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11. 发明授权

US07843567B2 Methods of identifying an analyte and nucleic acid analysis 有权
标题翻译：识别分析物和核酸分析的方法
公开(公告)号：US07843567B2
公开(公告)日：2010-11-30
申请号：US12644255
申请日：2009-12-22
申请人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
发明人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
IPC分类号： G01N21/25
CPC分类号： G01N33/552 , G01N21/4788 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/7743 , G01N33/54306 , G01N33/54313 , G01N33/54366 , G01N33/54386 , G03H1/0005 , G03H1/02 , G03H1/0236 , G03H1/26 , G03H2001/0033 , G03H2001/0044 , G03H2210/53 , G03H2210/63 , G03H2230/10 , G03H2250/12 , G06K19/04 , G06K19/06009
摘要： A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.
摘要翻译：识别分析物的方法。该方法包括提供多个微粒。微粒具有沿相应微粒的主体延伸的光学检测码。微粒具有附着于其上的化学探针。每个化学探针与相应的一个代码相关联。该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。该方法还包括使用代码位置和标签位置来分析目标分析物。

12. 发明授权

US08049893B2 Methods of identifying analytes and using encoded particles 有权
标题翻译：识别分析物和使用编码的粒子的方法
公开(公告)号：US08049893B2
公开(公告)日：2011-11-01
申请号：US12941568
申请日：2010-11-08
申请人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
发明人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
IPC分类号： G01N21/25
CPC分类号： G01N33/552 , G01N21/4788 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/7743 , G01N33/54306 , G01N33/54313 , G01N33/54366 , G01N33/54386 , G03H1/0005 , G03H1/02 , G03H1/0236 , G03H1/26 , G03H2001/0033 , G03H2001/0044 , G03H2210/53 , G03H2210/63 , G03H2230/10 , G03H2250/12 , G06K19/04 , G06K19/06009
摘要： A method of identifying analytes that react with probes on encoded particles. The method includes providing a support substrate that has a plurality of the particles randomly distributed on the support substrate. The particles have elongated bodies with codes that extend along the corresponding bodies. The codes identify probes that are attached to the corresponding bodies, wherein at least some of the probes include fluorescent labels from reactions with the analytes. The method also includes detecting fluorescent signals that are emitted from the fluorescent labels. The fluorescent signals emit from random spatial locations along the support substrate. The method also includes detecting the codes of the particles at the random spatial locations along the support substrate and analyzing the codes and the fluorescent signals to identify the analytes that react with the probes on the particles.
摘要翻译：识别与编码粒子上的探针反应的分析物的方法。该方法包括提供具有随机分布在支撑衬底上的多个颗粒的支撑衬底。颗粒具有细长体，其具有沿相应体部延伸的代码。代码识别附着于相应体的探针，其中至少一些探针包括与分析物反应的荧光标记。该方法还包括检测从荧光标记物发射的荧光信号。荧光信号沿着支撑衬底从随机空间位置发射。该方法还包括沿着支撑衬底的随机空间位置检测颗粒的代码并分析代码和荧光信号以识别与颗粒上的探针反应的分析物。

13. 发明授权

US07901630B2 Diffraction grating-based encoded microparticle assay stick 有权
$Diffraction grating-based encoded microparticle assay stick$
标题翻译：基于衍射光栅的编码微粒测定棒
公开(公告)号：US07901630B2
公开(公告)日：2011-03-08
申请号：US11226914
申请日：2005-09-13
申请人： Martin A. Putnam , John A. Moon , Tuo Li
发明人： Martin A. Putnam , John A. Moon , Tuo Li
IPC分类号： G01N33/00 , G01N33/556 , G03H1/00 , C12M1/34 , C12M3/00
CPC分类号： G01N21/4788 , G01N21/6428 , G03H1/26 , G03H2001/0033
摘要： An assay stick 7 includes a transparent reaction vessel or tube 14 having one or more microbeads 8 disposed therein. The microbeads 8 have a plurality of unique identification digital codes based on a diffraction grating 12 disposed therein that are detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the tube 14 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The assay stick 7 may be reused or disposed upon completion of the assay. Alternatively, the beads may be attached to a strip or planar surface. The encoded beads can also provide traceability, quality-control, and authenticity of each bead 8 to its source and/or to the chemistry on each bead 8. Also, the low sample volume of the assay stick allows for faster reactions and better sensitivity.
摘要翻译：测定棒7包括其中设置有一个或多个微珠8的透明反应容器或管14。微珠8具有基于设置在其中的衍射光栅12的多个独特的识别数字代码，其被入射光24照射时检测。入射光24可以横向地被引导到管14的一侧或一端上，其中窄带（单波长）或多波长源，在这种情况下，码分别由光或波长光谱的空间分布表示。测定棒7可以在测定完成后重复使用或放置。或者，珠可以附接到条或平面表面。编码的珠粒还可以提供每个珠粒8到其来源和/或每个珠粒8上的化学物质的可追溯性，质量控制和真实性。而且，测定棒的低样本体积允许更快的反应和更好的灵敏度。

14. 发明授权

US07659983B2 Hybrid random bead/chip based microarray 有权
标题翻译：混合随机珠/芯片基微阵列
公开(公告)号：US07659983B2
公开(公告)日：2010-02-09
申请号：US11607837
申请日：2006-11-30
申请人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
发明人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
IPC分类号： G01N21/25
CPC分类号： G01N33/552 , G01N21/4788 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/7743 , G01N33/54306 , G01N33/54313 , G01N33/54366 , G01N33/54386 , G03H1/0005 , G03H1/02 , G03H1/0236 , G03H1/26 , G03H2001/0033 , G03H2001/0044 , G03H2210/53 , G03H2210/63 , G03H2230/10 , G03H2250/12 , G06K19/04 , G06K19/06009
摘要： A method and apparatus for performing an assay process, featuring providing microbeads in a solution, each microbead having a particle substrate with a grating with a superposition of different predetermined regular periodic variations of the index of refraction disposed in the particle along a grating axis and indicative of a code; placing the microbeads on an alignment substrate; reading codes of the microbeads and the position thereof on the alignment substrate; reading the fluorescence on each microbead and the position order thereof on the alignment substrate; and determining an assay result based on bead position order and bead code of the earlier reading steps.
摘要翻译：用于鉴定分析物的方法。该方法包括提供多个微粒，其中每个微粒具有可光学检测的代码和与代码相关联的化学探针。该方法还包括将微粒暴露于选择性结合至少一个微粒上的化学探针的靶分析物。至少一个微粒上的光学可检测标记表明目标分析物已结合到化学探针上。将微粒以随机方式提供到基底上。该方法还包括确定基片上代码的代码和代码位置，并检测至少一个微粒上的标签和基片上标签的标签位置。此外，该方法包括使用代码位置和标签位置来分析目标分析物。

15. 发明授权

US07441703B2 Optical reader for diffraction grating-based encoded optical identification elements 有权
$Optical reader for diffraction grating-based encoded optical identification elements$
标题翻译：用于衍射光栅编码光学识别元件的光学读取器
公开(公告)号：US07441703B2
公开(公告)日：2008-10-28
申请号：US10956791
申请日：2004-10-01
申请人： John A. Moon , David R. Fournier , Martin A. Putnam , Alan D. Kersey , Tuo Li
发明人： John A. Moon , David R. Fournier , Martin A. Putnam , Alan D. Kersey , Tuo Li
IPC分类号： G06K7/10
CPC分类号： G06K7/12 , B01J2219/005 , B01J2219/0056 , G06K7/1094 , G06K19/06009 , G06K2019/06225 , G06K2019/06234 , G06K2019/0629 , G07D7/0032 , G07D7/004
摘要： An optical reader system 7 for diffraction grating-based encoded microbeads (or bead reader system), comprises a reader box 100, which accepts a bead cell (or cuvette) 102 that holds the microbeads 8, having an embedded code therein. The reader box 100 interfaces along lines 103 with a known computer system 104. The reader box 100 interfaces with a stage position controller 112 and the controller 112 interfaces along a line 115 with the computer system 104 and a manual control device (or joy stick) 116 along a line 117. The reader interrogates the microbeads to determine the embedded code and/or the fluorescence level on the beads. The reader provides information similar to a bead flow cytometer but in a planar format, i.e., a virtual cytometer.
摘要翻译：用于基于衍射光栅的编码微珠（或珠读取器系统）的光学读取器系统7包括读取器盒100，其接收保持微珠8的珠细胞（或比色杯）102，其中具有嵌入代码。读取器箱100沿着线103与已知的计算机系统104相接口。读取箱100与平台位置控制器112连接，并且控制器112沿着线115与计算机系统104和手动控制装置（或操纵杆）读取器询问微珠以确定珠上的嵌入代码和/或荧光水平。读者提供类似于珠流式细胞仪的信息，但是以平面格式，即虚拟血细胞计数器。

16. 发明授权

US07126755B2 Method and apparatus for labeling using diffraction grating-based encoded optical identification elements 有权
$Method and apparatus for labeling using diffraction grating-based encoded optical identification elements$
标题翻译：使用基于衍射光栅的编码光学识别元件进行标记的方法和设备
公开(公告)号：US07126755B2
公开(公告)日：2006-10-24
申请号：US10661082
申请日：2003-09-12
申请人： John A. Moon , Martin A. Putnam , Alan D. Kersey , Tuo Li , James Dunphy , F. Kevin Didden
发明人： John A. Moon , Martin A. Putnam , Alan D. Kersey , Tuo Li , James Dunphy , F. Kevin Didden
IPC分类号： G02B5/18
CPC分类号： G03H1/0272 , B01J2219/00459 , B01J2219/00463 , B01J2219/0047 , B01J2219/005 , B01J2219/00547 , B01J2219/00576 , B01J2219/00702 , B01L3/502761 , B01L3/5085 , B01L2200/0636 , B01L2200/0668 , B01L2300/0654 , B01L2400/0409 , B01L2400/0457 , B01L2400/0487 , G03H2210/53 , G03H2230/10 , G03H2270/20 , G03H2270/24
摘要： A method and apparatus for labeling an item using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or more colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 (or from an end) with a narrow band (single wavelength) or multiple wavelength source, and the code is represented by a spatial distribution of light or a wavelength spectrum, respectively, or a combination thereof. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The encoded element 8 may be used to label any desired item, such as large or small objects, products, solids, powders, liquids, gases, plants, minerals, cells and/or animals, or any combination of or portion of one or more thereof. The label may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products.
摘要翻译：使用基于衍射光栅的编码光学识别元件8来标记物品的方法和设备包括具有设置在其中的至少一个衍射光栅12的光学基板10。光栅12具有一个或多个共同定位的间距Lambda，其表示当被入射光24照射时检测到的唯一识别数字码。入射光24可以从具有窄带（单波长）或多个波长源的基板10的一侧（或从一端）横向引导，并且代码由光或波长光谱的空间分布表示，或其组合。元件8可以提供大量独特的代码，例如大于6700万个代码，并且可以承受恶劣的环境。编码元件8可以用于标记任何期望的物品，例如大的或小的物体，产品，固体，粉末，液体，气体，植物，矿物，细胞和/或动物，或者一个或多个的任何组合或部分其中。该标签可用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。

17. 发明授权

US07190522B2 Chemical synthesis using diffraction grating-based encoded optical elements 有权
$Chemical synthesis using diffraction grating-based encoded optical elements$
标题翻译：使用基于衍射光栅的编码光学元件进行化学合成
公开(公告)号：US07190522B2
公开(公告)日：2007-03-13
申请号：US10661254
申请日：2003-09-12
申请人： John Moon , Martin A. Putnam
发明人： John Moon , Martin A. Putnam
IPC分类号： G02B5/18
CPC分类号： G03H1/0272 , B01J2219/00459 , B01J2219/00463 , B01J2219/0047 , B01J2219/005 , B01J2219/00547 , B01J2219/00576 , B01J2219/00702 , B01L3/502761 , B01L3/5085 , B01L2200/0636 , B01L2200/0668 , B01L2300/0654 , B01L2400/0409 , B01L2400/0457 , B01L2400/0487 , G03H2210/53 , G03H2230/10 , G03H2270/20 , G03H2270/24
摘要： An optical identification element having a synthesized chemical attached thereto includes an optical substrate having at least one diffraction grating disposed therein, the grating having a resultant refractive variation at a grating location, said grating being embedded within a substantially single material of said optical substrate; the grating providing an output optical signal indicative of a code when illuminated by an incident light signal propagating in free space, the code identifying at least one of the element and the chemical, the output signal not being a result of laser action with the grating when illuminated by said incident light signal; and the synthesized chemical being attached to the substrate.
摘要翻译：具有附着于其上的合成化学品的光学识别元件包括具有设置在其中的至少一个衍射光栅的光学基底，光栅在光栅位置处具有合成的折射变化，所述光栅嵌入在所述光学基底的基本上单一的材料内; 所述光栅提供指示当由在自由空间中传播的入射光信号照射时的代码的输出光信号，所述代码识别元件和化学品中的至少一个，所述输出信号不是与光栅的激光作用的结果由所述入射光信号照亮; 并且合成的化学品附着到基底上。

18. 发明授权

US08073293B2 Sensing device having a large diameter D-shaped optical waveguide 有权
标题翻译：具有大直径D形光波导的感测装置
公开(公告)号：US08073293B2
公开(公告)日：2011-12-06
申请号：US10756183
申请日：2004-01-13
申请人： Alan D. Kersey , Paul E. Sanders , Martin A. Putnam , Edward Michael Dowd
发明人： Alan D. Kersey , Paul E. Sanders , Martin A. Putnam , Edward Michael Dowd
IPC分类号： G02B6/00 , G02B6/02
CPC分类号： G01B11/18 , G01D5/35377 , G01D5/3538 , G01K11/32 , G01L1/242 , G02B6/02052 , G02B6/02057 , G02B6/274 , G02B6/2817 , G02B6/2821 , G02B6/2826 , G02B6/29334 , G02B6/4214 , H01S3/06708 , H01S3/0675 , H01S3/094003 , H01S3/094007 , H01S3/094019
摘要： An optical sensor formed from an optical waveguide having at least one core surrounded by a cladding and a large diameter generally D-shaped portion is disclosed. Axial or compressive strain across the D-shaped cross section may be determined by measuring the change in polarization or birefringence of the light output from the sensor. A layer responsive to a parameter may be disposed on a flat portion of the D-shaped portion of the sensor. The refractive index of the layer changes and/or the layer applies a strain on the sensor in response to the parameter. Changes in the refractive index of the layer alters the light output from the sensor, which is measured over time and correlated to the parameter.
摘要翻译：公开了一种由光波导形成的光学传感器，该光波导具有由包层围绕的至少一个核心和大直径大致D形的部分。可以通过测量从传感器输出的光的偏振或双折射的变化来确定穿过D形横截面的轴向或压缩应变。响应于参数的层可以设置在传感器的D形部分的平坦部分上。层的折射率改变和/或层响应于参数在传感器上施加应变。层的折射率变化改变了传感器的光输出，其随时间测量并与参数相关。

19. 发明申请

US20110033948A9 METHOD OF READING ENCODED PARTICLES 有权
标题翻译：读取编码颗粒的方法
公开(公告)号：US20110033948A9
公开(公告)日：2011-02-10
申请号：US11544309
申请日：2006-10-06
申请人： John A. Moon , Martin A. Putnam
发明人： John A. Moon , Martin A. Putnam
IPC分类号： G01N21/00
CPC分类号： G01N21/6428 , G01N21/645 , Y10T436/143333
摘要： Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The code may be digital binary or may be other numerical bases. The micro-particles 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The micro-particles 8 are functionalized by coating them with a material/substance of interest, which are then used to perform multiplexed experiments involving chemical processes, e.g., DNA testing and combinatorial chemistry.
摘要翻译：微粒8包括其中设置有至少一个衍射光栅12的光学基板10。光栅12具有多个共同定位的间距Λ，其表示当被入射光24照射时检测到的唯一识别数字码。入射光24可以从基底10的侧面以窄带（单波长）横向地引导，或多个波长源，在这种情况下，代码分别由光或波长光谱的空间分布表示。代码可以是数字二进制的，也可以是其他的数字基础。微粒子8可以提供大量唯一的代码，例如大于6700万个代码，并且可以承受恶劣的环境。通过用感兴趣的材料/物质涂覆微粒8来进行官能化，然后将其用于进行涉及化学过程（例如DNA测试和组合化学）的复合实验。

20. 发明授权

US07623624B2 Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction 有权
$Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction$
标题翻译：使用以X射线衍射为特征的光学识别元件进行标记的方法和装置
公开(公告)号：US07623624B2
公开(公告)日：2009-11-24
申请号：US11601584
申请日：2006-11-16
申请人： John A. Moon , Martin A. Putnam , Alan D. Kersey , Paul Szczepanek
发明人： John A. Moon , Martin A. Putnam , Alan D. Kersey , Paul Szczepanek
IPC分类号： G01N23/20
CPC分类号： G03H5/00 , G01N23/2005 , G03H2001/0016 , G07D7/003
摘要： An optical identification element for identifying an item. The optical identification element includes a binder material and one or more materials embedded in the binder material. The one or more materials provides an encoded composite X-ray diffraction pattern when illuminated by an X-ray beam. The encoded composite X-ray diffraction pattern is indicative of the item.
摘要翻译：一种用于识别物品的光学识别元件。光学识别元件包括粘合剂材料和嵌入粘合剂材料中的一种或多种材料。一种或多种材料在由X射线束照射时提供编码的复合X射线衍射图案。编码的复合X射线衍射图表示该项目。

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