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11. 发明申请

US20120244171A1 CYTOTOXIC BENZODIAZEPINE DERIVATIVES 有权
公开(公告)号：US20120244171A1
公开(公告)日：2012-09-27
申请号：US13397195
申请日：2012-02-15
申请人： Wei Li , Michael Miller , Nathan Fishkin , Ravi V.J. Chari
发明人： Wei Li , Michael Miller , Nathan Fishkin , Ravi V.J. Chari
IPC分类号： A61K31/5517 , C07K16/28 , A61K39/395 , A61P35/00 , A61P13/12 , A61P19/08 , A61P31/00 , A61P31/12 , A61P25/28 , A61P1/18 , C07D487/04 , A61P37/00
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
摘要翻译：本发明涉及具有抗增殖活性的新型苯并二氮杂衍生物，更具体地涉及式（I） - （VII）的新型苯并二氮杂化合物。本发明还提供了与细胞结合剂连接的苯并二氮杂类化合物的缀合物。本发明还提供了使用本发明的化合物或缀合物来抑制哺乳动物异常细胞生长或治疗增殖性病症的组合物和方法。

12. 发明申请

US20120238731A1 METHODS OF PREPARATION OF CONJUGATES 有权
标题翻译：共混物的制备方法
公开(公告)号：US20120238731A1
公开(公告)日：2012-09-20
申请号：US13397205
申请日：2012-02-15
申请人： Nathan Fishkin , Michael Miller , Wei Li , Rajeeva Singh
发明人： Nathan Fishkin , Michael Miller , Wei Li , Rajeeva Singh
IPC分类号： C07K16/46
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
摘要翻译：本发明涉及制备细胞结合剂和药物（例如细胞毒性化合物）的缀合物的方法。所述方法包括使用亚胺反应性化合物以使细胞毒性化合物与细胞结合剂的有效缀合。

13. 外观设计

USD667081S1 Showerhead 有权
公开(公告)号：USD667081S1
公开(公告)日：2012-09-11
申请号：US29403991
申请日：2011-10-13
申请人： Man Ki Yoo , Michael Miller , Geraint Krumpe
设计人： Man Ki Yoo , Michael Miller , Geraint Krumpe

14. 发明授权

US08101881B2 Arc resistant switchgear vertical exhaust system 有权
标题翻译：电弧开关柜垂直排气系统
公开(公告)号：US08101881B2
公开(公告)日：2012-01-24
申请号：US12420337
申请日：2009-04-08
申请人： Michael Miller , Abraham de la Cruz
发明人： Michael Miller , Abraham de la Cruz
IPC分类号： H01H33/02
CPC分类号： H02B13/025
摘要： An exhaust system for exhausting gases and molten debris caused by an electric arc within a switchgear. The exhaust system includes a switchgear having lower and upper compartments and an exhaust unit externally mounted to the switchgear. A wall panel of the switchgear includes blow out panels coinciding with openings in the lower compartment and corresponding ventilation flaps in a top surface of the exhaust unit to exhaust gas from the lower compartment out the blow out panels in a vertical direction, exiting through the flaps. The upper compartment includes ventilation flaps for exhausting gas in a vertical direction directly through the flaps and optionally through side-mounted blow out panels that communicate with the vertical vent path to the flaps in the top of the exhaust unit. A bus compartment in the exhaust unit includes a vent path to flaps in the top of the exhaust unit for exhausting gas produced by bus arcing.
摘要翻译：用于排出由开关设备内的电弧引起的气体和熔融碎屑的排气系统。排气系统包括具有下隔室和上隔室的开关装置和外部安装到开关装置的排气单元。开关柜的墙板包括与下隔室中的开口重合的吹出面板和排气单元的顶表面中的相应的通风翼，以从垂直方向排出来自下隔室的排气板，通过翼片。上隔室包括用于在垂直方向上直接排出气体的通风翼片，并且可选地通过与排气单元顶部的翼片垂直通风通道连通的侧面安装的吹出面板。排气单元中的总线室包括在排气单元顶部襟翼的通气路径，用于排出由总线电弧产生的气体。

15. 发明申请

US20120001148A1 STRESS-ENGINEERED RESISTANCE-CHANGE MEMORY DEVICE 有权
标题翻译：应力工程电阻变化记忆装置
公开(公告)号：US20120001148A1
公开(公告)日：2012-01-05
申请号：US13233937
申请日：2011-09-15
申请人： Michael Miller , Prashant Phatak , Tony Chiang
发明人： Michael Miller , Prashant Phatak , Tony Chiang
IPC分类号： H01L45/00 , H01L21/02 , H01L47/00
CPC分类号： H01L45/1233 , H01L23/5228 , H01L23/525 , H01L27/2409 , H01L45/08 , H01L45/146 , H01L45/1641 , H01L2924/0002 , H01L2924/00
摘要： A resistance-change memory device using stress engineering is described, including a first layer including a first conductive electrode, a second layer above the first layer including a resistive-switching element, a third layer above the second layer including a second conductive electrode, where a first stress is created in the switching element at a first interface between the first layer and the second layer upon heating the memory element, and where a second stress is created in the switching element at a second interface between the second layer and the third layer upon the heating. A stress gradient equal to a difference between the first stress and the second stress has an absolute value greater than 50 MPa, and a reset voltage of the memory element has a polarity relative to a common electrical potential that has a sign opposite the stress gradient when applied to the first conductive electrode
摘要翻译：描述了使用应力工程的电阻变化存储器件，包括第一层，包括第一导电电极，第一层上方的第二层，包括电阻式开关元件，第二层上方的第三层包括第二导电电极，在加热存储元件时在第一层和第二层之间的第一界面处在开关元件中产生第一应力，并且其中在第二层和第三层之间的第二界面处在开关元件中产生第二应力加热。等于第一应力和第二应力之间的差的应力梯度具有大于50MPa的绝对值，并且存储元件的复位电压具有相对于具有与应力梯度相反的符号的公共电位的极性，施加到第一导电电极

16. 发明授权

US08062918B2 Surface treatment to improve resistive-switching characteristics 有权
标题翻译：表面处理提高电阻开关特性
公开(公告)号：US08062918B2
公开(公告)日：2011-11-22
申请号：US12345576
申请日：2008-12-29
申请人： Michael Miller , Prashant Phatak , Tony Chiang , Xiying Chen , April Schricker , Tanmay Kumar
发明人： Michael Miller , Prashant Phatak , Tony Chiang , Xiying Chen , April Schricker , Tanmay Kumar
IPC分类号： H01L21/00
CPC分类号： H01L45/16 , H01L21/265 , H01L21/31155 , H01L27/2463 , H01L29/8615 , H01L45/08 , H01L45/10 , H01L45/12 , H01L45/1233 , H01L45/146 , H01L45/1608 , H01L45/1616 , H01L45/1625 , H01L45/1641 , H01L45/165
摘要： This disclosure provides a method of fabricating a semiconductor device layer and associated memory cell structures. By performing a surface treatment process (such as ion bombardment) of a semiconductor device layer to create defects having a deliberate depth profile, one may create multistable memory cells having more consistent electrical parameters. For example, in a resistive-switching memory cell, one may obtain a tighter distribution of set and reset voltages and lower forming voltage, leading to improved device yield and reliability. In at least one embodiment, the depth profile is selected to modulate the type of defects and their influence on electrical properties of a bombarded metal oxide layer and to enhance uniform defect distribution.
摘要翻译：本公开提供了制造半导体器件层和相关联的存储单元结构的方法。通过进行半导体器件层的表面处理（例如离子轰击）以产生具有有意深度分布的缺陷，可以创建具有更一致的电参数的多层存储单元。例如，在电阻式开关存储单元中，可以获得设定和复位电压的更紧密的分配和较低的成形电压，从而提高器件的产量和可靠性。在至少一个实施例中，选择深度轮廓以调制缺陷的类型及其对被轰击的金属氧化物层的电性能的影响并增强均匀的缺陷分布。

17. 发明申请

US20110243178A1 HIGH POWER VCSEL WITH IMPROVED SPATIAL MODE 审中-公开
标题翻译：具有改进的空间模式的高功率VCSEL
公开(公告)号：US20110243178A1
公开(公告)日：2011-10-06
申请号：US13133740
申请日：2009-12-01
申请人： Johanna S. Kolb , Michael Miller , Sebastien Winterstein , Uwe Ernst
发明人： Johanna S. Kolb , Michael Miller , Sebastien Winterstein , Uwe Ernst
IPC分类号： H01S3/08
CPC分类号： B41J2/451 , H01S5/0207 , H01S5/0656 , H01S5/18347 , H01S5/18388 , H01S5/423
摘要： The present invention relates to a VCSEL device comprising an optical gain medium (8) arranged between a first DBR (9) and a second DBR (7). The first and the second DBR form a laser cavity and are designed to allow self-contained lasing in the laser cavity, said second DBR (7) being partially transparent for laser radiation resonating in the laser cavity. An optical element is arranged on a side of the second DBR (7) outside of the laser cavity on the optical axis of the laser cavity. The optical element has a concave surface (5) facing the second DBR (7) and being designed to reflect a portion of laser radiation emitted through the second DBR (7) back into the laser cavity. The ratio R/d of the radius of curvature R of the concave surface (5) and the distance d between the concave surface (5) and the gain medium (8) is in the range between 1 and 2. With the proposed VCSEL device a high power output with an improved mode distribution and mode stabilization is achieved.
摘要翻译：本发明涉及一种VCSEL设备，其包括布置在第一DBR（9）和第二DBR（7）之间的光学增益介质（8）。第一和第二DBR形成激光腔并被设计成允许在激光腔中自包含激光，所述第二DBR（7）对于在激光腔中共振的激光辐射部分透明。光学元件布置在第二DBR（7）的位于激光腔的光轴外侧的一侧。光学元件具有面向第二DBR（7）的凹面（5），并被设计成将通过第二DBR（7）发射的激光辐射的一部分反射回激光腔。凹面（5）的曲率半径R与凹面（5）与增益介质（8）的距离d的比值R / d在1〜2的范围内。利用所提出的VCSEL装置实现了具有改进的模式分布和模式稳定的高功率输出。

18. 发明申请

US20110174894A1 SHOWERHEAD WITH MULTIPLE AERATING ORIFICE PLATES 审中-公开
标题翻译：淋浴与多个加速器板
公开(公告)号：US20110174894A1
公开(公告)日：2011-07-21
申请号：US12690138
申请日：2010-01-20
申请人： Michael Miller , Shixiong Lin , Lieyong Huang
发明人： Michael Miller , Shixiong Lin , Lieyong Huang
IPC分类号： B05B1/14
CPC分类号： B05B1/185 , B05B1/1654
摘要： A device for use in a shower head that discharges a fluid, such as water, has a plurality of nozzles, each nozzle having an opening for discharging the fluid and a plurality of apertures spaced away from the opening having a bore through which the fluid flows, and a face through which the opening extends. The nozzles each create droplets that are large enough to retain heat and moving slowly enough to minimize irritation to a user.
摘要翻译：用于排出诸如水的流体的淋浴喷头的装置具有多个喷嘴，每个喷嘴具有用于排放流体的开口和与开口间隔开的多个孔，该孔具有通过该孔流动的流体流过的孔，以及开口延伸穿过的面。喷嘴各自产生足够大的液滴以保持热量并足够缓慢地移动以最小化对使用者的刺激。

19. 外观设计

USD634810S1 Faceplate for showerhead 有权
标题翻译：花洒面板
公开(公告)号：USD634810S1
公开(公告)日：2011-03-22
申请号：US29361081
申请日：2010-05-05
申请人： Man Ki Yoo , Julian Giggs , Michael Miller
设计人： Man Ki Yoo , Julian Giggs , Michael Miller

20. 发明授权

US07912525B2 Method and apparatus for enhancing the integrity of an implantable sensor device 有权
标题翻译：用于增强可植入传感器装置完整性的方法和装置
公开(公告)号：US07912525B2
公开(公告)日：2011-03-22
申请号：US11606837
申请日：2006-11-30
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

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