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11. 发明申请

US20070202555A1 Method for judging feature of malignant tumor 失效
标题翻译：判断恶性肿瘤特征的方法
公开(公告)号：US20070202555A1
公开(公告)日：2007-08-30
申请号：US11711053
申请日：2007-02-27
申请人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
发明人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57415 , C12Q1/485 , G01N2333/4739 , G01N2333/9121 , G06F19/24
摘要： A method for judging feature of malignant tumor is described. The method comprises obtaining step, first comparing step, second comparing step and judging step. The obtaining step comprises obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell. The first comparing step comprises comparing a first threshold value with the third parameter. The second comparing comprises comparing a second threshold value with the fourth parameter. The judging step comprises judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.
摘要翻译：描述了判断恶性肿瘤特征的方法。该方法包括获得步骤，第一比较步骤，第二比较步骤和判断步骤。获得步骤包括基于包含在恶性肿瘤的肿瘤细胞中的第一细胞周期蛋白依赖性激酶（第一CDK）的活性和表达水平获得第一参数，第二参数基于第二细胞周期蛋白依赖性激酶的活性和表达水平（第二CDK），基于第一参数和第二参数的第三参数，以及基于包含在肿瘤细胞中的细胞周期蛋白的表达水平的第四参数。第一比较步骤包括将第一阈值与第三参数进行比较。第二比较包括将第二阈值与第四参数进行比较。判断步骤包括基于第一比较步骤和第二比较步骤的比较结果判断恶性肿瘤的特征。

12. 发明授权

US07754442B2 Reagent kit for determining characteristic of tissue 失效
标题翻译：用于确定组织特征的试剂盒
公开(公告)号：US07754442B2
公开(公告)日：2010-07-13
申请号：US11529998
申请日：2006-09-29
申请人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
发明人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
IPC分类号： G01N33/53
CPC分类号： C12Q1/485 , G01N2333/912 , Y10S435/81 , Y10S436/808
摘要： A reagent kit that is used for determining a characteristic of tissue obtained from a patient is described. The reagent kit comprising expression measurement reagents for measuring expression level of cyclin-dependant kinase (CDK) and activity measurement reagents for measuring activity value of CDK. The expression measurement reagents comprise first reagents and second reagents, and the activity measurement reagents comprise third reagents and fourth reagents. In the reagent kit, a first reagent set of the first and third reagents is stored under a first storage condition relating to temperature, and a second reagent set of the second and fourth reagents is stored under a second storage condition relating to temperature.
摘要翻译：描述了用于确定从患者获得的组织特征的试剂盒。该试剂盒包含用于测量细胞周期蛋白依赖性激酶（CDK）的表达水平的表达测量试剂和用于测量CDK的活性值的活性测量试剂。表达测量试剂包含第一试剂和第二试剂，活性测量试剂包括第三试剂和第四试剂。在试剂盒中，第一和第三试剂的第一试剂组在与温度有关的第一储存条件下储存，第二和第四试剂的第二试剂组在与温度有关的第二储存条件下储存。

13. 发明申请

US20060173632A1 Method for predicting effectiveness of chemotherapy 有权
标题翻译：预防化疗有效性的方法
公开(公告)号：US20060173632A1
公开(公告)日：2006-08-03
申请号：US11330137
申请日：2006-01-12
申请人： Yasuhiro Torikoshi , Yuko Kawasaki , Satoshi Nakayama , Hideki Ishihara , Tomoko Matsushima
发明人： Yasuhiro Torikoshi , Yuko Kawasaki , Satoshi Nakayama , Hideki Ishihara , Tomoko Matsushima
IPC分类号： G06F19/00
CPC分类号： C12Q1/485 , G01N33/57484 , G01N2800/52
摘要： A method for predicting an effectiveness of chemotherapy is described. The method comprises a comparing step and a predicting step. The comparing step is a step of comparing a threshold value with a parameter of a cyclin dependent kinase (CDK) included in a sample containing a tumor cell obtained from a human patient. The predicting step is a step of predicting the effectiveness based on a comparison result of said comparing step. Above stated parameter is selected from the group consisting of an activity, an expression level, and a ratio of activity to expression level.
摘要翻译：描述了一种预测化疗有效性的方法。该方法包括比较步骤和预测步骤。比较步骤是将阈值与包含在从人类患者获得的肿瘤细胞的样品中包含的细胞周期蛋白依赖性激酶（CDK）的参数进行比较的步骤。预测步骤是基于所述比较步骤的比较结果来预测有效性的步骤。上述参数选自活性，表达水平以及活性与表达水平之比组成的组。

14. 发明申请

US20110136131A1 Method for measuring enzyme activity and column for use in measuring enzyme activity 审中-公开
标题翻译：测定酶活性的方法和用于测定酶活性的色谱柱
公开(公告)号：US20110136131A1
公开(公告)日：2011-06-09
申请号：US11628063
申请日：2005-05-27
申请人： Satoshi Nakayama , Kanako Nagaoka , Hironori Kobayashi , Hideki Ishihara
发明人： Satoshi Nakayama , Kanako Nagaoka , Hironori Kobayashi , Hideki Ishihara
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54306 , G01N33/573 , G01N33/57407 , G01N2333/91215
摘要： A method of measuring an enzyme activity, which comprises the steps of: (1) introducing a sample containing an enzyme to be measured into a column packed with a packing material comprising a water-insoluble support and an antibody which is immobilized onto the support and which recognizes the enzyme to be measured, to thereby capture the enzyme with the antibody; (2) introducing a substrate for the enzyme into the column to react the enzyme captured by the antibody with the substrate; and (3) detecting a product obtained by the reaction. The above method allows the rapid measurement of an enzyme activity with good reaction efficiency.
摘要翻译：一种测量酶活性的方法，其包括以下步骤：（1）将含有待测酶的样品引入填充有包含水不溶性载体和固定在载体上的抗体的填充物的柱中，其识别要测量的酶，从而用抗体捕获酶; （2）将酶的底物引入柱中以使由抗体捕获的酶与底物反应; 和（3）检测通过反应获得的产物。上述方法允许快速测量具有良好反应效率的酶活性。

15. 发明申请

US20070003438A1 Column, sample preparation apparatus using the column, and auto analyzer 审中-公开
标题翻译：柱，样品制备装置使用色谱柱和自动分析仪
公开(公告)号：US20070003438A1
公开(公告)日：2007-01-04
申请号：US11451066
申请日：2006-06-12
申请人： Hironori Kobayashi , Hideki Ishihara , Koichi Yamagata , Satoshi Nakayama
发明人： Hironori Kobayashi , Hideki Ishihara , Koichi Yamagata , Satoshi Nakayama
IPC分类号： G01N33/48 , B01L11/00
CPC分类号： G01N1/405 , G01N2030/085 , G01N2035/1053
摘要： A column is described, as representative one of which includes: a disposable column used in a measuring sample preparator, comprising: a support immobilized a substance capable of conjugating a protein, a support holding part for holding the support, a fluid connecting part for connecting to the sample preparator, and a liquid storing part for receiving a liquid through the support held by the support holding part and storing the liquid to be collectively from the top.
摘要翻译：描述了一列，其代表性的一个包括：用于测量样品制备器中的一次性柱，包括：固定有能够结合蛋白质的物质的载体，用于保持载体的支撑保持部分，用于连接的流体连接部分以及用于通过由支撑保持部保持的支撑体接收液体并将液体从顶部集中储存的液体收容部。

16. 发明授权

US07957910B2 Method for predicting effectiveness of chemotherapy 有权
标题翻译：预防化疗有效性的方法
公开(公告)号：US07957910B2
公开(公告)日：2011-06-07
申请号：US11330137
申请日：2006-01-12
申请人： Yasuhiro Torikoshi , Yuko Kawasaki , Satoshi Nakayama , Hideki Ishihara , Tomoko Matsushima
发明人： Yasuhiro Torikoshi , Yuko Kawasaki , Satoshi Nakayama , Hideki Ishihara , Tomoko Matsushima
IPC分类号： G01N33/48 , C12Q1/68
CPC分类号： C12Q1/485 , G01N33/57484 , G01N2800/52
摘要： A method for predicting an effectiveness of chemotherapy is described. The method comprises a comparing step and a predicting step. The comparing step is a step of comparing a threshold value with a parameter of a cyclin dependent kinase (CDK) included in a sample containing a tumor cell obtained from a human patient. The predicting step is a step of predicting the effectiveness based on a comparison result of the comparing step. Above stated parameter is selected from the group consisting of an activity, an expression level, and a ratio of activity to expression level.
摘要翻译：描述了一种预测化疗有效性的方法。该方法包括比较步骤和预测步骤。比较步骤是将阈值与包含在从人类患者获得的肿瘤细胞的样品中包含的细胞周期蛋白依赖性激酶（CDK）的参数进行比较的步骤。预测步骤是基于比较步骤的比较结果来预测有效性的步骤。上述参数选自活性，表达水平以及活性与表达水平之比组成的组。

17. 发明申请

US20070077601A1 Reagent kit fr determining characteristic of tissue 失效
标题翻译：试剂盒确定组织的特征
公开(公告)号：US20070077601A1
公开(公告)日：2007-04-05
申请号：US11529998
申请日：2006-09-29
申请人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
发明人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
IPC分类号： G01N33/567
CPC分类号： C12Q1/485 , G01N2333/912 , Y10S435/81 , Y10S436/808
摘要： A reagent kit that is used for determining a characteristic of tissue obtained from a patient is described. The reagent kit comprising expression measurement reagents for measuring expression level of cyclin-dependant kinase (CDK) and activity measurement reagents for measuring activity value of CDK. The expression measurement reagents comprise first reagents and second reagents, and the activity measurement reagents comprise third reagents and fourth reagents. In the reagent kit, a first reagent set of the first and third reagents is stored under a first storage condition relating to temperature, and a second reagent set of the second and fourth reagents is stored under a second storage condition relating to temperature.
摘要翻译：描述了用于确定从患者获得的组织特征的试剂盒。该试剂盒包含用于测量细胞周期蛋白依赖性激酶（CDK）的表达水平的表达测量试剂和用于测量CDK的活性值的活性测量试剂。表达测量试剂包含第一试剂和第二试剂，活性测量试剂包括第三试剂和第四试剂。在试剂盒中，第一和第三试剂的第一试剂组在与温度有关的第一储存条件下储存，第二和第四试剂的第二试剂组在与温度有关的第二储存条件下储存。

18. 发明授权

US08257916B2 Method for detecting integrated HPV DNA 有权
标题翻译：检测HPV整合的方法
公开(公告)号：US08257916B2
公开(公告)日：2012-09-04
申请号：US12262508
申请日：2008-10-31
申请人： Noriko Oka , Masahiro Kajita , Hideki Ishihara
发明人： Noriko Oka , Masahiro Kajita , Hideki Ishihara
IPC分类号： C12Q1/70 , C12P19/34
CPC分类号： C12Q1/6886
摘要： A method for detecting integrated HPV DNA is described herein. This method comprises obtaining first and second samples, obtaining first and second information, and detecting, based on the first and second information, the HPV DNA integrated into the genome of a cell derived from a subject. The second sample comprises DNA derived from the cell, which is treated with an enzyme having exonuclease activity. The first information is related to the amount of HPV DNA in the first sample, and the second information is related to the amount of HPV DNA in the second sample.
摘要翻译：本文描述了用于检测整合的HPV DNA的方法。该方法包括获得第一和第二样本，获得第一和第二信息，并且基于第一和第二信息检测整合到从受试者得到的细胞的基因组中的HPV DNA。第二个样品包含源自细胞的DNA，其用具有核酸外切酶活性的酶处理。第一个信息与第一个样本中HPV DNA的数量相关，第二个信息与第二个样品中HPV DNA的数量有关。

19. 发明授权

US08039725B2 Electronic keyboard instrument 有权
标题翻译：电子键盘乐器
公开(公告)号：US08039725B2
公开(公告)日：2011-10-18
申请号：US12646346
申请日：2009-12-23
申请人： Takashi Kato , Takashi Fujita , Hideki Ishihara , Akiko Shinjo , Akito Oba
发明人： Takashi Kato , Takashi Fujita , Hideki Ishihara , Akiko Shinjo , Akito Oba
IPC分类号： G10H1/32 , G10H3/00
CPC分类号： G10H1/32
摘要： An electronic keyboard instrument that emits sounds in both upward and downward directions from speakers solely for upward sound emission and from speakers solely for downward sound emission to realize acoustics similar to that of acoustic piano, and constitutes rear parts of resonance chambers in a speaker box by a common partition plate to prevent the speaker box from becoming complicated in construction. Woofers directed downward are disposed at a lower part of the speaker box, and squawker directed upward are disposed at an upper part of the speaker box. The internal space of the speaker box is partitioned by one horizontal partition plate into an upper space where resonance chambers for the squawkers are defined by vertical partition plates and a lower space where resonance chambers for the woofers are defined by vertical partition plates. Rear parts of the resonance chambers are constituted by the horizontal partition plate.
摘要翻译：一种电子键盘乐器，从扬声器向上和向下方向发出声音，仅用于向上发出声音，仅从扬声器发出向下的声音发射，以实现类似于原声钢琴的声学，并构成扬声器盒中谐振腔的后部一种通用的隔板，用于防止扬声器盒的结构复杂化。扬声器箱的下部布置有向下的闷器，并且在扬声器箱的上部设置有朝上的歹徒。扬声器箱的内部空间由一个水平隔板分隔成上部空间，其中用于冲击者的共振室由垂直隔板限定，低空间用于竖式隔板限定低音单元的共鸣室。共振室的后部由水平隔板构成。

20. 发明申请

US20100240042A1 METHOD OF DETECTING METHYLATED CYTOSINE 有权
标题翻译：检测甲基化胞嘧啶的方法
公开(公告)号：US20100240042A1
公开(公告)日：2010-09-23
申请号：US12674648
申请日：2008-08-20
申请人： Masahiro Kajita , Noriko Oka , Noriaki Yamamoto , Ayako Sakai , Hideki Ishihara
发明人： Masahiro Kajita , Noriko Oka , Noriaki Yamamoto , Ayako Sakai , Hideki Ishihara
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： C12Q1/6827 , C12Q2537/164 , C12Q2525/119 , C12Q2523/115
摘要： The method for detecting a methylated cytosine of the present invention comprises the steps of:hybridizing a sample DNA with an oligonucleotide which can hybridize with a region of the sample DNA containing a cytosine suspected of being methylated and has an a basic site at the position complementary to the cytosine;reacting the hybridized sample DNA obtained in the previous step with an oxidizing agent to oxidize the cytosine when it is methylated; anddetecting the oxidized methylated cytosine.
摘要翻译：检测本发明的甲基化胞嘧啶的方法包括以下步骤：将样品DNA与能够与疑似被甲基化的胞嘧啶的样品DNA的区域杂交的寡核苷酸杂交，并且在互补位置具有基本位点到胞嘧啶; 使上一步获得的杂交样品DNA与氧化剂反应，以在甲基化时氧化胞嘧啶; 并检测氧化的甲基化胞嘧啶。

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