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11. 发明申请

US20050272031A1 Viral variants and uses therefor 审中-公开
标题翻译：病毒变体及用途
公开(公告)号：US20050272031A1
公开(公告)日：2005-12-08
申请号：US11002999
申请日：2004-12-03
申请人： Thomas Bock , Hans Tillmann , Michael Manns , Christian Trautwein , Stephen Locarnini , Joseph Torresi
发明人： Thomas Bock , Hans Tillmann , Michael Manns , Christian Trautwein , Stephen Locarnini , Joseph Torresi
IPC分类号： A61K39/29 , C07K14/02 , C12N7/00 , C12N7/01 , C12N15/36 , C12N15/54 , C12Q1/68 , C12Q1/70 , G01N33/576
CPC分类号： C07K14/005 , C12N7/00 , C12N2730/10122 , G01N33/5761 , G01N2333/02 , G01N2500/10
摘要： Disclosed are viral variants exhibiting reduced sensitivity to particular agents including nucleoside analogues and immunological mediators such as immunoglobulins and immune cells. Also provided are hepatitis B virus (HBV) variants which exhibit a level of replication fitness in the presence of a nucleoside analogue similar to or greater than in the absence of the nucleoside analogue. The present invention also provides methods of treating HBV infection, including a method for identifying a need to change or otherwise alter an existing therapeutic regimen. Also disclosed are methods for monitoring the development in a subject of an increased HBV load in the presence of a nucleoside analogue. The present invention further provides the use of nucleoside analogue-resistant HBV variants which exhibit a similar or increased replication fitness in the presence of the nucleoside analogue compared to in the absence of the nucleoside analogue to screen for medicaments to treat HBV infection.
摘要翻译：披露的是对特定试剂（包括核苷类似物和免疫介体如免疫球蛋白和免疫细胞）具有降低的敏感性的病毒变体。还提供了乙型肝炎病毒（HBV）变体，其在核苷类似物存在下表现出与在不存在核苷类似物时相似或更大的复制水平。本发明还提供了治疗HBV感染的方法，包括鉴定需要改变或改变现有治疗方案的方法。还公开了用于在核苷类似物存在下监测受试者中HBV负荷增加的发展的方法。本发明进一步提供核苷类似物抗性HBV变体的用途，与在不存在核苷类似物以筛选用于治疗HBV感染的药物的情况下，在核苷类似物存在下表现出相似或增加的复制适应性。

12. 发明授权

US06869948B1 Meloxicam for oral administration 有权
标题翻译：美洛昔康用于口服
公开(公告)号：US06869948B1
公开(公告)日：2005-03-22
申请号：US09277049
申请日：1999-03-26
申请人： Thomas Bock , Paul Saegmueller , Peter Sieger , Dietrich Tuerck
发明人： Thomas Bock , Paul Saegmueller , Peter Sieger , Dietrich Tuerck
IPC分类号： A61K9/20 , A61K9/48 , A61K31/54 , C07D279/16
CPC分类号： A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866
摘要： The invention relates in its first aspect to a rapidly decomposing tablet for pain therapy containing meloxicam [4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide] in the form of a salt with an inorganic or organic base providing rapid absorption of the active substance, the process of its preparation by direct tabletting, and furthermore relates in a second aspect to the crystalline meloxicam meglumin salt mono- and dihydrate and the preparation thereof.
摘要翻译：本发明的第一方面涉及一种包含美洛昔康[4-羟基-2-甲基-N-（5-甲基-2-噻唑基）-2H-1,2-苯并噻嗪-3-甲酰胺 - 1,1-二氧化物]与无机或有机碱形式的盐形式，其提供活性物质的快速吸收，其通过直接压片制备的方法，此外在第二方面涉及结晶美洛昔康，和二水合物及其制备。

13. 发明授权

US06454209B1 Comfort and illumination apparatus for a passenger space 有权
标题翻译：乘客空间的舒适和照明设备
公开(公告)号：US06454209B1
公开(公告)日：2002-09-24
申请号：US09591879
申请日：2000-06-12
申请人： Thomas Bock , Andrew Muin , Markus Schumacher
发明人： Thomas Bock , Andrew Muin , Markus Schumacher
IPC分类号： B64D1100
CPC分类号： B64D11/00 , B60Q3/43 , B60Q2500/20 , B61D29/00
摘要： A comfort and illumination unit especially for a passenger space in an aircraft is constructed for cooperation with a straight wall panel that can be integrated in or secured to a vertical straight wall and/or a horizontal straight ceiling wall. The unit has a mounting base and a cover with passenger convenience elements mounted to the base under the cover which is provided with cut-outs for access to the convenience elements. Fluorescent bulbs form a frame around the convenience elements.
摘要翻译：特别适用于飞机乘客空间的舒适和照明单元被构造成与可以集成在或固定到垂直直壁和/或水平直的天花板壁的直壁板协作。该单元具有安装基座和具有乘客便利元件的盖子，该盖子安装到盖下面的基座上，该基座设置有用于接近便利元件的切口。荧光灯在方便元件周围形成一个框架。

14. 发明授权

US5434114A Method of modifying molecular sieves by means of solid state ion exchange 失效
标题翻译：通过固态离子交换法改性分子筛的方法
公开(公告)号：US5434114A
公开(公告)日：1995-07-18
申请号：US197481
申请日：1994-02-16
申请人： Jens Weitkamp , Stefan Ernst , Thomas Bock , Thomas Kromminga , Akos Kiss , Peter Kleinschmit
发明人： Jens Weitkamp , Stefan Ernst , Thomas Bock , Thomas Kromminga , Akos Kiss , Peter Kleinschmit
IPC分类号： B01J20/18 , B01J29/064 , B01J29/70 , B01J29/72 , B01J29/74 , B01J37/30 , C01B39/02 , C07C5/03 , B01J29/068
CPC分类号： B01J37/30 , B01J29/74
摘要： Molecular sieves are modified by an ion exchange process where metal cations are introduced into the molecular sieves by means of solid state ion exchange. The solid state ion exchange can be carried out as follows: a weighed amount of calcined and activated zeolite is intimately mixed with a precalculated amount of PtCl.sub.2, PdCl.sub.2, RhCl.sub.3, CuCl.sub.2, V.sub.2 O.sub.5 or another compound of the noble metals (e.g., corresponding halides or oxides), the solids mixture is then heated in a current of inert gas (e.g., a current of helium gas or of nitrogen) to temperatures of 400.degree. to 600.degree. C., then cooled down to room temperature and subsequently reduced in a current of hydrogen for 10 to 14 hours at 280.degree. to 350.degree. C. in order to produce small metal clusters from the cationically introduced metal.
摘要翻译：分子筛通过离子交换方法进行改性，其中通过固态离子交换将金属阳离子引入分子筛中。固态离子交换可以如下进行：称重量的煅烧和活化的沸石与预先计算量的PtCl 2，PdCl 2，RhCl 3，CuCl 2，V 2 O 5或贵金属的另一种化合物（例如，相应的卤化物或氧化物），然后将固体混合物在惰性气体（例如，氦气或氮气流）中加热至400至600℃的温度，然后冷却至室温，随后减少电流的氢气在280〜350℃下进行10〜14小时，以从阳离子导入的金属产生小的金属簇。

15. 发明授权

US09043080B2 Method and device for activating and deactivating a valet parking function 有权
标题翻译：用于激活和停用代客泊车功能的方法和装置
公开(公告)号：US09043080B2
公开(公告)日：2015-05-26
申请号：US13493213
申请日：2012-06-11
申请人： Thomas Bock , Joerg Havemann
发明人： Thomas Bock , Joerg Havemann
IPC分类号： G06F7/00 , G05B19/00 , G05D1/00 , G06F17/00 , B60R25/04
CPC分类号： G06F17/00 , B60R25/04
摘要： A method and device for activating and deactivating a valet parking function for a motor vehicle is provided. An activated valet parking function prevents access to one or more lockable areas in the motor vehicle. The method including the steps of checking whether a freely operable control element has been actuated. If the actuation of a control element has been detected, the valet parking function is activated to prevent exclusively the access to the lockable area in the motor vehicle, particularly to a trunk.
摘要翻译：提供一种用于激活和停用用于机动车辆的代客泊车功能的方法和装置。激活的代客泊车功能可以防止机动车辆中一个或多个可锁定区域的进入。该方法包括检查可自由操作的控制元件是否被致动的步骤。如果已经检测到控制元件的致动，则启动代客泊车功能，以专门地防止对机动车辆中的可锁定区域的访问，特别是对行李箱的访问。

16. 外观设计

USD688618S1 Gap covering device for aircraft wall panels 有权
标题翻译：飞机墙板间隙覆盖装置
公开(公告)号：USD688618S1
公开(公告)日：2013-08-27
申请号：US29375534
申请日：2010-09-23
申请人： Thomas Bock , Michael Auburger , Patrique Doemeland , Brigitte Gerner , Florian Schuephaus , Silvan Fiedler
设计人： Thomas Bock , Michael Auburger , Patrique Doemeland , Brigitte Gerner , Florian Schuephaus , Silvan Fiedler
CPC分类号： B64C1/066

17. 发明申请

US20100176242A1 Gap Covering Device 有权
标题翻译：间隙覆盖装置
公开(公告)号：US20100176242A1
公开(公告)日：2010-07-15
申请号：US12532343
申请日：2008-03-25
申请人： Thomas Bock , Michael Auburger , Patrique Doemeland , Brigitte Gerner , Florian Schuephaus , Silvan Fiedler
发明人： Thomas Bock , Michael Auburger , Patrique Doemeland , Brigitte Gerner , Florian Schuephaus , Silvan Fiedler
IPC分类号： B64C99/00
CPC分类号： B64C1/066
摘要： A gap covering device (10) for covering a gap (16) between two mutually adjacent first aircraft interior components (12, 14) comprises a visible portion (18) as well as a retaining portion (20) connected to the visible portion (18) and extending opposite the visible portion (18). A receiving structure is fastened to an inner surface of the visible portion (18) and/or of the retaining portion (20) and has a receiving contour adapted to an edge contour of the first aircraft interior components (12, 14).
摘要翻译：用于覆盖两个彼此相邻的第一飞行器内部部件（12,14）之间的间隙（16）的间隙覆盖装置（10）包括可见部分（18）以及连接到可见部分（18）的保持部分（20））并且与可见部分（18）相对延伸。接收结构紧固到可见部分（18）和/或保持部分（20）的内表面，并具有适于第一飞行器内部部件（12,14）的边缘轮廓的接收轮廓。

18. 发明授权

US6145437A Anilox inking unit for a rotary offset printing machine 失效
标题翻译：用于旋转胶版印刷机的网纹印花机
公开(公告)号：US6145437A
公开(公告)日：2000-11-14
申请号：US274630
申请日：1999-03-23
申请人： Thomas Bock , Ernst Marny , Norbert Dylla
发明人： Thomas Bock , Ernst Marny , Norbert Dylla
IPC分类号： B41F31/00 , B41F31/02
CPC分类号： B41F31/027 , B41F31/007
摘要： An anilox inking unit for an offset printing machine having an anilox roll having a rotation direction and a fluid blowing device arranged along the anilox roll . The blowing device is disposed downstream of a working doctor with respect to the rotation direction of the anilox roll and upstream of the ink transfer point. In accordance with one embodiment, the fluid being blown by the blowing device is ambient air.
摘要翻译：一种用于胶版印刷机的网纹辊着墨单元，其具有沿着网纹辊布置的具有旋转方向的网纹辊和流体吹送装置。吹风装置相对于网纹辊的旋转方向和墨水转移点的上游设置在工作刮刀的下游。根据一个实施例，由吹风装置吹送的流体是环境空气。

19. 发明授权

US5545784A Method of modifying molecular sieves by means of solid state ion exchange, and a method for hydrogenating olefinic compounds 失效
标题翻译：通过固态离子交换法改性分子筛的方法，以及烯烃化合物的氢化方法
公开(公告)号：US5545784A
公开(公告)日：1996-08-13
申请号：US419896
申请日：1995-04-11
申请人： Jens Weitkamp , Stefan Ernst , Thomas Bock , Thomas Kromminga , Akos Kiss , Peter Kleinschmit
发明人： Jens Weitkamp , Stefan Ernst , Thomas Bock , Thomas Kromminga , Akos Kiss , Peter Kleinschmit
IPC分类号： B01J20/18 , B01J29/064 , B01J29/70 , B01J29/72 , B01J29/74 , B01J37/30 , C01B39/02 , C07C5/03 , C07C5/08
CPC分类号： B01J37/30 , B01J29/74
摘要： Molecular sieves are modified by an ion exchange process where metal cations are introduced into the molecular sieves by means of solid state ion exchange. The solid state ion exchange can be carried out as follows: a weighed amount of calcined and activated zeolite is intimately mixed with a precalculated amount of PtCl.sub.2, PdCl.sub.2, RhCl.sub.3, CuCl.sub.2, V.sub.2 O.sub.5 or another compound of the noble metals (e.g., corresponding halides or oxides), the solids mixture is then heated in a current of inert gas (e.g., a current of helium gas or of nitrogen) to temperatures of 400.degree. to 600.degree. C., then cooled down to room temperature and subsequently reduced in a current of hydrogen for 10 to 14 hours at 280.degree. to 350.degree. C. in order to produce small metal clusters from the cationically introduced metal.
摘要翻译：分子筛通过离子交换方法进行改性，其中通过固态离子交换将金属阳离子引入分子筛中。固态离子交换可以如下进行：称重量的煅烧和活化的沸石与预先计算量的PtCl 2，PdCl 2，RhCl 3，CuCl 2，V 2 O 5或贵金属的另一种化合物（例如，相应的卤化物或氧化物），然后将固体混合物在惰性气体（例如，氦气或氮气流）中加热至400至600℃的温度，然后冷却至室温，随后减少电流的氢气在280〜350℃下进行10〜14小时，以从阳离子导入的金属产生小的金属簇。

20. 发明授权

US4399820A Process and device for regulating the stimulation frequency of heart pacemakers 失效
标题翻译：调节心脏起搏器刺激频率的过程和装置
公开(公告)号：US4399820A
公开(公告)日：1983-08-23
申请号：US346315
申请日：1982-02-05
申请人： Alexander Wirtzfeld , Roland Heinze , Thomas Bock , Hans D. Liess
发明人： Alexander Wirtzfeld , Roland Heinze , Thomas Bock , Hans D. Liess
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61N1/365 , A61N1/36
CPC分类号： A61N1/36557 , A61B5/1459
摘要： A process and a device for regulating the stimulation frequency of heart pacemakers are disclosed. The process comprises generating with the aid of light emitted by a light-emitting element, reflected by the blood of a patient, and received by a light-receiving element, a current flow which causes, in a measuring probe, an increasing of the current flow at a constant probe voltage or a damping of the probe voltage at constant current flow. Thereafter, one of the possible changing values is measured and the change, with time, is evaluated as a measured quantity proportional to the change, with time, of the blood oxygen saturation, and, as a function of the measured quantity, the stimulation frequency of the heart pacemaker is regulated in such a manner that the greatest possible blood oxygen saturation is always achieved with the lowest stimulation frequency. The device for practicing the invention comprises a measuring probe containing at least one combination of only two active optoelectronic elements, one light-emitting element and one light-receiving element; a control circuit electrically connected to the measuring probe; a stimulation catheter in which the measuring probe is incorporated, and at least two electric lines leading through the stimulation catheter and electrically connecting the measuring probe to the control circuit of the measuring probe.
摘要翻译：公开了一种用于调节心脏起搏器刺激频率的过程和装置。该过程包括借助由发光元件发射的光产生，由患者的血液反射并由光接收元件接收的电流，其在测量探针中引起电流的增加在恒定电流下以恒定的探针电压或探针电压的阻尼流动。此后，测量可能的变化值之一，随时间的变化被评估为与血氧饱和度随时间的变化成比例的测量量，并且作为测量量的函数，刺激频率心脏起搏器的调节方式是以最低的刺激频率始终实现最大可能的血氧饱和度。用于实施本发明的装置包括测量探头，其包含仅两个有源光电元件，一个发光元件和一个光接收元件的至少一个组合; 电连接到所述测量探针的控制电路; 其中结合有测量探针的刺激导管和通过刺激导管的至少两条电线，并将测量探针电连接到测量探针的控制电路。

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