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11. 发明申请

US20050099999A1 Systems for providing information to users via communication networks 审中-公开
标题翻译：通过通信网络向用户提供信息的系统
公开(公告)号：US20050099999A1
公开(公告)日：2005-05-12
申请号：US10703968
申请日：2003-11-07
申请人： Daniel Phillips , Mark Goodman , David Hostetter , Donny McDonald
发明人： Daniel Phillips , Mark Goodman , David Hostetter , Donny McDonald
IPC分类号： H04L12/66 , H04M1/02 , H04M1/247 , H04M1/253 , H04M3/432 , H04M7/00
CPC分类号： H04M7/006 , H04M1/02 , H04M1/2477 , H04M1/2535 , H04M3/432 , H04M2250/22 , H04M2250/58
摘要： System for providing information to a user via a communication network are provided. One such system incorporates an integrated appliance that includes a housing. The housing mounts a display, a telephone, a keyboard and a first passthrough communication portal. The display is operative to display information to the user. The telephone is located adjacent to the display and is operative to provide voice communication to and from the user. The keyboard is located adjacent to and in front of the display and is operative to receive inputs from the user. The first passthrough communication portal includes a first receptacle located adjacent to the display, a second receptacle and a communication link. The first receptacle is operative to receive a communication connector of a computing device. The second receptacle is operative to receive another communication connector for communicating with a communication network such that the communication link propagates information between the computing device and the communication network.
摘要翻译：提供了通过通信网络向用户提供信息的系统。一种这样的系统包括包括壳体的集成设备。外壳装有一个显示器，一个电话机，一个键盘和一个第一通道通信门户。显示器用于向用户显示信息。电话位于显示器附近，并且可操作以向用户提供语音通信。键盘位于显示器的旁边和前面，并可操作以接收来自用户的输入。第一通道通信门户包括位于显示器附近的第一插座，第二插座和通信链路。第一容器可操作以接收计算装置的通信连接器。第二容器可操作以接收用于与通信网络通信的另一通信连接器，使得通信链路在计算设备和通信网络之间传播信息。

12. 发明申请

US20130233355A1 WASHING APPARATUS AND METHOD WITH SPIRAL AIR FLOW FOR DRYING 有权
标题翻译：用于干燥的螺旋空气流的洗涤装置和方法
公开(公告)号：US20130233355A1
公开(公告)日：2013-09-12
申请号：US13885227
申请日：2011-11-16
申请人： Martin A. Alpert , Mark Goodman , Charles H. Smoot
发明人： Martin A. Alpert , Mark Goodman , Charles H. Smoot
IPC分类号： A47L15/48
CPC分类号： A47L15/48 , A47K10/48 , A47K2210/00 , A47L15/0089 , A47L15/4242 , A47L15/486 , B08B3/024 , B08B5/02
摘要： An apparatus and method for washing and drying objects includes a rotating washing fluid sprayer having several nozzles to direct washing fluid, e.g., water, at an object being washed in a chamber. A drying fluid is directed at the object in the chamber to dry the object. The drying fluid, e.g., air, is directed in a spiral pattern against the object to urge washing liquid away from the object to dry the object and to push the drying liquid away from edges of the object. The air may be directed at the object simultaneously with the water to increase the energy with which the water impinges on the object and to urge dirt from the object being washed.
摘要翻译：用于洗涤和干燥物体的装置和方法包括旋转的洗涤液喷雾器，其具有若干喷嘴，以在待洗涤的物体在室中引导洗涤流体，例如水。将干燥流体引导到室中的物体以干燥物体。干燥流体例如空气以螺旋图案被引导到物体上以将清洗液体从物体推出以干燥物体并将干燥液体推离物体的边缘。空气可以与水同时地引导到物体上，以增加水撞击在物体上的能量，并且促使来自被洗涤物体的污物。

13. 发明申请

US20060292073A1 Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging 审中-公开
标题翻译：用于肿瘤成像的氨基酸类似物的立体选择性合成
公开(公告)号：US20060292073A1
公开(公告)日：2006-12-28
申请号：US11425051
申请日：2006-06-19
申请人： Mark Goodman , Weiping Yu
发明人： Mark Goodman , Weiping Yu
IPC分类号： A61K51/00 , C07F13/00 , C07D345/00 , C07C61/04
CPC分类号： C07D235/02 , A61K51/04 , A61K51/0402 , C07C61/04 , C07C227/20 , C07C233/81 , C07C233/84 , C07C271/24 , C07C303/28 , C07C2601/04 , C07C2601/14 , C07C309/73 , C07C229/48 , C07C309/65
摘要： The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn-[18F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn-[123I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.
摘要翻译：放射性标记的非天然氨基酸1-氨基-3-环丁烷-1-羧酸（ACBC）及其类似物是用于正电子发射断层扫描和单光子发射计算机断层摄影的候选肿瘤成像剂，由于它们对肿瘤细胞的选择性亲和力。本发明提供了立体选择性合成syn-ACBC类似物的方法。所公开的合成策略是可靠和有效的，并且可以用于合成一定数量的ACBC类似物，特别是顺式 - [F 18 F] -1-氨基-3-氟环丁烷的各种顺式异构体 -1-羧酸（FACBC）和顺式 - [123 I] -1-氨基-3-碘代环丁烷-1-羧酸（IACBC）酸类似物。

14. 发明申请

US20050192458A1 Tumor imaging compounds 有权
标题翻译：肿瘤成像化合物
公开(公告)号：US20050192458A1
公开(公告)日：2005-09-01
申请号：US10507221
申请日：2003-04-24
申请人： Mark Goodman , Jonathan McConathy
发明人： Mark Goodman , Jonathan McConathy
IPC分类号： G01T1/161 , A61K51/00 , A61K51/04 , C07C229/20 , C07C229/22 , C07F13/00 , C07C61/00 , C07C61/08
CPC分类号： C07F13/005 , A61K51/04 , A61K51/0478 , A61K51/0487 , C07B2200/05 , C07C229/20 , C07C229/22
摘要： The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properties of halogen sustituents, including certain useful halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. In addition the compounds can be labeled with technetium and rhenium isotopes using known chelation complexes. The amino acid compounds disclosed herein have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds include [18F] FAMP, ([18F]5a) and [18F]N-MeFAMP, ([18F]5b). The invention further features pharmaceutical compositions comprised of an α-amino acid moiety attached to eiher a four, five or a six member carbon-chain ring. The labeled amino acid compounds are useful as imaging agents in detecting and/or monitoring tumors in a subject by Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT).
摘要翻译：本发明提供了用于检测和评价脑和体肿瘤的新型氨基酸化合物。这些化合物结合了α-氨基异丁酸（AIB）类似物的有利性质，即它们在肿瘤中的快速摄取和延长的保留性，其具有卤素支持物质的性质，包括某些有用的卤素同位素如氟-18，碘-123，碘-124 ，碘-125，碘-131，溴-75，溴-76，溴-77，溴-82，ast ine -21，ast ine -211和其他ast同位素。此外，化合物可以使用已知的螯合络合物用锝和铼同位素标记。当在体内施用于受试者时，本文公开的氨基酸化合物对靶位点具有高特异性。优选的氨基酸化合物包括[[SUP] 18F] FAMP，（[[18 F] 5a）和[ - 18 F] N-MeFAMP，（[ F）5b）。本发明进一步包括由连接四个，五个或六个碳链环的更多的α-氨基酸部分组成的药物组合物。标记的氨基酸化合物可用作通过正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）检测和/或监测受试者的肿瘤的成像剂。

15. 发明授权

US4416145A Ultrasonic leak detecting method and apparatus 失效
标题翻译：超声波检漏方法及装置
公开(公告)号：US4416145A
公开(公告)日：1983-11-22
申请号：US347584
申请日：1982-02-10
申请人： Mark Goodman , John R. Zeno , Marty Borruso
发明人： Mark Goodman , John R. Zeno , Marty Borruso
IPC分类号： G01M3/24 , G01N29/032 , G01N29/34 , G01N29/36 , G01N29/04
CPC分类号： G01M3/24 , G01N29/032 , G01N29/34 , G01N29/36 , G01N2291/02433
摘要： Leaks or thin spots in containers, as well as mechanical faults, e.g. worn bearings, are detected by an ultrasonic energy indicator that includes a modulator that heterodynes ultrasonic signals received by a transducer and creates an audio signal related thereto. The transducer includes a series arrangement of piezoelectric crystals feeding a field-effect transistor amplifier and the modulator operates in an amplitude modulation, suppressed-carrier mode which can be stabilized by a feedback loop. For indicating the presence of the audio signal, either headphones or a meter or both are employed. When leaks in a container are being detected, an ultrasonic generator is used which varies its output frequency slowly over a band of frequencies. The leak detection technique can be improved by applying a thin layer of a liquid to the container surface so that pressure introduced into the container causes the formation and bursting of bubbles in the liquid that results in the production of ultrasonic energy.
摘要翻译：容器中的泄漏或薄斑，以及机械故障，例如。磨损的轴承由超声能量指示器检测，超声波能量指示器包括调制器，该调制器外差由换能器接收的超声波信号并产生与之相关的音频信号。换能器包括馈送场效应晶体管放大器的压电晶体的串联布置，并且调制器以可由反馈回路稳定的幅度调制抑制载波模式工作。为了指示音频信号的存在，使用耳机或仪表或两者。当检测到容器中的泄漏时，使用超声波发生器，其在频带上缓慢地改变其输出频率。泄漏检测技术可以通过向容器表面施加薄层的液体来提高，从而导致容器内的压力导致液体中气泡的形成和破裂，从而产生超声能量。

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