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    • 20. 发明授权
    • Process for preparing isopimaric acid
    • 异海松酸的制备方法
    • US08946469B2
    • 2015-02-03
    • US12927097
    • 2010-11-04
    • Zhendong ZhaoXingdi LiLiangwu BiYuxiang ChenYan GuDongmei LiJing Wang
    • Zhendong ZhaoXingdi LiLiangwu BiYuxiang ChenYan GuDongmei LiJing Wang
    • C07C61/29C07C51/43
    • C07C61/29C07C51/43C07C2603/22C07C61/35
    • Disclosed is a process for preparing isopimaric acid, comprising the following steps: First step: dissolving thermally isomerized rosin in acetone, adding in drops a solution of isobutanolamine in acetone to form a precipitate, standing, filtering, washing with ethanol, and drying to obtain crude ammonium salt of isopimaric acid; recrystallizing the crude ammonium salt of isopimaric acid according to multi-recrystallization, and drying to obtain purified crystal of ammonium salt of isopimaric acid; Second step: dissolving the purified crystal of ammonium salt of isopimaric acid obtained in the first step in ether, adding hydrochloric acid in portions until the crystal of ammonium salt of isopimaric acid disappears, removing a water layer and washing the ether layer with water to neutral, evaporating the ether, dissolving the residue in acetone, adding water slowly into the solution dropwise until crystals cease to grow, then filtering and drying to obtain purified isopimaric acid.
    • 公开了一种制备异海松酸的方法,包括以下步骤:第一步:将热异构松香溶解在丙酮中,滴加异丁醇胺的丙酮溶液形成沉淀,静置,过滤,用乙醇洗涤,并干燥得到 异海松酸的粗铵盐; 根据多重结晶重结晶异海松酸的粗铵盐,干燥,得到异海松酸铵盐的纯化结晶; 第二步:将纯化的第一步获得的异海松酸铵盐的结晶溶解在乙醚中,分几次加入盐酸,直到异海松酸的铵盐结晶消失,去除水层,用水洗涤乙醚层至中性 蒸发乙醚,将残余物溶解在丙酮中,慢慢加入水中直到晶体停止生长,然后过滤并干燥,得到纯化的异海松酸。