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11. 发明授权

US06192275B1 Adaptive evoked response sensing for automatic capture verification 有权
标题翻译：自适应诱发响应检测用于自动捕获验证
公开(公告)号：US06192275B1
公开(公告)日：2001-02-20
申请号：US09309925
申请日：1999-05-11
申请人： Qingsheng Zhu , Mark Gryzwa , Geng Zhang , Arthur Olive
发明人： Qingsheng Zhu , Mark Gryzwa , Geng Zhang , Arthur Olive
IPC分类号： A61N1362
CPC分类号： A61N1/3712
摘要： An implantable cardiac rhythm management device adapted to receive and digitize electrocardiogram signals from leads placed on or in the heart and capable of automatically adjusting an evoked response detection threshold dependent upon a modulation of the amplitude of the evoked response. Respiration, activity level, and lead maturation, among others, all effect the modulation of the evoked response and the amplitude of a signal associated with evoked response. The present invention automatically adjusts the evoked response detection threshold to account for this modulation. Without limitation, the automatic adjustment of the evoked response detection threshold may be utilized during an automatic capture verification sequence. In the event of non-capture or fusion beats during an automatic adjustment, the evoked response detection threshold is not adjusted.
摘要翻译：一种植入式心律管理装置，适于从放置在心脏上或心脏上的引线接收和数字化心电图信号，并且能够根据诱发反应的振幅的调制来自动调整诱发响应检测阈值。呼吸，活动水平和铅成熟等都影响诱发反应的调制和与诱发反应相关的信号的振幅。本发明自动调整诱发响应检测阈值以解决该调制。不受限制，可以在自动捕获验证序列期间利用诱发响应检测阈值的自动调整。在自动调整期间不捕获或融合跳动的情况下，不调整诱发响应检测阈值。

12. 发明申请

US20050065587A1 Implantable lead with magnetic jacket 审中-公开
标题翻译：带有外套的可植入导线
公开(公告)号：US20050065587A1
公开(公告)日：2005-03-24
申请号：US10670156
申请日：2003-09-24
申请人： Mark Gryzwa
发明人： Mark Gryzwa
IPC分类号： A61N1/05 , A61N1/08 , A61N1/16
CPC分类号： A61N1/16 , A61N1/056 , A61N1/08
摘要： An implantable lead assembly includes a lead body extending from a proximal end to a distal, where the lead body has an intermediate portion therebetween. The lead body includes an insulating layer and a conductor disposed within the insulating layer. The insulating layer surrounds the conductor. An electrode is coupled to the lead body, and the electrode is in electrical communication with the conductor. At least one magnetic jacket is disposed within the insulating layer, and the at least one magnetic jacket surrounds the conductor.
摘要翻译：可植入引线组件包括从近端延伸到远端的引线主体，其中引线主体在其间具有中间部分。引线体包括绝缘层和布置在绝缘层内的导体。绝缘层围绕导体。电极耦合到引线体，并且电极与导体电连通。至少一个磁性护套设置在绝缘层内，并且至少一个磁性护套围绕导体。

13. 发明授权

US5941903A Pacemaker for detection of evoked response 失效
标题翻译：起搏器检测诱发反应
公开(公告)号：US5941903A
公开(公告)日：1999-08-24
申请号：US70158
申请日：1998-04-30
申请人： Qingsheng Zhu , Michael Lyden , Scot Boon , Mark Gryzwa
发明人： Qingsheng Zhu , Michael Lyden , Scot Boon , Mark Gryzwa
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3716
摘要： A method and apparatus for attenuating polarization voltages or "afterpotentials" which develop at the heart tissue/electrode interface following the delivery of a pacing stimulus to the heart tissue such that the evoked response of the heart may be accurately detected to determine whether each pacing stimulus resulted in heart capture or contraction, thereby facilitating improved tracking of the capture threshold for minimizing power consumption while assuring therapeutic efficacy. The conventional large capacitance coupling capacitor used to suppress DC components of the pacing pulse is reduced to effectively lower the equivalent capacitance of the pacing and coupling capacitors following delivery of the pacing pulse, allowing shorter recharge and blanking intervals. As a result, the evoked response is more easily detected.
摘要翻译：一种在将起搏刺激递送到心脏组织之后，衰减极化电压或“后电位”的方法和装置，其在心脏组织/电极界面处发展，从而可以精确地检测心脏的诱发反应以确定每个起搏刺激导致心脏捕获或收缩，从而有助于改善捕获阈值的跟踪以最小化功率消耗，同时确保治疗功效。用于抑制起搏脉冲的DC分量的常规大电容耦合电容器被减少以有效地降低起搏脉冲递送后的起搏和耦合电容器的等效电容，从而允许较短的再充电和消隐间隔。结果，更容易检测到诱发反应。

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