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11. 发明授权

US07805009B2 Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权
标题翻译：用于使用来自成像系统的一系列部分图像来测量对象的运动的方法和装置
公开(公告)号：US07805009B2
公开(公告)日：2010-09-28
申请号：US11389351
申请日：2006-03-24
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
IPC分类号： G06K9/68 , G06K9/00
CPC分类号： A61B3/102 , A61B3/113
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.
摘要翻译：行扫描成像器用于确定被摄体的运动。将来自行扫描成像器的每行图像数据与参考图像进行比较。参考图像中匹配线的位置显示了被摄体的位移。可以基于每行图像数据来确定当前被摄体位移。所得到的位移信息可用于将其他光束正确地放置在被摄体上。该方法可以应用于跟踪人眼以便于用光束照射进行测量，成像或处理。

12. 发明授权

US08363958B2 Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权
公开(公告)号：US08363958B2
公开(公告)日：2013-01-29
申请号：US13276203
申请日：2011-10-18
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
IPC分类号： G06K9/68 , G06K9/00
CPC分类号： A61B3/102 , A61B3/113
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

13. 发明申请

US20120128222A1 METHOD AND APPARATUS FOR MEASURING MOTION OF A SUBJECT USING A SERIES OF PARTIAL IMAGES FROM AN IMAGING SYSTEM 有权
标题翻译：用于使用成像系统的一系列部分图像测量主体的运动的方法和装置
公开(公告)号：US20120128222A1
公开(公告)日：2012-05-24
申请号：US13276203
申请日：2011-10-18
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
IPC分类号： G06K9/00
CPC分类号： A61B3/102 , A61B3/113
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.
摘要翻译：行扫描成像器用于确定被摄体的运动。将来自行扫描成像器的每行图像数据与参考图像进行比较。参考图像中匹配线的位置显示了被摄体的位移。可以基于每行图像数据来确定当前被摄体位移。所得到的位移信息可用于将其他光束正确地放置在被摄体上。该方法可以应用于跟踪人眼以便于用光束辐射进行测量，成像或处理。

14. 发明授权

US08045176B2 Methods for mapping tissue with optical coherence tomography data 有权
标题翻译：用光学相干断层扫描数据绘制组织的方法
公开(公告)号：US08045176B2
公开(公告)日：2011-10-25
申请号：US12822054
申请日：2010-06-23
申请人： Matthew J. Everett , Paul F. Stetson , Scott A. Meyer , Shahram Shawn Dastmalchi
发明人： Matthew J. Everett , Paul F. Stetson , Scott A. Meyer , Shahram Shawn Dastmalchi
IPC分类号： G01B11/02 , G06K9/00
CPC分类号： A61B3/10 , A61B3/00 , A61B3/102 , A61B5/0059 , A61B5/0066 , G01B9/02048 , G01B9/02089 , G01B9/02091 , G01N21/4795 , G06F19/00
摘要： Various methods are disclosed for mapping optical coherence tomography (OCT) data to facilitate review and diagnosis. In one aspect, high resolution 2D line scans are obtained along with lower density 3D cube scans and displayed in a manner to provide context to the clinician. In another aspect, OCT data is analyzed to provide information about non-uniformities of the tissue. Binary image maps of maps useful for determining tautness of membranes are also disclosed.
摘要翻译：公开了各种用于映射光学相干断层扫描（OCT）数据的方法以便于检查和诊断。在一个方面，获得高分辨率2D线扫描以及较低密度的3D立方体扫描，并以向临床医生提供上下文的方式显示。在另一方面，分析OCT数据以提供关于组织的非均匀性的信息。还公开了可用于确定膜紧张度的地图的二进制图像映射。

15. 发明授权

US07508525B2 High efficiency balanced detection interferometer 失效
标题翻译：高效平衡检测干涉仪
公开(公告)号：US07508525B2
公开(公告)日：2009-03-24
申请号：US12150375
申请日：2008-04-28
申请人： Yan Zhou , Matthew J. Everett , Martin Hacker
发明人： Yan Zhou , Matthew J. Everett , Martin Hacker
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02091 , G01B2290/40
摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In one set of embodiments, a pair of cascaded 2×2 couplers is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.
摘要翻译：公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。在一组实施例中，使用一对级联的2x2耦合器来沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

16. 发明授权

US07391520B2 Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver 有权
标题翻译：采用扫频多波长激光和多通道接收机的傅里叶域光学相干断层扫描
公开(公告)号：US07391520B2
公开(公告)日：2008-06-24
申请号：US11174158
申请日：2005-07-01
申请人： Yan Zhou , Matthew J. Everett
发明人： Yan Zhou , Matthew J. Everett
IPC分类号： G01B9/02
CPC分类号： G01J3/10 , A61B3/1005 , A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02004 , G01B9/02069 , G01B9/02091 , G01B2290/45 , G01J3/0259 , G01J3/4532 , G01J2003/1239 , G01N21/4795
摘要： The present invention is an alternative Fourier domain optical coherence system (FD-OCT) and its associated method. The system comprises a swept multi-wavelength laser, an optical interferometer and a multi-channel receiver. By employing a multi-wavelength laser, the sweeping range for each lasing wavelength is substantially reduced as compared to a pure swept single wavelength laser that needs to cover the same overall spectral range. The overall spectral interferogram is divided over the individual channels of the multi-channel receiver and can be re-constructed through processing of the data from each channel detector. In addition to a substantial increase in the speed of each axial scan, the cost of invented FD-OCT system can also be substantially less than that of a pure swept source OCT or a pure spectral domain OCT system.
摘要翻译：本发明是替代的傅里叶域光学相干系统（FD-OCT）及其相关方法。该系统包括扫频多波长激光器，光学干涉仪和多通道接收器。通过采用多波长激光器，与需要覆盖相同总光谱范围的纯扫频单波长激光器相比，每个激光波长的扫描范围显着降低。整个光谱干涉图在多通道接收机的各个通道上分配，并且可以通过处理来自每个通道检测器的数据来重新构建。除了每个轴向扫描的速度的显着增加之外，发明的FD-OCT系统的成本也可以显着小于纯扫频源OCT或纯谱域OCT系统的成本。

17. 发明授权

US07388672B2 High efficiency balanced detection interferometer 有权
标题翻译：高效平衡检测干涉仪
公开(公告)号：US07388672B2
公开(公告)日：2008-06-17
申请号：US11264871
申请日：2005-11-02
申请人： Yan Zhou , Matthew J. Everett , Martin Hacker
发明人： Yan Zhou , Matthew J. Everett , Martin Hacker
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B2290/40
摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In a first set of embodiments, a 3×3 coupler is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. In an alternate set of embodiments, a pair of cascaded 2×2 couplers provides a similar function. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.
摘要翻译：公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。在第一组实施例中，使用3x3耦合器沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。在另一组实施例中，一对级联的2x2耦合器提供类似的功能。干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

18. 发明授权

US07382464B2 Apparatus and method for combined optical-coherence-tomographic and confocal detection 有权
标题翻译：用于组合光学相干断层扫描和共焦检测的装置和方法
公开(公告)号：US07382464B2
公开(公告)日：2008-06-03
申请号：US11298105
申请日：2005-12-09
申请人： Matthew J. Everett , Yan Zhou
发明人： Matthew J. Everett , Yan Zhou
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/1025 , A61B5/0059
摘要： This invention provides a better apparatus and method for the generation of Optical Coherence Tomography (OCT) and Confocal Scanning Laser Ophthalmoscope (CSLO) images, using a dual-waveguiding module. A dual-waveguiding structure consists of a single-mode and a multi-mode waveguide each with optimum size and numerical aperture for highly efficient collection of the OCT and CSLO optical signals. Separation of the two signals is achieved by channeling most of the multi-mode guided optical power to a CSLO detector. The non-tapped single-mode guided optical wave is further sent to a pure single-mode fiber of a standard OCT system for OCT image generation. The present invention achieves highly efficient optical power usage and hence high signal to noise ratio, together with inherent pixel-to-pixel registration of the OCT and CSLO images, and a cost reduction of the OCT/CSLO combo system.
摘要翻译：本发明提供了使用双波导模块生成光学相干断层扫描（OCT）和共焦扫描激光眼镜（CSLO）图像的更好的装置和方法。双波导结构由单模和多模波导组成，每个具有最佳尺寸和数值孔径，用于高效收集OCT和CSLO光信号。通过将大多数多模式引导光功率传送到CSLO检测器来实现两个信号的分离。非点击式单模导波光被进一步发送到用于OCT图像生成的标准OCT系统的纯单模光纤。本发明实现了高效的光功率使用，因此实现了高信噪比，以及OCT和CSLO图像的固有像素到像素配准，以及OCT / CSLO组合系统的成本降低。

19. 发明授权

US07126693B2 Simple high efficiency optical coherence domain reflectometer design 有权
标题翻译：简单的高效光学相干域反射计设计
公开(公告)号：US07126693B2
公开(公告)日：2006-10-24
申请号：US10811748
申请日：2004-03-29
申请人： Matthew J. Everett , Yan Zhou
发明人： Matthew J. Everett , Yan Zhou
IPC分类号： G01B9/00
CPC分类号： G01M11/3181 , A61B5/0066 , A61B5/0084 , G01B9/0201 , G01B9/02044 , G01B9/02091 , G01B2290/40 , G01B2290/70 , G01N21/4795
摘要： The present invention discloses simple and yet highly efficient configurations of optical coherence domain reflectometry systems. The combined use of a polarizing beam splitter with one or two polarization manipulator(s) that rotate the returned light wave polarization to an orthogonal direction, enables one to achieve high optical power delivery efficiency as well as fixed or predetermined output polarization state of the interfering light waves reaching a detector or detector array, which is especially beneficial for spectral domain optical coherence tomography. In addition, the system can be made insensitive to polarization fading resulting from the birefringence change in the sample and reference arms. Dispersion matching can also be easily achieved between the sample and the reference arm for high resolution longitudinal scanning.
摘要翻译：本发明公开了光学相干畴反射系统的简单且高效的配置。将偏振分束器与一个或两个偏振操纵器组合使用，其将返回的光波偏振旋转到正交方向，使得能够实现高的光功率传递效率以及干涉的固定或预定的输出偏振状态光波到达检测器或检测器阵列，这对于光谱域光学相干断层扫描是特别有益的。此外，该系统可以对由样品和参考臂中的双折射变化导致的偏振衰落不敏感。也可以在样品和参考臂之间轻松实现色散匹配，实现高分辨率纵向扫描。

20. 发明授权

US07456957B2 Littrow spectrometer and a spectral domain optical coherence tomography system with a Littrow spectrometer 有权
标题翻译： Littrow光谱仪和具有Littrow光谱仪的光谱域光学相干断层扫描系统
公开(公告)号：US07456957B2
公开(公告)日：2008-11-25
申请号：US11196043
申请日：2005-08-03
申请人： Matthew J. Everett , Yan Zhou , Jochen M. M. Horn , Keith O'Hara , James P. Foley
发明人： Matthew J. Everett , Yan Zhou , Jochen M. M. Horn , Keith O'Hara , James P. Foley
IPC分类号： G01J3/28
CPC分类号： G01N21/4795 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0216 , G01J3/0224 , G01J3/0256 , G01J3/0286 , G01J3/18 , G01J3/22 , G02B5/1814 , G02B27/4244
摘要： A compact conical diffraction Littrow spectrometer is disclosed. The distortion of the conically diffracted spectral component beams is compensated and as a result, the diffracted spectral beams can still be focused into a substantially straight line to shine onto a detector array. A spectral domain optical coherence tomography (SD-OCT) system incorporating a Littrow spectrometer or a spectrometer having one or more shared focusing element(s) and an SD-OCT system incorporating a spectrometer that is substantially polarization independent are also disclosed.
摘要翻译：公开了一种紧凑的圆锥衍射Littrow光谱仪。对锥形衍射光谱分量光束的失真进行补偿，结果衍射的光束束仍可被聚焦成基本上直线以照射到检测器阵列上。还公开了包含Littrow光谱仪或具有一个或多个共享聚焦元件的光谱仪的光谱相干光学相干断层扫描（SD-OCT）系统和包含基本上偏振无关的光谱仪的SD-OCT系统。

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