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11. 发明申请

US20060079478A1 Anti-cancer phosphonate analogs 失效
标题翻译：抗癌膦酸类似物
公开(公告)号：US20060079478A1
公开(公告)日：2006-04-13
申请号：US10833293
申请日：2004-04-26
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号： A61K31/7076 , A61K31/7072 , C07H19/04 , A61K31/675
CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

12. 发明申请

US20060035866A1 Phosphonate compounds having immuno-modulatory activity 失效
标题翻译：具有免疫调节活性的膦酸酯化合物
公开(公告)号：US20060035866A1
公开(公告)日：2006-02-16
申请号：US10833295
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Alan Huang , Thorsten Kirschberg , Christopher Lee , Richard Mackman , Peter Nelson , Hyung-Jung Pyun , Adrian Ray , William Watkins , Jennifer Zhang , Sundaramoorthi Swaminathan
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Alan Huang , Thorsten Kirschberg , Christopher Lee , Richard Mackman , Peter Nelson , Hyung-Jung Pyun , Adrian Ray , William Watkins , Jennifer Zhang , Sundaramoorthi Swaminathan
IPC分类号： A61K31/66
CPC分类号： A61K47/548 , A61K47/542
摘要： The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

13. 发明申请

US20050261237A1 Nucleoside phosphonate analogs 审中-公开
标题翻译：核苷类磷酸酯类似物
公开(公告)号：US20050261237A1
公开(公告)日：2005-11-24
申请号：US10832810
申请日：2004-04-26
申请人： Constantine Boojamra , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , David Oare , Vidya Prasad , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins
发明人： Constantine Boojamra , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , David Oare , Vidya Prasad , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins
IPC分类号： A61K31/675 , A61K31/7072 , A61K31/7076
CPC分类号： C07F9/65616 , C07F9/65586 , C07F9/6561 , C07H7/04 , C07H19/056 , C07H19/06 , C07H19/14 , C07H19/173
摘要： The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的核苷化合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

14. 发明申请

US20070027116A1 Therapeutic phosphonate derivatives 审中-公开
标题翻译：治疗性膦酸酯衍生物
公开(公告)号：US20070027116A1
公开(公告)日：2007-02-01
申请号：US11406750
申请日：2006-04-19
申请人： Aesop Cho , Thorsten Kirschberg , William Watkins , Maria Fardis , Lee Chong
发明人： Aesop Cho , Thorsten Kirschberg , William Watkins , Maria Fardis , Lee Chong
IPC分类号： A61K31/665 , C07F9/655
CPC分类号： C07D307/88 , A61K47/548 , C07F9/65517 , C07F9/65586
摘要： Phosphorus substituted mycophenolate derivatives with anti-cancer, anti-viral, anti-inflammatory and anti-tissue/organ transplant rejection properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit tumor growth, viral growth, inflammation, and tissue/organ transplant rejection and/or are useful therapeutically for the treatment or prevention of cancer, viral infection, inflammation and tissue/organ transplant rejection, as well as in assays for the detection of cancer, viral infection, inflammation and tissue/organ transplant rejection.
摘要翻译：公开了具有用作治疗剂和用于其它工业目的的抗癌，抗病毒，抗炎和抗组织/器官移植排斥物质的磷取代的霉酚酸衍生物。组合物抑制肿瘤生长，病毒生长，炎症和组织/器官移植排斥和/或治疗用于治疗或预防癌症，病毒感染，炎症和组织/器官移植排斥以及用于检测的检测癌症，病毒感染，炎症和组织/器官移植排斥。

15. 发明申请

US20060264404A1 Therapeutic phosphonate compounds 有权
标题翻译：治疗性膦酸酯化合物
公开(公告)号：US20060264404A1
公开(公告)日：2006-11-23
申请号：US11258621
申请日：2005-10-25
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号： A61K31/675 , C07F9/6512
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译：本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。

16. 发明申请

US20060199788A1 Anti-inflammatory phosphonate compounds 失效
标题翻译：抗炎膦酸盐化合物
公开(公告)号：US20060199788A1
公开(公告)日：2006-09-07
申请号：US10833294
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Thorsten Kirschberg , Christopher Lee , Kuei-Ying Lin , Richard Mackman , Peter Nelson , David Oare , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Thorsten Kirschberg , Christopher Lee , Kuei-Ying Lin , Richard Mackman , Peter Nelson , David Oare , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
IPC分类号： A61K31/66 , C07F9/02
CPC分类号： C07F9/65583 , A61K31/60 , A61K47/548 , C07F9/4006 , C07F9/4021 , C07F9/46 , C07F9/572 , C07F9/5728 , C07F9/65031 , C07F9/65038 , C07F9/650905 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561 , C07F9/65616
摘要： The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

17. 发明申请

US20070284954A1 TOTALLY ENCLOSED FAN COOLED MOTOR 有权
标题翻译：全封闭风扇冷却电机
公开(公告)号：US20070284954A1
公开(公告)日：2007-12-13
申请号：US11759730
申请日：2007-06-07
申请人： Chih Lin , William Watkins , Oscar Romero , Janice Fitzgerald , John Belko , Ming Kuo
发明人： Chih Lin , William Watkins , Oscar Romero , Janice Fitzgerald , John Belko , Ming Kuo
IPC分类号： H02K9/00 , H02K9/06 , H02K11/00
CPC分类号： H02K9/14 , H02K5/18 , H02K11/33
摘要： A motor assembly comprises a first end frame, a second end frame including at least one air outlet aperture, an air shroud surrounding a stator between the first end frame and the second end frame, the air shroud cooperating with the stator to form at least one air passage, and cooperating with the first end frame to form at least one air inlet aperture. The motor assembly also comprises a fan mounted on the rotating shaft, the fan operable to generate an air flow of ambient air through the at least one air inlet aperture, the at least one air passage and the at least one air outlet aperture.
摘要翻译：电动机组件包括第一端框架，第二端框架，其包括至少一个空气出口孔，围绕第一端框架和第二端框架之间的定子的空气护罩，空气罩与定子配合以形成至少一个空气通道，并且与第一端框配合以形成至少一个空气入口孔。所述马达组件还包括安装在所述旋转轴上的风扇，所述风扇可操作以产生通过所述至少一个空气入口孔，所述至少一个空气通道和所述至少一个空气出口孔的环境空气的空气流。

18. 发明申请

US20060069575A1 Process for advance payment real estate listing 审中-公开
标题翻译：预付款房地产上市流程
公开(公告)号：US20060069575A1
公开(公告)日：2006-03-30
申请号：US10949894
申请日：2004-09-24
申请人： William Watkins
发明人： William Watkins
IPC分类号： G06Q99/00
CPC分类号： G06Q10/10 , G06Q50/16
摘要： A process for advance payment real estate listing. with the steps of: Payment for listing real estate is made in advance where the real estate has not yet come to market. Process will use proprietary computer and web based systems for management of information systems and data processing. (a) computer processor for processing data, (b) storage for storing data on a storage medium, (c) first for initializing the storage medium, d) second for processing data regarding cost of service being computed on percentage of present value of home or by average of market value and assessed value as assessed by local assessing authority, (e) third for processing data regarding local real estate and economic market conditions (d) fourth for processing data regarding clients real property. (f) five for processing data regarding buyer of real estate.
摘要翻译：预付款房地产上市流程。具体步骤如下：房地产尚未上市的提前付款。流程将使用专有的基于计算机和网络的系统来管理信息系统和数据处理。（a）用于处理数据的计算机处理器，（b）用于在存储介质上存储数据的存储，（c）首先用于初始化存储介质; d）第二，用于处理关于服务成本的数据，该数据是根据家庭现值的百分比计算的或按地方评估机构评估的市场价值和评估值的平均值，（e）处理有关当地房地产和经济市场状况的数据的第三个（d）第四个处理客户不动产数据。（f）五个处理房地产买家资料。

19. 发明申请

US20060032214A1 THERMALLY STABLE LEAN NOx TRAP 有权
标题翻译：耐温稳定的氮氧化物捕捉
公开(公告)号：US20060032214A1
公开(公告)日：2006-02-16
申请号：US10710922
申请日：2004-08-12
申请人： John Li , William Watkins , Christian Goralski
发明人： John Li , William Watkins , Christian Goralski
IPC分类号： F01N3/00 , F01N3/10
CPC分类号： B01D53/9422 , B01D2255/102 , B01D2255/204 , B01D2255/2047 , B01D2255/2066 , B01D2255/2073 , B01D2255/91 , B01J23/58 , B01J23/6562 , F01N3/0807 , Y02T10/20
摘要： The present invention provides a method of removing harmful gases from an automobile exhaust. The method of the invention comprises contacting a thermally stable NOx trap composition with a first exhaust gas mixture at a temperature of at least 200° C. The first exhaust gas mixture includes exhaust gases from an internal combustion engine operating in a fuel-lean condition. After, NOx has been absorbed onto the NOx absorber material, the NOx trap composition is then contacted with a second exhaust gas composition. In this step, the second exhaust gas mixture includes exhaust gases from an internal combustion engine operating in a fuel-rich condition. The present invention also provides the NOx trap composition used in the method. The NOx trap of the invention includes a precious metal, a NOx absorber material, an oxide that inhibits the decrease in NOx storing ability of the NOx trap composition, and a support material.
摘要翻译：本发明提供一种从汽车尾气除去有害气体的方法。本发明的方法包括在至少200℃的温度下使热稳定的NO x X捕集组合物与第一废气混合物接触。第一废气混合物包括来自内燃机在燃料贫乏状态下运行。之后，NO x x吸收剂被吸收到NO x吸收剂材料上，然后将NO XSM捕集组合物与第二废气组合物接触。在该步骤中，第二废气混合物包括来自富燃料条件的内燃机的废气。本发明还提供了该方法中使用的NO x陷阱组合物。本发明的NO X阱捕集器包括贵金属，NO x x吸收材料，抑制NO x x存储能力降低的氧化物的防水组合物，以及载体材料。

20. 发明申请

US20080039427A1 Method and compositions for treating hematological malignancies 审中-公开
标题翻译：用于治疗血液恶性肿瘤的方法和组合物
公开(公告)号：US20080039427A1
公开(公告)日：2008-02-14
申请号：US11803822
申请日：2007-05-16
申请人： Adrian Ray , Daniel Tumas , Hans Reiser , William Watkins , William Lee , Lee Chong
发明人： Adrian Ray , Daniel Tumas , Hans Reiser , William Watkins , William Lee , Lee Chong
IPC分类号： A61K31/675 , A61P35/00 , A61P35/02 , C07F9/46
CPC分类号： C07F9/65616
摘要： A compound of formula 1 and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.
摘要翻译：式1化合物和/或其盐，互变异构体或溶剂合物用于治疗血液恶性肿瘤。在一个实施方案中，提供化合物1的有机酸盐，用于一般用于治疗赘生物，并且在另一个实施方案中，所述盐用碳水化合物稳定。

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