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11. 发明授权

US07033829B2 Method to inhibit cell growth using oligonucleotides 失效
公开(公告)号：US07033829B2
公开(公告)日：2006-04-25
申请号：US10122633
申请日：2002-04-12
申请人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar
发明人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar
IPC分类号： C12Q3/00
CPC分类号： A61K31/711 , A61K31/7125 , A61K41/0057 , A61K48/00 , A61K48/005 , C12N15/85 , C12N2830/001
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.

12. 发明授权

US06867179B1 Methods of inducing hair growth and coloration 失效
标题翻译：诱导毛发生长和着色的方法
公开(公告)号：US06867179B1
公开(公告)日：2005-03-15
申请号：US09632748
申请日：2000-08-04
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/64 , A61K38/00 , A61K38/12 , A61K38/18 , A61Q7/00 , C07K7/64 , C12N15/113 , A61K38/08 , A61K38/17
CPC分类号： A61K31/713 , A61K8/64 , A61K38/12 , A61K38/185 , A61Q7/00 , C07K7/64 , C12N15/113 , C12N15/1138 , C12N2310/315
摘要： Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.
摘要翻译：公开了控制或操纵黑素细胞和角化细胞死亡的方法。特别地，公开了一种防止由于脊椎动物中的损伤引起的表皮黑素细胞细胞损失的方法。还公开了一种在脊椎动物中诱导毛发生长的方法，在脊椎动物中诱发毛发颜色的方法，在脊椎动物中诱导肤色的方法，治疗个体中秃发的方法以及治疗斑秃的方法个人。

13. 发明授权

US06696303B2 Identifying substances using cells that express p75NTR 失效
标题翻译：使用表达p75NTR的细胞识别物质
公开(公告)号：US06696303B2
公开(公告)日：2004-02-24
申请号：US09866898
申请日：2001-05-29
申请人： Barbara A. Gilchrest , Mina Yaar
发明人： Barbara A. Gilchrest , Mina Yaar
IPC分类号： G01N33563
CPC分类号： C07K5/0815 , A61K38/00 , C07K14/4711 , C07K14/48 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Methods for evaluating the risk of an individual to develop Alzheimer's disease using cultured neural crest-derived melanocytes are described. Also described are methods of therapy for Alzheimer's disease using peptides that bind to the neurotrophin receptor (p75NTR) and competitively inhibit the binding of &bgr;-amyloid to the p75NTR.
摘要翻译：描述了使用培养的神经嵴衍生的黑素细胞评估个体发展阿尔茨海默病的风险的方法。还描述了使用结合神经营养因子受体（p75 ）并竞争性抑制β-淀粉样蛋白与p75 的结合的肽来治疗阿尔茨海默氏病的方法。

14. 发明授权

US5643556A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
标题翻译：通过DNA片段或单链DNA刺激鞣制
公开(公告)号：US5643556A
公开(公告)日：1997-07-01
申请号：US493251
申请日：1995-06-06
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K48/00 , A61K7/42 , A61K47/30
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of stimulating pigment production in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of stimulating pigment production in mammalian cells, a method of stimulating melanogenesis in mammalian melanocytes, and a culture medium for stimulating melanin production. Preparations useful in the present methods are additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, dinucleotides, or dinucleotide dimers, in an appropriate vehicle, such as a liposomal preparation or propylene glycol. The preparations include DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers and an appropriate delivery vehicle, such as liposomes or a propylene glycol. The DNA fragments, deoxynucleotides, or dinucleotides used in the methods or in the preparations can be ultraviolet-irradiated. The preparations are sunlight-independent tanning or melanogenesis-stimulating agent.
摘要翻译：公开了刺激哺乳动物皮肤中颜料产生的方法，以及保护哺乳动物皮肤免受紫外线损害。还公开了刺激哺乳动物细胞中颜料产生的方法，刺激哺乳动物黑素细胞中黑素生成的方法，以及用于刺激黑色素生成的培养基。另外公开了本发明方法中有用的制剂。所述方法包括向合适的载体（例如脂质体制剂或丙二醇）向表皮或细胞施用单链或双链或二者或脱氧核苷酸二核苷酸或二核苷酸二聚体的DNA片段。制备物包括DNA片段，脱氧核苷酸，二核苷酸或二核苷酸二聚体和合适的递送载体，例如脂质体或丙二醇。在方法或制剂中使用的DNA片段，脱氧核苷酸或二核苷酸可以被紫外线照射。制剂是无阳光独立的鞣制或黑素生成刺激剂。

15. 发明授权

US5580547A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
公开(公告)号：US5580547A
公开(公告)日：1996-12-03
申请号：US463425
申请日：1995-05-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K37/22 , A61K9/50
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.

16. 发明授权

US5962417A Methods of modulating melanin synthesis 有权
标题翻译：调节黑色素合成的方法
公开(公告)号：US5962417A
公开(公告)日：1999-10-05
申请号：US160126
申请日：1998-09-24
申请人： Barbara A. Gilchrest , Hee-Young Park
发明人： Barbara A. Gilchrest , Hee-Young Park
IPC分类号： C12N15/09 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/60 , A61K8/64 , A61K8/66 , A61K8/72 , A61K31/00 , A61K38/55 , A61P17/00 , A61Q5/08 , A61Q19/02 , C12N9/02 , C12N15/88 , D06L3/00 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/573 , A61K38/00 , C12N9/16
CPC分类号： D06L3/00 , A61K8/11 , A61K8/14 , A61K8/606 , A61K8/64 , A61Q19/02 , A61Q5/08 , C12N15/88 , A61K2800/782 , A61K2800/86
摘要： Methods are described whereby vertebrate skin, hair, wool or fur may be lightened, or darkened, in color by administration of a substance, e.g., peptide, antibody, antibody fragment or DNA sequence encoding a peptide, that modulates the protein kinase C-beta-mediated activation of tyrosinase, the rate-limiting enzyme in melanogenesis.
摘要翻译：描述了通过施用调节蛋白激酶C-β的物质例如肽，抗体，抗体片段或编码肽的DNA序列的物质，可以使脊椎动物皮肤，毛发，羊毛或毛皮变亮或变暗的方法介导的酪氨酸酶的活化，黑素生成中的限速酶。

17. 发明申请

US20080221052A1 Modulation of Wrn-Mediated Telomere-Initiated Cell Signaling 审中-公开
标题翻译：编码介导的端粒起始细胞信号传导
公开(公告)号：US20080221052A1
公开(公告)日：2008-09-11
申请号：US11569243
申请日：2005-05-19
申请人： Barbara A. Gilchrest , Mark S. Eller
发明人： Barbara A. Gilchrest , Mark S. Eller
IPC分类号： A61K31/70 , C12Q1/68 , G01N33/574 , A61P43/00 , C12Q1/02 , G01N33/566
CPC分类号： G01N33/5041 , C12N15/1137 , C12N2310/13 , G01N33/5008 , G01N33/5011 , G01N33/6875 , G01N2510/00
摘要： The use of modulators of WRN is described. Activators of WRN may be used to induce growth arrest, apoptosis or proliferative senescence, whereas inhibitors of WRN may be used to reduce growth arrest, apoptosis or proliferative senescence. Methods of identifying modulators of WRN are also described.
摘要翻译：描述了使用WRN的调制器。 WRN的活化剂可用于诱导生长停滞，凋亡或增殖衰老，而WRN抑制剂可用于减少生长停滞，细胞凋亡或增殖衰老。还描述了识别WRN调节剂的方法。

18. 发明授权

US5352440A Methods for increasing melanin content in melanocytes using diacylglycerols and uses thereof 失效
标题翻译：使用二酰基甘油增加黑素细胞中黑色素含量的方法及其用途
公开(公告)号：US5352440A
公开(公告)日：1994-10-04
申请号：US934872
申请日：1992-08-21
申请人： Barbara A. Gilchrest , Philip R. Gordon
发明人： Barbara A. Gilchrest , Philip R. Gordon
IPC分类号： A61K8/30 , A61K8/00 , A61K8/37 , A61K31/23 , A61P3/00 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q5/10 , A61Q19/00 , A61Q19/04 , C07C69/10 , C07C69/18 , C07C69/30 , C07C69/58 , C07C69/587 , C12N5/071 , A61K7/18 , A61K31/22 , A61K31/225
CPC分类号： A61Q19/04 , A61K8/375 , A61Q5/10 , C12N5/0626 , C12N2500/36
摘要： A method for inducing melanin synthesis in melanocytes, thereby increasing the melanin content of melanocytes and, thus, increasing pigmentation, melanocytes with increased melanin content produced by these methods, and uses thereof.
摘要翻译：一种在黑素细胞中诱导黑色素合成的方法，从而增加黑素细胞的黑色素含量，从而增加色素沉积，这些方法产生的黑色素含量增加的黑素细胞及其用途。

19. 发明授权

US08183222B2 Method to inhibit cell growth using oligonucleotides 失效
标题翻译：使用寡核苷酸抑制细胞生长的方法
公开(公告)号：US08183222B2
公开(公告)日：2012-05-22
申请号：US12715242
申请日：2010-03-01
申请人： Barbara A. Gilchrest , Mark S. Eller
发明人： Barbara A. Gilchrest , Mark S. Eller
IPC分类号： A61K48/00 , C07H21/04 , C07H21/02 , C12N15/85
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译：描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸端粒突出重复。治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法皮肤癌的发展也被公开。组合物和方法也可用于治疗其它癌症。

20. 发明申请

US20090209747A1 METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES 审中-公开
标题翻译：使用寡核苷酸抑制细胞生长的方法
公开(公告)号：US20090209747A1
公开(公告)日：2009-08-20
申请号：US12275089
申请日：2008-11-20
申请人： Barbara A. Gilchrest , Mark S. Eller
发明人： Barbara A. Gilchrest , Mark S. Eller
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译：描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸端粒突出重复。治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法皮肤癌的发展也被公开。组合物和方法也可用于治疗其它癌症。

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