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11. 发明申请

US20090312742A1 DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE 有权
标题翻译：药物输送泵和制造方法
公开(公告)号：US20090312742A1
公开(公告)日：2009-12-17
申请号：US12463251
申请日：2009-05-08
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
IPC分类号： A61M5/142
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
摘要翻译：可植入电解泵的实施例包括第一可膨胀隔膜和第二柔性隔膜，以及每个用于容纳流体的第一和第二室，其中第一可膨胀隔膜分隔第一和第二室并在其间提供流体阻挡物，第二室形成在第一可膨胀膜片和第二柔性膜片之间。泵还可以包括在第一室内的电解电极，用于在其中产生气体，从而使可膨胀隔膜膨胀，使得流体被迫从第二室进入套管。

12. 发明授权

US07252006B2 Implantable mechanical pressure sensor and method of manufacturing the same 有权
标题翻译：可植入式机械压力传感器及其制造方法
公开(公告)号：US07252006B2
公开(公告)日：2007-08-07
申请号：US11148124
申请日：2005-06-07
申请人： Yu-Chong Tai , Ellis Meng , Po-Jui Chen , Damien C. Rodger , Mark Humayun
发明人： Yu-Chong Tai , Ellis Meng , Po-Jui Chen , Damien C. Rodger , Mark Humayun
IPC分类号： G01L9/00
CPC分类号： A61B3/16 , A61B2562/02 , A61B2562/028 , G01L7/045
摘要： A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention includes a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.
摘要翻译：提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压可以不断监控。

13. 发明申请

US20060247664A1 Micromachined tissue anchors for securing implants without sutures 审中-公开
标题翻译：微加工组织锚，用于固定植入物，无缝线
公开(公告)号：US20060247664A1
公开(公告)日：2006-11-02
申请号：US11371219
申请日：2006-03-07
申请人： Ellis Meng , Yu-Chong Tai , Damien Rodger , Po-Jui Chen , Mark Humayun
发明人： Ellis Meng , Yu-Chong Tai , Damien Rodger , Po-Jui Chen , Mark Humayun
IPC分类号： A61F2/02 , A61B3/16
CPC分类号： A61B3/16 , A61B5/6821 , A61B5/6882
摘要： Systems and methods for attaching an implant device to tissue by mechanically (and non-invasively) anchoring the device to the tissue. The systems and methods provide a safe, practical way to attach an implant device to tissue in a non-invasive, or less invasive manner. According to the present invention, an implant device includes one or more protruding anchor-like structures for securely attaching to tissue. One or more device features, such as sensing elements, may be incorporated on the implant device. The anchor structures are configured and arranged to match the topology and features of the tissue environment where implant is to occur.
摘要翻译：通过机械地（而非侵入式）将装置固定在组织上来将植入装置附着到组织的系统和方法。该系统和方法提供了以非侵入性或较小侵入性方式将植入装置附接到组织的安全且实用的方式。根据本发明，植入装置包括用于牢固地附接到组织的一个或多个突出的锚固结构。可以在植入装置上并入一个或多个装置特征，例如感测元件。锚结构被配置和布置成匹配将要进行植入的组织环境的拓扑和特征。

14. 发明授权

US08585630B2 Implantable intraocular pressure drain 失效
公开(公告)号：US08585630B2
公开(公告)日：2013-11-19
申请号：US13555329
申请日：2012-07-23
申请人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
发明人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61B3/16 , A61B5/4836 , A61B5/6821 , A61B2562/0247 , A61B2562/028 , A61B2562/12 , F16K99/0009 , F16K99/0057 , F16K2099/0086
摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

15. 发明申请

US20120234433A1 INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP 审中-公开
标题翻译：用于填充植入式药液泵的仪器和方法
公开(公告)号：US20120234433A1
公开(公告)日：2012-09-20
申请号：US13419968
申请日：2012-03-14
申请人： Jason Shih , Sean Caffey , Mark Humayun , Fukang Jiang , Changlin Pang , Raymond Peck , Yu-Chong Tai
发明人： Jason Shih , Sean Caffey , Mark Humayun , Fukang Jiang , Changlin Pang , Raymond Peck , Yu-Chong Tai
IPC分类号： B65B31/00
CPC分类号： A61M5/14276
摘要： A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir.
摘要翻译：一种用于重新填充具有至少一个储存器的可植入泵的工具。该工具包括多个独立的流体通道; 流体储存器，其与所述流体通道中的第一流体流体连通; 流体地联接到流体通道的至少一个泵，所述至少一个泵和独立流体通道在数量上彼此不同，其中（i）泵构造成对第一流体通道施加正压以驱动流体并且（ii）泵构造成对第二流体通道施加负压; 以及用于将所述流体通道可移除地连接到所述至少一个储存器的连接器。

16. 发明授权

US08246569B1 Implantable intraocular pressure drain 有权
标题翻译：植入式眼内压排水
公开(公告)号：US08246569B1
公开(公告)日：2012-08-21
申请号：US11205757
申请日：2005-08-16
申请人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
发明人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61B3/16 , A61B5/4836 , A61B5/6821 , A61B2562/0247 , A61B2562/028 , A61B2562/12 , F16K99/0009 , F16K99/0057 , F16K2099/0086
摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.
摘要翻译：植入的聚对二甲苯管分流器可减轻眼内压力。该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。在一个实施例中，仅植入眼睛前房的管的第一端是开放的。然后监测眼内压（IOP），例如利用植入的传感器。当眼压超过临界值时，从业人员介入，用激光穿刺位于眼睛外部的管的薄化区域，从而引起流体排出并释放压力。根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

17. 发明授权

US08231608B2 Drug-delivery pumps and methods of manufacture 有权
标题翻译：药物输送泵和制造方法
公开(公告)号：US08231608B2
公开(公告)日：2012-07-31
申请号：US12463251
申请日：2009-05-08
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
IPC分类号： A61K9/22 , A61M5/142
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
摘要翻译：可植入电解泵的实施例包括第一可膨胀隔膜和第二柔性隔膜，以及每个用于容纳流体的第一和第二室，其中第一可膨胀隔膜分隔第一和第二室并在其间提供流体阻挡物，第二室形成在第一可膨胀膜片和第二柔性膜片之间。泵还可以包括在第一室内的电解电极，用于在其中产生气体，从而使可膨胀隔膜膨胀，使得流体被迫从第二室进入套管。

18. 发明申请

US20090306585A1 IMPLANTABLE PUMPS AND CANNULAS THEREFOR 有权
标题翻译：可植入的泵和腋窝
公开(公告)号：US20090306585A1
公开(公告)日：2009-12-10
申请号：US12463265
申请日：2009-05-08
申请人： Changlin Pang , Jason Shih , Fukang Jiang , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Jason Shih , Fukang Jiang , Sean Caffey , Mark Humayun , Yu-Chong Tai
IPC分类号： A61M5/168 , A61M5/165
CPC分类号： A61M5/14276 , A61F9/00781 , A61M5/148 , A61M5/16804 , A61M5/16854 , A61M2005/14204 , A61M2205/3331 , A61M2205/3368 , A61M2210/0612 , A61M2210/0693
摘要： In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components.
摘要翻译：在各种实施例中，可植入泵包括插管。泵（例如其套管）可以包括例如流量传感器，压力传感器，过滤器和/或其它部件。

19. 发明申请

US20080039792A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 有权
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20080039792A1
公开(公告)日：2008-02-14
申请号：US11686310
申请日：2007-03-14
申请人： Ellis Meng , Yu-Chong Tai , Mark Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M5/00
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： An implantable device for delivering a therapeutic agent to a patient is provided. The device includes a reservoir configured to contain a liquid comprising the therapeutic agent. The device further includes a cannula in fluid communication with the reservoir. The cannula has an outlet configured to be in fluid communication with the patient. The device further includes a first electrode and a second electrode, at least one of the first electrode and the second electrode is planar. The device further includes a material in electrical communication with the first and second electrodes. A voltage applied between the first electrode and the second electrode produces gas from the material, the gas forcing the liquid to flow from the reservoir to the outlet.
摘要翻译：提供了一种用于将治疗剂递送至患者的可植入装置。该装置包括构造成容纳包含治疗剂的液体的储存器。该装置还包括与储存器流体连通的套管。套管具有被配置成与患者流体连通的出口。该装置还包括第一电极和第二电极，第一电极和第二电极中的至少一个是平面的。该装置还包括与第一和第二电极电连通的材料。施加在第一电极和第二电极之间的电压从材料产生气体，气体迫使液体从储存器流出到出口。

20. 发明申请

US20160262876A1 Intraocular Lens with Enhanced Depth of Focus and Reduced Aberration 审中-公开
标题翻译：增强焦距和减少畸变的人工晶状体
公开(公告)号：US20160262876A1
公开(公告)日：2016-09-15
申请号：US15065380
申请日：2016-03-09
申请人： Charles DeBoer , Mark Humayun , Yu-Chong Tai
发明人： Charles DeBoer , Mark Humayun , Yu-Chong Tai
IPC分类号： A61F2/16
CPC分类号： A61F2/1659 , A61F2/1637 , A61F2002/1699 , A61F2250/0004 , A61F2250/0053
摘要： Embodiments of intraocular lenses described herein include features that enhance depth of focus and/or reduce chromatic aberration. These features may include different optical fluids, multiplexed or asymmetric lens arrangement, dispersive or diffusive elements, and others.
摘要翻译：本文所述的眼内透镜的实施例包括增强焦点深度和/或减少色差的特征。这些特征可以包括不同的光学流体，多路复用或不对称的透镜布置，分散或漫射元件等。

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