
IPC分类号： C07K14/705 , A61K38/17 , A61P25/00 , A61P25/28 , A61P35/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes.
摘要翻译：本发明一般涉及低密度脂蛋白受体相关蛋白（RAP）的受体选择性变体及其组合物，产生这些变体的方法和使用这种受体选择性RAP变体组合物用于治疗目的的方法。

17. 发明申请

US20100028370A1 MEGALIN-BASED DELIVERY OF THERAPEUTIC COMPOUNDS TO THE BRAIN AND OTHER TISSUES 有权
标题翻译：基于马盖林的治疗化合物向脑和其他组织的递送
公开(公告)号：US20100028370A1
公开(公告)日：2010-02-04
申请号：US12508956
申请日：2009-07-24
申请人： TODD ZANKEL , Christopher M. Starr
发明人： TODD ZANKEL , Christopher M. Starr
IPC分类号： A61K39/395 , C07K16/00 , A61P25/00
CPC分类号： C07K14/705 , A61K38/00 , A61K47/64 , C07K2319/00 , C07K2319/22 , C07K2319/23
摘要： The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
摘要翻译：本发明涉及受体介导的药物递送的方法和组合物，特别是跨血脑屏障。

18. 发明申请

US20090269346A1 Compositions Comprising Receptor-Associated Protein (RAP) Variants Specific for LRP2 and Uses Thereof 有权
标题翻译：包含LRP2特异性的受体相关蛋白（RAP）变体及其用途的组合物
公开(公告)号：US20090269346A1
公开(公告)日：2009-10-29
申请号：US11576506
申请日：2006-06-14
申请人： Christopher M. Starr , Todd C. Zankel
发明人： Christopher M. Starr , Todd C. Zankel
IPC分类号： A61K39/395 , C07K14/47 , C07K16/18 , A61K38/17 , C07H21/00 , G01N33/566
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes. The invention also relates to antibodies that bind to one or a small subset of CR-containing proteins.
摘要翻译：本发明一般涉及低密度脂蛋白受体相关蛋白（RAP）的受体选择性变体及其组合物，产生这些变体的方法和使用这种受体选择性RAP变体组合物用于治疗目的的方法。本发明还涉及结合至含有CR的蛋白质的一个或一小组的抗体。

19. 发明授权

US09062126B2 Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof 有权
标题翻译：包含对含CR蛋白特异的受体相关蛋白（RAP）变体的组合物及其用途
公开(公告)号：US09062126B2
公开(公告)日：2015-06-23
申请号：US11576502
申请日：2006-09-18
申请人： Todd C. Zankel , Christopher M. Starr
发明人： Todd C. Zankel , Christopher M. Starr
IPC分类号： A61K38/16 , A61K47/42 , C07K14/47 , C07K14/705 , A61K47/48 , A61K38/17
CPC分类号： C07K14/705 , A61K38/00 , A61K38/1709 , A61K47/64 , C07K14/47
摘要： The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes.
摘要翻译：本发明一般涉及低密度脂蛋白受体相关蛋白（RAP）的受体选择性变体及其组合物，产生这种变体的方法和使用这种受体选择性RAP变体组合物用于治疗目的的方法。

20. 发明申请

US20120251444A1 TREATMENT OF LIVER DISORDERS BY ADMINISTRATION OF RAP CONJUGATES 有权
标题翻译：通过治疗RAP并发症治疗肝脏疾病
公开(公告)号：US20120251444A1
公开(公告)日：2012-10-04
申请号：US12441618
申请日：2007-09-18
申请人： Christopher M. Starr , Todd C. Zankel
发明人： Christopher M. Starr , Todd C. Zankel
IPC分类号： A61K38/17 , A61P31/12 , A61P31/10 , A61P35/04 , A61P1/16 , A61P31/04 , A61P33/00 , A61P37/06 , A61K51/08 , A61P35/00
CPC分类号： A61K38/17 , A61K31/704 , A61K31/715 , A61K33/24 , A61K38/168 , A61K38/177 , A61K39/395 , A61K45/06 , A61K47/64 , A61N5/1001 , C07K14/705 , Y02A50/403 , A61K2300/00
摘要： The present invention relates to the use of receptor-associate protein (RAP) and fragments and variants thereof to improve delivery of therapeutic compounds to the liver and provides methods to treat liver disorders and conditions, such as hepatic carcinoma, by administering RAP or RAP variants conjugated to active agents.
摘要翻译：本发明涉及受体相关蛋白（RAP）及其片段和变体的用途，以改善治疗化合物向肝脏的递送，并提供通过施用RAP或RAP变体来治疗肝脏疾病和病症如肝癌的方法与活性剂缀合。

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