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12. 发明授权

US07163939B2 Macrocyclic kinase inhibitors 有权
标题翻译：大环激酶抑制剂
公开(公告)号：US07163939B2
公开(公告)日：2007-01-16
申请号：US10980740
申请日：2004-11-03
申请人： Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
发明人： Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
IPC分类号： C07D513/08 , A61K31/529
CPC分类号： C07D487/08
摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：具有下式的化合物可用于抑制蛋白激酶。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

13. 外观设计

USD962386S1 Water toy 有权
公开(公告)号：USD962386S1
公开(公告)日：2022-08-30
申请号：US29735843
申请日：2020-05-26
申请人： Le Wang
设计人： Le Wang

14. 发明授权

US08803250B2 Metal-oxide-semiconductor field-effect transistor and method for manufacturing the same 有权
标题翻译：金属氧化物半导体场效应晶体管及其制造方法
公开(公告)号：US08803250B2
公开(公告)日：2014-08-12
申请号：US13807308
申请日：2011-11-18
申请人： Le Wang
发明人： Le Wang
IPC分类号： H01L29/02 , H01L29/66 , H01L29/78 , H01L29/10
CPC分类号： H01L29/78 , H01L29/1033 , H01L29/66477 , H01L29/66651
摘要： A Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) is disclosed. The MOSFET includes a substrate, a well region formed in the substrate, a shallow channel layer, a channel, a gate oxide layer, a gate region, a source region, and a drain region. The shallow channel layer is formed on a portion of the well region and includes a first shallow channel region and a second shallow channel region. The channel is arranged between the first shallow channel region and the second shallow channel region and connects the first shallow channel region and the second shallow channel region. Further, the gate oxide layer is formed on a portion of the well region between the first shallow channel region and the second shallow channel region and includes a first gate oxide region and a second gate oxide region arranged on different sides of the channel. The gate region is formed on the channel and the gate oxide layer; the source region is formed in the first shallow channel region and vertically extends into the well region under the first shallow channel region; and the drain region is formed in the second shallow channel region and vertically extends into the well region under the second shallow channel region.
摘要翻译：公开了一种金属氧化物半导体场效应晶体管（MOSFET）。 MOSFET包括衬底，形成在衬底中的阱区，浅沟道层，沟道，栅极氧化物层，栅极区，源极区和漏极区。浅沟道层形成在阱区的一部分上，并且包括第一浅沟道区和第二浅沟道区。通道布置在第一浅沟道区域和第二浅沟道区域之间，并且连接第一浅沟道区域和第二浅沟道区域。此外，栅极氧化层形成在第一浅沟道区域和第二浅沟道区域之间的阱区域的一部分上，并且包括布置在沟道的不同侧上的第一栅极氧化物区域和第二栅极氧化物区域。栅极区形成在沟道和栅极氧化物层上; 源极区域形成在第一浅沟道区域中并垂直延伸到第一浅沟道区域下方的阱区域中; 并且所述漏极区域形成在所述第二浅沟道区域中并且垂直延伸到所述第二浅沟道区域下方的阱区域中。

15. 发明申请

US20110124628A1 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
公开(公告)号：US20110124628A1
公开(公告)日：2011-05-26
申请号：US12951344
申请日：2010-11-22
申请人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号： A61K31/496 , C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14 , A61K31/5377 , A61K31/517 , A61K31/541 , A61P35/00 , A61P35/02
CPC分类号： C07D471/04 , C07D491/052 , C07D519/00
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

16. 发明申请

US20100210622A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE 有权
标题翻译：杂环化合物和使用方法
公开(公告)号：US20100210622A1
公开(公告)日：2010-08-19
申请号：US12641141
申请日：2009-12-17
申请人： Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Peter Czabotar , Danette A. Dudley , Wayne J. Fairbrother , John A, Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Lisa A. Hasvold , Andrew M. Petros , Andrew J. Souers , Zhi-Fu Tao , Le Wang , Xilu Wang , Kurt Deshayes
发明人： Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Peter Czabotar , Danette A. Dudley , Wayne J. Fairbrother , John A, Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Lisa A. Hasvold , Andrew M. Petros , Andrew J. Souers , Zhi-Fu Tao , Le Wang , Xilu Wang , Kurt Deshayes
IPC分类号： A61K31/4725 , C07D417/14 , A61P35/02 , A61P35/00 , A61P9/00 , A61P7/02 , C07D471/04 , A61K31/5377 , C07D487/04 , A61K31/519 , A61K31/496 , C07D471/06 , A61K31/4745
CPC分类号： C07D417/14 , C07D471/06 , C07D473/00 , C07D487/04 , C07D495/04 , C07D513/04 , C07D513/06
摘要： In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
摘要翻译：一方面，本发明提供了其中变量X1a，X1b，X1c，X1d，Q，A，R1，B，L，E和下标m和n具有如本文所述的含义的式I化合物。另一方面，本发明提供包含式I化合物的药物组合物以及使用式I化合物治疗以表达或过表达为特征的疾病和病症（例如，癌症，血小板增多症等）的方法的Bcl-2抗凋亡蛋白，例如抗凋亡Bcl-xL蛋白。

18. 发明申请

US20090172495A1 Methods and Apparatuses for Parallel Decoding and Data Processing of Turbo Codes 审中-公开
标题翻译： Turbo码并行解码和数据处理的方法与装置
公开(公告)号：US20090172495A1
公开(公告)日：2009-07-02
申请号：US12344302
申请日：2008-12-26
申请人： Le Wang , Hongwen Yang , Hong Kui Yang
发明人： Le Wang , Hongwen Yang , Hong Kui Yang
IPC分类号： H03M13/05 , G06F11/10
CPC分类号： H03M13/2987 , H03M13/2957 , H03M13/3966 , H03M13/3972
摘要： Methods and apparatuses for parallel decoding and data processing of Turbo codes are provided. The method includes: a codeword dividing step for dividing a whole codeword into Q sub-blocks to form a plurality of boundaries between adjacent sub-blocks of the Q sub-blocks so as to decode the Q sub-blocks, wherein the decoding process comprises P times of decoding iterations, and wherein Q is a positive integer and Q>1 and P is a positive integer and P>1; and a boundary moving step for moving at least one position of the boundaries formed in a pth decoding iteration by an offset Δ before performing a (p+n)th decoding iteration, wherein p is a positive integer and 1≦p
摘要翻译：提供Turbo码并行解码和数据处理的方法和装置。该方法包括：码字分割步骤，用于将整个码字划分为Q个子块，以在Q个子块的相邻子块之间形成多个边界，以对Q个子块进行解码，其中解码过程包括 P次解码迭代，其中Q是正整数，Q> 1，P是正整数，P> 1; 以及边界移动步骤，用于在执行第（p + n）个解码迭代之前将形成在第p解码迭代中的边界的至少一个位置移动偏移量Δt，其中p是正整数，1 <= p

19. 发明授权

US07323570B2 Farnesyltransferase inhibitors 有权
标题翻译：法呢基转移酶抑制剂
公开(公告)号：US07323570B2
公开(公告)日：2008-01-29
申请号：US11459745
申请日：2006-07-25
申请人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号： C07D401/10 , C07D401/12 , A61K31/44
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译：具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。

20. 发明授权

US07211595B2 Farnesyltransferase inhibitors 有权
标题翻译：法呢基转移酶抑制剂
公开(公告)号：US07211595B2
公开(公告)日：2007-05-01
申请号：US09997323
申请日：2001-11-30
申请人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号： A61K31/415 , C07D401/04 , C07D401/12 , C07D233/32
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译：具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。

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