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11. 发明申请

US20060051403A1 Microprojection array with improved skin adhesion and compliance 审中-公开
标题翻译：具有改善皮肤粘附和顺应性的微型投影阵列
公开(公告)号：US20060051403A1
公开(公告)日：2006-03-09
申请号：US11222297
申请日：2005-09-07
申请人： James Matriano , Michel Cormier , Peter Daddona
发明人： James Matriano , Michel Cormier , Peter Daddona
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/703 , A61K9/7084 , A61M2037/0023 , A61M2037/0046
摘要： A transdermal delivery system having a microprojection array with one or more voids configured to allow an adhesive backing to attach to a user's skin and, hence, improve retention of the system thereto. Radial voids can be configured to enhance compliance of the array to conform more readily to non-flat areas of the skin.
摘要翻译：一种透皮递送系统，具有一个具有一个或多个空隙的微突出物阵列，其被配置为允许粘合剂背衬附着于使用者的皮肤，并因此改善系统对其的保持。径向空隙可以被配置为增强阵列的顺应性以更容易地符合皮肤的非平坦区域。

12. 发明申请

US20050271684A1 Apparatus and method for transdermal delivery of multiple vaccines 审中-公开
标题翻译：用于多种疫苗透皮递送的装置和方法
公开(公告)号：US20050271684A1
公开(公告)日：2005-12-08
申请号：US11084635
申请日：2005-03-18
申请人： Joseph Trautman , Peter Daddona , Michel Cormier
发明人： Joseph Trautman , Peter Daddona , Michel Cormier
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , A61K39/295 , A61M31/00 , A61M37/00 , C12Q1/70
CPC分类号： A61M37/0015 , A61K9/0021 , A61K39/00 , A61K2039/525 , A61K2039/54 , A61M37/00 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection array that includes a plurality of microprojections that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection array having a plurality of array regions, each of the array regions having a different biocompatible coating disposed thereon, wherein at least one of the array region coatings includes an immunologically active agent. In one embodiment, each coating on the array regions includes a different immunologically active agent. In another embodiment, the biocompatible coating on a first array region includes an immunologically active agent and the biocompatible coating on a second array region includes an immune response augmenting adjuvant.
摘要翻译：一种用于透皮递送免疫活性剂的装置和方法，其包括具有微突出物阵列的递送系统，所述微突出物阵列包括适于刺穿角质层进入下面的表皮层或表皮和真皮层的多个微突出物，所述微突出物阵列具有多个阵列区域，所述阵列区域中的每一个具有设置在其上的不同生物相容性涂层，其中所述阵列区域涂层中的至少一个包括免疫活性剂。在一个实施方案中，阵列区域上的每个涂层包括不同的免疫活性剂。在另一个实施方案中，第一阵列区上的生物相容性涂层包括免疫活性剂，第二阵列区上的生物相容性涂层包括免疫应答增强佐剂。

13. 发明申请

US20060142691A1 Apparatus and method for piercing skin with microprotrusions 有权
公开(公告)号：US20060142691A1
公开(公告)日：2006-06-29
申请号：US11092800
申请日：2005-03-28
申请人： Joseph Trautman , Richard Keenan , Ahmad Samiee , WeiQi Lin , Michel Cormier , James Matriano , Peter Daddona
发明人： Joseph Trautman , Richard Keenan , Ahmad Samiee , WeiQi Lin , Michel Cormier , James Matriano , Peter Daddona
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150908 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.

14. 发明申请

US20050025778A1 Microprojection array immunization patch and method 审中-公开
标题翻译：微量阵列免疫贴片及方法
公开(公告)号：US20050025778A1
公开(公告)日：2005-02-03
申请号：US10884603
申请日：2004-07-01
申请人： Michel Cormier , James Matriano , Juanita Johnson , Wendy Young , Peter Daddona
发明人： Michel Cormier , James Matriano , Juanita Johnson , Wendy Young , Peter Daddona
IPC分类号： A61B17/20 , A61M37/00 , A61K39/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0023 , A61M2037/0046
摘要： Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.
摘要翻译：公开了具有含有抗原剂的储液器的微喷射构件（10）和使用这些构件对哺乳动物（例如人）进行疫苗接种的方法。微喷射构件用于经皮递送具有显着减少的皮肤反应的抗原剂（例如疫苗抗原）。这是通过递送诱导量并随后递送一个或多个后续加强量来实现的。诱导量比增压量大。该技术广泛适用于各种各样的治疗性疫苗，以提高使用的功效和使用方便性。

15. 发明申请

US20060074377A1 Microprojection array immunization patch and method 审中-公开
标题翻译：微量阵列免疫贴片及方法
公开(公告)号：US20060074377A1
公开(公告)日：2006-04-06
申请号：US11267563
申请日：2005-11-04
申请人： Michel Cormier , James Matriano , Peter Daddona , Juanita Johnson , Wendy Young
发明人： Michel Cormier , James Matriano , Peter Daddona , Juanita Johnson , Wendy Young
IPC分类号： A61B17/20 , A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0046 , A61M2037/0061 , Y02A50/401
摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.
摘要翻译：公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥，并使用冲击施加器施用于待接种疫苗的皮肤。微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。可以控制抗原剂量和穿透深度。该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

16. 发明申请

US20060034902A1 Microprojection apparatus and system with low infection potential 审中-公开
标题翻译：具有低感染潜力的微型投影仪和系统
公开(公告)号：US20060034902A1
公开(公告)日：2006-02-16
申请号：US11201617
申请日：2005-08-10
申请人： Michel Cormier , Peter Daddona , Rolfe Anderson
发明人： Michel Cormier , Peter Daddona , Rolfe Anderson
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/06 , A61M2037/0023 , A61M2037/0046
摘要： A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.
摘要翻译：具有低感染潜能的透皮药物递送装置和系统包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或其阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，微突出物构件包括具有至少一种生物活性剂和设置在其中的至少一种抗微生物剂的生物相容性涂层。在另一个实施方案中，微突出物构件包括具有至少一种生物活性剂和至少一种抗微生物剂的水凝胶制剂。在另一个实施方案中，微突出物构件包括具有至少一种抗微生物剂和具有至少一种生物活性剂的固体膜的水凝胶制剂。

17. 发明申请

US20060200069A1 Transdermal drug delivery devices having coated microprotrusions 有权
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US20060200069A1
公开(公告)日：2006-09-07
申请号：US11347779
申请日：2006-02-02
申请人： Michel Cormier , Wendy Young , Kofi Nyam , Peter Daddona , Wei-Qi Lin
发明人： Michel Cormier , Wendy Young , Kofi Nyam , Peter Daddona , Wei-Qi Lin
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.
摘要翻译：提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

18. 发明申请

US20060093658A1 Apparatus and method for transdermal delivery of desmopressin 审中-公开
标题翻译：去氨加压素经皮递送的装置和方法
公开(公告)号：US20060093658A1
公开(公告)日：2006-05-04
申请号：US11259010
申请日：2005-10-25
申请人： Gayatri Sathyan , Richard Weyers , Peter Daddona , Peter Staehr , Suneel Gupta , Mahmound Ameri , Michel Cormier
发明人： Gayatri Sathyan , Richard Weyers , Peter Daddona , Peter Staehr , Suneel Gupta , Mahmound Ameri , Michel Cormier
IPC分类号： A61F13/02 , A61M31/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering desmopressin comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the desmopressin is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译：一种用于透皮递送去氨加压素的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），其适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，去氨加压素包含在应用于微喷射构件的生物相容性涂层中。

19. 发明申请

US20070100274A1 Transdermal Electrotransport Delivery Device Including An Antimicrobial Compatible Reservoir Composition 有权
标题翻译：透皮电传递装置包括一种抗微生物兼容的储层组成
公开(公告)号：US20070100274A1
公开(公告)日：2007-05-03
申请号：US11556413
申请日：2006-11-03
申请人： Wendy Young , Michel Cormier
发明人： Wendy Young , Michel Cormier
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
摘要翻译：具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。还提供了一种制备透皮电转运药物递送装置的方法。

20. 发明申请

US20070078096A1 Buffered drug formulations for transdermal electrotransport delivery 审中-公开
标题翻译：用于经皮电转运的缓冲药物制剂
公开(公告)号：US20070078096A1
公开(公告)日：2007-04-05
申请号：US11356339
申请日：2006-02-16
申请人： Michel Cormier , Sara Sendelbeck , Anna Muchnik , Iris Leung
发明人： Michel Cormier , Sara Sendelbeck , Anna Muchnik , Iris Leung
IPC分类号： A61K38/04 , A61N1/30
CPC分类号： A61K38/27 , A61K9/0009 , A61K9/0014 , A61K38/28 , A61K47/183 , A61K47/38 , A61N1/0424 , A61N1/044 , A61N1/0444 , A61N1/30 , A61N1/327
摘要： Buffered drug formulations for transdermal electrotransport delivery are disclosed. The formulations utilize a dipeptide as a buffer and allow for more efficient electrotransport delivery of drugs, e.g., polypeptide drugs, via the transdermal route.
摘要翻译：公开了用于透皮电转运递的缓冲药物制剂。制剂利用二肽作为缓冲液，并允许通过经皮途径更有效地电转运药物，例如多肽药物。

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