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11. 发明授权

US09744031B2 Prosthetic heart valve and endoprosthesis comprising a prosthetic heart valve and a stent 有权
公开(公告)号：US09744031B2
公开(公告)日：2017-08-29
申请号：US13114582
申请日：2011-05-24
申请人： Michael J. Girard , Randy Lane , Arnulf Mayer
发明人： Michael J. Girard , Randy Lane , Arnulf Mayer
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0025 , A61F2220/0075 , A61F2240/001
摘要： The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10).

12. 发明授权

US08468667B2 Device for compressing a stent 失效
标题翻译：用于压缩支架的装置
公开(公告)号：US08468667B2
公开(公告)日：2013-06-25
申请号：US12778625
申请日：2010-05-12
申请人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
发明人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
IPC分类号： B21D39/04
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/95 , A61F2002/9522 , Y10T29/5367 , Y10T29/53878 , Y10T29/53952
摘要： The present disclosure relates to a device for compressing a stent or a stent with a prosthetic heart valve affixed thereto, as well as a method for loading a stent into a medical delivery system. The device may comprise a compressing mechanism designed so as to exert a compressive force in radial direction on at least parts of a stent accommodated within the compressing mechanism such that the cross-section of the stent is reduced to a predefinable value at least at certain areas. The device may further comprise a manipulating mechanism moveable relative to the compressing mechanism for moving at least one clamping means in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism.
摘要翻译：本公开涉及一种用于压缩固定在其上的假体心脏瓣膜的支架或支架的装置，以及用于将支架装载到医疗输送系统中的方法。该装置可以包括压缩机构，该压缩机构设计成在容纳在压缩机构内的支架的至少一部分上沿径向施加压缩力，使得至少在某些区域将支架的横截面减小到可预定值。该装置还可以包括可相对于压缩机构移动的操纵机构，用于沿径向方向移动至少一个夹紧装置，以调节压缩机构的内部横截面直径。

13. 发明授权

US06176876B1 Leaflet positioning for a mechanical heart valve 有权
标题翻译：机械心脏瓣膜的小叶定位
公开(公告)号：US06176876B1
公开(公告)日：2001-01-23
申请号：US09205673
申请日：1998-12-04
申请人： Tanya Shipkowitz , Paul J. Fordenbacher , Yi-Ren Woo , Michael J. Girard , Stephen A. Petersen
发明人： Tanya Shipkowitz , Paul J. Fordenbacher , Yi-Ren Woo , Michael J. Girard , Stephen A. Petersen
IPC分类号： A61F224
CPC分类号： A61F2/2403 , A61F2/2472
摘要： A bi-leaflet prosthetic heart valve, comprising an annular body having an upstream edge, a downstream edge and a passageway therebetween includes first and second leaflets pivotally mounted in the annular body. Each leaflet has an upstream edge, a downstream edge and a leaflet length therebetween. First and second pivot axes associated respectively with the first and second leaflets are provided and each leaflet rotates about its respective pivot axes between an open position allowing blood flow through the passageway of the annular body and a closed position blocking blood flow. The valve is configured such that the leaflets have an angle in the naturally open position of more than about 85°.
摘要翻译：一种双瓣假体心脏瓣膜，包括具有上游边缘，下游边缘和其间的通道的环形体，包括枢转地安装在环形体中的第一和第二小叶。每个小叶具有上游边缘，下游边缘和它们之间的小叶长度。提供分别与第一和第二小叶相关联的第一和第二枢转轴线，并且每个小叶围绕其相应的枢转轴线在允许血液流过环形体的通道的打开位置和阻塞血液流动的关闭位置之间旋转。阀构造成使得小叶在自然打开位置具有大于约85°的角度。

14. 发明申请

US20100292780A1 DEVICE FOR COMPRESSING A STENT AS WELL AS SYSTEM AND METHOD FOR LOADING A STENT INTO A MEDICAL DELIVERY SYSTEM 失效
标题翻译：用于压缩作为系统的步骤的装置和用于将固定装入医疗交付系统的方法
公开(公告)号：US20100292780A1
公开(公告)日：2010-11-18
申请号：US12778625
申请日：2010-05-12
申请人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
发明人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
IPC分类号： A61F2/84
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/95 , A61F2002/9522 , Y10T29/5367 , Y10T29/53878 , Y10T29/53952
摘要： The invention relates to a device (1a-1d) for compressing a stent (100) or a stent (100) with a prosthetic heart valve affixed thereto. The invention further relates to a system as well as a method for loading a stent (100) into a medical delivery system. The device (1a-1d) according to the invention comprises a compressing mechanism (10a-10d), within which a stent (100) to be compressed can be at least partly accommodated, wherein the compressing mechanism (10a-10d) comprises externally-manipulatable clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) and is designed so as to exert a compressive force in radial direction on at least parts of a stent (100) accommodated within the compressing mechanism (10a-10d) such that the cross-section of the stent (100) is reduced to a predefinable value at least at certain areas. The inventive device (1a-1d) further comprises a manipulating mechanism (40a-40d) for manipulating the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n), said manipulating mechanism (40a-40d) being moveable relative to the compressing mechanism (10a-10d) for moving the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism (10a-10d).
摘要翻译：本发明涉及一种用于用固定在其上的假体心脏瓣膜来压缩支架（100）或支架（100）的装置（1a-1d）。本发明还涉及一种系统以及将支架（100）装载到医疗输送系统中的方法。根据本发明的装置（1a-1d）包括压缩机构（10a-10d），其中可以至少部分地容纳待压缩的支架（100），其中压缩机构（10a-10d）可操纵的夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）并且被设计成在径向方向上施加压缩力至少在容纳在压缩机构（10a-10d），使得至少在某些区域将支架（100）的横截面减小到预定值。本发明的装置（1a-1d）还包括用于操纵至少一个夹持装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）的操纵机构（40a-40d），所述操纵机构（40a-40d）可相对于所述压缩机构（10a-10d）移动，用于将所述至少一个夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）移动到所述径向方向，以调节压缩机构（10a-10d）的内部横截面直径。

15. 发明授权

US5984973A Integral supporting structure for bioprosthetic heart valve 失效
标题翻译：生物假体心脏瓣膜的整体支撑结构
公开(公告)号：US5984973A
公开(公告)日：1999-11-16
申请号：US876769
申请日：1997-06-16
申请人： Michael J. Girard , Todd D. Campbell , M. William Mirsch, II , Kristen L. Swanson
发明人： Michael J. Girard , Todd D. Campbell , M. William Mirsch, II , Kristen L. Swanson
IPC分类号： A61F2/24
CPC分类号： A61F2/2418
摘要： A stent for receiving and supporting a tissue heart valve for ultimate implantation into a human, the heart valve including tissue leaflets joined at circumferentially spaced commissures, wherein the stent includes at least one commissure support post and at least one sinus support structure each sinus support structure being disposed between but not functionally connected to an adjacent commissure support post.
摘要翻译：一种用于接收和支撑用于最终植入人体的组织心脏瓣膜的支架，所述心脏瓣膜包括在周向间隔开的合缝处连接的组织小叶，其中支架包括至少一个连合支撑柱和至少一个窦支撑结构，每个窦支撑结构被布置在相邻的连合支撑柱之间但不是功能性地连接。

16. 发明授权

US5735842A Low profile manipulators for heart valve prostheses 失效
标题翻译：用于心脏瓣膜假体的低调操纵器
公开(公告)号：US5735842A
公开(公告)日：1998-04-07
申请号：US526530
申请日：1995-09-11
申请人： Kurt D. Krueger , Michael J. Girard , Guy P. Vanney
发明人： Kurt D. Krueger , Michael J. Girard , Guy P. Vanney
IPC分类号： A61M1/10 , A61F2/24 , A61B17/00
CPC分类号： A61F2/2427
摘要： A manipulable low profile heart valve holder that can be pivotally attached to a handle that permits the heart valve holder and a retained heart valve prosthesis to be manipulated remotely during implantation. The heart valve holder is pivotable from a position wherein the plane of the orifice of a retained heart valve is parallel to the axis of the handle, to a second position wherein the plane of the retained heart valve is substantially 90.degree. to the axis of the handle. This pivoting arrangement particularly aids in manipulation of the heart valve prosthesis during implantation using trocars for access to the body cavity. Manipulation is accomplished by having controllable elements on the handle and retained on the exterior of the patient. Manipulation of the heart valve holder also may be done through separate instruments operating through separate trocars.
摘要翻译：可操纵的低轮廓心脏瓣膜保持器，其可枢转地附接到手柄，其允许在植入期间远程操作心脏瓣膜保持器和保留的心脏瓣膜假体。心脏瓣膜保持器可从保持的心脏瓣膜的孔的平面平行于手柄的轴线的位置枢转到第二位置，其中保留的心脏瓣膜的平面基本上相对于处理。该枢转装置特别有助于在植入期间使用套管针进入体腔的操纵心脏瓣膜假体。通过在手柄上具有可控元件并保留在患者的外部来实现操作。心脏瓣膜支架的操作也可以通过使用单独的套管针操作的单独的器械完成。

17. 发明授权

US5716417A Integral supporting structure for bioprosthetic heart valve 失效
公开(公告)号：US5716417A
公开(公告)日：1998-02-10
申请号：US472744
申请日：1995-06-07
申请人： Michael J. Girard , Todd D. Campbell , M. William Mirsch, II , Kristen Swanson
发明人： Michael J. Girard , Todd D. Campbell , M. William Mirsch, II , Kristen Swanson
IPC分类号： A61F2/24
CPC分类号： A61F2/2418
摘要： A stent for receiving and supporting a tissue heart valve for ultimate implantation into a human, the heart valve including tissue leaflets joined at circumferentially spaced commissures, wherein the stent includes at least one commissure support post and at least one sinus support structure each sinus support structure being disposed between but not functionally connected to an adjacent commissure support post.

18. 发明授权

US08790395B2 Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient 有权
标题翻译：用于在患者心脏中的植入部位中定位和锚定瓣膜假体的支架
公开(公告)号：US08790395B2
公开(公告)日：2014-07-29
申请号：US13896905
申请日：2013-05-17
申请人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2412 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

19. 发明授权

US08100821B2 Low friction delivery tool for a cardiac support device 有权
标题翻译：用于心脏支持装置的低摩擦递送工具
公开(公告)号：US08100821B2
公开(公告)日：2012-01-24
申请号：US12333045
申请日：2008-12-11
申请人： Aaron J. Hjelle , Louis Labrousse , Robert G. Walsh , Paul Andrew Pignato , Michael J. Girard
发明人： Aaron J. Hjelle , Louis Labrousse , Robert G. Walsh , Paul Andrew Pignato , Michael J. Girard
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , A61F2002/2484
摘要： A delivery device for efficiently delivering a cardiac support device of the type having a jacket. The device includes a body, a deployment mechanism and an actuating mechanism. The deployment mechanism is for releasable connection to a cardiac support device and movable within the jacket between retracted and extended states to drive the jacket between collapsed and open configurations. At least portions of the deployment mechanism within the jacket have a lubricious surface to substantially reduce friction between the jacket and a heart onto which the jacket is being positioned. The actuating mechanism moves the deployment mechanism between the retracted and extended states.
摘要翻译：一种用于有效地输送具有护套的类型的心脏支持装置的输送装置。该装置包括主体，展开机构和致动机构。展开机构用于可释放地连接到心脏支撑装置，并且在收缩和伸展状态之间在护套内可移动，以在收缩和打开构型之间驱动护套。护套内的展开机构的至少部分具有光滑的表面，以显着地减少外套与夹套所在的心脏之间的摩擦。致动机构使展开机构在缩回状态和伸展状态之间移动。

20. 发明申请

US20100249923A1 COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES WITH NATIVE CALCIFIED LEAFLET RETENTION FEATURES 有权
标题翻译：具有先前计算的叶片保持特征的可拆卸/可扩展的前置心脏瓣膜
公开(公告)号：US20100249923A1
公开(公告)日：2010-09-30
申请号：US12733763
申请日：2008-09-26
申请人： Yousef F. Alkhatib , Michael J. Girard
发明人： Yousef F. Alkhatib , Michael J. Girard
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve is circumferentially collapsible for less invasive delivery into a patient. The valve re-expands to operating size at the implant site in the patient. A frame structure of the valve includes restraining structure that can help to push one or more of the patient's native heart valve leaflets radially outwardly so that this native leaflet tissue does not interfere with the operation or service life of the prosthetic valve.
摘要翻译：假体心脏瓣膜是周向可折叠的，用于较少侵入性地输送到患者体内。瓣膜在病人的植入部位重新扩大到操作尺寸。阀的框架结构包括限制结构，其可以帮助推动病人的天然心脏瓣膜叶片中的一个或多个径向向外，使得该天然小叶组织不会干扰人工瓣膜的操作或使用寿命。

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